logP (Partition Coefficient) and Lipid Solubility of Drugs || Junaid Asghar PhD
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- เผยแพร่เมื่อ 21 ส.ค. 2024
- - Why 1-Octanol?
You could, in theory, use any non-polar solvent that is immiscible with water for the determination of logP. However, the properties of 1-octanol are thought to resemble those of lipid bilayer membranes rather well (i.e., the distribution of chemicals/drugs into 1-octanol simulates their ability to passively diffuse across membranes in living systems). Until someone discovers a better solvent system, water/1-octanol will remain as the standard.
- Under the European Union’s chemicals legislation, logP has to be determined for every substance manufactured or imported in 1 ton or more per year.
- logP of a compound can be determined by high-performance liquid chromatography (HPLC). Because compounds differ widely in their solubilities and analytical properties, various analytical methods have been used for this purpose, such as acid/base titration, ultraviolet (UV) photometry, gas chromatography analysis, and other chromatographic techniques.
- Crucially, the acid/base profile of a compound has a direct effect on the lipophilicity (logP) of a substance in the body as governed by the ionization constants (pKa values) of the key "Functional Groups" in different environments (pH).
Lecture on PKa of a drug:
• Drug Absorption | Conc...
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thank you sir for this video, literally spent all none going trough Remington and Alton just to fully build a concept...
Thank you for such an elegant and detailed explanation. Truly genius.
Thank you for an excellent and easy to understand lecture. Much appreciated
Thanku
Very nicely explained.
Thank you sir.
Sir g Zabardast
Well sir G
Thnks
Its helpful
Nice ❤
Thank you very much
Thank you ser !
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Love u sir
Please doctorat we need à video on pKa and solubility Please
Thank you so much
Babai