I did my WGS a couple years ago and when I started wegovy I was at 218 lbs and down to 146 in 5 months. I pulled all the GLP1 genes and found out I am a extreme hyper responder. Genes to look at are GLP1R, TCF7L2, MC4R, FGF21, UCP1, PCSK1 for how someone will respond. My interest in immunology and genetics will keep me from getting into serious trouble if I don't lower the dose. I was always around 140 lbs before dealing with an autoinflammatory disorder that prevented my body from losing weight due to the inflammation in the adipose tissue. Once I started losing weight my body's natural GLP1 kicked in and now I am losing weight too fast.
Has anyone else checked out dr Tyna Moore? She is amazing in her knowledge and success with these glp-1s. I learned so much from her videos. And she does it with low doses.
I have been on Mourjaro since November 2022 pre-diabetic I’ve only made it to 7.5 mcg dose I’ve lost 88 lbs. that’s almost 30% weightloss Don’t give up but give up the things that do not serve your new lifestyle. Mine was several things Stress Alcohol Diet that wasn’t making me feel good. I eat a higher protein diet but not everyday I’m living and working towards a better relationship with myself and life! This isn’t for everybody but it’s only going to work with efforts of changing your mind set!
Also hypo-respnders may need additional hormone therapy like microdosing estrogen etc. they could have adrenal, parathyroid tumors, cortisol issues. Everyones bodies are SO unique as is everyones health journey. I’ve literally only lost one and a half pounds a week over 14 weeks. Some weeks were actually more some. There was no weight loss. I’m just averaging it out. I hope no one gives up. I’m so happy to hear about staying at lower doses and Microdosing so many people probably would’ve been better off starting and staying lower not everybody but many.
You're right about hormones. My estrogen, dhea and testosterone are really low and corsitol high. I am on 10mg and not losing weight. I also don't have any appetite and food noise suppression. My naturopath suggested few supplements. I am hoping they will improve my hormones and assist with weight loss.
This was very helpful for me as I have been called a "Super-Responder" and I wanted to learn more. I'm reading studies and watching doctors of all kinds talk about why someone might be a hypo- or hyper-responder. It is a fascinating topic, for sure. Some say those who were sickest seem to be hypo-responders, but I defy that category having lost 205 lbs of my 405 lbs in two years. First on Trulicity for a year, now on Mounjaro for 6 months. I did 4 months on my own by not eating Uber Eats. When I started, I was as sick as they come... heart and lung issues from COVID, unable to walk, HbA1c 9.0, MASLD, CKD 3B, etc. You know the drill. And I still lost all this weight. Pretty fast, I might say. I'm still losing, but it has slowed to 5-10 pounds a month. Still nothing to sneeze at. Btw, allllll my labs are either near normal or normal. Even my CKD has moved to 3A and rising. HbA1c is 5.1. Hurrah! Thank you for this really informative and easy-to-understand video. I'm linking it to my latest blog post about the medication shortages. My Mounjaro 15mg. is nowhere to be found! Again, thank you both!
Would like to know how many people have done better on Tirzepatide (Mounjaro/Zepbound) compared to Semiglutide (ozempic/Wegovy)? I have been going low and slower on Ozempic but switching to Mounjaro this week. will start at a the lowest dose and stay there as long as i can. I lost 20 lbs over 14 weeks at the lowest dose of Ozempic. still have a ways to go but not giving up. focusing on meeting protein macros, walking 10k a day and drinking enough water each day also staying away from carbs etc.
I think there is a placebo aspect to the medicine as well. Before I took my first dose I lost five pounds, because I was already changing my life style. I felt less hungry probably hy projecting myself forward in anticipation of what was to come, if that makes sense?
I have lost 64 pounds on 2.5 mg and continue to lose. I also made major lifestyle changes. I walk 3 miles every day. I do weights at the gym 3-4 days each week. I eat in a calorie deficit and drink 1 gallon of water every day.
I did semaglutide last year and lost 18# in 6 months. My biggest was 4# first month. Got off. Just started Tirzepitide, and lost 5# in first week low dose 2.5. I eat healthy, walk, am physical at my work. But seems like Tirzep is a better choice. But I will talk to my provider about doing a sub-clinical dose of 1.25 going forward for a while. I have no appetite and have to force eating.
How long do I continue? I am on week 21 at 7.5 due to shortage I am just going to start 10 mg. I am not losing anything. I am playing with 3 lbs. so discouraging.
Same here. I've been on 2.5, 5.0, and now halfway through first month on 7.5 of Zepbound and have lost 5 pounds by going hungry all the time. I typically don't feel any appetite suppression, maybe two or three days through this whole 2.5 month journey. I just don't get why my experience (and yours) is so different from most.
I lost 10.88% in 583 days on August 27th my best loss was 15.08% I am on 10mg of Mounjaro. Should I consider and increase to 12.5 or should I try more exercise first. I know that it's better to lose weight slowly as that tends to help you keep it off. I am a type 2 diabetic and I understand that type 2 diabetics usually also lose less than those that are on this medication and not diabetic. I think I'll make an appointment with my healthcare provider to explore the possibility of increasing from 10 mg to 12.5 and will again try to increase my physical exercise.
The definition of success being 5% is kinda bs. Case in point. I started tirzepatide 9 months ago, 5'4, 195lb. I lost 10lb in the first 2 weeks. I believe this was water weight, not fat loss. I haven't lost anything else. Sure I've fluctuated by a few lbs in either direction, but I'm still down that initial 10lb. I have studied extensively to ensure I'm doing all the things, daily exercise, eating well, 1400-1800 daily calories, great sleep habits, well managed stress, intermittent fasting 14-16 hours. It's terribly frustrating to pay so much every month as a low-non resonder. BTW I've been on max 15mg dose 4-1/2 mo
Same here!! Now I’m with Weighless MD and wellness. Excellent programs and results. Six weeks and down 21 pounds. Look her up on TH-cam. She’s a dietitian with her masters degree and other certifications. She has had a brick and mortar business in Wisconsin since 2015 but they can work with anyone in the US-I live in Florida.
My clinician (I feel) wrote 10 extra starting pounds by mistake. She said I’m not a hypo responder because I lost 16 pounds in 2 months. I believe it’s only 6 pounds. Starting month 3 on whatever the 3rd dose of senaglutide is. I’m not sure it’s gonna work but -
What about switching from semaglutide to tirzepatide? I’ve heard tirzepatide is more effective . Would it help with someone who doesn’t respond to semaglutide?
@akelaward6475 My weight is #150, bmi 27; I may not be over 200 but I've definitely gained 30+ pounds rapidly in the last 4 years which has compromised activity and mobility.
I am going to assume that you are running a 500 calorie deficit from your TDEE and doing strength training 3 times a week. Are you insulin resistant? If so, check out Lumen. You can use it to get rid of the insulin resistance.
@@rachelshepherd3624 Hi, I have the same problem. I am on 10mg but no weight loss for months. I don't have any insulin resistance, vitamins/minerals deficiency, thyroid issues. I walk, go to gym 3 times per week, following high protein calorie deficit diet. I need to lose 20kgs. I don't want to up the dose even though I hardly have any appetite or food noise suppression on the current dose. Any suggestion for a Hypo responder like me? Thanks.
Surely the definition on non responders are those that get non or very little fullness or appetite suppression. If they have thus then the drug is working , weight loss comes from a calorie deficit which is helped by the appetite suppression
@archerandthemouse I relate and appreciate your observant, detailed description of your experience. I feel like I can't predict what will feel/taste good anymore. 35 pounds may seem little compared to many, but when those 35 arrived rapidly in a menopause rush, there's a certain desperation to take back control; the glp-1 alas has not been giving me that sense of agency over what's going on in my body. More exercise helps me, but that's not always possible everyday. I feel like I had more success last year when I got very serious about intermittent fasting of rolling 36 hour fasts, (I was not on a glp-1) last year. Odd experience for me so far.
It is hilarious that this fine expert discussion gets interrupted every 2 minutes by a lady advertising a homemade ‘Mounjaro’ that is ten times more effective than Ozempic!!!! I guess that means that since Ozempic leads to an average 15% weight loss, I could expect to lose 150% of my weight!!! Doctors, take note!
I did my WGS a couple years ago and when I started wegovy I was at 218 lbs and down to 146 in 5 months. I pulled all the GLP1 genes and found out I am a extreme hyper responder. Genes to look at are GLP1R, TCF7L2, MC4R, FGF21, UCP1, PCSK1 for how someone will respond. My interest in immunology and genetics will keep me from getting into serious trouble if I don't lower the dose. I was always around 140 lbs before dealing with an autoinflammatory disorder that prevented my body from losing weight due to the inflammation in the adipose tissue. Once I started losing weight my body's natural GLP1 kicked in and now I am losing weight too fast.
Has anyone else checked out dr Tyna Moore? She is amazing in her knowledge and success with these glp-1s. I learned so much from her videos. And she does it with low doses.
I have been on Mourjaro since November 2022 pre-diabetic I’ve only made it to 7.5 mcg dose I’ve lost 88 lbs. that’s almost 30% weightloss
Don’t give up but give up the things that do not serve your new lifestyle. Mine was several things
Stress
Alcohol
Diet that wasn’t making me feel good.
I eat a higher protein diet but not everyday
I’m living and working towards a better relationship with myself and life!
This isn’t for everybody but it’s only going to work with efforts of changing your mind set!
You mean mg right
I am on 10mg and it does not suppress my appetite and hunger anymore.
I seem to be Hyper responsive. Down 10lb in 1st week on 0.25mg! I have PCOS and started at 240lb 5'7".
Also hypo-respnders may need additional hormone therapy like microdosing estrogen etc. they could have adrenal, parathyroid tumors, cortisol issues. Everyones bodies are SO unique as is everyones health journey. I’ve literally only lost one and a half pounds a week over 14 weeks. Some weeks were actually more some. There was no weight loss. I’m just averaging it out. I hope no one gives up. I’m so happy to hear about staying at lower doses and Microdosing so many people probably would’ve been better off starting and staying lower not everybody but many.
You're right about hormones. My estrogen, dhea and testosterone are really low and corsitol high. I am on 10mg and not losing weight. I also don't have any appetite and food noise suppression. My naturopath suggested few supplements. I am hoping they will improve my hormones and assist with weight loss.
This was very helpful for me as I have been called a "Super-Responder" and I wanted to learn more. I'm reading studies and watching doctors of all kinds talk about why someone might be a hypo- or hyper-responder. It is a fascinating topic, for sure. Some say those who were sickest seem to be hypo-responders, but I defy that category having lost 205 lbs of my 405 lbs in two years. First on Trulicity for a year, now on Mounjaro for 6 months. I did 4 months on my own by not eating Uber Eats. When I started, I was as sick as they come... heart and lung issues from COVID, unable to walk, HbA1c 9.0, MASLD, CKD 3B, etc. You know the drill. And I still lost all this weight. Pretty fast, I might say. I'm still losing, but it has slowed to 5-10 pounds a month. Still nothing to sneeze at. Btw, allllll my labs are either near normal or normal. Even my CKD has moved to 3A and rising. HbA1c is 5.1. Hurrah! Thank you for this really informative and easy-to-understand video. I'm linking it to my latest blog post about the medication shortages. My Mounjaro 15mg. is nowhere to be found! Again, thank you both!
Wow. You’ve done amazing. Well done
only fascinating when you are a super-responder, not so much for a hyper responder.
@@reneeredding4861 They are the same thing. Did you mean hypo? Low responder?
@@HealthAtAnyCost I am on 10mg and not losing weight. It does not even suppress my appetite and food noise. Not sure if upping to 15mg will help me.
That would be great for the insurance to cover weightloss injection because its preventative and need it to keep medical issues in control.
I’m confused it’s not fun to take a drug which is not providing the expected results.
Would like to know how many people have done better on Tirzepatide (Mounjaro/Zepbound) compared to Semiglutide (ozempic/Wegovy)? I have been going low and slower on Ozempic but switching to Mounjaro this week. will start at a the lowest dose and stay there as long as i can. I lost 20 lbs over 14 weeks at the lowest dose of Ozempic. still have a ways to go but not giving up. focusing on meeting protein macros, walking 10k a day and drinking enough water each day also staying away from carbs etc.
I think there is a placebo aspect to the medicine as well. Before I took my first dose I lost five pounds, because I was already changing my life style. I felt less hungry probably hy projecting myself forward in anticipation of what was to come, if that makes sense?
I have lost 64 pounds on 2.5 mg and continue to lose. I also made major lifestyle changes. I walk 3 miles every day. I do weights at the gym 3-4 days each week. I eat in a calorie deficit and drink 1 gallon of water every day.
I haven’t had any side effects either.
So inspiring, its a tool along with all of those lifestyle changes you've made 🥰
Good stuff guys, thank you.! ✨
I did semaglutide last year and lost 18# in 6 months. My biggest was 4# first month.
Got off.
Just started Tirzepitide, and lost 5# in first week low dose 2.5.
I eat healthy, walk, am physical at my work. But seems like Tirzep is a better choice. But I will talk to my provider about doing a sub-clinical dose of 1.25 going forward for a while.
I have no appetite and have to force eating.
How long do I continue? I am on week 21 at 7.5 due to shortage I am just going to start 10 mg. I am not losing anything. I am playing with 3 lbs. so discouraging.
Same here. I've been on 2.5, 5.0, and now halfway through first month on 7.5 of Zepbound and have lost 5 pounds by going hungry all the time. I typically don't feel any appetite suppression, maybe two or three days through this whole 2.5 month journey. I just don't get why my experience (and yours) is so different from most.
@@ElizabethMays-q7p Hi, have you had any luck? I am on 10mg but no weight loss, no appetite or food noise suppression. I have idea what to do now
Surgery didn't work either been there done that. My appetite is small eating about 1500 per day 100 grams protein.
Me too
I lost 10.88% in 583 days on August 27th my best loss was 15.08% I am on 10mg of Mounjaro. Should I consider and increase to 12.5 or should I try more exercise first. I know that it's better to lose weight slowly as that tends to help you keep it off. I am a type 2 diabetic and I understand that type 2 diabetics usually also lose less than those that are on this medication and not diabetic. I think I'll make an appointment with my healthcare provider to explore the possibility of increasing from 10 mg to 12.5 and will again try to increase my physical exercise.
The definition of success being 5% is kinda bs. Case in point. I started tirzepatide 9 months ago, 5'4, 195lb. I lost 10lb in the first 2 weeks. I believe this was water weight, not fat loss. I haven't lost anything else. Sure I've fluctuated by a few lbs in either direction, but I'm still down that initial 10lb. I have studied extensively to ensure I'm doing all the things, daily exercise, eating well, 1400-1800 daily calories, great sleep habits, well managed stress, intermittent fasting 14-16 hours. It's terribly frustrating to pay so much every month as a low-non resonder. BTW I've been on max 15mg dose 4-1/2 mo
I lost 12lbs in 2 months then nothing for the next 4 months. So only lost 6%. Can't continue if don't lose more weight to much money.
Same here!! Now I’m with Weighless MD and wellness. Excellent programs and results. Six weeks and down 21 pounds. Look her up on TH-cam. She’s a dietitian with her masters degree and other certifications. She has had a brick and mortar business in Wisconsin since 2015 but they can work with anyone in the US-I live in Florida.
My clinician (I feel) wrote 10 extra starting pounds by mistake. She said I’m not a hypo responder because I lost 16 pounds in 2 months. I believe it’s only 6 pounds. Starting month 3 on whatever the 3rd dose of senaglutide is. I’m not sure it’s gonna work but -
6 pounds in 2 months is very normal and acceptable…unless you started morbidly obese
What about switching from semaglutide to tirzepatide? I’ve heard tirzepatide is more effective . Would it help with someone who doesn’t respond to semaglutide?
I’m responding to tirzepatide about the same regarding weight loss, but side effects are much better
If im a hyporesponder (1 pound after 3+ months, currently @ 10 mg Tirzepatide), should i titrate down if i want to stop?
Wow, 1 pound. Hmmm, it has been three months? Are you under 245lbs?
@akelaward6475 My weight is #150, bmi 27; I may not be over 200 but I've definitely gained 30+ pounds rapidly in the last 4 years which has compromised activity and mobility.
I am going to assume that you are running a 500 calorie deficit from your TDEE and doing strength training 3 times a week. Are you insulin resistant? If so, check out Lumen. You can use it to get rid of the insulin resistance.
@@ChristineWilliams-id3owhow tall are you?
@@rachelshepherd3624 Hi, I have the same problem. I am on 10mg but no weight loss for months. I don't have any insulin resistance, vitamins/minerals deficiency, thyroid issues. I walk, go to gym 3 times per week, following high protein calorie deficit diet. I need to lose 20kgs. I don't want to up the dose even though I hardly have any appetite or food noise suppression on the current dose. Any suggestion for a Hypo responder like me? Thanks.
Surely the definition on non responders are those that get non or very little fullness or appetite suppression. If they have thus then the drug is working , weight loss comes from a calorie deficit which is helped by the appetite suppression
Take compound. It’s much cheaper
@archerandthemouse I relate and appreciate your observant, detailed description of your experience. I feel like I can't predict what will feel/taste good anymore. 35 pounds may seem little compared to many, but when those 35 arrived rapidly in a menopause rush, there's a certain desperation to take back control; the glp-1 alas has not been giving me that sense of agency over what's going on in my body. More exercise helps me, but that's not always possible everyday. I feel like I had more success last year when I got very serious about intermittent fasting of rolling 36 hour fasts, (I was not on a glp-1) last year. Odd experience for me so far.
It is hilarious that this fine expert discussion gets interrupted every 2 minutes by a lady advertising a homemade ‘Mounjaro’ that is ten times more effective than Ozempic!!!! I guess that means that since Ozempic leads to an average 15% weight loss, I could expect to lose 150% of my weight!!! Doctors, take note!