This who video is really setting up the premise of a question and not answering any questions. I personally wish I didn't spend 20 minutes watching it.
Yeah…. Maybe put in title “sneak peak”. Who knows if the next time I click on a video from this show that it will be a waste of time. Who knows if I’ll even click again…?
Negative side effects of these drugs are sometimes the same as that which you get from large caloric deficit.... That can, for example, include significant sleep disruption which can in turn result in negative psychological impacts. The suicidal ideation side effect imho is possibly a indirect side effect of disrupted sleep, particularly certain phases of sleep that we need most for mood regulation (refer to matt walker for more on that)
And yet these drugs can help people overcome sleep apnea. BTW, there are many drugs that warn against suicidal ideation. Even if it's close to the placebo, it still has to be included.
Sorry bruh, despite being someone who has a HUGE doubts about Peter's nutrution statements and expertise, I must defend him here: anyone who works on content that solid for that long, especially when it's also that important for people AND making it wrong could harm people's health, he completely deserves money he makes. And yes, MAKES, not takes without permission. It's not yours to say he has to give it free. You want free? Go read thousands of studies on your own, make your MD or PHD. Also, I'd like to point out that he doesn't do this nonsense sponsoring ads mid-video I hate to my bones personally. The guy has a team, has years of hard work in the field, has reputation to maintain, research to keep up or even do himself. Do you think stuff like this is being made with minimum vage salary? Stop being jealous commie and make something of yourself instead of hating everyone who has more.
Not sure I even want to hear Attia’s latest ‘deep-dive’ on GLP-1s (not that we were in any danger of getting any real takes in this very long ‘preview’). 😒 Why? Well, ‘cuz Peter often ‘says weird things’ about these meds. Stuff like, “I’m seeing that half the weight loss is lean mass, and sometimes it’s two-thirds lean mass”… and then literally everyone else is like, “Yeah… we’re not seeing that. That seems pretty exaggerated.” Dr Spencer Nadolsky, for one. For myself, it’s been more like one-third… which is pretty much bang in-line with what it was for me with ‘natural’/non-GLP-1 weight-loss. IOW, no difference. 🤷🏻♂️ So, not sure what’s up with Peter on this. Maybe the latest deep-dive is an attempt by him to ‘evolve’ on some of the things he’s maintained in the past. If so, and to the extent that’s the case, cool… but other clinicians had access to the same data Peter did back when Peter said the stuff he did, and did not come to what were some fairly odd conclusions, in retrospect. 🤔 It just does not lend confidence, at the end of the day. One does not have to like GLP-1s… but if one is an outlier on ‘what the nature of reality is’, then yeah, it gets kinda weird. 🫤 I think for GLP-1s, at least, I gotta get my info from other clinicians.
While I agree this was almost devoid of content, the AMA have always been like this, just a sneak peek of the full episodes. I've stopped listening to the AMA and just mine the comments to get the gist of what's happening. Anyway Peter puts out a lot of good free content in YT, that's enough for me.
Wow. A 20 min advertisement for your premium subscription and you didn't explain anything. You're making it really hard to use you as a source of information
I'm surprised you haven't had Dr. Tyna Moore on your show to do a deep dive in the research and the clinical implications and results with individualized dosing of GLP1s. It's research driven relevance your audience would appreciate and would also give a snapshot of the future of these peptides given that 20+ more are going to hit the market in the next 18 months. It seems she's being interviewed on this as a frontrunner in customized medicine for her approach in this everywhere but here!
Attia doesn't sell Wegovy. As a doctor, he prescribes it. Novo Nordisk and Eli Lilly are the two major companies who are profiting off of these GLP-1 or GIP type drugs.
Re: long term safety. You know, it's not good statistical reasoning to say that some novel side effect will be found once these drugs are used in the general population. The whole point of randomized human trials is to make a valid statistical inference from the trial group to the general population. If novel side-effects occur, it means the trials were poorly conducted.
Why would randomized trials show effects of these drugs on dementia for example if these trials are not designed to do that? I’m not an expert or anything close to that but I don’t understand why you would expect all “novel side effects” be accounted for.
No, this is not true at all. You almost always end up with novel side-effects after releasing drugs to the general population because of the limitations of RCTs. You may miss some small subsegment of the population that has some crazy genetic mutation that you have absolutely no clue that the drug would interact with this genetic mutation at all. Our bodies are extremely complicated and mechanistically, we only know so much about how any drug interacts with our bodies. The secondary point is that RCTs can only go for so long. You could do trials for 10 years or more, but you don't see longer term side-effects until the 20 or 30 year mark. RCTs are not perfect, they will never be perfect, and their imperfections are not because they're "poorly conducted."
@@nichtsistkostenlos6565 I agree up to a point. I'm primarily reacting to those crackpot diet gurus who upload videos warning about the DIRE THREAT of taking GLP-1 drugs, e.g., "You don't know how it's going to affect your body 10 years from now. It could KILL you" Then they follow up by offering an expensive diet planning app -- which, of course, has never been subjected to randomized testing.
I agree ! What a waste of time ! Like in this economy we all have 20 bucks a month to purchase a blog . You are very smart Peter but that is just dumb !
I am a Type 2 diabetic and take .5 MG Ozempic. The 1 MG dose is too much for my GI system. I am very pleased with seeing my blood glucose going down and am not as hungry as I used to be. However, I do NOT think it is for non-diabetics.
Why do you say that? Obesity is linked with cardiovascular problems much more so than is diabetes. Besides while they're the same drug, Ozempic is branded for diabetics and Wegovy is branded for obesity management. (Same with Mounjaro and Zepbound.) We should not be dictating who should receive treatment or not, or who should receive a drug or go without.
Studies are showing it's very beneficial for many systems in the body. It's been really beneficial to my partner with heart issues, his cardiologist is thrilled with the results. My partner isn't a diabetic. This isn't just for diabetics. By the way I'm T1 for 40 years and it's amazing what it's done for me too
Is it the wegovy or are you experiencing the side effects of nutritional deficiencies? Did you Hedonistically eat before you started? Did you replace the hedonistic eating with another habit that creates dopamine, like walking or exercising?
Attia. I like your interviewer he had a lot of light on in his room and he had books in the background that’s a nice background books always but you just sitting in the dark that’s not very appealing just giving you some feedback if you wanna know about your new studio
If this Sneak Peek was pushed out because it was SOOOO important, you would not put the full podcast behind a paywall. I've been on Ozempic for 2 months as a T2 diabetic !! I probably could benefit from your information, but I'm not paying $20 to get it. LOOOSER !!!
I love what you're doing! Keep it up! Congrats on the new studio. I only watched a few minutes of this one and would echo what someone else had commented on about the new studio--needs to be brighter.
Hosts video is still highly distracting, disturbing. Commentary is fine, but the video appears AI generated, the head motions seem jerky like low frame rate. Watching items in the background they move up and down like the camera is bouncing, but not as much as previous videos.
![Pros and cons of GLP-1 weight loss drugs and metformin as a geroprotective agent [AMA 45 sneak peek]](http://i.ytimg.com/vi/GCCHOBLTiCk/mqdefault.jpg)
![Pros and cons of GLP-1 weight loss drugs and metformin as a geroprotective agent [AMA 45 sneak peek]](/img/tr.png)
This who video is really setting up the premise of a question and not answering any questions. I personally wish I didn't spend 20 minutes watching it.
agree!
and new studio too dark!
Wow! _Twenty minutes_ without saying anything at all!
That's a record for you, Peter.
Please don't attempt to beat it.
It was impressive, in its own weird way.
Well, that was a drag and waste of time.
20 seconds in and just read your comment so I'm out 😂
bought 3 copies of your book Peter.
Should be able to watch whole podcast for free.
You make pkenty of $$$$.
Why gouge us?
That’s it for me. Unsubscribe and previously a big fan .
No more. You are now all about $$$
not health.
Exactly. Why can’t you just read 45 ads like Huberman, at least we can skip through those.
I agree, unsubscribing. It was nice while it lasted Peter.
Yeah…. Maybe put in title “sneak peak”. Who knows if the next time I click on a video from this show that it will be a waste of time. Who knows if I’ll even click again…?
First clickbait-only video of Peter Attia.
Seriously, wtf.
Negative side effects of these drugs are sometimes the same as that which you get from large caloric deficit....
That can, for example, include significant sleep disruption which can in turn result in negative psychological impacts. The suicidal ideation side effect imho is possibly a indirect side effect of disrupted sleep, particularly certain phases of sleep that we need most for mood regulation (refer to matt walker for more on that)
I believe the majority around 95 percent of serotonin is made in the gut.
And yet these drugs can help people overcome sleep apnea. BTW, there are many drugs that warn against suicidal ideation. Even if it's close to the placebo, it still has to be included.
Great video & information.
Panic! We are releasing this podcast early so we can inform you about all the important matters around GLP-1 inhibitors. So long as you pay me 💸
shocking
he us all about $$$ now
Sorry bruh, despite being someone who has a HUGE doubts about Peter's nutrution statements and expertise, I must defend him here: anyone who works on content that solid for that long, especially when it's also that important for people AND making it wrong could harm people's health, he completely deserves money he makes. And yes, MAKES, not takes without permission. It's not yours to say he has to give it free. You want free? Go read thousands of studies on your own, make your MD or PHD.
Also, I'd like to point out that he doesn't do this nonsense sponsoring ads mid-video I hate to my bones personally. The guy has a team, has years of hard work in the field, has reputation to maintain, research to keep up or even do himself. Do you think stuff like this is being made with minimum vage salary?
Stop being jealous commie and make something of yourself instead of hating everyone who has more.
@@Gref75 it’s more that the whole thing was a trailer with zero information 🤪 but whatever.
Not sure I even want to hear Attia’s latest ‘deep-dive’ on GLP-1s (not that we were in any danger of getting any real takes in this very long ‘preview’). 😒
Why? Well, ‘cuz Peter often ‘says weird things’ about these meds.
Stuff like, “I’m seeing that half the weight loss is lean mass, and sometimes it’s two-thirds lean mass”… and then literally everyone else is like, “Yeah… we’re not seeing that. That seems pretty exaggerated.” Dr Spencer Nadolsky, for one.
For myself, it’s been more like one-third… which is pretty much bang in-line with what it was for me with ‘natural’/non-GLP-1 weight-loss. IOW, no difference. 🤷🏻♂️
So, not sure what’s up with Peter on this. Maybe the latest deep-dive is an attempt by him to ‘evolve’ on some of the things he’s maintained in the past.
If so, and to the extent that’s the case, cool… but other clinicians had access to the same data Peter did back when Peter said the stuff he did, and did not come to what were some fairly odd conclusions, in retrospect. 🤔
It just does not lend confidence, at the end of the day.
One does not have to like GLP-1s… but if one is an outlier on ‘what the nature of reality is’, then yeah, it gets kinda weird. 🫤
I think for GLP-1s, at least, I gotta get my info from other clinicians.
wants our money!
While I agree this was almost devoid of content, the AMA have always been like this, just a sneak peek of the full episodes. I've stopped listening to the AMA and just mine the comments to get the gist of what's happening. Anyway Peter puts out a lot of good free content in YT, that's enough for me.
Would love to see the whole episode, but 19 dollars is a bit much for a fee. Love your videos!
especially if we shelled out $30 for his book. x 3 for me to give to family. WTF?
Wow. A 20 min advertisement for your premium subscription and you didn't explain anything. You're making it really hard to use you as a source of information
19.00 a month for the full video. That's right folks...
no way
already pay for premium YT woth no ads
why would I Pay $20
a month to hear whole program because
you don’t have ads on your podcast Peter?
I'm surprised you haven't had Dr. Tyna Moore on your show to do a deep dive in the research and the clinical implications and results with individualized dosing of GLP1s. It's research driven relevance your audience would appreciate and would also give a snapshot of the future of these peptides given that 20+ more are going to hit the market in the next 18 months. It seems she's being interviewed on this as a frontrunner in customized medicine for her approach in this everywhere but here!
Sales pitch
nothing more and waste of time
Attia doesn't sell Wegovy. As a doctor, he prescribes it. Novo Nordisk and Eli Lilly are the two major companies who are profiting off of these GLP-1 or GIP type drugs.
Re: long term safety. You know, it's not good statistical reasoning to say that some novel side effect will be found once these drugs are used in the general population. The whole point of randomized human trials is to make a valid statistical inference from the trial group to the general population. If novel side-effects occur, it means the trials were poorly conducted.
Isn’t that what phase 4 monitoring is for?
Why would randomized trials show effects of these drugs on dementia for example if these trials are not designed to do that? I’m not an expert or anything close to that but I don’t understand why you would expect all “novel side effects” be accounted for.
No, this is not true at all. You almost always end up with novel side-effects after releasing drugs to the general population because of the limitations of RCTs. You may miss some small subsegment of the population that has some crazy genetic mutation that you have absolutely no clue that the drug would interact with this genetic mutation at all. Our bodies are extremely complicated and mechanistically, we only know so much about how any drug interacts with our bodies. The secondary point is that RCTs can only go for so long. You could do trials for 10 years or more, but you don't see longer term side-effects until the 20 or 30 year mark. RCTs are not perfect, they will never be perfect, and their imperfections are not because they're "poorly conducted."
Ummm... No lol. That is incorrect.
@@nichtsistkostenlos6565 I agree up to a point. I'm primarily reacting to those crackpot diet gurus who upload videos warning about the DIRE THREAT of taking GLP-1 drugs, e.g., "You don't know how it's going to affect your body 10 years from now. It could KILL you"
Then they follow up by offering an expensive diet planning app -- which, of course, has never been subjected to randomized testing.
Where are the answers?
This was bad. Unsubscribed.
Well, there goes 20 mins into nothing
I agree ! What a waste of time ! Like in this economy we all have 20 bucks a month to purchase a blog . You are very smart Peter but that is just dumb !
I am a Type 2 diabetic and take .5 MG Ozempic. The 1 MG dose is too much for my GI system. I am very pleased with seeing my blood glucose going down and am not as hungry as I used to be. However, I do NOT think it is for non-diabetics.
You’ll be thrilled that the drug manufacturers are now looking at expanding the use case to anyone “at risk of overweight”.
Why do you say that? Obesity is linked with cardiovascular problems much more so than is diabetes. Besides while they're the same drug, Ozempic is branded for diabetics and Wegovy is branded for obesity management. (Same with Mounjaro and Zepbound.) We should not be dictating who should receive treatment or not, or who should receive a drug or go without.
@@VernCrisler just my opinion.
Studies are showing it's very beneficial for many systems in the body. It's been really beneficial to my partner with heart issues, his cardiologist is thrilled with the results. My partner isn't a diabetic. This isn't just for diabetics. By the way I'm T1 for 40 years and it's amazing what it's done for me too
Where is the full episode?????
on his website for members. $19 a month
he wants us to pay!
It’s actually not on the website.
I don’t care for the dark background. I like light. Dr Attia. Turn more lights on. Have a pretty background. Why a plain brown background ? Hmmm
Give me back my 20 minutes.
I was on Wegovy for about 4-5 months and I feel it took away my dopamine. I’m not excited about ANYTHING. How to I get it back? 😩
Is it the wegovy or are you experiencing the side effects of nutritional deficiencies? Did you Hedonistically eat before you started? Did you replace the hedonistic eating with another habit that creates dopamine, like walking or exercising?
What dose were you taking?
@@Justin-xs2yo I walk for an hour while I was on it since my body was too weak to lift weights
@@VernCrisler the lowest dosage
@@vvc_551 It's all in your head then. The lowest dose just gets you used to the drug; it does not get you into the therapeutic range.
I wonder the effect of these on glucagon secretion for fuel mobilization during exercise.
Waste of time , this guy used to be useful..
Attia. I like your interviewer he had a lot of light on in his room and he had books in the background that’s a nice background books always but you just sitting in the dark that’s not very appealing just giving you some feedback if you wanna know about your new studio
I thought the same exact thing!
I find it's easier to focus on what's being said than focusing on the stuff around. I like his background much better 🤭
@@SKyser-i5kcan’t see him talking
you didnt answer anything
If this Sneak Peek was pushed out because it was SOOOO important, you would not put the full podcast behind a paywall. I've been on Ozempic for 2 months as a T2 diabetic !!
I probably could benefit from your information, but I'm not paying $20 to get it. LOOOSER !!!
-Could you explain the 101 of this in 4 sentences?
- Proceeds with answering with a PhD thesis which essencially answers nothing.
Common.
I like the new studio, but I will miss the race car tire on the wall.
TN State Employees insurance will no longer cover these meds. There's a few women I work with on them.
Interesting listening on a good topic. What's up with the Huberman looking studio and black button-down shirt ??? LOL
Peter trolling us. 😂
One big ad to get sign up for paying them. Disappointing that they hid all medical information and wasted time on this disgraceful ad.
It was not a good look for them, no.
I love what you're doing! Keep it up! Congrats on the new studio. I only watched a few minutes of this one and would echo what someone else had commented on about the new studio--needs to be brighter.
don’t love it
terrible look
How does this guy have so much spare time to dribble and that blab. Just tell us you wanna sell your podcasts
Thoughts on meth-blue
Wow, I hope I remember not to watch your videos again!
lighting is really bad!
Cannot see you!
Novo Nordisk is a $500 billion dollar 💵 corporation- biggest company in Denmark 🇩🇰 follow the money 💰
Eli Lilly is pretty big too.
When are you going to talk about schweaty balls? This has a real NPR tone.
This is a sad bait and switch.
Why increase insulin if you have resistance?
To prevent diabetes.
Hosts video is still highly distracting, disturbing. Commentary is fine, but the video appears AI generated, the head motions seem jerky like low frame rate. Watching items in the background they move up and down like the camera is bouncing, but not as much as previous videos.
That was annoying.
Ummmm 🤨 maybe a 180 shift
Why did I listen to this? Utter guff
Shill
I agree. Waste of time.
👌