- 33
- 133 505
Junaid Asghar PhD
Pakistan
เข้าร่วมเมื่อ 6 พ.ย. 2020
This is the official channel of Dr. Junaid Asghar, where he educates on Medical Sciences viz. Pharmacology, Research breakthroughs, Cutting-edge technologies, Disease states and much more...
Qualification:
PhD (Biomedical Sciences)/
Post-doctorate (Pharmacology and Drug Discovery)
Linkedin: www.linkedin.com/in/m-j-asghar-64959a26/
His PhD focused on Studies on the biased signalling of novel delta opioid receptor agonists. The TH-cam channel is operated in English where Dr. Junaid shares his expert opinion on the medical science and interacts with his fans.
Qualification:
PhD (Biomedical Sciences)/
Post-doctorate (Pharmacology and Drug Discovery)
Linkedin: www.linkedin.com/in/m-j-asghar-64959a26/
His PhD focused on Studies on the biased signalling of novel delta opioid receptor agonists. The TH-cam channel is operated in English where Dr. Junaid shares his expert opinion on the medical science and interacts with his fans.
Type I Hypersensitivity Reaction | Junaid Asghar PhD
Hypersensitivity reactions are exaggerated responses of the immune system to harmless substances called allergens, resulting in tissue damage and inflammation.
STEPS:
1. Activation of Immune System by the Antigen (Allergen):
Upon initial exposure to the allergen, antigen-presenting cells (APCs) capture and present it to T helper cells (CD4+ T cells). This activates T helper cells, leading to the production of cytokines such as IL-4, IL-5, and IL-13.
2. Antigen Presentation to T Helper Cells by Antigen-Presenting Cells (APCs):
Specialized immune cells, such as dendritic cells, capture the allergen and present it to T helper cells to initiate an immune response.
3. T Helper Cell Activation and Production of Immunoglobulin E (IgE) Antibodies:
Activated T helper cells stimulate B cells to produce allergen-specific IgE antibodies. These IgE antibodies bind to Fc receptors on mast cells and basophils.
4. Recognition and Binding to the Allergen:
Upon re-exposure to the allergen, it binds to multiple IgE antibodies, crosslinking them on the surface of mast cells and basophils.
5. Role of Mast Cells and Basophils:
Cross-linking of IgE antibodies triggers degranulation of mast cells and basophils, leading to the release of inflammatory mediators such as histamine, leukotrienes, and prostaglandins. These mediators cause vasodilation, increased vascular permeability, smooth muscle contraction, and recruitment of inflammatory cells, resulting in the typical symptoms of Type I hypersensitivity reaction.
Symptoms Clinical Manifestations of Type I Hypersensitivity Reaction:
Symptoms range from mild irritation to severe anaphylaxis with systemic involvement. Common examples include allergic asthma, allergic rhinitis (hay fever), rhinorrhea (runny nose), anaphylaxis, angioedema, urticaria (hives), and food allergies.
STEPS:
1. Activation of Immune System by the Antigen (Allergen):
Upon initial exposure to the allergen, antigen-presenting cells (APCs) capture and present it to T helper cells (CD4+ T cells). This activates T helper cells, leading to the production of cytokines such as IL-4, IL-5, and IL-13.
2. Antigen Presentation to T Helper Cells by Antigen-Presenting Cells (APCs):
Specialized immune cells, such as dendritic cells, capture the allergen and present it to T helper cells to initiate an immune response.
3. T Helper Cell Activation and Production of Immunoglobulin E (IgE) Antibodies:
Activated T helper cells stimulate B cells to produce allergen-specific IgE antibodies. These IgE antibodies bind to Fc receptors on mast cells and basophils.
4. Recognition and Binding to the Allergen:
Upon re-exposure to the allergen, it binds to multiple IgE antibodies, crosslinking them on the surface of mast cells and basophils.
5. Role of Mast Cells and Basophils:
Cross-linking of IgE antibodies triggers degranulation of mast cells and basophils, leading to the release of inflammatory mediators such as histamine, leukotrienes, and prostaglandins. These mediators cause vasodilation, increased vascular permeability, smooth muscle contraction, and recruitment of inflammatory cells, resulting in the typical symptoms of Type I hypersensitivity reaction.
Symptoms Clinical Manifestations of Type I Hypersensitivity Reaction:
Symptoms range from mild irritation to severe anaphylaxis with systemic involvement. Common examples include allergic asthma, allergic rhinitis (hay fever), rhinorrhea (runny nose), anaphylaxis, angioedema, urticaria (hives), and food allergies.
มุมมอง: 231
วีดีโอ
Mean SD and SEM in Excel | Junaid Asghar PhD @DrJunaidAsghar
มุมมอง 342ปีที่แล้ว
Calculating the mean, standard deviation (SD), and standard error of the mean (SEM) is a common practice in research. These measures provide valuable information about the central tendency, variability, and reliability of our data. By understanding these aspects, we can effectively interpret our data and communicate our research findings with clarity. Mean: The mean, also known as the average, ...
How to Perform t-test in Excel || Junaid Asghar PhD
มุมมอง 254ปีที่แล้ว
A t-test is a statistical method used to compare the means of two groups or samples to determine if there is a significant difference between them. It helps researchers assess whether the observed difference in means is likely due to chance or if it represents a true difference in the population. The t-test is based on the t-distribution, which takes into account the sample size, variability of...
Antagonist | Basic Pharmacology | Junaid Asghar PhD
มุมมอง 110ปีที่แล้ว
Antagonists play a crucial role in pharmacology research and clinical practice. In research, they serve as valuable tools for studying the functions of specific receptors. In clinical settings, antagonists are employed to block unwanted receptor activity or counteract the effects of particular agonists or drugs. By selectively inhibiting receptors, antagonists effectively modulate and regulate ...
Hypertension | Detailed Review | Dr Junaid Asghar
มุมมอง 7262 ปีที่แล้ว
Hypertension, also known as high blood pressure, is a long term medical condition in which the blood pressure in the arteries is persistently elevated. Hypertension is the most common primary diagnosis in the worldwide and is a major risk factor for stroke, myocardial infarction, vascular disease, and chronic kidney disease. Facebook: @drjunaidA #Hypertension #SignsAndSymtoms #Pathophysiology
Half Life (t1/2) of a Drug | Pharmacokinetics || Junaid Asghar PhD
มุมมอง 19K3 ปีที่แล้ว
The half-life of a drug is an estimate of how long it takes for the concentration or amount of that drug in the body to be reduced by exactly one half (50%). The symbol for half-life is t½. #HalfLifeOfaDrug #PlasmaHalfLife #BiologicalHalfLife #Pharmacology
Angina Pectoris | Pathophysiology and Pharmacotherapy || Junaid Asghar PhD
มุมมอง 2.3K3 ปีที่แล้ว
Angina is a type of chest pain caused by reduced blood flow to the heart. Angina comes as a warning sign of coronary artery disease. Although angina is relatively common, sometimes it can still be hard to distinguish from other types of chest pain, such as the discomfort of indigestion. Angina symptoms include chest pain and discomfort, possibly described as pressure, squeezing, burning or full...
Anti-hypertensive Drugs | Comprehensive Review | CVS || Dr Junaid Asghar
มุมมอง 8003 ปีที่แล้ว
This is a comprehensive lecture on pharmacotherapy of hypertension, including a detailed overview of the various classes of anti-hypertensive drugs employed in medical care, as well as their mechanisms of action and clinical uses. #PharmacotherapyofHypertension #AntihypertensiveDrugs
Cholinergic Agonists | A Vintage Blackboard Lecture || Junaid Asghar PhD
มุมมอง 2353 ปีที่แล้ว
- Nicotinic Receptors: Ligand-gated ion channels Agonist effects blocked by tubocurarine - Muscarinic Receptors: G-protein coupled receptor system Agonist effects blocked by atropine - Direct vs. Indirect-Acting Cholinomimetics: A direct-acting cholinomimetic drug produces its pharmacological effect by receptor activation. An indirect-acting drug inhibits acetylcholinesterase, thereby increasin...
Adrenergic Blockers || Junaid Asghar PhD
มุมมอง 3313 ปีที่แล้ว
Beta-blockers, or β-adrenergic receptor antagonists: e.g. propranolol as an example is a nonselective β-adrenergic antagonist that has equal affinity for β1 and β2 receptors. Drugs like metoprolol and atenolol are examples of selective β1 antagonists as a result of their greater affinity for β1 receptors.The most frequently used antiadrenergic drugs for hypertension therapy are the selective β-...
Spare Receptors | Reserve Receptors || Junaid Asghar PhD
มุมมอง 4.6K3 ปีที่แล้ว
The receptor reserve or spare receptors refer to the percentage of receptors not required for production of maximal response. It is quite common for the full agonists to achieve their maximal effect without occupying all of the relevant receptors in a cell. This is because extra receptors are present. This phenomenon is called the spare receptor concept or receptor reserve. #SpareReceptors #Rec...
Full Agonist | Partial Agonist | Inverse Agonist || Junaid Asghar PhD
มุมมอง 1.2K3 ปีที่แล้ว
Different agonists can display a range of different intracellular effects. The video thoroughly explains these differences. #FullAgonist #PartialAgonist #InverseAgonist #JunaidAsgharPhD GraphPad Prism Video: Title: How to determine EC50 (Potency)? Link: th-cam.com/video/2js_cNqRI8Y/w-d-xo.html
Efficacy | Potency || Junaid Asghar PhD
มุมมอง 6K3 ปีที่แล้ว
The efficacy of a drug is the maximum response achievable from a drug regardless of the drug potency. A drug can be less potent but still highly efficacious (Emax = 100%). Do not get confused by this concept. Remember potency and efficacy are independent of each other. #Efficacy #Potency #JunaidAsgharPhD GraphPad Prism Video: Title: How to determine EC50 (Potency)? Link: th-cam.com/video/2js_cN...
Agonist-Receptor Interactions | Intrinsic Activity | Agonist Types | Spare Receptors
มุมมอง 8073 ปีที่แล้ว
Time Stamps: 00:00 Resting State of the Receptor and Receptor Activation 01:21 Intrinsic Activity/ Intrinsic Efficacy 03:20 Intrinsic Activity of Full, Partial and Inverse Agonists 09:15 Full, Partial and Inverse Agonists on a bar graph 12:48 Concentration-Response Curve (CRC) or Dose-response Curve (DRC) 14:54 Efficacy and Potency 26:39 Spare Receptors/ Reserve Receptors The efficacy of a drug...
Concentration-Response Curve (CRC) || Junaid Asghar PhD
มุมมอง 3843 ปีที่แล้ว
Concentration-response graphs plot the response/ effect of a drug against its concentration (dose). The curve we obtain as a result is know as concentration-response curve or dose-response curve. #ConcentrationReponseCurve #DoseResponseCurve #JunaidAsgharPhD
Transport of Drugs Across the Cell Membrane || Junaid Asghar PhD
มุมมอง 1.4K3 ปีที่แล้ว
Transport of Drugs Across the Cell Membrane || Junaid Asghar PhD
Drug Absorption Basics || Junaid Asghar PhD
มุมมอง 4253 ปีที่แล้ว
Drug Absorption Basics || Junaid Asghar PhD
Drug Distribution | Apparent Volume of Distribution (Vd) || Junaid Asghar PhD
มุมมอง 7723 ปีที่แล้ว
Drug Distribution | Apparent Volume of Distribution (Vd) || Junaid Asghar PhD
Drug Absorption | Concept of pKa and Drug Ionization || Junaid Asghar PhD
มุมมอง 5K3 ปีที่แล้ว
Drug Absorption | Concept of pKa and Drug Ionization || Junaid Asghar PhD
logP (Partition Coefficient) and Lipid Solubility of Drugs || Junaid Asghar PhD
มุมมอง 17K3 ปีที่แล้ว
logP (Partition Coefficient) and Lipid Solubility of Drugs || Junaid Asghar PhD
Cell Membrane | Lipid Solubility and Drug Absorption || Junaid Asghar PhD
มุมมอง 4.2K3 ปีที่แล้ว
Cell Membrane | Lipid Solubility and Drug Absorption || Junaid Asghar PhD
Intrinsic Activity of an Agonist || Junaid Asghar PhD
มุมมอง 2.4K3 ปีที่แล้ว
Intrinsic Activity of an Agonist || Junaid Asghar PhD
Affinity | Ligand-Receptor Interactions || Junaid Asghar PhD
มุมมอง 4673 ปีที่แล้ว
Affinity | Ligand-Receptor Interactions || Junaid Asghar PhD
GraphPad Prism 8 | Finding IC50 value | Junaid Asghar PhD
มุมมอง 38K3 ปีที่แล้ว
GraphPad Prism 8 | Finding IC50 value | Junaid Asghar PhD
How to Find Potency - EC50 value in Prism? | Slow but Sure || Junaid Asghar PhD
มุมมอง 10K3 ปีที่แล้ว
How to Find Potency - EC50 value in Prism? | Slow but Sure || Junaid Asghar PhD
What is Agonist | Pharmacodynamics || Junaid Asghar PhD
มุมมอง 1753 ปีที่แล้ว
What is Agonist | Pharmacodynamics || Junaid Asghar PhD
What is Receptor | Pharmacodynamics || Junaid Asghar PhD
มุมมอง 4443 ปีที่แล้ว
What is Receptor | Pharmacodynamics || Junaid Asghar PhD
Routes of Drug Administration | Pharmacology || Junaid Asghar PhD
มุมมอง 2803 ปีที่แล้ว
Routes of Drug Administration | Pharmacology || Junaid Asghar PhD
What is Pharmacodynamics? | Pharmacology || Junaid Asghar PhD
มุมมอง 6293 ปีที่แล้ว
What is Pharmacodynamics? | Pharmacology || Junaid Asghar PhD
What is Pathology? || Junaid Asghar PhD
มุมมอง 4803 ปีที่แล้ว
What is Pathology? || Junaid Asghar PhD
Thank you sir... You explained very well... 👏
your videos are very helpful. i hope you post more content. -Pharmacy student
Sure
please post more videos!! i am a pharmacy student
As salamu alikum.... migraine k liye khuch bata sakhte hai.... plz
You such a genius❤
Thank you
This is the best explanation of this topic that I have seen. Thank you for sharing this!!!!
Thank you a lot it was so helpful
how to make probit regression in SPSS?
dr ka addrss ya contact num plz??
dr ka addrss ya contact num plz??
dr ka addrss ya contact num plz??
V. Informative❤
Very well explained
Too good ❤
D Sab ka watsap no ya kalank no
hi doctor why there is no repulsion between unionized drug and polar head in phospho bilayer head?
Babai
thanks proof
Thanku
Thank you dr But i think there’s something you have to clarify, you said (t 1/2 )1 is 50% and this is correct, then you said (t1/2)2 is 25 but its 75% eliminated not 25 And (t1/2)3 it should be 87.5% not 12.5 and so on . Many thanks
Dr sahab ap kaunsay city may hoty hain ?
Excellente 🎉
Please doctorat we need à video on pKa and solubility Please Thank you so much
Aslam o alikum sir Are there any scholarships in foreign for masters in pharm-D Plz make a video about it
Such a great explanation, thank you Sir. I would to ask about the EC50, you said at 11:16 the EC50 will be explained later because the value is so little. Based on your data, the range is about 1-10 uM, but the IC50 is under the lowest concentration. Meanwhile, the percentage/transform data shows 0-100% inhibition. Does it mean the IC50 concentration should be in the range of 1-10uM too? I have similar results and problems. Thank you very much for you answer.
Very informative ❤
Masha Allah
proud of u sir ❤
Nice ❤
thank you sir for this video, literally spent all none going trough Remington and Alton just to fully build a concept...
What is terminal half life ?
Terminal half life refers to the time it takes for the concentration of a drug in the body to decrease by half during the elimination phase. It represents the final phase of drug elimination from the body.
Plasma 1/2 life of gentamycin is 3 hours.Terminal half life is 50 hours. Why. Must be accumulated in various organ and the again diffuse back in plasma
👍✨✨✨✨✨👌
very nice video, thanks!😃
❤❤❤❤
Thank you for such an elegant and detailed explanation. Truly genius.
Can you please tell me what is the difference between IC50 and EC50?
The difference between EC and IC is just a matter of naming conventions and doesn't reflect any significant differences in meaning. EC stands for effective concentration IC stands for inhibitory concentration and is used to denote dose-response curves that go down because the drug inhibits the response.
@@JunaidAsgharPhD thank you 🙂
Love u sir
سلام ڈاکٹر صاحب میری عمر 60 سال ہے جسم میں فیٹس بنتے رہتے ہیں کھانے پینے کا معمول دن میں دو بار پھیکی چائے اور صبح شام دو بار کھانا ہے پھر بھی فیٹس بنتے رہتے ہیں جسم میں کسی قسم کے ڈس آرڈر کی وجہ سے ایسا ہے اس کا بھی کوئی علاج ہے براہ مہربانی رہنمائی فرمائیں بہت زیادہ پریشانی ہے
Thank you!
sir if some one wants to ask something related to profession how can contact u?
Yes you can. You may contact on the Facebook page, given in the description below.
Why we take concentration in log form .. reason to take log??
It's a good question. Basically when we use a linear scale, the data points may become too spread out or clustered in certain regions, making it difficult to visualize and interpret the relationship between drug concentration or dose and the pharmacological response. In contrast, a log scale compresses the data, allowing for a more even distribution of data points across the entire range of concentrations or doses. This enables a clearer depiction of trends, patterns, and potential non-linear relationships. By using a log scale, we can effectively capture and analyze the full spectrum of drug responses, including the lower and higher ends of the concentration or dose range, without sacrificing data resolution or interpretability.
Do these definitions, like efficacy, affinity donot reply to antagonist?
They only apply to agonists.
thank you
Very nicely explained. Thank you sir.
thanks, good video