NEW Weight-Loss Drug: Retatrutide Revolutionizing Obesity Treatment? | Dr. Dan Obesity Expert
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- เผยแพร่เมื่อ 25 ส.ค. 2024
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In this captivating video, I delve deep into the revolutionary realm of obesity management with a spotlight on Retatrutide, a triple hormone receptor agonist poised to redefine the landscape of weight loss solutions. Join me on an enlightening journey as I unpack the intricacies of this innovative medication, exploring its unique mechanism of action and potential impact on individuals struggling with obesity.
Through meticulous analysis of a phase 2 clinical trial involving over 300 participants, I unveil compelling insights into Retatrutide's efficacy. From its ability to mimic three crucial satiety hormones-GLP-1, GIP, and GCG-to its remarkable outcomes in weight reduction percentages, this video offers a comprehensive overview of Retatrutide's transformative potential.
But my exploration doesn't stop there. I address important considerations such as side effects, including gastrointestinal discomfort and the emerging concern of cardiac arrhythmias. With balanced scrutiny, I navigate through the complexities of Retatrutide's safety profile, highlighting both its promises and potential challenges.
As we peer into the future, I discuss the ongoing phase 3 trials and the anticipated timeline for Retatrutide's availability in the market. Amidst the excitement of medical innovation, I underscore the significance of continued research and data dissemination, emphasizing the importance of informed decision-making in the realm of healthcare.
Watch my previous videos about how to fight obesity and about the best medicine for weight loss:
▪️ Watch This Before Taking Mounjaro: • Watch This Before Taki...
▪️ From Ozempic to Mounjaro: • How to Switch from Oze...
▪️ Muscle Loss with Ozempic, Wegovy & Mounjaro: • Muscle Loss with Ozemp...
▪️ Managing Nausea from Ozempic, Wegovy and Trulicity!: • Managing Nausea from O...
▪️ Ozempic: Stomach Paralysis Update: • Ozempic: Stomach Paral...
▪️ How to Switch from Ozempic (or Wegovy) to Mounjaro: • How to Switch from Oze...
▪️ Ozempic Paralyzed My Stomach: • Ozempic Paralyzed My S...
▪️ How to Inject Mounjaro: step-by-step tutorial: • How to Inject Mounjaro...
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#weightloss #obesity #obesitymedicine
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Thanks for watching! Download my FREE GLP-1/GIP Medication Information Sheet: eepurl.com/gdB2qn
Dr. which ( “ GLP-1’s “ ) show most effective over Ozempic as of yet ??
Thanks in advance !
❤your content, SO amazing and in depth !!!!!
I’m in the triumph study and on Retatrutide. I’m not supposed to know it, but the 40# weight loss since October gave it away 😅 I’m particularly excited about it.
Wonderful, do you know what dose you were on?
What were the side effects like?
ooohhh so you didn't know if you were getting the real thing or a placebo?
also, 40lbs in 6 months is pretty good (this was posted 1 month ago).....congrats :---).
How do you get on these studies?
@@shopece8807if you knew it's placebo then it wouldn't be a placebo 😅
I don't know the accuracy of a Dexascan, but I took one before and after using Semaglutide for about 3 months. I lost 25 pounds, but according to the Dexascan, about 60% of my weight loss was lean tissue. Not eating, not exercising, and not consuming protein isn't exactly a good thing. I later have found using a very low dose to where I feel like eating 2 small meals a day was better and has less side effects. You can lower your dose until you feel like eating a little bit, or your hunger is suppressed a little. During my first try I didn't feel like eating anything at all. I'd eventually get dizzy from not eating at the end of the day. So I'd eat a little bit, but felt like I was eating when I was already too full.
Interesting. Semaglutide did nothing for me with weight loss. I made sure to get enough lean protein. It slowed gastric emptying, but it did nothing in regards to lowering my overall caloric appetite.
How did the Dexascan reveal the lean body mass loss. Not on my Dexascan.
Tirzepatide is supposed to be a bit more gentle on lean muscle mass loss, but yes high protein intake and resistance training should be mandatory on these meds.
Hug😮ghjnnhnjnv nn😢😢 8:33 😢😢😮gf😮😮
Maybe you lost a lot of water weight sometimes losing water weight effects the DEXA Scan that is also detecting how much lean tissue you have.
The level of clarity you provide is super welcome. Also, appreciate the nicely timed and appropriate animations 👍
Yeah, we gotta ask Dan sometime where he gets all those animations. 🤔
He’s got *so many,* and they’re all on-point with what’s being discussed! 😯
My actual goal... My kidneys are about 55%. I keep being told that the best thing I can do to help them is lose weight. I was just over 300lbs last April, started Wegovy in August at about 280, and I'm currently at about 245.
I was on dialysis for a couple of months in the hospital, but got off that just before I got out. I'm about 50, and assume as I get older and my kidneys naturally decline I'm eventually going to end up on dialysis again. I want to postpone that as long as possible. Fitting in the world better is a massive bonus, but the real goal is kidney health.
I think that’s really smart. Delay or obviate the need for dialysis at all costs.
Ppl on dialysis tend not to live for tremendously long periods of time once that stage is reached (maybe long if they’re young to start with)… not to put too fine a point on it. 😕
Wish you much luck and strength in your journey towards health. 🙏
Follow the kidney diet not high protein keto etc.
Kidneys need minerals to be healthy. The arteries to the kidneys get clogged. Serrapeptase and/or Nattokinase may help this but are blood thinners so be cautious.
Hey Dr Dan, nice basic overview of Reta. 👌
Especially liked when you went into a bit of detail about the possible high-dose arrhythmia issue, and how ‘too much’ weight loss can actually be a bad side effect. 🤔
Just a heads-up: You can probably hit us a little bit harder on the science and the deets without losing us. One of the things that really differentiates your content is that you are super-knowledgeable and can talk about things in a slightly deeper way. 👍
Look forward to more vids on the ‘star’ next-gen drugs, like CagriSema, Maritide, VK2735/‘Vikingtide’, Orforglipron, Mazdutide, etc.
Vikingtide in fact just dropped Phase 2 results today, and they were pretty stellar. ✨
I agree. I just like to keep my vids under 15 mins and not provide an entire lecture if possible haha. So I will be going over more details at a later point but that is a separate video all on its own!
Look forward to it, Dan. 👍
Oh and btw, in the Members Live, the common (at higher doses) Retatrutide side effect reported in the trials I was referring to was Cutaneous hyperesthesia, or hypersensitive skin.
It was hard at first to get what the gent asking the question was referring to, but seems like he was talking about either that, a response to injection (strong pain for about a minute), or both.
Hard to say for certain without more details. 🤷♂️
@cloakster thank you. Yes, that is what I think he was asking as well. I'll have to go back and look at that data.
You are absolutely fantastic with your information on these types of medication.
Wow! These drug scientists are on a role. Soon everyone who can afford it will be a healthy BMI. I would love to be 118 pounds like I was when I was 19😂 so I’m all for this triple threat ❤ but serious this really is exciting news.
Well, the morbidly obese (BMI 40+) will still be waiting awhile, or will need some combination of bariatric surgery and GLP-1 meds… but for most other ppl, yeah, it is kind of a ‘brave new world’ where obesity is starting to become optional. 😯 🌍
Well, if you have access that is, as you say. 💵
@@cloakster hopefully insurances see these meds as different from the past appetite suppressants that eventually stopped working or couldn't be taken long term
I wish you success in developing your channel)
You need to take a multivitamin, up your protein intake with lean chicken, fish such as salmon, and exercise at least 3x a week. Also, drinking about a gallon of water per day. That alone will reduce GI side effects. Take a magnesium suppliment before bedtime as well.
I truly appreciate the clarity of information you provide us. By-the-way; I love Scooby Doo as well❣️
Me too! But Scrappy-Doo has ‘issues’.🤨
please do a video on Cagrisema
Yes, totally. This is probably going to be the first of the ‘next-ten’ drugs to be released, and the weight-loss numbers look comparable to Retatrutide. 😯
Yet, almost no one’s talking about CagriSema. It’s really weird, especially considering it’s coming from Novo Nordisk, makers of Ozempic, and this is basically ‘Ozempic 2.0’
It should be the biggest story in coming WL meds, and yet… hardly a peep. 🤷♂️
Word. It’s probably going to be the first of the next-gen drugs to be released, and has excellent weight-loss results on par with Retatrutide. And it’s made by Novo, makers of Ozempic.
And yet, no one’s talking about it. It’s really weird. 🤷♂️
Fantastic info doc! Thank you!
***could you do a video on getting these peptides from compounding pharmacies and online***. They are A LOT cheaper for those who do not have insurance and can get prescriptions but can’t fill them because of the $$. Is this alternative safe?
Stay tuned for a couple weeks from now.
I am anxious for the day when one of these options is deemed better that the others based on the cause of our obesity. I definitely have PCOS and I would love the day when a study shows those with PCOS respond best with a triple-G or whichever. I suppose I will be at a healthy BMI from Zepbound before researchers have that knowledge but maybe in my daughters' lifetime, since their doctors are suspecting they have PCOS too.
Even then there will be inter individual differences etc. There will never be a one size fits person or disease!
Pls do a video on Livagen and Survodutide.. both for those with serious liver disease and cirrhosis…and kisspeptin too?!!!
Hello, Dr. Dan! I wonder if you'd be willing to do a video on foods that increase GLP-1 secretions. I was reading a study (via NIH site) regarding protein with a milk-mineral rich supplement as being optimal. I had VSG in 2014 and the docs wanted us to drink protein shakes. i understand better why. With MJ doing less appetite suppression, I'd like some tools for increasing GLP-1 secretions. The food noise isn't really there on 10mg, but the weight loss has been stalled for months or else excruciatingly low. losing the food noise is a bigger deal for me, I think, but I still have a long way to go and I worry about hitting the MJ max and having nowhere to go. Love your channel. Thank you.
I can definitely add this to my list.
I appreciate your straightforward, fact-based, non-sensationalist information.
I would like to suggest that you lower the volume on your little bell dings. They kind of hurt my ears when I'm on a headset.
I'm staying tuned to learn more about compounding pharmacies as I want to find one that is both certified and also experience at compounding these particular drugs.
Are you located in the US or Canada?
The video is already up! I am located in Canada.
@@theofficialdrdan Thanks, I found it :) Your suggestion that insurance should cover these drugs doesn't consider the outrageous cost for them in the US. I did a bit of arithmetic, and if Medicare were to pay for, say, Wegovy for all their obese patients, it would literally cost more than 100% of Medicare's entire budget! If they added in the merely overweight, it would cost over 200% of the budget, thus tripling Medicare's total costs. I agree that drug companies deserve to recoup their R&Dn and testing costs and make a good profit, but there is absolutely no need for them to be charging the astronomical prices they do in the US. China just announced approval of branded Ozempic (yes, they have their own knockoffs,) and the price there will be $150/month.
I've simply decided to call all GLP-1 and GIP drugs "unobtainium." I managed to lose about 50 lbs over a period of 5 years, but got stuck 2 years ago at 200 lbs. At 5'9" that puts my right on the edge of merely overweight vs obese. I'm feeling quite despondent about it. I know what to do, but it just isn't working any more :(
My only hope is that perhaps my Chinese or Danish relatives can bring me some from their countries.
Ive been on reta for a couple months and @6mg i am getting raised HR. When stationary i sit just over 100bpm and during any regular activity it is around 115-135bpm.
Same here on all 3 I tried. You should be taking magnesium supplement. Ask your doc
6mg a week seems like a big dose. Did you start off in 3 mg a week for a while?
Where are you getting your Retatrutide?
Retatrutide is not yet on the market.
@@billyhw5492 you can still get it though
You and the info you share are fantastic and easy to understand. Thank you so much ❤
I’m trying to gain mobility and get out of my walker. I want to go shopping and travel. I can’t really right now. It’s a huge event to even go out.
Keep going!
Do you have a chart on how to mix Retatrutide please
Thank you! I appreciate staying ahead and the detailed factual information. Semaglutide has been a game changer for me. I recently started using rapid dissolving tablets which are not as effective so far…
I’m in a head to head clinical trial for zepbound vs cagrisema. I don’t see a lot of people talking about cagrisema. It most likely will come out before this one
You’re very likely right. ✅
Hey Dr Dan, another Reta Q:
Glucagon, a Reta component, apparently has some catabolic effects.
Anything to worry about, in terms of retaining muscle mass while on Reta?
And if so, to what extent? 🤔
This is going to be something we will need to tease out in the phase 3 trials. Sarcopenia is a very real possibility especially since individuals in this phase 2 trial lost 'too much weight'. There is some interesting rodent studies that show with glucagon alone there is significant weight-loss including substantial muscle loss, however, when the mice are given amino acids to counter losses the weightloss benefit goes away. So I feel it will be something we need to take into consideration and have an understanding regarding it but to what extent it will be is a good question. And I am not sure at present!
Thanks much for going into a bit of detail here. 🙏
It does worry me some. Reta would be fantastic for my (moderate) fatty liver. But, I don’t want to lose a lot of muscle mass simultaneously. 🤦
Great video. The ‘Ding’ noise is too loud when I’m listening on headphones though fyi…
Which one doesn't cause hair loss?
I'm curious about these lyophilized powder version of Reta (found a few well-tested vendors but nervous about rolling the dice). Wish I could have gotten in on one of actual trials.
Dr. Dan, what do you recommend for managing nausea? I don't see that in the lists above.. I may have missed it! Thank you.
Shoot I was unaware of the heart rate side effect.
You are extremely "bright"!! I just discovered you a few days ago. My wish for you is lots of subscriptions & more. Blessings young man. Smiles.. Bobbi
I wonder if Retatrutide will have the same problems with shortages that we have with Tirzepitide. We need competitor companies to Eli Lilly making dual and triple agonists. Like Viking pharmaceuticals
Hopefully not. The more agents on the market, the more variety and options. Therefore, shortages should be better managed.
The shortages haven't been the drug from what I'm aware, but the pens/needles for delivery.
Hey could you comment on Terns Pharmaceuticals and altimmune
Where can I join your group please?
Excellent as usual. Makes the difficult easier to understand
Where can retratutride be bought from
How does one get on those trials??
I take it and it’s amazing !
I just got the peptide and am excited to start it. Can it be combined with the semoriline peptide? I don't want to loose whe muscle indo have!
How do you dose it ?
hope this works
Do you think that your body can become accustomed to the med and stop actually working? I’ve been on Mounjaro for a year and half and I am type two diabetic. I’ve lost about 25 pounds but it has stalled. I haven’t lost any weight in 6 months and I’ve been on the highest dose for almost a year now. I should say that it is still working on keeping my blood sugars down but, the hunger is back and even though im not gaining I haven’t lost any either so I just wonder if I am use to the dose now. Just curious.
The medications don't stop working. They continue to suppress your appetite and food seeking behaviors. However, we need to keep in mind that losing weight requires calories in < calories out. So if you aren't losing you aren't a calorie deficit consistently enough. The medications aren't magic they only make it a bit easier to get into a calorie deficit. So you still need to ensure you are actively achieving a calorie deficit via tracking your calories or what have you.
As for the hunger coming back I reviewed that in detail via this video: th-cam.com/video/fV_8TKYyW_M/w-d-xo.html
Caste it’s suppose to be used only a year only
@@nikkiturnup1688 that is incorrect.
@@nikkiturnup1688 not for diabetes it isn’t. It’s supposed to be used as a life long med for that.
Bio adaptability. I heard Glp works better on people with higher blood sugar to lose weight.
How big of a heart rate increase were they seeing ? For those of us with tachycardia, it’s a concern .
Average was 7 beats/min
Wait! It's not good to look emaciated? *And* I have to eat food still...
Is this product a trial sign up? Or prescription?
Are the side effects the same as worse than those for Mounjaro/Wegovy/Ozempic/Zepbound et al?
Yes this is y u go through the doses
Thoughts on reza peptides from china
Run away
Where can i buy
Core peptide has it. Just ordered 2 vials
So why doers anyone actually go with Ozempic over Zepbound if semaglutide is actually not that effective. I hate when people see skinny celebrities' and they say "Oh shes got that ozempic" and im just thinking "No way is ozempic going to cause that much loss"
How are people losing 100lbs on semaglutide if its saying it helps with 15%? I’m just not understanding the math on that
Outliers and human bias. Human's tend to only notice the shocking or really good results of a few vs. the OK results of the many.
There’s always going to be a few ‘high-responders’ to any kind of weight-loss medication.
And also, there are those ppl on social media who lie/exaggerate their results, for attention or reasons of insecurity. 🤷♂️
@@cloakster good point of view!
One other possibility: there definitely are ppl out there who weigh 500+ lbs.
So if *they* lose 100 lbs, it’s not that unusual. 🤔
those who lost 100 pounds started eating healthy, healthy food, counting calories and exercising
can semoriline be taken along side with reta to help with not so much muscle loss?
Adequate protein (1.6 grams per KG of target body weight) and modest resistance training with protect against lean mass loss.
60 buckes per month for 5mg retra. Not 1k
Only WITH insurance is it $60
Would taking Tirzepatide at the same time as retatrutide cancel out the glucagon benefit of Reta?
No doctor would prescribe both of them at the same time.
A human can live longer without Oxygen than they can live without blood glucose.
How dare you promote cookie gluttony! Kidding, haha.
❤
i can barely hear you. you need a better microphone.
Join my membership page and maybe I can afford one!
I like to see all these people just scrambling like hell to bring more Ozempic clones to market! LOL! So now everyone is going to add something to Ozempic to try to make the big bucks. I'm glad to see it, however, for there is a really bad lack of supply of these drugs now and some diabetics can't get them because all the rich folk with connections are using them so they can fit in their tiny dresses.
Ozempic is not even the first GLP-1 medication to hit the market… Byetta beat it by 12 years. 😯
‘Ozempic clone’? 😒
Ozempic’s not even the first medication of this type to hit the market (‘GLP-1s’)… Byetta beat it by 12 years.
‘Ozempic clone’? 😒
Ozempic’s not even the first medication of this type (‘GLP-1s’)… Byetta beat it by 12 years.
@@cloakster But Ozempic is getting all the fame!
That part is true.
It’s probably because Oz was the first highly effective one… though it’s not the most effective one currently on the market.
♥️❤️💗
Weight does not equal fat unfortunately. It melts your muscle away too.
It doesn't melt muscle 💪🏽. You not eating enough protein melts muscle.
U just gotta make sure you get good amount of protein and lift weights. At least 1.8g of protein per kg of body weight
Dr. Dan, how do you feel about diabetics getting run over by rich people, who want to lose weight and can pay full price for these drugs, that are making them not available for diabetics that the drugs were developed for, and that the drugs are a crucial part of our therapy who can no longer get them because of shortages? I would love to see at least one or two of the many TH-cam doctors who are talking about these drugs, and spinning up the demand for them, talk a bit about all the off label prescribing that is making diabetics have to chase these drugs from pharmacy to pharmacy, and frequently change dosages or completely change drugs or go completely without any because people are getting these drugs that should not. There is only one of these meds that is approved for weight loss.
You're using a strawman argument. These drugs were developed for people with chronic diseases, both diabetes and obesity. Both chronic and progressive diseases. You are creating an us vs. them dynamic because it's easy to be mad at your fat neighbor Joe vs. understanding and trying to change the government and pharmaceutical systems that led to these issues in the first place.
If we take things a step further, and we use your logic. There are more people with obesity than diabetes. Therefore, these drugs should be allocated just as they are, and people with obesity should be up in arms that people with diabetes are being prescribed these meds. Especially since people with diabetes have multiple drugs and classes of drugs to treat their condition. Does that sound reasonable?
Personally, I don't want to see either scenario. You're mad at the wrong people, Jeff. Direct your energy towards changing the actual problem vs. your neighbor Joe, and maybe we can see some real change!
Why do you think a diabetics needs are more important than overweight peoples needs? Why do you think a so-called "rich" person doesnt deserve medical care too? You've made some shallow, illogical, ignorant arguments.