In this episode, we discuss: 0:00:10 - The motivation behind this journal club conversation 0:06:33 - Why Peter chose a paper on metformin, how metformin works, and why it generated excitement as a longevity-enhancing agent 0:13:45 - Defining insulin resistance and its underlying causes 0:19:28 - Metformin as a first-line treatment for type 2 diabetes, and Peter’s evolving interest in metformin as a geroprotective drug 0:22:20 - Defining the term “geroprotection” 0:23:31 - The 2014 study that got the anti-aging community interested in metformin 0:30:43 - Peter presents the 2022 paper that repeats the analytical approach from the 2014 Bannister study 0:37:30 - Greater mortality in the metformin group: how results differed between the 2022 paper and the 2014 paper 0:49:20 - Understanding statistical significance, statistical power, sample size, and why epidemiology uses enormous cohorts 0:54:18 - Interpreting the hazard ratios from the 2022 metformin study, and the notable takeaways from the study 1:06:10 - Drugs that may extend lifespan, why Peter stopped taking metformin, and a discussion of caloric restriction 1:18:29 - Current thoughts on the use of metformin for longevity 1:20:05 - Could there be any longevity benefit to short periods of caloric restriction? 1:23:53 - Peter and Andrew’s process for reading scientific papers 1:30:05 - The biological effects of belief, and how “belief effects” differ from placebo effects 1:37:19 - The neurobiology of nicotine: a precursor conversation before delving into the paper Andrew chose 1:43:00 - Andrew presents a paper that demonstrates the impact of belief 1:52:02 - Analyzing the fascinating results of the Perl paper 2:00:45 - Exciting implications of the findings about “belief effects”
I reached only 11 seconds of this podcast when I KNEW I was going to love it. The joy radiating between these two is so palpable. There is a bit of a zing going on between them, meeting a fellow "geek" with so much in common. Can't wait to watch the rest. Such a gift to the universe these two are.
Loved that. Dream journal club! Would have wished my post-grad students be as prepared to think aloud when not entirely sure of the correct answer instead of being frozen scarred to be wrong. 👏
Great job guys! The belief paper really could spawn a lot of interesting new investigations. Perhaps even one including physicians as the subject. Take docs who are just starting to prescribe a new drug. Will the docs who believe the drug should do a great job evaluate the subjective feedback from patients more positively than docs who think the drug might be okay but not really terrific? Or from a slightly different angle, will a drug with great TV and print ads get a better response from patients than one with crappy ads? You could run two different ads in different cities and compare patient satisfaction.
To your comment on Situs Inversus: As a Radiology Tech, I did in fact have a patient with Situs Inversus. Exceptionally fascinating to see this condition. In our imaging on a GI study,we had to, of course mirror everything-from the Fluoro real-time imaging to the overhead views.
For anyone interested in learning more about the physiological effects of the belief system, I can recommend a book called "Cure: A Journey into the Science of Mind Over Body" by Jo Marchant. The book covers a wide range of topics, but I was most intrigued by the measurable physiological changes (pain receptors, immune response, etc.). The author discusses the work of Fabrizio Benedetti (University of Turin), Jon Levine (UCal) and others. It's not a woo-woo book, she takes a serious scientific approach, but it helps to read the book with an open mind.
Thank you for this! Currently obsessed with reading the many recent scientific papers on inositol. Please a podcast on inositol! Mood stabalizers depelete it, depeletion causes hypothyroidism, metabolic syndrome, etc...omg the transformational potential of this compound!
The metformin paper was very interesting. Downloaded and read through the link - thank you for that. However, as a professional biostatistician (recently retired) can I make a plea to please try and include a statistician on your podcast next time you review a paper like this? The comment that 'some statistician listening is going to hate this' was not wrong. Now, Cox proportional hazards models and Kaplan-Meier curves ARE very difficult to explain but that was rough. I know my colleagues don't have the best reputations for explaining things to non-statisticians, but you could add one to your discussion and then ask them questions to help explain things.
All calculations/studies/papers/arguments/contracts hinge on assumptions. Unfortunately, assumptions may not be spelled out. Always make sure to identify the assumptions.
Great episode! I'm interested to know more about the paper about ATP binding cassette in cholesterol absorption mentioned at ~2'30'' of the episode. Would it be possible to share the reference to the article?
Risk data needs to include: diet, amount of exercise, education (the number of lectures on diabetes, diet, exercise), level of interest. No wonder these studies don't show how to improve life expectancy with diabetes.😊
When I first started smoking at the age of 15 or so every time I sneaked a cigarette from my dad who smoked Dunhill red the effect would make me sit down for minutes and make me feel fussy while mums Winfield red didn’t and apparently had the same strength, but dad use to go on all the time about how strong his cigarettes wher. Luckily I gave up in my early 20s 😅
Even after Huberman explaining it for like 10 min, I don't understand the difference between this "belief effect" and placebo. It just seems like a more specific form of placebo. I'll have to go back and read it, but in the literature on placebo, I'm pretty sure it's documented that placebo effects cause real physiological changes to body chemistry, not just psychological motivation. It's why things like acupuncture have been used for thousands of years despite it being proven completely bunk again and again.
I think with a true placebo whatever reaction you have is whatever you think might be possible, which may actually be more powerful than a belief effect as it is not based on any prior history with that substance, only on your belief or trust that it will do something (this pill will grow my hair back, or this pheromone spray will make people like me more). Whereas in the belief effect, the response you get in your body appears to be more of a trained, very specific, response based on something you already do (or have done) where you can then choose to frame it in a specific way and then get direct physiological effects based off that belief (nicotine makes me focus, or physical activity makes me lose weight) They are very similar and I'm not 100% sure that even describes it correctly. I remember reading a study years ago where they found that if you give someone a real medication using a distinctive pill (so think red pill that smells like strawberries) for a specific condition over a long enough set of time, you could then give that same person a dummy pill (so red and smelled like strawberries) with no medication in it and you would still have the same physiological response to the dummy pill as to the real pill. Because the body had been conditioned to have a set biochemical response when that pill was taken. In a very real way, the pill (real or fake) was like a power switch that said to the body "ok, we're taking the pill, go ahead and start doing all the things the pill would make us do", well before any medication (there or not) could have an effect. The body became conditioned to do x,y, and z when it noticed the stimulus of taking the pill. I also vaguely think I remember that it did not matter at all if the person knew it was a real pill or a fake pill, it worked either way. Is that a placebo? Not really. It's more like operant conditioning. We conditioned your body to respond in x way to y stimulus. This "belief effect" seems to work in much the same way. The body is conditioned to smoking giving nicotine (y) and then the body responds to it with increased focus and attention (x). Regardless of the actual nicotine content. The really cool thing in this study is the dose-dependent part. Not only can you condition your body to respond like you have taken something, but you can make it believe it was a higher or lower dose, regardless of the actual dose, and it will then respond in kind. That is truly amazing and shows a super fine-tuned kind of distinction.
could not stop focusing on the mason jar -tea-juice drink by Peter (still, I absorbed the material along the way , as always on their podcasts MASON JAR TEA JUICE DRINK was centerstage whole time
Hi Peter, I love your podcasts and I also started to read your book. I just wanted to ask one question as you do mention this sometimes but it is still unclear to me. I tend to be a very stressed person, 43 years old, I think it comes from the multiple children family, and I did tests myself feeling unwell and losing weight. So I got the results with cortisol elevated but not passing over the top limit, but not far from it, and also sugar the same story, this is related as I found out from your podcasts. I started to take ashwaganda, rhodiola, and berberine to reduce all this. But my question is, how should we train when cortisol is on the higher side? I started to implement zone 2 but I would also like to build the muscle I noticed that it's so much harder now than it was maybe 2 years ago, ( when I was a crossfiter and CrossFit coach). could you advise or maybe point me to one of your videos where you mention this. Or should I stick with zone 2 for now until the cortisol is sufficiently reduced? I'm sorry for bothering you, but I really appreciate you as a person helping others. You are changing my life and giving me awareness. Thank you from the bottom of my heart.
A carnivore diet, specifically ribeye only helped massively for me in mood and building muscle. I saw results instantly. Combine this with cold showers and you'll feel like you can take on the entire world with no problems.
First question, Peter would ask how’s your sleep as he is a scholar of Matthew walker (sleep diplomat), if your sleep is inadequate, if so, Peter would do everything in his tool kit to address and fix it before he even talks about anything else.
@@aclasscali my sleep is good I would say. I aim to sleep from 22pm till 7am everyday including weekend. I'm interested in info on how to train with elevated coritisol but thanks for your input.
love these two... would hypochondria be the classic old definition for brain-reacting-on-belief for developing every type of side effects symptoms to a drug?!? Just saying... :)
I do not need to take Metformin for any diabetic condition but I started taking it a year ago for possible gero-protection assistance. More recently, I read it might impact my workout benefits so I only take it 2-3 times a week. When I am seeking VO2 Max benefits I avoid it but have no idea if this makes sense.
yup, or at least low intake of non processed slow carbs only + meats/keto-ish diet (salad, brocolli -ok, pasta, bread - no no) I believe would have similar effects. Plus fats, loads of good fats (beef tallow i.e)
When I first heard Peter mention muscle loss as an adverse consequence of fasting (not here, but at an earlier time), it made sense to me. Then I heard a podcast with Jason Fung who was incredulous at this postulation and asked where it came from, so now I'm a little confused if fasting really does lead to the amount of muscle loss Peter says it does.
@@annarae5717 I think we would benefit from a deeper dive into this. Peter seems to create quite a wake of enthusiasm ("wake" that a boat leaves behind) whenever he gets into a new idea which then seems to swamp his old enthusiasms (in this case, fasting). I would like some more discussion on this as fasting is (still) a key tool in many people's toolboxes to use a much overused cliche.
SGLT2 is a member of the sodium glucose cotransporter family, which are sodium-dependent glucose transport proteins. SGLT2 is the major cotransporter involved in glucose reabsorption in the kidney.
SGLT2 inhibitors, also called gliflozins or flozins, are a class of medications that modulate sodium-glucose transport proteins in the nephron (the functional units of the kidney), unlike SGLT1 inhibitors that perform a similar function in the intestinal mucosa.
A possible interpretation of the twins is that the diabetic twin had to destroy their system so throughly to become diabetic that their chance of dying naturally skyrocketed. And in the other arm the hazard ratio dropped for diabetics who didn’t die because they were more fit.
I think you are right + not to eat that much in overall. .. and not to blend all things in a meal. I heard a good sentence few years back and I think it's so true: God created food, devil created cooks/chiefs.
Huberman definitely took something a little stronger than Alpha GPC and Yerba during this podcast. Facial flushing is indicative of a beta blocker potentially? Genuinely curious
I don't have words for your supposition. Maybe it was to warm for him. Some of you , instead of listening to the fantastic talk , you are wondering about their face color ,and so on ,so on.. Common guys!
My face is red when I take B3 on empty stomach. Too many variables to make a conclusion. As someone mentioned - could've been the temperature, or simply excitement about the conversation. Doesn't matter, really :)
Aren't Danish different from British to start with? I would hypothesize that British general population is as sick as Americans (95% metabolically I'll), while Danish are not. There you have the big difference!
I live in UK(moved 20 years ago) and don't need to study papers to be sure Danish are healthier. Especially when looking at lower income group of population here, I see zero interest in anything, zero knowledge about nutrition. Case probably changes when start comparing lower middle class and up in each of the mentioned countries. Also - both countries are north - much less sunny days and UK's humidity crinkles your fingers on your way from the airport already, once you arrive here ;)
Yet, Peter was smiling more than ever. I think they are good friends, hence the more relaxed structure. Plus remember - scientists are known for their bigger than average ego - they often can speak and speak until interrupted. I have noticed Andrew making more "interrupting" jokes when he enjoys the conversation. It must be a state of DELIGHT. Also, I find it cute he tries (and succeeds) to make people laugh, not every scientist has a sense of humor, quite a % of them can be seen as "dry". Give him a slack :)
In this episode, we discuss:
0:00:10 - The motivation behind this journal club conversation
0:06:33 - Why Peter chose a paper on metformin, how metformin works, and why it generated excitement as a longevity-enhancing agent
0:13:45 - Defining insulin resistance and its underlying causes
0:19:28 - Metformin as a first-line treatment for type 2 diabetes, and Peter’s evolving interest in metformin as a geroprotective drug
0:22:20 - Defining the term “geroprotection”
0:23:31 - The 2014 study that got the anti-aging community interested in metformin
0:30:43 - Peter presents the 2022 paper that repeats the analytical approach from the 2014 Bannister study
0:37:30 - Greater mortality in the metformin group: how results differed between the 2022 paper and the 2014 paper
0:49:20 - Understanding statistical significance, statistical power, sample size, and why epidemiology uses enormous cohorts
0:54:18 - Interpreting the hazard ratios from the 2022 metformin study, and the notable takeaways from the study
1:06:10 - Drugs that may extend lifespan, why Peter stopped taking metformin, and a discussion of caloric restriction
1:18:29 - Current thoughts on the use of metformin for longevity
1:20:05 - Could there be any longevity benefit to short periods of caloric restriction?
1:23:53 - Peter and Andrew’s process for reading scientific papers
1:30:05 - The biological effects of belief, and how “belief effects” differ from placebo effects
1:37:19 - The neurobiology of nicotine: a precursor conversation before delving into the paper Andrew chose
1:43:00 - Andrew presents a paper that demonstrates the impact of belief
1:52:02 - Analyzing the fascinating results of the Perl paper
2:00:45 - Exciting implications of the findings about “belief effects”
Gv ok o k en. Já cm
Un ok n j a 🎉😮a🎉 en 😮tnimlni Mty jmtmt
🙏🏻Thank you!
I reached only 11 seconds of this podcast when I KNEW I was going to love it. The joy radiating between these two is so palpable. There is a bit of a zing going on between them, meeting a fellow "geek" with so much in common. Can't wait to watch the rest. Such a gift to the universe these two are.
Do this again Peter with Andrew. So enjoyed this.
my 2 favorite podcasters/doctors in 1 show? plus i learn and laugh too? what a treat!
AGREE!!!
Loved that. Dream journal club!
Would have wished my post-grad students be as prepared to think aloud when not entirely sure of the correct answer instead of being frozen scarred to be wrong. 👏
Interesting!! Gratitude for these two brilliant guys!!
I truly respect and love both of these guys.
Great discussion guys - thank you both for sharing so much important and valuable information with us all. Keep it coming!
Finally, something worth listening to
Best anime crossover ever - Peter Attia and Andrew Huberman ❤
This isn't anime...
Hey @thomabow8949, just so you know, he's only joking.
😆🫸✨💥✨🫷🤩
What a wonderful combo
Reading "Outlive" right now, going to be purchasing more books and sending them out as gifts, thank you Dr. Great Book!
Best idea! Thank you! I’m getting so smart over here, let me tell ya!
Great job guys! The belief paper really could spawn a lot of interesting new investigations.
Perhaps even one including physicians as the subject. Take docs who are just starting to prescribe a new drug. Will the docs who believe the drug should do a great job evaluate the subjective feedback from patients more positively than docs who think the drug might be okay but not really terrific?
Or from a slightly different angle, will a drug with great TV and print ads get a better response from patients than one with crappy ads? You could run two different ads in different cities and compare patient satisfaction.
To your comment on Situs Inversus:
As a Radiology Tech, I did in fact have a patient with Situs Inversus.
Exceptionally fascinating to see this condition.
In our imaging on a GI study,we had to, of course mirror everything-from the Fluoro real-time imaging to the overhead views.
Great discussion as always. As an aside... Andrew, please release this elixir. I was thinking maybe "Dewberman Juice" or simply "HuberDew"?
This is amazing :) Love Outlive and everything you do, the way you breakdown the science and explain everything.
Shocked there aren't more views. How is this possible?!?
love this episode! learned so much about metformin
Choosing to watch on Peter’s channel due to no ads
There are no ads on the podcast version ( Apple , etc.)
Fantastic!🎉 Andrew and Peter, please do more of these. I enjoyed this tremendously
So looking forward to this!
For anyone interested in learning more about the physiological effects of the belief system, I can recommend a book called "Cure: A Journey into the Science of Mind Over Body" by Jo Marchant. The book covers a wide range of topics, but I was most intrigued by the measurable physiological changes (pain receptors, immune response, etc.). The author discusses the work of Fabrizio Benedetti (University of Turin), Jon Levine (UCal) and others. It's not a woo-woo book, she takes a serious scientific approach, but it helps to read the book with an open mind.
Brilliant, just BRILLIANT
The dynamic duo!!! ❤
More Journal Club, Please. Thanks
This was fantastic!
Amazing 👏🏼👏🏼 My dream would be a conversation or journal club with David Deutsch.
After 48 years in veterinary medicine I have seen total situs inversus one time in my career. But we sure do hear about it!
Thank you for this! Currently obsessed with reading the many recent scientific papers on inositol. Please a podcast on inositol! Mood stabalizers depelete it, depeletion causes hypothyroidism, metabolic syndrome, etc...omg the transformational potential of this compound!
Loved this
The metformin paper was very interesting. Downloaded and read through the link - thank you for that. However, as a professional biostatistician (recently retired) can I make a plea to please try and include a statistician on your podcast next time you review a paper like this? The comment that 'some statistician listening is going to hate this' was not wrong. Now, Cox proportional hazards models and Kaplan-Meier curves ARE very difficult to explain but that was rough. I know my colleagues don't have the best reputations for explaining things to non-statisticians, but you could add one to your discussion and then ask them questions to help explain things.
Thank you, sir, really appreciate both your efforts..🎉
And so it begins :)
All calculations/studies/papers/arguments/contracts hinge on assumptions. Unfortunately, assumptions may not be spelled out. Always make sure to identify the assumptions.
That was F"ing epic!
Great episode! I'm interested to know more about the paper about ATP binding cassette in cholesterol absorption mentioned at ~2'30'' of the episode. Would it be possible to share the reference to the article?
Attia was smiling? 🤯
I know! and so many times! I think Peter is more palatable when in presence of Andrew :)
Risk data needs to include: diet, amount of exercise, education (the number of lectures on diabetes, diet, exercise), level of interest.
No wonder these studies don't show how to improve life expectancy with diabetes.😊
I love it
1:08:00 couldnt he take just 1mg instead of 2mg and not to go zero and lose the benefits.
wow i would tailor my cloth to take that elixir everywhere too
When I first started smoking at the age of 15 or so every time I sneaked a cigarette from my dad who smoked Dunhill red the effect would make me sit down for minutes and make me feel fussy while mums Winfield red didn’t and apparently had the same strength, but dad use to go on all the time about how strong his cigarettes wher.
Luckily I gave up in my early 20s 😅
Even after Huberman explaining it for like 10 min, I don't understand the difference between this "belief effect" and placebo. It just seems like a more specific form of placebo. I'll have to go back and read it, but in the literature on placebo, I'm pretty sure it's documented that placebo effects cause real physiological changes to body chemistry, not just psychological motivation. It's why things like acupuncture have been used for thousands of years despite it being proven completely bunk again and again.
I think with a true placebo whatever reaction you have is whatever you think might be possible, which may actually be more powerful than a belief effect as it is not based on any prior history with that substance, only on your belief or trust that it will do something (this pill will grow my hair back, or this pheromone spray will make people like me more).
Whereas in the belief effect, the response you get in your body appears to be more of a trained, very specific, response based on something you already do (or have done) where you can then choose to frame it in a specific way and then get direct physiological effects based off that belief (nicotine makes me focus, or physical activity makes me lose weight)
They are very similar and I'm not 100% sure that even describes it correctly.
I remember reading a study years ago where they found that if you give someone a real medication using a distinctive pill (so think red pill that smells like strawberries) for a specific condition over a long enough set of time, you could then give that same person a dummy pill (so red and smelled like strawberries) with no medication in it and you would still have the same physiological response to the dummy pill as to the real pill. Because the body had been conditioned to have a set biochemical response when that pill was taken. In a very real way, the pill (real or fake) was like a power switch that said to the body "ok, we're taking the pill, go ahead and start doing all the things the pill would make us do", well before any medication (there or not) could have an effect. The body became conditioned to do x,y, and z when it noticed the stimulus of taking the pill. I also vaguely think I remember that it did not matter at all if the person knew it was a real pill or a fake pill, it worked either way. Is that a placebo? Not really. It's more like operant conditioning. We conditioned your body to respond in x way to y stimulus. This "belief effect" seems to work in much the same way. The body is conditioned to smoking giving nicotine (y) and then the body responds to it with increased focus and attention (x). Regardless of the actual nicotine content.
The really cool thing in this study is the dose-dependent part. Not only can you condition your body to respond like you have taken something, but you can make it believe it was a higher or lower dose, regardless of the actual dose, and it will then respond in kind. That is truly amazing and shows a super fine-tuned kind of distinction.
could not stop focusing on the mason jar -tea-juice drink by Peter (still, I absorbed the material along the way , as always on their podcasts MASON JAR TEA JUICE DRINK was centerstage whole time
Hi Peter, I love your podcasts and I also started to read your book. I just wanted to ask one question as you do mention this sometimes but it is still unclear to me. I tend to be a very stressed person, 43 years old, I think it comes from the multiple children family, and I did tests myself feeling unwell and losing weight. So I got the results with cortisol elevated but not passing over the top limit, but not far from it, and also sugar the same story, this is related as I found out from your podcasts. I started to take ashwaganda, rhodiola, and berberine to reduce all this. But my question is, how should we train when cortisol is on the higher side? I started to implement zone 2 but I would also like to build the muscle I noticed that it's so much harder now than it was maybe 2 years ago, ( when I was a crossfiter and CrossFit coach). could you advise or maybe point me to one of your videos where you mention this. Or should I stick with zone 2 for now until the cortisol is sufficiently reduced? I'm sorry for bothering you, but I really appreciate you as a person helping others. You are changing my life and giving me awareness. Thank you from the bottom of my heart.
A carnivore diet, specifically ribeye only helped massively for me in mood and building muscle. I saw results instantly. Combine this with cold showers and you'll feel like you can take on the entire world with no problems.
First question, Peter would ask how’s your sleep as he is a scholar of Matthew walker (sleep diplomat), if your sleep is inadequate, if so, Peter would do everything in his tool kit to address and fix it before he even talks about anything else.
@@aclasscali my sleep is good I would say. I aim to sleep from 22pm till 7am everyday including weekend. I'm interested in info on how to train with elevated coritisol but thanks for your input.
love these two... would hypochondria be the classic old definition for brain-reacting-on-belief for developing every type of side effects symptoms to a drug?!? Just saying... :)
That’s why I like Yom Kippor. Fasting is mandatory 😮😮
I do not need to take Metformin for any diabetic condition but I started taking it a year ago for possible gero-protection assistance. More recently, I read it might impact my workout benefits so I only take it 2-3 times a week. When I am seeking VO2 Max benefits I avoid it but have no idea if this makes sense.
Ps: On VO2 days I crank the treadmill up to 15 on an incline and the speed from 3.5-3.8 ( I work up to that over an hour)
It’s gero-protection
Thank you Miss Thistlebottom😉😉 @@mohanish
Seems to me that a keto or ketovore diet will solve the inflammation that leads to all of the diseases too much inflammation causes.
yup, or at least low intake of non processed slow carbs only + meats/keto-ish diet (salad, brocolli -ok, pasta, bread - no no) I believe would have similar effects. Plus fats, loads of good fats (beef tallow i.e)
Great episode
So is vape good for us or not ?
When I first heard Peter mention muscle loss as an adverse consequence of fasting (not here, but at an earlier time), it made sense to me. Then I heard a podcast with Jason Fung who was incredulous at this postulation and asked where it came from, so now I'm a little confused if fasting really does lead to the amount of muscle loss Peter says it does.
U meant muscle loss at the end of your paragraph?
YES! Will correct. @@contrerasmcr100
but even lossing ANY doesn't make sense, why would that happen
@@annarae5717
@@annarae5717 I think we would benefit from a deeper dive into this. Peter seems to create quite a wake of enthusiasm ("wake" that a boat leaves behind) whenever he gets into a new idea which then seems to swamp his old enthusiasms (in this case, fasting). I would like some more discussion on this as fasting is (still) a key tool in many people's toolboxes to use a much overused cliche.
Peter talks about taking a SGLT2 drug as a geroprotective agent. Which drug is this?
SGLT2 is a member of the sodium glucose cotransporter family, which are sodium-dependent glucose transport proteins. SGLT2 is the major cotransporter involved in glucose reabsorption in the kidney.
SGLT2 inhibitors, also called gliflozins or flozins, are a class of medications that modulate sodium-glucose transport proteins in the nephron (the functional units of the kidney), unlike SGLT1 inhibitors that perform a similar function in the intestinal mucosa.
Just because you 2 can't figure out how to use metformin and Berberine, when carefully titrated, both are needed to reduce metformin side effects 😊
I'm wondering what Peter is smoking cause I'd some of those dreams too :D
Is it "the receptor is named after the drug," or "the drug was named after the receptor?" I heard both.
Same thought. How would the nicotine receptor be called as such without the knowledge of it reacting to nicotine first?
More play time!!!!🎉❤ yes! Nicotine makes me sick.
Exercise is not the best, it is the only way to lower glucose.
What about Psilocybin 😅😮
Wait, they're two different people?
A possible interpretation of the twins is that the diabetic twin had to destroy their system so throughly to become diabetic that their chance of dying naturally skyrocketed. And in the other arm the hazard ratio dropped for diabetics who didn’t die because they were more fit.
Peter Attia talks about dreams quite often. Maybe he is still secretly taking phenibut.
I wonder what his thoughts are on Phenibut
You need to learn to not eat so much as you age to feel better
I think you are right + not to eat that much in overall. .. and not to blend all things in a meal. I heard a good sentence few years back and I think it's so true: God created food, devil created cooks/chiefs.
Andrew should just show up in Austin with a big ol' case of Diet Mountain Dew
Huberman definitely took something a little stronger than Alpha GPC and Yerba during this podcast. Facial flushing is indicative of a beta blocker potentially? Genuinely curious
Do u think Andrew has stage fright? For him to be taking a beta blocker?
I don't have words for your supposition. Maybe it was to warm for him. Some of you , instead of listening to the fantastic talk , you are wondering about their face color ,and so on ,so on.. Common guys!
My face is red when I take B3 on empty stomach. Too many variables to make a conclusion. As someone mentioned - could've been the temperature, or simply excitement about the conversation. Doesn't matter, really :)
I drink my coffee out of a mason jar too!
Is Peter drinking ale 😂
Over 2 hours cmon
Aren't Danish different from British to start with? I would hypothesize that British general population is as sick as Americans (95% metabolically I'll), while Danish are not. There you have the big difference!
I live in UK(moved 20 years ago) and don't need to study papers to be sure Danish are healthier. Especially when looking at lower income group of population here, I see zero interest in anything, zero knowledge about nutrition. Case probably changes when start comparing lower middle class and up in each of the mentioned countries. Also - both countries are north - much less sunny days and UK's humidity crinkles your fingers on your way from the airport already, once you arrive here ;)
Andrew was interrupting Peter all the time with silly jokes, and not letting him complete his thoughts
Yet, Peter was smiling more than ever. I think they are good friends, hence the more relaxed structure. Plus remember - scientists are known for their bigger than average ego - they often can speak and speak until interrupted. I have noticed Andrew making more "interrupting" jokes when he enjoys the conversation. It must be a state of DELIGHT. Also, I find it cute he tries (and succeeds) to make people laugh, not every scientist has a sense of humor, quite a % of them can be seen as "dry". Give him a slack :)
Andrew interrupts a bit too much.
He’s got a lot of work to do after looking at Americans lifestyles. 😅😅😅😅😅😢😢😢
Jesus fucking christ i'll loose my mind ❤️
😂😂😂😂😂
I suspect your cortisol levels are a bit up ;) Or is it dopamine?
Peter is logical and scientific and Andrew just does not have the knowledge it is like an MD talking to arrogant kid. 😂
Or maybe you are arrogant? Both specialize in different aspects, both learn from each other and admit when were not aware of X or Y.