Your videos are amazing as usual, and I love the way this was organized and presented from discussing Limited Scleroderma to diffuse. However, It seems like there are some slightly conflicting complications with CREST syndrome. In medical school and Boards and Beyond, one major complication associated with limited scleroderma is pulmonary HTN and interstitial fibrosis, which is the feared complication and major cause of mortality. This means there is one major visceral organ involved, despite sparing the heart and kidneys (contrast to diffuse).
Scleroderma - *High yield info* - Most sensitive Ab - *ANA* Most specific Ab - *anti-scl 70* - associated with PF & PVD Anticentromere Ab - *CREST* syn RNA polymerase III Ab - *acute onset,scleroderma renal crisis & cancer*
To understand in basic terms how scleroderma develops.....also known as the pathogenesis..... 1. An etiologic agent causes your immune system's one single leukocyte type to abnormally release autoantibodies into the bloodstream. 2. The excess autoantibodies then attack the bloodstream by causing ischemia, vasoconstriction-induced hypoxia as nitric oxide and other vasodilators in the blood are depleted, and endotheliln 1 and other vasoconstrictors are overdeveloped. 3. PDGF and TGF beta are also produced, worsening current ischemic injury to already damaged endothelium, releasing fibroblasts to numbers out of control, and the fibroblasts release excess amounts of collagen, leading to fibrosis.
Therefore we give mycofenolate mofetil to inhibit enzymes insides lymphocytes from synthesizing and releasing those antibodies thus preventing fibrosis. This drug also given after organ transplants. Goal is to prevent antibodies release
hello, this is an informative video on scleroderma. my boss was also suffering from this condition. he visited many hospitals but didnt get any relief. then one day he visited planet ayurveda and got sclero care pack. now he is fine and fit. thanks to planet ayurveda
Your videos are amazing as usual, and I love the way this was organized and presented from discussing Limited Scleroderma to diffuse. However, It seems like there are some slightly conflicting complications with CREST syndrome. In medical school and Boards and Beyond, one major complication associated with limited scleroderma is pulmonary HTN and interstitial fibrosis, which is the feared complication and major cause of mortality. This means there is one major visceral organ involved, despite sparing the heart and kidneys (contrast to diffuse).
Thanks for helping us. You're good!
Scleroderma -
*High yield info* -
Most sensitive Ab - *ANA*
Most specific Ab - *anti-scl 70* - associated with PF & PVD
Anticentromere Ab - *CREST* syn
RNA polymerase III Ab - *acute onset,scleroderma renal crisis & cancer*
15:40 Bro the action of d pencillamine is it has antifibrotic activity, prevent maturation of new collagen synthesis by preventing cross linking....
ya brooo
Thank you for you helpful lectures, doctor!
I assume that penicillamine works for scleroderma due to its ability to interrupt collagen synthesis.
very good videos keep them
D pencillamine works because it interferes with collagen synthesis thus prevents thickening of the skin.
thank you.
To understand in basic terms how scleroderma develops.....also known as the pathogenesis.....
1. An etiologic agent causes your immune system's one single leukocyte type to abnormally release autoantibodies into the bloodstream.
2. The excess autoantibodies then attack the bloodstream by causing ischemia, vasoconstriction-induced hypoxia as nitric oxide and other vasodilators in the blood are depleted, and endotheliln 1 and other vasoconstrictors are overdeveloped.
3. PDGF and TGF beta are also produced, worsening current ischemic injury to already damaged endothelium, releasing fibroblasts to numbers out of control, and the fibroblasts release excess amounts of collagen, leading to fibrosis.
Etiologic agents that could cause the disease can be certain chemicals (like silica), or illnesses like eosinophilic fasciitis.
Therefore we give mycofenolate mofetil to inhibit enzymes insides lymphocytes from synthesizing and releasing those antibodies thus preventing fibrosis.
This drug also given after organ transplants. Goal is to prevent antibodies release
Who is doctor here
Thank you🌷 itwas very helpfull. How can i have the notes?
Faezeh Bonyadinezhad
screenshots.. it works
Thanks Doctor. I have a question though. If sclerodermal renal crisis behaves like bilateral renal artery stenosis, should we not avoid ACEI?
This is pretty outdated information that needs an update
Thank you dr
Thanks doctor :)
hello, this is an informative video on scleroderma. my boss was also suffering from this condition. he visited many hospitals but didnt get any relief. then one day he visited planet ayurveda and got sclero care pack. now he is fine and fit. thanks to planet ayurveda
Thanks for the info… can you provide any other detail info on recovery of the patient and planet ayurveda
Costa, what do you think about this topic?
Raynaud was a french doc, so the "d" is silent lol.
LMFAO