Hi Naveen. I have sent my SMIRK model for your information on immune response model which focus on antibody kinetics. It is all theoretical with no experimental data of my own for verification, but mainly based on the available data from the scientific Literature.
Hello - I don't have a specific recommendation, but I am curious why you want to test after vaccination? do you just want to make sure your immune system is responding to the vaccine?
Sir, I have sinus and bp bacause of cholesterol. I have low Immunity. What test to be taken before vaccination. Thank you very much for such a wonderful answers.
Hi - I am not aware of any requirements for testing before getting the Covid vaccine. Due to your health conditions, it would be best to consult with your doctor to see if there may be a chance of any side effects for you. I don't believe so, but you should seek professional medical advice. Stay safe and be well.
Thank you very much Dr Naveen. A very informative talk on Covid Ab. I hope you can give us a precise and concrete value of Antibody titer that would serve as referrence for our patients. Keep safe always and Good Day.
Hello - thank you for the question. I would like to understand more about what you are looking for. When you say antibody titer that would serve as a reference, what do you mean by that?
@@NaveenAgarwalPhD As of now, we as frontliners often recieved questions from vaccinated individuals as to how will they know if they already need a booster dose of covid vaccine after the period of vaccine efficacy lapsed or reverted. With Semi-Quantitative Detection of IgG Antibody test, we now can suggest sibjection of these individuals to the test to consider future booster vaccination. But often they will ask what is the normal antibody titer or level to be considered protected or still safe when using Semi-Quantitative Detection of IgG Antibody testing? Thank you Very Much.
I’m still confused… I had an IgG test through quest diagnostics that measured 2.2 and showed a positive antinbody response but I’m wondering how close to the threshold I really am?
Hi - the good news is that you were positive for antibodies response. More important to see how it changes over time. If you have a chance to repeat the test after a couple of months (same test), that will be a good way to see if your antibody levels are stable.
Hello - yes according to the test results, you have antibodies in your system. Take a look at these two very short videos to understand these results th-cam.com/video/XXF3QNzFYDQ/w-d-xo.html th-cam.com/video/CbRtna3r8uE/w-d-xo.html
Doctor I have performed two tests at different labs 🧪 : 1. Anti SARS CoV 2-S Antibodies = 13.45 (Reference range is less than 0.80 is negative). 2. Covid 19 Antibody IgM = 3.1 COI (Reference range is less than 1 is negative) *Could you please interpret these tests results.
Hello Hassan - It seems to me that the first test is measuring total antibodies and the second is measuring only IgM. Measured levels are higher than the reference, therefore you can conclude you have these antibodies present in your system. Keep in mind IgM develop early in the lifecycle of the infection and disappear quickly, IgG take longer to develop but persist much longer. But in your case, I cannot say if the first test is giving you IgG or not. Did you develop any symptoms of COVID and recovered? How do you feel now?
Sir I have tested covid 19 total antibodies (IgG+ IgM) and scored 70.where preferred range is above 9 is positive and below 9 is negative..what does it implies on me?
Hi Milind - it confirms your immune system response. This test is measuring both IgG and IgM and the result is higher than the minimum. It also confirms a prior infection even if you did not have any symptoms.
Hi doctor Thanks for the detailed video, the first day of covid symptom for me was on 12th April, I lost my smell on 17th April and got the smell and taste back on 26th April. I had taken the covid antibody test on 6th may 2021. Covid antibody IGG C.L.I.A = 3.43 index reference range is >=1 index is positive and 1.00 Actually during the entire cycle of covid infection I had very mild symptoms. With low level of antibody like 3.43, does that mean I’m asymptotic?
my index value for IGg antobodies is 6. the report just says unit is index. Index reference range less than 1 is found nagitive to IGg and greater than equal to 1 is found positive.( method C.L.I.A ) The antibody test is almost taken 1 month after i was detected positive in RT-PCR. I have 2 question 1- Since there is no upper range in index that you have been mentioning in replies , what index value could still determine strong immune respone to infection 2- How do we know cutoff necessary to qualify convalescent donor plasma for use in donations based on such reports.
Hello Rati - there is an upper value for each test, but it is not generally publicized. You will need to look at the technical documentation for the test. This information is typically available in the IFU or maybe the lab knows. I will answer your questions based on my current understanding. 1- There is no general correlation between antibody level and a "strong" immune response. Each individual is different. The most important thing to understand is that if the result is positive, then your immune system has responded to the virus. It does not represent a "strong" or "weak" response. Also, note that the antibody level will change over time and may not correlate to the new variants. 2- On your question about the cut-off for convalescent plasma - again, there is no universal cutoff or minimum value. Not all convalescent plasma will be equally effective. It should be derived from someone known to have recovered. I know, they will likely want to have a high level of antibodies in the plasma, but I am not aware of any cutoff that is generally applied before plasma is accepted. So what to do? Continue to be cautious. Get the vaccine as soon as it is available to you. Let me know if this helps.
Hi Doctor I'm 65 years old male. As on 6th Feb, 2022, I'm Covid negative as per Rtpcr. While my wife is positive . As per my snti spike, semi quantitative IgG test done on 4th Feb, my reading is 162.5. Does that mean, Im already infected by Covid, but recovered ? My Covishield booster dose is due, when should I take it ? I'm travelling to the US, on 1st of March. Would you assist please. Thanks Doctor !!
Hi - If I understand correctly, you did a antibody test on 4th Feb, which was positive with a result of 162.5. This could also be due to the antibodies in your system from the vaccine. You mention that you are due for the Covidshield booster, so I am assuming you have completed the primary vaccine series. I would strongly recommend you to take the booster dose if you are eligible, and if you did not have any serious side effects from the primary vaccination. Also, always consult with your doctor for the final recommendation. Hope this helps.
@@NaveenAgarwalPhD Thanks Doctor for the reply. My Doctor as well as the situation say that I might have been infected by Covid within last 10 days. As I had a few symptoms & was bedridden for 2 days. My wife is also recovering from Covid now. I have only 20 days in Kochi, India. Is it useful if I take my eligible Covishield booster dose ?
@@surajithkm Hi - I just saw your message. I would definitely consider taking the booster even if you have recovered, unless there are specific medical reasons not to do so. The booster will start showing its effect in about 2 weeks for continued protection. Keep in mind, you can still get infected, but you will be protected against very serious effects of COVID.
Dr my wife had immunoglobulin G serum high at 180 when the range was 600 to 1640. Does this have anything to do with the moderna vaccine being in her system Thank you
Hi - how long after the vaccination was the test done? Also, was it after the first dose or the second dose? You mention that the result was 180 when the range was 600-1640. This would mean that the result was below the lower end of the range. Can you confirm?
@@mattjohn8257 Hi - ok that makes more sense. Good news that the level of IgG is sufficiently high, meaning her immune system has responded well. Did she have any side effects that were intolerable? Best wishes and stay safe.
Hello sir, my igg index value is 1.05 using CLIA technique by Siemens kit where a value>1 is considered positive. Also, my total antibody (igg+igm) OD ratio is 4.56 using ELISA technique where >1 is considered positive. Around how long back would I have got infected?
Hi Sushant - these results mean that your immune system responded to the infection. Here is another quick video you can watch to learn more. th-cam.com/video/XXF3QNzFYDQ/w-d-xo.html In terms of "when" you got infected, typically it takes 2-3 weeks after full recovery for antibodies to show up in your system. You could estimate based on this.
I just did a test in quest the result is positive but I do not understand the number :Your COVID-19 Antibody Test (SARS-CoV-2 AB IgG), Semi-Quantitative Result COVID-19 Antibody Test (SARS-CoV-2 AB IgG), Semi-Quantitative POSITIVE Current Result >20.00 index Reference Range
Hi - it means your antibody level was above the upper limit of the test. This is good news. How long ago did you take the second dose of the Pfizer vaccine. Depending on your situation, you may be eligible for a booster dose. Check out my video about boosters th-cam.com/video/oziQ_tXVstY/w-d-xo.html
My result is 19.83 at 120 days ... I can't find out what this means? is this high or low? my reference value says ,1.00 index (SARA Cov 2 AB (egg) Spike, Semi QN)
Hi - it is not always a question of less or more. The good news is that you have a positive level of antibodies in your system. Please watch this quick video to understand better what these numbers actually mean in practical terms th-cam.com/video/XXF3QNzFYDQ/w-d-xo.html
Thank you sir , very informative! I have got my sars-cov IgG test done in last week, but result came as 8.8 OD. I couldn't comprehend the quantity with this unit as there was no reference range given in my report( it was from thyrocare labs), the report only said positive IgG with 8.8 OD. But after watching ur video I can say that I have pretty good high level of antibody. But I have one little doubt, if this reference rage (1-10 OD) can vary from instrument to instruments deployed to carry out detection test??
Hi - the good news is that you have antibodies in your system. The exact value is not that important. Plus, it also changes over time. You are right that the exact number may depend on a variety of factors. It will also be different for different types of tests from different manufacturers.
Hi Marko - every test is different, therefore, it is not possible to compare them directly. Only the test developer can specify the range for positive, negative and uncertain. It all depends on the signal-to-noise ratio for the test. In this case, your result show you are unlikely to have IgG antibodies, which means it is very unlikely that you had a prior infection. You mention that you took the test about 3 months after your exposure. Since you did not have any symptoms, it is possible that you had a quick immune response to any virus you may have acquired and that you didn't really develop a high level of IgG antibodies, which typically appear 2 weeks after the initial exposure. Or, the more likely scenarios is that you were not infected. I would recommend discussing with you doctor to see if you should do a second test. In the meantime, best to continue practice social distancing and using a face mask or a face shield when in public. Best of luck and stay safe!
Hi - IgG levels are expected to rise after vaccination (you may need to wait for sometime), but I am not sure about the number 20 as the limit for "effectiveness". Could you share how you got the number 20 as a limit?
Hello sir , I got my covid-19 igG antibodies test done 30 days post first symptoms , the result showed level at 73.20 au/ml , though I had slight fever my RT -PCR one month ago had come negative ..do I need to take vaccination right now or should I wait for the 3 months period ?
Hi Ankur - If you are eligible to take the vaccine, that is what I would recommend. Do not rely on a past infection and antibody test to assume you have immunity.
@@AbdulKareem-uz3pe Ok thank you. In that case, the test is showing that antibodies are present. This is the first time I am learning about a test like this used for a young baby. I hope your baby is doing well now. You asked about the risk level. The level of antibody shown by a test is not directly related to a level of "immunity" or "protection". It just means that they have antibodies in their system. Please continue to take precautions especially when out in public.
Good day doctor, your explanation was fantastic please kindly explain me the following scenario. I was positive for covid 3 weeks back. But I didn't have any symptoms and I did the antibody test IGG/IGM both were positive. Do I need to vaccinate myself?
Hi - thank you for your comment. I would strongly recommend getting vaccinated unless you have some pre-existing medical conditions that might be of concern. A positive antibody test indicates a past infection. It does give you a level of protection but when you get the vaccine, you are more protected. Of course there is no such thing as absolute immunity, and even those who are vaccinated are at risk of re-infection. But you will lower your risk by a lot if you get vaccinated. Good luck and be safe.
Sir I got my antibody test and the value came out to be 73.77u/ml. Is it sufficient to protect from future reinfection? Also is the antibody less or more according to what you encounter in your practice?
Hi - unfortunately, there is no "official" number yet that we can use to figure out your risk of reinfection. Compare your result to the range of the test method used (min to max). Also, you cannot compare results from two different tests. It is best to monitor the change in the antibody level over time by using the SAME test. Hope this helps.
@@Amy-ve3ei Hi - I think you could get your primary care doctor to write a referral. Not sure but you could also call Quest directly and see if they could do a test at a location near you. Best wishes.
1.5 months before I had faced sever illness with fever for 14 days, before going to get vaccine I had did IGG and test came with a result of 250 U/ml Anti body... I haven't taken vaccine yet, should I get vaccine now.? Iam facing severe hair fall from one week
Hi - yes I would strongly recommend you to get vaccinated, unless you have medical conditions that might be an issue for you. In that case, please consult with your doctor. Best wishes and stay safe.
Hi - It means there are antibodies present after COVID-19. The value of 145 is hard to interpret because we don't know the reference point. A higher number should indicate more antibodies in the system.
@@joseluizfialho6216 It does look like the vaccine is working for you! You always compare the number to the reference for the same test. The higher the number, the higher the amount of antibody in your system. This is good news! Are you experiencing any symptoms?
Hi Ajaz - you should compare the number to the reference value for the same test. Without the reference number, it is difficult to interpret. In general, a higher number means you have more antibodies in your system. Keep in mind that this level will change over time, so you may not have the same level after say 6 months or so. Current data shows that most people who have recovered from COVID are able to maintain a good antibody level for up to 6 months.
Hi Doctor I was on ECMO and survived Covid. I just took an antibody test to get peace of mind and it came back POSITIVE but it also said >20.00 do you know what that means? Thanks for this video because it was very informative!!
Hi Nilesh - watch this video to learn more th-cam.com/video/XXF3QNzFYDQ/w-d-xo.html This should not be a deciding factor for getting the vaccine. My recommendation is to get the vaccine as soon as you become eligible.
Hi Krishna - it depends on the vaccine and when the antibody levels are measured. There is some information in the clinical trials data for the vaccines authorized in the US. But they are all different and based on different tests.
Hi Akshay - you need to compare it to the reference value and the range of the test. Each test is different. If they are reporting the number to you, it means that this level is above the minimum level for the test and that you have IgG in your system. We cannot say high or low.
Hi - your result means that your immune system has responded to the infection. Please see this video to learn more about how you should understand the level th-cam.com/video/XXF3QNzFYDQ/w-d-xo.html
Halo sir I did not know when I got infected but one day faced breathlessness so tested myself but was negative at that time so now after one month I did antibody test and it shows igG - 2.38 Is it good enough antibody and can I get to know the timing of my infection by looking at value of igG? Test was -CLIA Reference no . =1 reactive..
Hi Yogesh - good to hear you have recovered and your antibody test result indicates that. Take a look at this quick video to learn more about what the level of antibody means th-cam.com/video/XXF3QNzFYDQ/w-d-xo.html In general, IgG appear 2-3 weeks after full recovery. So if you did this test one month after you think you got infected, then that is about the right amount of time.
@@yogeshrana8385 You cannot compare the level of antibody from one test to another or one person to another. The important thing is that you have antibodies and that is a good sign that your immune system has responded.
My igG clia is 4.85 Ref point less than 0.8 is negative .8 to 1 is equivocal Greater than 1 is positive How good is my immunity i had covi in 6 sep 20 n this test is on 31 march 21
Hi Rahul - all we can say is that you have positive antibody level. There is no correlation to a level of immunity with this number. It tells you that your immune system responded to the virus and you have antibodies.
@@NaveenAgarwalPhD sir, does higher Igg number means higher immunity to covid? If person A has igg of 1.67 and person B has 5.6 does it mean Person B is more immune than person A? Thankyou!
@@SagarGol many people are looking into this question. So far, there is no clear answer in terms of a minimum level of IgG to ensure some immunity. Note that you cannot compare the results from two different tests. In general, a higher number will also suggest a higher amount of "neutralizing" antibody, which is not the same as IgG. Take a look at this video th-cam.com/video/CbRtna3r8uE/w-d-xo.html
Hi sir, I was infected with Corona virus in November 2020, I did igg antibody test in May,21 and the score comes out to be 288 au/ml . Can you please tell if this score is sufficient to prevent reinfection?
Hi Harsh - according to the test, you do have a good level of antibodies in your system. But this does not mean you have absolute immunity See this video to learn more th-cam.com/video/XXF3QNzFYDQ/w-d-xo.html
Hi Avinash - you need to compare it to the reference value and the maximum value of the specific test you took. Each test is different. It means that you have a positive level of antibodies to SARS CoV 2 that indicates your immune system has responded to the virus.
serum Covid 19 lgG antibody test (against spike protein) methodology: chemiluminescense Immonuassay Value 15.2 U/ml. Can you kindly tell what it means?
Hello - you need to compare this number against the reference value for the specific test. Each test is different. You can usually find the reference value in the IFU for the test. In general, higher number means more antibodies, but we don't yet know the exact correlation between the amount of antibodies and immunity.
hello doctor , thanks for the information i appreciate that one thing i wanted to know i got my antibody test on march 1 2021 anti-sars cov2 igG is 7.06 S/C bio ref range
Hi Manoj - I am not familiar with this specific test. I would say that your level is higher than the min of 1, but not sure how it compares with the upper end of the range. I am surprised you had a negative RT-PCR even though you were asymptomatic. This could be the case if the specific RT-PCR you had did not have good sensitivity. Another possibility is that you got COVID again after Sept 2020 and were again asymptomatic. This could result in antibodies in your system as shown by the test in March. We cannot say much about the "level of immunity" looking at your IgG number. Practically speaking, this number is not very useful. Just the fact it is positive is more important to know. Best wishes and stay safe.
@@NaveenAgarwalPhD i think less than 1 is non reactive for sars cov2 and greater than 1 is reactive for covid19 . Also i lost my taste and smell perhaps in sept and thus doubt that the sampling done by test person was not correct . do i have some protection from new strains (i mean not to get severe case result if again getting reinfected) , although i think thanks to my mask and other safety protocols i followed the viral load in first infection made me asymptomatic , again thanks doctor for your comment
Hi Manoj - some of the symptoms you describe, such as loss of taste and smell, are consistent with reports of COVID-19. Since you are getting a reactive antibody test results, it means your immune system has responded to the infection. To what extent you have immunity against new variants remains unknown. The risk may be lower but not zero. So you are doing the right thing by using a mask and social distancing. I would advise you to keep doing that. Best wishes again and stay safe.
Hi Doctor. I had Covid Mild symptoms and after 15 days Got IGG Anti Spike protien done. However the result was 35634 AU/Ml quantitative antispike Sars cov igG antibody @CMIA. I haven't heard of this much antibodies. Is this normal or good immune response or something to deep dive on.
Hi - I am not aware of this test. Also, I would not expect IgG to be so high only 15 days after the infection. Please check with the test manufacturer for clarification.
Dear Doctor, I also got IgG quantitative antibody test through CMIA method for my wife after 5 weeks of Covid symptoms first appeared, her antibody levels were 9952 au/ml, the test reference range is as follows , Negative 50 to 80,000 au/ml. During Covid time, my wife had mild pneumonia and was on low dose steroids for 24 days, her Oxygen levels always maintained with out any support, however she had persistent cough but there was no hospitalisation, She did all household activities and performed daily chores. After antibody test, when I saw such a high level of antibodies value, then I got her retested next day through CLIA method and the result was positive again with antibody >150 Au/ml, this time reference range was - negative if less than 1 au/ml and positive when more than 1, I think that laboratory's test range could calculate up to 150 only, so in my case result was shown >150. I showed her report to a MBBS, MD Doctor along with her latest CBC, LFT, KFT, Thyroid, electrolytes and other routine blood test values which were almost normal. Doctor said there is nothing to worry. My wife has not been vaccinated. At that time her CRP( C reactive protein value) was on slightly higher side - 8mg/litre, Please comment on antibody levels.
Hello sir I'm testing two times please reply anybody levels good or bad 1) September 2020 igg 5.53 c.m.i.a method 2) April 2021 igg 14.15 c.l.i.a method
Hi - These are two different methods, so a direct comparison is not possible. Good news is that you have antibodies in your system and they are still present after 8 months. Watch this video to learn more th-cam.com/video/XXF3QNzFYDQ/w-d-xo.html
IgM and IgG are two very different kind of antibodies. IgM is generated in the early phase of the infection and disappears more quickly. IgG appears later and lasts for a longer time. It depends on the type of test and the timing of the test. Absolute numbers are not easy to interpret unless you know the reference values of the test. Also, note that IgG does not always mean that that these antibodies are able to "neutralize" the virus, but they are a sign that your immune system is responding to the infection.
Hello Surajit - it is hard to interpret the IgG value without any reference. IgG is one type of antibody, which may or may not neutralize SARS-CoV-2. There are other tests which measure the neutralizing antibody levels. Your question about immunity is still being studied since COVID-19 is so new and not much is known yet. So far, there is data that shows that neutralizing antibody levels can persist for up to 50 days.
Hello Sir, I'm just wondering. I already had 3 positive test i on 5th, 8th, 14th. And the doctor told me that my CT is 32.47. What is the normal CT? and if I reach that then the result will be negative? and how can I put up my CT then? Thank you.
Hi Chris - I am not very familiar with how CT is used to diagnose COVID and what is considered normal. Also, I do not understand what the CT number of 32.47 mean in your case. My understanding of a CT-based COVID diagnosis is that the scans can show different patterns (spots, opacity, thickening etc.). So you should ask your doctor what exactly do they see and what they would consider as a normal level. Having said that, even if your CT returns to whatever "normal" is, it does not mean you have no virus in your system. It may just be circulating somewhere else. Please share additional info as you learn more - I am very interested. Thank you and wishing you a speedy recovery.
@@NaveenAgarwalPhD The doctor told me Sir that its the Transmission of the Virus. id its still high or low. and he told me that the normal is like 40 to be negative. So they will be the one to decide if my result is negative or positive, am I right sir? I think its called ycle threshold
@@atlechris Oh ok I understand better now. I misunderstood CT to mean a CT scan. The CT, in this case, is Cycles threshold and 40 is the upper limit. Above 40, the test result is considered negative. In a way, the closer you are to 40, the less virus you have in your system. Does this help?
@@NaveenAgarwalPhD yes sir i think this is it. I have a question, is there anything that I have to do inorder to get a higher CT? and is it possible that it will go up daily?
i agree tangible proof of Immunity is what we should be proving and measuring, and not just taking additional vaccines and boosters without measuring our antibody levels first. You don't add oil to the engine without first looking at the dipstick first to see how much it may need!
Thanks for sharing your thoughts. Are you saying that it would be better to first measure the antibody level and if it is low, or has fallen down by a lot after the 2nd dose, then we should take the booster dose? I think that makes a lot of sense. In general, you can expect to see a reduction in antibody levels 5-6 months after your last vaccine dose for the mRNA vaccines. But again for some people this may be too long or too short a time gap.
@@NaveenAgarwalPhD That's my thought, ether through natural immunity or vaccinated immunity, why is a PCR test, or your number of shots the tool for measuring, why is proof of vaccination the requirement? if the goal is antibody's then we should be testing and providing proof of antibody's.
@@James_Dahlen Hi - you are raising very important questions. I see it this way - there is a public health policy issue at the overall population level, then there is an individual health issue at an individual level. I don't talk about policy issues and decisions on my channel. But I think we should understand the data in a general sense to figure out what decisions we should be making at a personal/individual level. I emphasize frequently that every individual is different. The best course of action is to talk to your doctor with a full understanding of general information and how it may or may not apply in your individual situation.
@@NaveenAgarwalPhD Thanks! I just had my bloodwork done and i have IgG of >800.0 Semi-Quant of >2500.0 and Nucleocapsid Positive and Spike Ab Positive, i had the J&J In April of 21 am i correct in thinking i shouldn't need the J&J booster at this time?
@@James_DahlenHi - so far, I have not heard any advice or guidance based on antibody levels alone. At an individual level, I always advise to look at your whole situation, including your exposure level and the transmission rate in your area, your medical history etc. This decision is best taken after a carful look at your individual situation and talking to your doctor.
Hi - you need to compare it against the reference level for the test. Each test is different and the absolute value does not mean much unless it is compared against the reference value. In general, a higher number means more antibodies, but remember there is not direct correlation between the level of antibody and immunity against the virus. It depends on the type of antibody.
Thank you for your revert and details. Really appreciate it. I also got the igG result and the value is 4.08. Does that mean good immunity? Can I be a plasma donor?
@@pranshusharma7600 hi - just to clarify, this is not a copy/paste, but the answer to many of these questions is the same. I have decided to post a quick 2-min video in next couple of weeks. Having said that, let me know your specific question.
Hi Rohit - the absolute number is difficult to understand unless you know the baseline number. The reactive result 6 months after infection means you have antibodies but it is hard to understand how much. Also, note that not every test measures what they call "neutralizing antibodies". If you take the same test over time, you can compare the numbers.
FYI: you mentioned that you were focusing on the ADVIA analyzer but your data is from the Atellica analyzer. The index range for the ADVIA Centaur is 0.05-10.
@@pranshusharma7600 Ok, this is a type of a test that can give you the level of total antibody in your system. Do you know the range of the specific ECLIA test you did? Does it tell you the minimum and maximum amounts measured by this test? There is one test from Roche Diagnostics that is authorized by the FDA in the USA. I am not sure if this is the same test for you, but this one has a range from 0.8-250. Now, keep in mind that the absolute number may not mean much in terms of your "immunity". It just means you have the antibodies and your immune system has responded to the virus.
Hi Shahzad - it means you have IgG antibodies according to the test you took. Whether it is high or low, depends on the reference value of the test. Each test is different. Also, note that IgG are only one kind of antibodies in response to COVID-19 infection.
Sir i got SARS-COV2 (covid-19) IgG antibody test done 14 days after second does of vaccine and the result came 6.73 positive reference range being >1.0(index) positive but on 23rd day o got the same test done again and result came 1.82(positive) why did the numbers decrease pls explain
Thank you dr. Agarwal. What does a result of 2.09 measured in index mean? I tested positive on the 10th of April, and last symptoms on 17th April. My IgG test results of 2.09 came back 26th apr (sampled on 25th apr)
I had covid December 2020 and yesterday, 9/9/21, had antibody levels drawn again via Roche Elecsys and my level was 931 with positive level anythinng over 0.80. I haven't been sick since; obviously, I am immune, and yet I'm having my employer shove the jab down my throat or I get fired.
Hi - thank you for sharing. Have you shown your antibody test results to them? What does your doctor recommend? This is a difficult time for everyone. Best wishes to you and stay safe.
@@NaveenAgarwalPhD My employer explicitly states it will not take antibody tests as proof of immunity. It's either get the jab, get an exemption (I got a religious exemption, actually) or get fired. Due to this, I haven't bothered discuss with my doctor.
@@fredharvey2720 Thanks for sharing. I guess this policy may be because FDA has advised against making any correlation of immunity with the level of antibodies in a test. There are still a lot of unanswered questions about immunity to Covid-19. I would recommend you to continue monitoring your situation and take all the precautions you can. Best wishes to you. Stay safe and god bless.
@@NaveenAgarwalPhD So why are they making correlations of immunity with the level of antibodies the vaccine produces? To me, this reeks of politics and I strongly suspect Big Pharma is paying off politicians to ignore natural antibodies to market more doses. This selective recognition of antibodies makes no sense at all.
@@fredharvey2720 You make a great point. Most of the antibody testing data is in the clinical trial results for vaccines. One point to remember is that they also did more sophisticated tests to show increase in the level of neutralizing antibodies. These tests are generally not available to the public. They are showing it to prove the vaccine works but the effectiveness data comes from counting the number of infections and comparing against those who did not receive the vaccine in clinical trials. It is not possible to correlate but I am sure there are mixed messages going out in different sources of information.
Hi - it is difficult to interpret the number 0.19 without any reference. The test should also tell you a yes/no result for presence of IgG. If there IgG test for SARS-CoV-2 shows a positive result, then you were exposed.
Hi Anshika - if the test is giving you a number, it means it is a positive result indicating your immune response to the virus. Did you have any symptoms?
@@NaveenAgarwalPhD yes sir I had all the symptoms.. cold..cough.. fever around >99 , so if the number it gave was 0.19 so it means I was exposed to the virus?
@@ansh01019 Yes that is most likely correct. How many days after recovery did you take the antibody test? It should be at least 2 weeks after full recovery.
Hi everyone - many of you have been asking me a similar question about the antibody levels from your test. So, I decided to make a quick video. Please see here th-cam.com/video/XXF3QNzFYDQ/w-d-xo.html
Hi Doctor my Antibody Test result shows Reactive and observed value shows >175. Refrence Range for Reactive is >/= 1.000 Cutoff Index. What does this means??
Hello Wahid - the cutoff value means any number more that 1 is a positive result. Observed value of 175 needs to be compared to the max value of the specific test. It means you have antibodies in your system (most likely IgG).
Hello Prashant - do you know which test was done and what is the reference value in that test? It is not easy to understand what this number means unless you know the reference number. In general, a higher number means more antibodies in the system.
Hi - this means the test has detected antibodies in your system at a level higher than the minimum. Check out this video to learn more th-cam.com/video/XXF3QNzFYDQ/w-d-xo.html
![ร้อยพ่อพันแม่ - WanMai [Official MV]](http://i.ytimg.com/vi/XY2pNYASEbg/mqdefault.jpg)
What a wonderful doctor...taking the time to explain and answer questions. 🏆🏆🏆
Thank you!
Hello dr my igm level is 1.3 . Please tell me how to make COVID igm low
Hi Naveen. I have sent my SMIRK model for your information on immune response model which focus on antibody kinetics. It is all theoretical with no experimental data of my own for verification, but mainly based on the available data from the scientific Literature.
Sir will u suggest a good antibody test to know antibody statues after vaccination ?
Hello - I don't have a specific recommendation, but I am curious why you want to test after vaccination? do you just want to make sure your immune system is responding to the vaccine?
Sir, I have sinus and bp bacause of cholesterol. I have low Immunity. What test to be taken before vaccination. Thank you very much for such a wonderful answers.
Hi - I am not aware of any requirements for testing before getting the Covid vaccine. Due to your health conditions, it would be best to consult with your doctor to see if there may be a chance of any side effects for you. I don't believe so, but you should seek professional medical advice. Stay safe and be well.
Great work Dr Agrawal. Thank for educating. God bless 🙌
Thank you! Please continue to send your questions and share with your friends/family. Best wishes and stay safe.
Thank you very much Dr Naveen. A very informative talk on Covid Ab. I hope you can give us a precise and concrete value of Antibody titer that would serve as referrence for our patients. Keep safe always and Good Day.
Hello - thank you for the question. I would like to understand more about what you are looking for. When you say antibody titer that would serve as a reference, what do you mean by that?
@@NaveenAgarwalPhD As of now, we as frontliners often recieved questions from vaccinated individuals as to how will they know if they already need a booster dose of covid vaccine after the period of vaccine efficacy lapsed or reverted. With Semi-Quantitative Detection of IgG Antibody test, we now can suggest sibjection of these individuals to the test to consider future booster vaccination. But often they will ask what is the normal antibody titer or level to be considered protected or still safe when using Semi-Quantitative Detection of IgG Antibody testing? Thank you Very Much.
@@jardr I understand.
Which test are you using?
I’m still confused… I had an IgG test through quest diagnostics that measured 2.2 and showed a positive antinbody response but I’m wondering how close to the threshold I really am?
Hi - the good news is that you were positive for antibodies response. More important to see how it changes over time. If you have a chance to repeat the test after a couple of months (same test), that will be a good way to see if your antibody levels are stable.
Hello Sir... My Igg covid result is 83.10 AU/ML.
Semi quantitative test
Please let me know if I have develop antibody.
Hello - yes according to the test results, you have antibodies in your system. Take a look at these two very short videos to understand these results
th-cam.com/video/XXF3QNzFYDQ/w-d-xo.html
th-cam.com/video/CbRtna3r8uE/w-d-xo.html
@@NaveenAgarwalPhD Thank you so much sir 🙂
Doctor I have performed two tests at different labs 🧪 :
1. Anti SARS CoV 2-S Antibodies = 13.45 (Reference range is less than 0.80 is negative).
2. Covid 19 Antibody IgM = 3.1 COI (Reference range is less than 1 is negative)
*Could you please interpret these tests results.
Hello Hassan - It seems to me that the first test is measuring total antibodies and the second is measuring only IgM. Measured levels are higher than the reference, therefore you can conclude you have these antibodies present in your system. Keep in mind IgM develop early in the lifecycle of the infection and disappear quickly, IgG take longer to develop but persist much longer. But in your case, I cannot say if the first test is giving you IgG or not. Did you develop any symptoms of COVID and recovered? How do you feel now?
Sir I have tested covid 19 total antibodies (IgG+ IgM) and scored 70.where preferred range is above 9 is positive and below 9 is negative..what does it implies on me?
Hi Milind - it confirms your immune system response. This test is measuring both IgG and IgM and the result is higher than the minimum. It also confirms a prior infection even if you did not have any symptoms.
@@NaveenAgarwalPhD Thank You so much Sir
Very useful and lucid.
Thank you!
Hi doctor
Thanks for the detailed video, the first day of covid symptom for me was on 12th April, I lost my smell on 17th April and got the smell and taste back on 26th April.
I had taken the covid antibody test on 6th may 2021. Covid antibody IGG C.L.I.A = 3.43 index reference range is >=1 index is positive and 1.00
Actually during the entire cycle of covid infection I had very mild symptoms. With low level of antibody like 3.43, does that mean I’m asymptotic?
Asymtompatic, you mean.
PCR tests are to determine if you HAVE covid. Antibody tests are for if you HAD it.
my index value for IGg antobodies is 6. the report just says unit is index. Index reference range less than 1 is found nagitive to IGg and greater than equal to 1 is found positive.( method C.L.I.A ) The antibody test is almost taken 1 month after i was detected positive in RT-PCR. I have 2 question
1- Since there is no upper range in index that you have been mentioning in replies , what index value could still determine strong immune respone to infection
2- How do we know cutoff necessary to qualify convalescent donor plasma for use in donations based on such reports.
Hello Rati - there is an upper value for each test, but it is not generally publicized. You will need to look at the technical documentation for the test. This information is typically available in the IFU or maybe the lab knows. I will answer your questions based on my current understanding.
1- There is no general correlation between antibody level and a "strong" immune response. Each individual is different. The most important thing to understand is that if the result is positive, then your immune system has responded to the virus. It does not represent a "strong" or "weak" response. Also, note that the antibody level will change over time and may not correlate to the new variants.
2- On your question about the cut-off for convalescent plasma - again, there is no universal cutoff or minimum value. Not all convalescent plasma will be equally effective. It should be derived from someone known to have recovered. I know, they will likely want to have a high level of antibodies in the plasma, but I am not aware of any cutoff that is generally applied before plasma is accepted.
So what to do? Continue to be cautious. Get the vaccine as soon as it is available to you. Let me know if this helps.
My mother antibody Igg result is 6.28 od ratio in Elisha test ... What does it signifies
Hi Doctor
I'm 65 years old male. As on 6th Feb, 2022, I'm Covid negative as per Rtpcr.
While my wife is positive .
As per my snti spike, semi quantitative IgG test done on 4th Feb, my reading is 162.5.
Does that mean, Im already infected by Covid, but recovered ? My Covishield booster dose is due, when should I take it ? I'm travelling to the US, on 1st of March. Would you assist please.
Thanks Doctor !!
Hi - If I understand correctly, you did a antibody test on 4th Feb, which was positive with a result of 162.5. This could also be due to the antibodies in your system from the vaccine. You mention that you are due for the Covidshield booster, so I am assuming you have completed the primary vaccine series. I would strongly recommend you to take the booster dose if you are eligible, and if you did not have any serious side effects from the primary vaccination. Also, always consult with your doctor for the final recommendation.
Hope this helps.
@@NaveenAgarwalPhD
Thanks Doctor for the reply.
My Doctor as well as the situation say that I might have been infected by Covid within last 10 days. As I had a few symptoms & was bedridden for 2 days.
My wife is also recovering from Covid now. I have only 20 days in Kochi, India.
Is it useful if I take my eligible Covishield booster dose ?
@@NaveenAgarwalPhD I know its difficult to give reply to every one.
I don't mind. But keep your good work going !!
@@surajithkm Hi - I just saw your message. I would definitely consider taking the booster even if you have recovered, unless there are specific medical reasons not to do so. The booster will start showing its effect in about 2 weeks for continued protection.
Keep in mind, you can still get infected, but you will be protected against very serious effects of COVID.
@@NaveenAgarwalPhD Thank You Doctor !!
Amazing service 🙏🏻
Dr my wife had immunoglobulin G serum high at 180 when the range was 600 to 1640. Does this have anything to do with the moderna vaccine being in her system
Thank you
Hi - how long after the vaccination was the test done? Also, was it after the first dose or the second dose? You mention that the result was 180 when the range was 600-1640. This would mean that the result was below the lower end of the range. Can you confirm?
@@NaveenAgarwalPhD Doctor I’m sorry it was 1800. She had two moderna tests. Second one was April of 2021. And she had this test done last week
@@mattjohn8257 Hi - ok that makes more sense. Good news that the level of IgG is sufficiently high, meaning her immune system has responded well. Did she have any side effects that were intolerable? Best wishes and stay safe.
@@NaveenAgarwalPhD not really. Just the norm. Sore Arm at site. That’s about it
@@mattjohn8257 Hi- that's good to hear. All the best, stay safe!
Hello sir, my igg index value is 1.05 using CLIA technique by Siemens kit where a value>1 is considered positive. Also, my total antibody (igg+igm) OD ratio is 4.56 using ELISA technique where >1 is considered positive.
Around how long back would I have got infected?
Hi Sushant - these results mean that your immune system responded to the infection. Here is another quick video you can watch to learn more.
th-cam.com/video/XXF3QNzFYDQ/w-d-xo.html
In terms of "when" you got infected, typically it takes 2-3 weeks after full recovery for antibodies to show up in your system. You could estimate based on this.
@@NaveenAgarwalPhD Thank you sir
@@sushantgupta2210 Happy to help. Best wishes and stay safe.
I just did a test in quest the result is positive but I do not understand the number :Your COVID-19 Antibody Test (SARS-CoV-2 AB IgG), Semi-Quantitative Result
COVID-19 Antibody Test (SARS-CoV-2 AB IgG), Semi-Quantitative POSITIVE
Current Result >20.00 index
Reference Range
Hi - it means your antibody level was above the upper limit of the test. This is good news. How long ago did you take the second dose of the Pfizer vaccine. Depending on your situation, you may be eligible for a booster dose. Check out my video about boosters
th-cam.com/video/oziQ_tXVstY/w-d-xo.html
@@NaveenAgarwalPhD Thank you so much ! I was vaccinated in April second dose 😊
@@joelle1059 It is over 6 months. So if you meet the eligibility criteria, you should be able to get the booster dose.
@@NaveenAgarwalPhD Thank you
My result is 19.83 at 120 days ... I can't find out what this means? is this high or low? my reference value says ,1.00 index (SARA Cov 2 AB (egg) Spike, Semi QN)
Sir my igg level is 2.5 OD ratio in elisa igg test
Reference value is >1 is positive
So level of antibodies is less ?
Hi - it is not always a question of less or more. The good news is that you have a positive level of antibodies in your system. Please watch this quick video to understand better what these numbers actually mean in practical terms
th-cam.com/video/XXF3QNzFYDQ/w-d-xo.html
Thank you sir , very informative! I have got my sars-cov IgG test done in last week, but result came as 8.8 OD. I couldn't comprehend the quantity with this unit as there was no reference range given in my report( it was from thyrocare labs), the report only said positive IgG with 8.8 OD. But after watching ur video I can say that I have pretty good high level of antibody. But I have one little doubt, if this reference rage (1-10 OD) can vary from instrument to instruments deployed to carry out detection test??
Hi - the good news is that you have antibodies in your system. The exact value is not that important. Plus, it also changes over time. You are right that the exact number may depend on a variety of factors. It will also be different for different types of tests from different manufacturers.
@@NaveenAgarwalPhD thank you Sir, for taking out time to reply to my query ! wish u a lot of success!!!
I had covid July 2020. I just got tested for antibodies Sept 2021. My score was 1,366. Is that considered a good number?
Covid test positive and observed value is 16? Is it moderate or mild please help to reply
So my IGG level was 11.5. The test in my country says 12-15 is Equivocal, >15 is positive, and
Hi Marko - every test is different, therefore, it is not possible to compare them directly. Only the test developer can specify the range for positive, negative and uncertain. It all depends on the signal-to-noise ratio for the test. In this case, your result show you are unlikely to have IgG antibodies, which means it is very unlikely that you had a prior infection.
You mention that you took the test about 3 months after your exposure. Since you did not have any symptoms, it is possible that you had a quick immune response to any virus you may have acquired and that you didn't really develop a high level of IgG antibodies, which typically appear 2 weeks after the initial exposure. Or, the more likely scenarios is that you were not infected.
I would recommend discussing with you doctor to see if you should do a second test. In the meantime, best to continue practice social distancing and using a face mask or a face shield when in public.
Best of luck and stay safe!
Indeed. Unsung Hero.
Thank you!
Does igg level post vaccination that has been reported as greater than 20 indicates vaccine success ? Level over 20 has not been calculated it seems.
Hi - IgG levels are expected to rise after vaccination (you may need to wait for sometime), but I am not sure about the number 20 as the limit for "effectiveness". Could you share how you got the number 20 as a limit?
Hello sir , I got my covid-19 igG antibodies test done 30 days post first symptoms , the result showed level at 73.20 au/ml , though I had slight fever my RT -PCR one month ago had come negative ..do I need to take vaccination right now or should I wait for the 3 months period ?
Hi Ankur - If you are eligible to take the vaccine, that is what I would recommend. Do not rely on a past infection and antibody test to assume you have immunity.
What about people with high antibodies 20 months after the vaccine?????
Hi,
My 13 month baby is having Antibodies 10.0, What should be the normal range and would be the risk level. Please help.
Hi - can you clarify if this is the antibody level measured using a COVID-19 antibody test?
@@NaveenAgarwalPhD Non Reactive is and my baby Index is 10.0
CLIA method
@@AbdulKareem-uz3pe Ok thank you. In that case, the test is showing that antibodies are present. This is the first time I am learning about a test like this used for a young baby. I hope your baby is doing well now.
You asked about the risk level. The level of antibody shown by a test is not directly related to a level of "immunity" or "protection". It just means that they have antibodies in their system. Please continue to take precautions especially when out in public.
Good day doctor, your explanation was fantastic please kindly explain me the following scenario. I was positive for covid 3 weeks back. But I didn't have any symptoms and I did the antibody test IGG/IGM both were positive. Do I need to vaccinate myself?
Hi - thank you for your comment. I would strongly recommend getting vaccinated unless you have some pre-existing medical conditions that might be of concern. A positive antibody test indicates a past infection. It does give you a level of protection but when you get the vaccine, you are more protected. Of course there is no such thing as absolute immunity, and even those who are vaccinated are at risk of re-infection. But you will lower your risk by a lot if you get vaccinated. Good luck and be safe.
Thanks a lot for your valuable tme and clear explanation
@@raiyaanrajabdeen3216 You are welcome!
Sir I got my antibody test and the value came out to be 73.77u/ml. Is it sufficient to protect from future reinfection? Also is the antibody less or more according to what you encounter in your practice?
Hi - unfortunately, there is no "official" number yet that we can use to figure out your risk of reinfection. Compare your result to the range of the test method used (min to max). Also, you cannot compare results from two different tests. It is best to monitor the change in the antibody level over time by using the SAME test. Hope this helps.
@@NaveenAgarwalPhD Thanks for the reply 🙏
How do you get your antibody levels tested. I live in the United States.
@@Amy-ve3ei Hi - I think you could get your primary care doctor to write a referral. Not sure but you could also call Quest directly and see if they could do a test at a location near you. Best wishes.
1.5 months before I had faced sever illness with fever for 14 days, before going to get vaccine I had did IGG and test came with a result of 250 U/ml Anti body... I haven't taken vaccine yet, should I get vaccine now.?
Iam facing severe hair fall from one week
Hi - yes I would strongly recommend you to get vaccinated, unless you have medical conditions that might be an issue for you. In that case, please consult with your doctor. Best wishes and stay safe.
@@NaveenAgarwalPhD Thank you for your kind reply, you are awesome sir
@@khalif2611 You are welcome!
Thank you for the clear explanation, Dr. Just wondering what an Antibody value of 145 means 3.5 months after testing RT-PCR positive
Hi - It means there are antibodies present after COVID-19. The value of 145 is hard to interpret because we don't know the reference point. A higher number should indicate more antibodies in the system.
@@NaveenAgarwalPhD thank you for the prompt response, sir
@@joseluizfialho6216 It does look like the vaccine is working for you! You always compare the number to the reference for the same test. The higher the number, the higher the amount of antibody in your system. This is good news!
Are you experiencing any symptoms?
Hi Ajaz - you should compare the number to the reference value for the same test. Without the reference number, it is difficult to interpret. In general, a higher number means you have more antibodies in your system.
Keep in mind that this level will change over time, so you may not have the same level after say 6 months or so. Current data shows that most people who have recovered from COVID are able to maintain a good antibody level for up to 6 months.
Hi Doctor I was on ECMO and survived Covid. I just took an antibody test to get peace of mind and it came back POSITIVE but it also said >20.00 do you know what that means? Thanks for this video because it was very informative!!
My IgG antibodies is 95 after 21 days of recovering for Covid.Is it low or high?When should I go for vaccination.
Hi Nilesh - watch this video to learn more
th-cam.com/video/XXF3QNzFYDQ/w-d-xo.html
This should not be a deciding factor for getting the vaccine. My recommendation is to get the vaccine as soon as you become eligible.
Sir Pls tell me.. How Much are average IGg antibodies levels after 1st and 2nd shot of vaccination on CLIA. Pls tell approximate levels. Thank you:-)
Hi Krishna - it depends on the vaccine and when the antibody levels are measured. There is some information in the clinical trials data for the vaccines authorized in the US. But they are all different and based on different tests.
@@NaveenAgarwalPhD Thanks for your information sir...
will person using cortisone 7.5 mg develop immunity
Hello - what do you mean by 7.5 mg?
Hi Sir, My IGg antibody test showed 2.59. I understand that I have antibodies but is this a high or low amount according to you?
Hi Vaib - the number needs to be compared to the reference value for the test you took. Each test is different.
My result for igg antibodies is 1.39. is it enough to undrstnd tht antibodies has been developed and is it low antibodies or high??
Hi Akshay - you need to compare it to the reference value and the range of the test. Each test is different. If they are reporting the number to you, it means that this level is above the minimum level for the test and that you have IgG in your system. We cannot say high or low.
@Naveen Agarwal, Ph.D. My spike antibody test result is 250 U/ml how is this result? I did this test after covid. It passed about 36 days later.
Hi - your result means that your immune system has responded to the infection. Please see this video to learn more about how you should understand the level th-cam.com/video/XXF3QNzFYDQ/w-d-xo.html
@@NaveenAgarwalPhD Thanks so much doctor. I will watch the video now. Best regards.
Halo sir
I did not know when I got infected but one day faced breathlessness so tested myself but was negative at that time so now after one month I did antibody test and it shows igG - 2.38
Is it good enough antibody and can I get to know the timing of my infection by looking at value of igG?
Test was -CLIA
Reference no . =1 reactive..
Hi Yogesh - good to hear you have recovered and your antibody test result indicates that. Take a look at this quick video to learn more about what the level of antibody means
th-cam.com/video/XXF3QNzFYDQ/w-d-xo.html
In general, IgG appear 2-3 weeks after full recovery. So if you did this test one month after you think you got infected, then that is about the right amount of time.
@@NaveenAgarwalPhD sir are these antibodies sufficient as I see many people claiming antibodies more than 20?
@@yogeshrana8385 You cannot compare the level of antibody from one test to another or one person to another. The important thing is that you have antibodies and that is a good sign that your immune system has responded.
My igG clia is 4.85
Ref point less than 0.8 is negative
.8 to 1 is equivocal
Greater than 1 is positive
How good is my immunity i had covi in 6 sep 20 n this test is on 31 march 21
Hi Rahul - all we can say is that you have positive antibody level. There is no correlation to a level of immunity with this number. It tells you that your immune system responded to the virus and you have antibodies.
@@NaveenAgarwalPhD sir, does higher Igg number means higher immunity to covid? If person A has igg of 1.67 and person B has 5.6 does it mean Person B is more immune than person A? Thankyou!
@@SagarGol many people are looking into this question. So far, there is no clear answer in terms of a minimum level of IgG to ensure some immunity. Note that you cannot compare the results from two different tests. In general, a higher number will also suggest a higher amount of "neutralizing" antibody, which is not the same as IgG.
Take a look at this video th-cam.com/video/CbRtna3r8uE/w-d-xo.html
Hi sir,
I was infected with Corona virus in November 2020, I did igg antibody test in May,21 and the score comes out to be 288 au/ml . Can you please tell if this score is sufficient to prevent reinfection?
Hi Harsh - according to the test, you do have a good level of antibodies in your system. But this does not mean you have absolute immunity See this video to learn more
th-cam.com/video/XXF3QNzFYDQ/w-d-xo.html
Sir sars-cov-2 (covid-19) total antibodies (igg+ igm )serum is 29. What dose it mean
Hi Avinash - you need to compare it to the reference value and the maximum value of the specific test you took. Each test is different. It means that you have a positive level of antibodies to SARS CoV 2 that indicates your immune system has responded to the virus.
Very informative.
Thank you Akash!
serum Covid 19 lgG antibody test (against spike protein)
methodology: chemiluminescense Immonuassay
Value 15.2 U/ml.
Can you kindly tell what it means?
Hello - you need to compare this number against the reference value for the specific test. Each test is different. You can usually find the reference value in the IFU for the test. In general, higher number means more antibodies, but we don't yet know the exact correlation between the amount of antibodies and immunity.
>400 au/ml CLIA what it means...
Reference is 15 positive
Sir I did antibody test after 20 days of complete recovery and it's says igg Antibody 26.40 AU/ml what does it means ?
Hi Ismail - please watch this video to learn more
th-cam.com/video/XXF3QNzFYDQ/w-d-xo.html
I'm from india ,
My igg level is 10.75
Please tell me how good is that ???
Hello doctor i did my covid igg antibody test last week...more than 1 is positive my range was 1.80...is this high or low please tell?
How many days after covid infection you took this test sir?
hello doctor , thanks for the information i appreciate that one thing i wanted to know i got my antibody test on march 1 2021 anti-sars cov2 igG is 7.06 S/C bio ref range
Hi Manoj - I am not familiar with this specific test. I would say that your level is higher than the min of 1, but not sure how it compares with the upper end of the range. I am surprised you had a negative RT-PCR even though you were asymptomatic. This could be the case if the specific RT-PCR you had did not have good sensitivity. Another possibility is that you got COVID again after Sept 2020 and were again asymptomatic. This could result in antibodies in your system as shown by the test in March.
We cannot say much about the "level of immunity" looking at your IgG number. Practically speaking, this number is not very useful. Just the fact it is positive is more important to know.
Best wishes and stay safe.
@@NaveenAgarwalPhD i think less than 1 is non reactive for sars cov2 and greater than 1 is reactive for covid19 . Also i lost my taste and smell perhaps in sept and thus doubt that the sampling done by test person was not correct . do i have some protection from new strains (i mean not to get severe case result if again getting reinfected) , although i think thanks to my mask and other safety protocols i followed the viral load in first infection made me asymptomatic , again thanks doctor for your comment
Hi Manoj - some of the symptoms you describe, such as loss of taste and smell, are consistent with reports of COVID-19. Since you are getting a reactive antibody test results, it means your immune system has responded to the infection. To what extent you have immunity against new variants remains unknown. The risk may be lower but not zero. So you are doing the right thing by using a mask and social distancing. I would advise you to keep doing that. Best wishes again and stay safe.
@@NaveenAgarwalPhD thanks doctor , wish you the same
Hi Doctor.
I had Covid Mild symptoms and after 15 days Got IGG Anti Spike protien done.
However the result was 35634 AU/Ml quantitative antispike Sars cov igG antibody @CMIA. I haven't heard of this much antibodies.
Is this normal or good immune response or something to deep dive on.
Hi - I am not aware of this test. Also, I would not expect IgG to be so high only 15 days after the infection. Please check with the test manufacturer for clarification.
Dear Doctor, I also got IgG quantitative antibody test through CMIA method for my wife after 5 weeks of Covid symptoms first appeared, her antibody levels were 9952 au/ml, the test reference range is as follows , Negative 50 to 80,000 au/ml. During Covid time, my wife had mild pneumonia and was on low dose steroids for 24 days, her Oxygen levels always maintained with out any support, however she had persistent cough but there was no hospitalisation, She did all household activities and performed daily chores. After antibody test, when I saw such a high level of antibodies value, then I got her retested next day through CLIA method and the result was positive again with antibody >150 Au/ml, this time reference range was - negative if less than 1 au/ml and positive when more than 1, I think that laboratory's test range could calculate up to 150 only, so in my case result was shown >150. I showed her report to a MBBS, MD Doctor along with her latest CBC, LFT, KFT, Thyroid, electrolytes and other routine blood test values which were almost normal. Doctor said there is nothing to worry. My wife has not been vaccinated. At that time her CRP( C reactive protein value) was on slightly higher side - 8mg/litre, Please comment on antibody levels.
Hi i got 73,000 ul , is this normal?
I had covid 3 months ago. I also got the moderna vaccines.
great work
Thank you! Let me know if you have any question or other topics of interest. Have you checked out my Quick 2-min Q&A video series?
Hello sir I'm testing two times please reply anybody levels good or bad
1) September 2020 igg 5.53 c.m.i.a method
2) April 2021 igg 14.15 c.l.i.a method
Hi - These are two different methods, so a direct comparison is not possible. Good news is that you have antibodies in your system and they are still present after 8 months. Watch this video to learn more th-cam.com/video/XXF3QNzFYDQ/w-d-xo.html
Thank you doctor, what I want to know how can I reduce my igm it’s 4.73, but my igg its 0.01 ?
IgM and IgG are two very different kind of antibodies. IgM is generated in the early phase of the infection and disappears more quickly. IgG appears later and lasts for a longer time. It depends on the type of test and the timing of the test. Absolute numbers are not easy to interpret unless you know the reference values of the test. Also, note that IgG does not always mean that that these antibodies are able to "neutralize" the virus, but they are a sign that your immune system is responding to the infection.
@@NaveenAgarwalPhD thanks doctor
My igg level is 3.80 .what is mean?
IgG value 0.63.
What is the interpretation of the value in term of immunity to Covid-19
Hello Surajit - it is hard to interpret the IgG value without any reference. IgG is one type of antibody, which may or may not neutralize SARS-CoV-2. There are other tests which measure the neutralizing antibody levels. Your question about immunity is still being studied since COVID-19 is so new and not much is known yet. So far, there is data that shows that neutralizing antibody levels can persist for up to 50 days.
@@NaveenAgarwalPhD Thanks sir
Hello Sir, I'm just wondering. I already had 3 positive test i on 5th, 8th, 14th. And the doctor told me that my CT is 32.47. What is the normal CT? and if I reach that then the result will be negative? and how can I put up my CT then? Thank you.
Hi Chris - I am not very familiar with how CT is used to diagnose COVID and what is considered normal. Also, I do not understand what the CT number of 32.47 mean in your case. My understanding of a CT-based COVID diagnosis is that the scans can show different patterns (spots, opacity, thickening etc.). So you should ask your doctor what exactly do they see and what they would consider as a normal level.
Having said that, even if your CT returns to whatever "normal" is, it does not mean you have no virus in your system. It may just be circulating somewhere else.
Please share additional info as you learn more - I am very interested. Thank you and wishing you a speedy recovery.
@@NaveenAgarwalPhD The doctor told me Sir that its the Transmission of the Virus. id its still high or low. and he told me that the normal is like 40 to be negative. So they will be the one to decide if my result is negative or positive, am I right sir? I think its called ycle threshold
@@atlechris Oh ok I understand better now. I misunderstood CT to mean a CT scan. The CT, in this case, is Cycles threshold and 40 is the upper limit. Above 40, the test result is considered negative. In a way, the closer you are to 40, the less virus you have in your system. Does this help?
@@NaveenAgarwalPhD yes sir i think this is it. I have a question, is there anything that I have to do inorder to get a higher CT? and is it possible that it will go up daily?
My antibody is 66.3 (ECLIA) method what it means???
Bro I have 53 .. please tell me also
i agree tangible proof of Immunity is what we should be proving and measuring, and not just taking additional vaccines and boosters without measuring our antibody levels first.
You don't add oil to the engine without first looking at the dipstick first to see how much it may need!
Thanks for sharing your thoughts. Are you saying that it would be better to first measure the antibody level and if it is low, or has fallen down by a lot after the 2nd dose, then we should take the booster dose? I think that makes a lot of sense. In general, you can expect to see a reduction in antibody levels 5-6 months after your last vaccine dose for the mRNA vaccines. But again for some people this may be too long or too short a time gap.
@@NaveenAgarwalPhD That's my thought, ether through natural immunity or vaccinated immunity, why is a PCR test, or your number of shots the tool for measuring, why is proof of vaccination the requirement? if the goal is antibody's then we should be testing and providing proof of antibody's.
@@James_Dahlen Hi - you are raising very important questions. I see it this way - there is a public health policy issue at the overall population level, then there is an individual health issue at an individual level. I don't talk about policy issues and decisions on my channel. But I think we should understand the data in a general sense to figure out what decisions we should be making at a personal/individual level. I emphasize frequently that every individual is different. The best course of action is to talk to your doctor with a full understanding of general information and how it may or may not apply in your individual situation.
@@NaveenAgarwalPhD Thanks!
I just had my bloodwork done and i have IgG of >800.0 Semi-Quant of >2500.0 and Nucleocapsid Positive and Spike Ab Positive, i had the J&J In April of 21 am i correct in thinking i shouldn't need the J&J booster at this time?
@@James_DahlenHi - so far, I have not heard any advice or guidance based on antibody levels alone. At an individual level, I always advise to look at your whole situation, including your exposure level and the transmission rate in your area, your medical history etc. This decision is best taken after a carful look at your individual situation and talking to your doctor.
My Covid antibody total result with C.L.I.A technology is >10 COI. How to interpret this? Is this good immunity?
Hi - you need to compare it against the reference level for the test. Each test is different and the absolute value does not mean much unless it is compared against the reference value. In general, a higher number means more antibodies, but remember there is not direct correlation between the level of antibody and immunity against the virus. It depends on the type of antibody.
Thank you for your revert and details. Really appreciate it.
I also got the igG result and the value is 4.08. Does that mean good immunity? Can I be a plasma donor?
@@NaveenAgarwalPhD sir do you know anything vor making fool by copy pasting same reply to every query
@@pranshusharma7600 hi - just to clarify, this is not a copy/paste, but the answer to many of these questions is the same. I have decided to post a quick 2-min video in next couple of weeks.
Having said that, let me know your specific question.
Sir antibody test result is reactive and score is 1.45.....is this sufficient?......i have tested this afer 6 month from infection
Hi Rohit - the absolute number is difficult to understand unless you know the baseline number. The reactive result 6 months after infection means you have antibodies but it is hard to understand how much. Also, note that not every test measures what they call "neutralizing antibodies". If you take the same test over time, you can compare the numbers.
@@NaveenAgarwalPhD thanks sir🙏
FYI: you mentioned that you were focusing on the ADVIA analyzer but your data is from the Atellica analyzer. The index range for the ADVIA Centaur is 0.05-10.
Sir my COI score is 53 ... please tell me what does this signify
Hi Pranshu - what is COI? Can you also give the name/type of test you did?
@@NaveenAgarwalPhD Sir ECLIA test
@@pranshusharma7600 Ok, this is a type of a test that can give you the level of total antibody in your system. Do you know the range of the specific ECLIA test you did? Does it tell you the minimum and maximum amounts measured by this test?
There is one test from Roche Diagnostics that is authorized by the FDA in the USA. I am not sure if this is the same test for you, but this one has a range from 0.8-250.
Now, keep in mind that the absolute number may not mean much in terms of your "immunity". It just means you have the antibodies and your immune system has responded to the virus.
@@NaveenAgarwalPhD thanks sir
Hello doc what does an igg of 28 mean ?
Hi Shahzad - it means you have IgG antibodies according to the test you took. Whether it is high or low, depends on the reference value of the test. Each test is different. Also, note that IgG are only one kind of antibodies in response to COVID-19 infection.
Sir i got SARS-COV2 (covid-19) IgG antibody test done 14 days after second does of vaccine and the result came 6.73 positive reference range being >1.0(index) positive but on 23rd day o got the same test done again and result came 1.82(positive) why did the numbers decrease pls explain
Hi Nakul - it is not uncommon for antibody levels to change over time. Are you sure it is reporting only IgG or does it also include IgM antibodies?
@@NaveenAgarwalPhD sir only IgG
Covid anitbody test result of 75.4 mean?
Hi - please take a look at this short video to understand better th-cam.com/video/XXF3QNzFYDQ/w-d-xo.html
Thank you dr. Agarwal. What does a result of 2.09 measured in index mean? I tested positive on the 10th of April, and last symptoms on 17th April. My IgG test results of 2.09 came back 26th apr (sampled on 25th apr)
Hello Doctor,
Anti SARS CoV 2 (Serum ECLIA) is 114, what does it mean??
IgG or igm
Hi sir my antibody test results IgG value >400 & unit AU/mL standard range
I had covid December 2020 and yesterday, 9/9/21, had antibody levels drawn again via Roche Elecsys and my level was 931 with positive level anythinng over 0.80. I haven't been sick since; obviously, I am immune, and yet I'm having my employer shove the jab down my throat or I get fired.
Hi - thank you for sharing. Have you shown your antibody test results to them? What does your doctor recommend? This is a difficult time for everyone. Best wishes to you and stay safe.
@@NaveenAgarwalPhD My employer explicitly states it will not take antibody tests as proof of immunity. It's either get the jab, get an exemption (I got a religious exemption, actually) or get fired.
Due to this, I haven't bothered discuss with my doctor.
@@fredharvey2720 Thanks for sharing. I guess this policy may be because FDA has advised against making any correlation of immunity with the level of antibodies in a test. There are still a lot of unanswered questions about immunity to Covid-19.
I would recommend you to continue monitoring your situation and take all the precautions you can. Best wishes to you. Stay safe and god bless.
@@NaveenAgarwalPhD So why are they making correlations of immunity with the level of antibodies the vaccine produces? To me, this reeks of politics and I strongly suspect Big Pharma is paying off politicians to ignore natural antibodies to market more doses. This selective recognition of antibodies makes no sense at all.
@@fredharvey2720 You make a great point. Most of the antibody testing data is in the clinical trial results for vaccines. One point to remember is that they also did more sophisticated tests to show increase in the level of neutralizing antibodies. These tests are generally not available to the public. They are showing it to prove the vaccine works but the effectiveness data comes from counting the number of infections and comparing against those who did not receive the vaccine in clinical trials. It is not possible to correlate but I am sure there are mixed messages going out in different sources of information.
Hello sir.. My iGg value is 0.19. What does this mean ? Have I been exposed to Covid 19 or not ?
Hi - it is difficult to interpret the number 0.19 without any reference. The test should also tell you a yes/no result for presence of IgG. If there IgG test for SARS-CoV-2 shows a positive result, then you were exposed.
Hi Anshika - if the test is giving you a number, it means it is a positive result indicating your immune response to the virus. Did you have any symptoms?
@@NaveenAgarwalPhD yes sir I had all the symptoms.. cold..cough.. fever around >99 , so if the number it gave was 0.19 so it means I was exposed to the virus?
@@ansh01019 Yes that is most likely correct. How many days after recovery did you take the antibody test? It should be at least 2 weeks after full recovery.
@@ansh01019 it means You still have virus
Hi everyone - many of you have been asking me a similar question about the antibody levels from your test. So, I decided to make a quick video. Please see here th-cam.com/video/XXF3QNzFYDQ/w-d-xo.html
My antibody IgG 7.its ok
Hi Doctor my Antibody Test result shows Reactive and observed value shows >175. Refrence Range for Reactive is >/= 1.000 Cutoff Index. What does this means??
Hello Wahid - the cutoff value means any number more that 1 is a positive result. Observed value of 175 needs to be compared to the max value of the specific test. It means you have antibodies in your system (most likely IgG).
My total antibody anti SARS cov 2 is 201 what it means
Hello Prashant - do you know which test was done and what is the reference value in that test? It is not easy to understand what this number means unless you know the reference number. In general, a higher number means more antibodies in the system.
@@NaveenAgarwalPhD I have done antibody test @ metropolis lab Bombay.
My result was reactive 201.
Bro do you conduct ECLIA test
@@pranshusharma7600
Total antibody test Yes eclia test
@@prassantjshirke6304 mine is 53 what does this indicate any idea
Sir please tell me my test report Anti SARS COV -2 33 reactive (ECLIA)?
Hi - this means the test has detected antibodies in your system at a level higher than the minimum. Check out this video to learn more
th-cam.com/video/XXF3QNzFYDQ/w-d-xo.html
My antibody Ig G corona 19 ,7.8
It's ok
Hi - please check out this short video to understand what these results mean
th-cam.com/video/XXF3QNzFYDQ/w-d-xo.html
Just make a subscription 😘