NEW weight loss drug BETTER than Mounjaro
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- เผยแพร่เมื่อ 16 ต.ค. 2024
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An experimental drug from Eli Lilly helped patients with obesity lose an average of 24% of their body weight over 48 weeks on the highest dose in a mid-stage study, the most weight loss seen yet in a new class of drugs that’s revolutionizing the field.
The medicine, called retatrutide, had similar side effects - mainly gastrointestinal in nature - as approved drugs in the class, including Ozempic, Wegovy and Mounjaro, researchers reported in a study, funded by Lilly, published Monday in the New England Journal of Medicine. The results were also presented at the American Diabetes Association conference in San Diego.
#weightloss #diet #getlean #doctor #healthtips #healthylifestyle
I went through the Eli Lilly site, and got the referral to a clinic doing clinical trials. I got through today. And the trial is for Terzipetide. I tried to get it for the new retatrutude. I hope to get the approval soon. I thank this channel for this video because it made me try this approach since Kaiser won't approve it off label. Thanks doc.
Hello can you please give me more information so I can try and get in the trial as well. What website do I go to so I can apply? Thank you!
I work in primary care. It's a nightmare getting insurance companies to cover ANY of the "tides".
Yep. They pretty much refuse it instantly.
There are other ways (wink wink) to get them.
Do tell( wink wink)
@@Spicydoc1 well? How?
PrEP is always covered though.
I lost 75 pounds in 52 weeks on a low carb keto diet and my blood work is normal in all areas. My bmi went from 33 to 20.
Here’s your gold star ⭐️
No one asked.
@@BoringTroublemakerthanks pos
my mom did keto for 1 year as well, she lost 50 lbs but unfortunately keto is not a lifestyle- its a diet so she didn’t keep it off
Yes, very very very hard to maintain as a lifestyle.
Fantastic!
Doctor Mike - Thank you for all of the great and accurate information you have shared over the years. This is another one of those gems.
Glad it was helpful!
As a type 2 diabetic, I wish the price on these products would come down to an affordable level.
If you have health insurance check to see if it covers it - check with the manufacturer to see if you are eligible for thier discount card.
You should look into the "black market"
Hey there are always alternative ways to get medications like these while they might come from shady sites they are still just as affective just a thought tho 🤷🏻♀️
Do you think insulin resistance might qualify in the future?
After all I learned about how drug companies bias their own research, control the academic journals, and have regulation capture of the regulatory bodies, I would recommend just eating less. COVID sure opened my eyes.
Better yet; eat foods that fill you up for hours like Greens and beans.
yes. pharma studies are BS. 90% aren't even published. find out who sponsors the study.
Eating a calorie-restricted diet will slow the metabolism unfortunately. Foods are incredibly complex. I'd love to have a big vegie garden.
Better: eat right. Lookup videos "Ozempic vs Nature's Ozempic" and "Weight-loss Drugs ... Dr. Neal Barnard"
Weight loss for many people is more complex than "eating less". Many don't have access to health food.
This seems promising. It's sweet when you find what works and start losing that unwanted weight. I lost 42 pounds in less than 3 months and have kept it off since then. Key thing to note is that I exercised daily for months, but my issue was the struggle with my calorie intake. It was just impossible for me to eat less. It felt like I wasn't in control of my actions. Adding Phenq pills to my journey just made things easier. Eating less became possible and I also had enough energy to exercise. I talked about this extensively on my channel, though
Thanks for the excellent rundown! BTW, the card or endscreen for your video didn’t have a link to the insulin resistance lab.
I assume it’s fasting insulin or HgA1c.
Good to hear about these products. Are these the drugs that I’m hearing you have to take them ongoing? Thank you for the information! Love your videos!!❤
What happens when the body cannot produce glp-1, gip, and glucagon (just like trt reduces testoterone production over time) - and the question goes to all the products (ozempic, wegovy, mounjaro, retatrutide, …) - is there any way for the body to regain its ability to produce glp-1, gip, glucagon, testosterone, … (for any hormone replacement therapy - when the body have gotten used to whichever hormone is being injected, for months or years - can it regain its ability to produce it again, or is it game over?)
Interesting q
I haven’t seen your channel for a while and you look amazing and fit ! 👏
A friend of mine lost 15 lbs on ozempic but ended up finding a lump on her neck that turned out to be thyroid cancer. Her doctor says its unlikely to be related but I'm not so convinced.
The box warning states possible thyroid cancer, prayers for your friends healing✨🙏🏼 google - some great videos on just this side effect exist.❤
Don't worry, we'll start to see the legal firm commercials soon. 😞
I guess one defining question might be, how long does thyroid cancer take to develop
@@narkybark Apparently in less than two months because the weight flies off with these drugs. It seems just as illogical to surmise that her weight gain was due to unknown thyroid cancer developing and was diagnosed after her weight loss. I am on Zepbound 7 weeks in and my "next size down" clothes are getting loose. 15lbs? Easy in 6 weeks with these medications.
Unfortunately pancreatic damage is real and ever so painful... Wish these drugs were free of side effects!❤
All medications have potential side effects and can have ill effects on kidneys, liver, pancreas..
So sorry but the comments here about losing weight are just uninformed. It is not just a matter of how much you eat or what you eat. It is a very complex problem. 95% of all dieters fail. Are they just weak or have no self control? . No, it may start with poor eating habits yes, but it does progress to a disease that needs to be treated. Poor people and seniors very often cannot afford the higher quality foods. There is also a genetic factor to weight and body type. I truly wish people understood the problem more and were more considerate to those who have struggled for a lifetime.
I was always really skinny my whole life until I was put on ssri’s then in 6 months I put on 60lbs. I stayed on it against my better judgement and gained another 40. I quit cold turkey over a year ago and only managed to lose 30 on my own. Now my face is swollen and I’m walking around with a pregnant belly and I’m a guy in my mid 30’s that’s never had a weight issue before.
If will power worked there would be no obesity.
We only need Oprah to prove this. She has battled for decades and look at her resources! Private chef for the best nutritious foods, private trainer and gym, any and all mental health she would need and she yo-yo dieted the same as my poor self! Now she is thin, now she has quit working with WW, now she is finally where she has always wanted to be. Why? A shot. some people cut down on calories and work out and do AMAZING things for their health. And then there are the people like us, you know, me and Oprah 😃
So exciting. Thanks for all the info.
Thank you doctor it is not easy to make the right choice sometimes when you have kids. Also I am looking forward for a help to control my sugar and fatty liver disease. Can’t wait to see if my doctor will prescribe me one of this medication. I been in constant pain in my joints for sometime due to an accident. And need some help to loose weight. 😢
It sounds like this is going to be a race to see who can produce the most weight loss drug. It sounds pretty confusing to me. When I was younger I took Phen Phen. It was taken off the market due to heart valve complications. I lost down to my goal weight with it. It made me feel “normal “ about food. I ate what I wanted, but didn’t over eat. I wasn’t always thinking about what I was going to eat next, but just like any weight loss without making life changes the weight returns. Very frustrating.
I'm struggling with how to make myself a priority. Once I had my baby, ME was a non-existent idea. He was super reflux-y and so it was all about him fir the first few months. Making sure he wasn't aspirating, and getting enough food. And me trying to make milk for him that I couldn't...
We need to figure out our way out of NOT paying attention and caring for ourselves as well as we care everyone else around us...
@@AndeeSaraDesignsyes! Cause without self care, it’s a straight path to burn out and resentment
New drugs always have unknown serious side effects that often take many years to become apparent.
Natural methods are far superior. Try meditation, for example...
I would love to try this retitrutide. But heart thing scared me. I've got A-fib and svt's. I sure don't need my heart rate going any higher.
I'm taking compounded Tirzepatide right now and it's working great! Excited for the new studies to come out.
Would you mind sharing the company you use for the compounded tirzeptide?
Excited for this to be FDA approved for obesity. 🎉
I did the cocaine and orange juice diet. Lost 100lbs, my house, my wife and my job. Take that Mounjaro.
@@billy77511 so you also saved money in the end, no need to pay rent for the house or anything for the wife. WIN WIN!
😂😂😂😂😂
OMG! 🎉😂❤😅
bet you miss it
Lmao
I cut out refined sugar and cut down carbs and have lost 58 lbs in 9 months. That’s my answer
That is the correct answer to the problem, A+
Glad that works for you. It doesn’t work for everyone
I tried to cut carbs and I lost weight but it caused my fasting glucose to increase and made me become pre diabetic.
@@lisacook9116How many carbs were you eating every day? “Cutting carbs” doesn’t mean anything specific. My sister cut carbs by going from 8 cookies a day to 5. Then she ate an extra big salad. She didn’t lose weight.
@@suzanneemerson9787 I only had a total of 30 grams of carbs per day and that was from green vegetables.
This sounds promising. Just imagine how many cases of OSA this could help!
Does this cover insulin resistance?
Can you talk about whether reoccurrance of weight gain happens upon discontinuation of these medications? Even when following an appropriate diet?
There is a reason the weight gain happened to begin with. For example, myself. I've been eating a 700-900 cal for over a uear now, and am stuck in the 250s, on a frame of 5'8"... If I were to take one of these medications for weightloss, and increased my intake to say 1500 cals/day. Would I regain?
Wow, that’s so few calories. Your metabolism has adapt. You should check your hormones. I have similar problem and my hormones are off. I do eat more like 2200 calories per day but I want to lose a few pounds. My doctor is helping me adjust my hormones now and I am doing HIIT.
@@ftmrivas3043 yep, I've just recently met with an endocrinologist, she is collecting all my information from my PCP. I also just met with a nutritionist, and she says with all the different diets I've tried in the last 5 years, my body just doesn't know what to expect so its clamping down and keeping whatever it does get. Esp with the low calorie intake. So, she told me quantities of food groups to eat. And I'll try that..., While waiting for my endocrinologist to get back to me. This weekend I will be food prepping again according to the ratios she gave me. Hoping I don't jist keep gaining.
I need to figure out how to eat on a consistent basis...how to infuse it into my busy life. I had a little boy and I don't know how to make myself a priority, js my biggest problem.
Night shift worker
Homeschool him by day and housework
Then I get ready to go again at night.
And in between all that I am trying to learn how to use Adobe Illustrator and Procreate to start my own business, and doing all the social media posts, and built my own website. I have to do this, because this is my way OUT of the hospital.
Donate blood. You will lose a pound and your metabolism has to rev up to reproduce the blood.
Far too low , dear ❤
I am a type 1 diabetic and use Mounjaro to help control my glucose levels. It does a great job in reducing my use of insulin too. I've lost some weight, but not a high amount.
I'm on Mounjaro - it's helping me lose weight but my glucose levels are still too high.
@@somerset6646 are you taking insulin? There are other options you can explore in conjunction with taking Mounjaro. I eat way too much ice cream. Nobody is perfect. Good luck.
Yes. I'm a type 1 diabetic.
I have been taking Mounjaro 10mg for almost four months and haven't lost any weight at all.
What dose level did you start off at?
@@seanakridge2971 I think it was 7.5mg. Now I am up to 15mg every five days, and still nothing. I'm sure it is helping my A1C, but if anything I am hungrier than before I started this med.
How do I sign up for this clinic trial? 👀
I've read that private insurers in the U.S. will not pay for any of these drugs if they are used off-label and not for their intended use in the treatment of Diabetes-type 2.
I'm a Federal worker, and Kaiser won't cover these. My BMI is 40.
Wegovy is approved for weight loss. Mounjaro still waiting for approval but maybe in a few months.
@@VernCrisler Kaiser in my region won't approve it.
It depends on the insurance company. However you are right, most private insurers are starting to deny Ozempic if there is not a diagnosis of T2D. Wegovy and Saxenda are FDA approved for weight loss but some insurance companies have them as plan exclusions.
@@monica93304 Won't approve Mounjaro or Wegovy?
I think people losing a lot of weight is going be feeling more anxious -depress . I think is very concerning !I hope people stay safe and do the right treatment and make good choices ❤
Are there studies on current or upcoming drugs that have a study group that do verified strength training?
Sounds wonderful.....but is that too quick a loss?
0.5-1% per week is a standard, healthy rate, so no
I was prediabetic, but traditional black seed oil fixed that. It also offers general health benefits.
I try my best to avoid artificial Rx drugs with undetermined side effects.
@@MeadeFatLoss Basically means "heading towards diabetes"
I read on a public medical journal article that this medication causes very similar GI side effects as Ozempic. That is a big no, no for me.
You compare Ozempic and max dose Mounjaro. What does of Ozempic are you comparing that max dose Mounjaro with?
Wonder how much the compound version of mounjaro cost?
Do we have numbers on body fat loss specifically?
Tirzepatide is amazing if this holds up we will have solved obesity and most DM2. I just hope it can be made fast enough and there are no long term morbidities.
Bariatric surgery may be over.
Can u give us the link to the article?
I believe NEJM is behind a paywall.
What happens when you stop taking the drug?
The weight comes back.
Glp-1 stimulates trpv1 and while trpv1 is an incretin, the insulin then up-regulates trpv1 receptors that put glucose into the cell independent of insulin and the insulin receptor. This creates insulin resistance and you will see this resistance after you stop the drug and do a combination 5 hour glucose tolerance test/c-peptide, insulin curves. Additionally you will find that while TRPV1 is force feeding the cells, hyperinsulinemia is taking place from over stimulation of trpv1 with the risk of beta cell dysfunction and loss. With the hyperinsulinemia and force feeding the cells glucose the cell’s antioxidant reserves run out and the mitochondria are damaged and too much reactive oxygen species are produced leading to atherosclerosis and other inflammatory diseases.
Try eating the low carb diet instead.
This was fascinating THANK YOU!
Sooo, using this med if you are not type 2 will put you in the car of insulin resistance on the road to type 2? Or have I had a brain crash.
@@hazelnutcase357 correct.
@@susanbeever5708 and I thought I was making pie in the sky assumptions when I made the comment (on other channels) that an ozempic side effect might be that you become type 2 afterwards.
Thank you for your scientific comment supporting my assumption.
I believe drugs that treat diabetes should not be used by those without the disease.
Has any of the pill forms came out yet?
No and I doubt they will for years if ever I would recommend just getting an off brand versions and learning to inject
…and it will be $1000 a month an insurance won’t cover it. So it’s useless to the average person…we can’t afford it.
All these quick fix drugs…….I am waiting for the long term studies. Intestinal blockages (impactions) which can go undetected for years is now becoming a common cause of death in those that have had weight loss surgery (shortening the intestines).
Is it true that that can go UNDETECTED FOR YEARS though 😮
Any videos on tesofensine?
Nothing, I repeat, Nothing is better than Mounjaro.
How much did mounjaro cost you a month. Thanks in advance
@beckyorton8312 It was around €450 a month when I used to use it beginning of last year.
@beckyorton8312 It was around US $500 a month, when I lived in the UAE. Now in Serbia, it does not exist.
@beckyorton8312 I pay $25 a box every 23 days until I reach my annual out of pocket expense of $500, then it's free the rest if the year. ❤💉
Is the weight loss with restricted calories?
I'm on Zepbound, I have issues with calorie restrictions because my brain screams for too much food. 7 weeks in and I have to remind myself to eat. It isn't appetite loss for me, it is a lack of the overwhelming, loud hunger that I've always had. Eating healthy is SO easy now. I feel like other people who can push a plate away now.
Lost 115 pounds via diet in 2020. Still need to lose 35 but I'm hitting a wall. Have t2d treated my metformin only. I eat 1200 or fewer calories per day (OMAD.) Was on Ozempic for 8 months after losing 115 pounds. Could not tolerate the pancreatitis. What's worth a try of all the drugs in pipeline?
From what I've read, as T2d you should be able to qualify for Mounjaro. If you have a history of pancreatitis, you should probably discontinue if you feel pain in your stomach. Definitely work with a doctor about it.
Can a person with one kidney take these new medications?
Yes you can :) I have only one working kidney and my nephrologist said it was fine when I was prescribed Ozempic:)
Excellent.
please pin the link for the insulin resistance level checking video
I want to join the phase 3 trial but they aren't enrolling yet
Can people use these even with out being diabetic ?
I think Mounjaro is for diabetics only. And there is still a big shortage.
The price will probably be one million dollars per does
OMG. Peoples should educate their childrens and teenagers on how to eat healthy. Adults must adhere to Diet and exercises regime instead of promote drugs.
I agree; all these drugs have unwanted side effects.
@@ronniemead805so does being overweight. The side effects are manageable and most people don't even have them. Stop whining about meds.
You are no authority.
Wow people. You don’t know Connie so why are you judging? Geez! Let people be different. It would be helpful if we all had easy access to quality, non gmo and non-hormonal food.
@@loismaddux4800 that is foolish.
What ever happened to eating fruits and vegetables, and exercising?
It's obvious you've never been obese
Boring
we want a pill. 💲💲💲💲💲💲😉😉😉😉
Oh shut all the way up.
Many people do just that and still have weight problems due to the complexity of obesity. It's a rare person who has it all together.
I do understand that being obese is a national epidemic, but I am concerned about the mentality behind just popping a pill (a very new one at that) to lose the weight and thereafter being tied to it for the rest of one's life. A friend of mine started losing weight at the beginning of this year through diet (eating one meal a day) and exercise. The last 30 days he has fasted, and in total has lost a total of 96 pounds (32 of which were from the fast). It can be done!
Eating one meal a day is not sustainable. He will most likely gain the weight back.
How is he getting enough protein and nutrients on just one meal a day ?
@@MeadeFatLoss Maybe he is ingesting Athletic Greens that all of the influencers are promoting. 🙄
This company is constantly under scrutiny. So many lawsuits. Do your research please
Thanks for the update on these meds, Dr. Mike. From the research I’ve read, it seems these GLP-1 meds have awful side effects. The risk of pancreatitis is the dealbreaker for me. I am glad my doctor steered me away from medical intervention for NAFLD, insulin resistance and pre-diabetes. I eliminated processed foods and limited my carbs to 25 grams per day on a clean keto lifestyle. My weight loss at one year exceeded 26 percent and has now passed 31 percent. If I can do it, anyone can. I wish I had done it sooner before my health was at risk.
Diabetic Delights Large Print Cookbook
Gep44 is what I'm waiting for.
is gooo good to take
Sweet. Just take a pill, forget exercise and enjoy all the foods you like. I'm can start eating the Arby's Meat Mountain with Cheese again !!!
It makes you not want to eat all the foods.
Covid-19 is not going any where still people getting sick -Any plans for the future topic-I will really appreciate it-i think an spike is happening now-No body wants to wear mask any more .Hope you read this I think you can help too .Thanks ❤how bad it can get like all over again this is bad
I will be your guiny pig send me stuff now
Why is this even a thing
💲💲💲💲💲💲💲💲💲💲💲💲💲💲
There is no shortcut to a healthy lifestyle.
Can we stop pushing weight loss drugs and instead push for people to eat healthy ans get off their asses?
You don't have it together any more than someone who is overweight. Half my family are in medicine, it is a rare person who is fit and healthy.
@Skelly777able How are you on-tipic with my comment? Just becuase there are a lot of unhealthy people out there doesn't mean we should all encourage the easy button to be used (which comes with baggage like side effects of the drugs).
40 years of shaming our population hasn't helped. We are a country based on capitalism and we advertise and sell unhealthy foods to our citizens. Also, politicians cater to the corn industry.
@@EarthsGeomancer Yeah! People should have to earn their fitness like you did! Right? You were obese and lost all that weight so you totally know what you're talking about! Right? Right?? ...no? Oh. Well then maybe stfu.
Weight loss drugs are for the weak minded. Put down the cheeseburger and pick up an apple
Strongly believe tht if a person is overweight they should just start eating correctly ...then the weight will go away naturally
Sorry but it is way more complicated than that. 95% of people who lose weight on diet restrictions only gain it back and more . Do you think that 95% of people don’t have will power? If a cancer treatment had a failure rate of 95% you wouldn’t blame it on the patient?
'promo sm' 😌
❤️❤️❤️🇱🇰
❤️❤️❤️🇲🇩
❤️❤️❤️🇨🇭
Why?
All these Type 2 Diabetic drugs being used for weight loss seem too good to be true. Just waiting for the legal commercials to start soon, "Did you take Ozempic, Wegovy or Mounjaro to lose weight and now have complications due to taking these drugs, if so, call our office."
And without a shadow of a doubt 24 % more immediate side effects and 50 % more side effects in the long run but hey! In the meantime enjoy the ride :)
Please stop with all the idiotic whoosh sounds already!
Or, just stop eating so much.
Unsubbbbbd
ANYONE who proposes drugs for weight loss is either a complete fool or a sociopath. someone who actually wants to help people would tell them to first start periodic fasting. but theres no money in fasting!
Stop giving these drugs a platform. We should be talking about diet and exercise as a treatment. Jeez….
If diet and exercise worked, half of the people of the US wouldn’t be obese.
Don’t use this…..
doc dapagliflozin helps a lot