Request for future content: Seeing as how Vit K is a major part of your work, and how you've mentioned it as successfully treating or preventing tooth decay, it would be awesome to hear your detailed approach to tooth decay in either a podcast or even just a comprehensive Lite video.
So helpful. I discovered macrocytic anemia on a routine blood test and everything pointed to B12 deficiency, so I now take regular injections (as Pernicious anemia is in my family and suspected) and bought the expensive methylated folate as a co-factor, fast forward 6 months and after an initial pick up in symptoms like peripheral neuropathy, everything starts to come back, I know I ran out of folate 2 months back so that was my first mistake, but I thought, hey i'm eating liver and green leafy veggies, it's ok. I was about to order some more 5-methylfolate but on seeing this I just popped to my local chemist and bought folic acid, I've been having extreme weakness in my arms and hands for over 3 weeks now, after taking high strength FA (5mg) for 2 days it's down by about 60%. I think I am someone that utilised FA far better than the methylated version. TY for this info
What about folinic acid Dr.Chris? Is this form able to do the same thing as syntetic folic acid without the side effect of a build up of the unusable form? Thanks in advance
fom what i read on folic acid , human capacity to utilize folic acid is 200mcg a day , so probably that should be upper limit to avoid bad side effects?
payman z I don't recommend it at all, but I don't think that's true either because there's a lot of variation, and split across meals the upper limit is likely to be per meal.
payman z Because there are lots of enzymes that don't have perfect substrate specificity. The natural function of the enzyme is to convert dihydrofolate to tetrahydrofolate, but that action is similar enough to converting folic acid to dihydrofolate that the enzyme will do both.
I took 400mcg Folic acid before getting pregnant yet my baby got spina bifida. Then I got to know about MTHFR mutation. But in my country it's not available. Should i take Methyl Folate or Folic Acid? Or both together will be good? Plz answer and help !!! @chris
Hi Chris, I use Megafood Multi which provides folate as "MTHF in broccoli." How does that fit into your discussion? (By the way, thank you for all the great information!)
I see papers that say food folate (i.e. a 5-MTHF salt, for the purposes of my question) has the same bioavailability (i.e. absorption, for the purposes of my question) as folic acid. Is this true? Does this contradict the end of this video when you say that folic acid doesnt require the same digestive processes as food folate? Or were you using the term "food folate"/"folate in food" to mean something other than 5-MTHF from a supplement? Thanks. I ask because I noticed a difference between a 5-MTHF supp vs. folic acid supp, although it could just have been that the former supp had half the 5-MTHF...
I took little dose inostol hexanicotinamide and I took High dose methylcobalamin 1000mq and I took folic acid 1500mq folic acid supp same day and I got prostate and lung problems can you help me
Chris my MCH is chronically low, every time I do bloodwork (about every three months). My MCV is "normal" but bottom of the range. Would a low level of MCH correlate to this issue as well?
Raymond Pecheone No that means deficient hemoglobin and it's likely due to a deficiency of iron, b6, copper, or a genetic issue with the relevant enzymes.
But I keep hearing that folic acid is carcinogenic. I do have pernicious anemia, it runs in my family, so I give myself b12 shots. I've been purposely buying more expensive b complex vitamins that don't contain folic acid!
Laurel Lovelace That's possible, but like I said in the video I'm not advocating the folic acid. This is the clue to the problem. More on the solution in the next video.
Request for future content: Seeing as how Vit K is a major part of your work, and how you've mentioned it as successfully treating or preventing tooth decay, it would be awesome to hear your detailed approach to tooth decay in either a podcast or even just a comprehensive Lite video.
Thomas, I've put this request in my topic requests folder. Great idea.
So helpful. I discovered macrocytic anemia on a routine blood test and everything pointed to B12 deficiency, so I now take regular injections (as Pernicious anemia is in my family and suspected) and bought the expensive methylated folate as a co-factor, fast forward 6 months and after an initial pick up in symptoms like peripheral neuropathy, everything starts to come back, I know I ran out of folate 2 months back so that was my first mistake, but I thought, hey i'm eating liver and green leafy veggies, it's ok. I was about to order some more 5-methylfolate but on seeing this I just popped to my local chemist and bought folic acid, I've been having extreme weakness in my arms and hands for over 3 weeks now, after taking high strength FA (5mg) for 2 days it's down by about 60%. I think I am someone that utilised FA far better than the methylated version. TY for this info
What about folinic acid Dr.Chris? Is this form able to do the same thing as syntetic folic acid without the side effect of a build up of the unusable form? Thanks in advance
have you found an answer to this question?
So another question is: what foods naturally contain the unmethylated form of folate?
fom what i read on folic acid , human capacity to utilize folic acid is 200mcg a day , so probably that should be upper limit to avoid bad side effects?
payman z I don't recommend it at all, but I don't think that's true either because there's a lot of variation, and split across meals the upper limit is likely to be per meal.
thanks,good idea.
if folic acid is totally unnatural then why we have enzyme that converts it to folate?
payman z Because there are lots of enzymes that don't have perfect substrate specificity. The natural function of the enzyme is to convert dihydrofolate to tetrahydrofolate, but that action is similar enough to converting folic acid to dihydrofolate that the enzyme will do both.
thanks!
I took 400mcg Folic acid before getting pregnant yet my baby got spina bifida. Then I got to know about MTHFR mutation. But in my country it's not available. Should i take Methyl Folate or Folic Acid? Or both together will be good? Plz answer and help !!! @chris
Hi Chris, I use Megafood Multi which provides folate as "MTHF in broccoli." How does that fit into your discussion?
(By the way, thank you for all the great information!)
This is methyl folate.
I don't eat fortified or enriched flours and take a multi that has 400mcg synthetic folic acid. Will this raise my risk of getting cancer?
I don't know, but it is better to take natural folate rather than folic acid.
In the book dirty genes the author says to avoid folic acid?!???!! Any thoughts?
I see papers that say food folate (i.e. a 5-MTHF salt, for the purposes of my question) has the same bioavailability (i.e. absorption, for the purposes of my question) as folic acid. Is this true? Does this contradict the end of this video when you say that folic acid doesnt require the same digestive processes as food folate? Or were you using the term "food folate"/"folate in food" to mean something other than 5-MTHF from a supplement? Thanks. I ask because I noticed a difference between a 5-MTHF supp vs. folic acid supp, although it could just have been that the former supp had half the 5-MTHF...
Is methocobalamin any better?
acjitsu Better than what? It is the worst form of B12 for the prevention of anemia, but I'm not sure what you're asking me to compare it to.
More specifically, if a person is going to use a synthetic B12, is methocobalamin a better choice than cyanocobalamin ?
Not for preventing anemia. But, in general, I don't like cyanocobalamin.
Chris! Off topic question, but what are your thoughts on male pattern baldness?!
an insight in the making. I don't have any, but Danny Roddy does.
What do you think of Calcium Folinate? Is it methylated?
It is not. It is formylated.
I took little dose inostol hexanicotinamide and I took High dose methylcobalamin 1000mq and I took folic acid 1500mq folic acid supp same day and I got prostate and lung problems can you help me
Chris my MCH is chronically low, every time I do bloodwork (about every three months). My MCV is "normal" but bottom of the range. Would a low level of MCH correlate to this issue as well?
Raymond Pecheone No that means deficient hemoglobin and it's likely due to a deficiency of iron, b6, copper, or a genetic issue with the relevant enzymes.
Ok cool thanks
How does MTHFR affect this?
Chelsea Thiede It doesn't.
where does this fall for people with the mthfr gene mutation?
what about Folinic acid?
It’s cool.
But I keep hearing that folic acid is carcinogenic. I do have pernicious anemia, it runs in my family, so I give myself b12 shots. I've been purposely buying more expensive b complex vitamins that don't contain folic acid!
Laurel Lovelace That's possible, but like I said in the video I'm not advocating the folic acid. This is the clue to the problem. More on the solution in the next video.
yay folic acid!