What is a distribution coefficient?

Partition coefficients and distribution coefficients are similar, but not the same! Here we look at the differences between them, focusing on the effect on ionisation. There is a related video on partitioning and it would be a really good idea to watch it first! Link here;
• What is a Partition Co...

[@aseelshihabhamad9674]

Why do we multiply the fraction of unionized solute with partition coefficient to get the distribution coefficient?
I don’t really get it, shouldn’t we multiply P with the ionized portion 🤔

[@ashirumustapha182]

Can you tell me more about the condition necessary for the experimental determination of partition coefficient?
I will gladly appreciate the video too. Thanks in advance.
You made pharmacy easy.

[@appreciatescience1525]

Thank you for this useful video!
So why do we use logD for? You said that we use logP to identify if the drug had greater affinity to water or to oil. But I did noylt understand what we use logD for.

[@PharmaDrama]

Thanks for your question - the answer is that really we always use logD. That's because when we measure partition coefficients experimentally we have no way of knowing what fraction, if any, of a compound has ionised. So if the compound is NOT an acid or base, the experimentally measured value will be a true logP, but it IS an acid or base the chances are it will have ionised to some extent and so we use logD.

[@atinukeakinola5464]

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