Peak and Trough

This video explains the peak and trough of medications and why it is important to measure these values.
You may also find these videos in my PHARMACOLOGY PLAYLIST helpful:
PHARMACOKINETICS - 1. Absorption:
• PHARMACOKINETICS - 1. ...
PHARMACOKINETICS - 2. Distribution:
• PHARMACOKINETICS - 2. ...
PHARMACOKINETICS - 3. Metabolism & 4. Excretion:
• PHARMACOKINETICS - 3. ...
Bioavailability of Medications:
• PHARMACOKINETICS - Bio...
First-pass Effect:
• First pass Effect #shorts
Medication Half-Life:
• Medication Half-Life #...
Creatinine Clearance:
• Creatinine Clearance
Therapeutic Window:
• Therapeutic Window
Peak and Trough:
• Peak and Trough
Therapeutic Index:
• Therapeutic Index

[@vanezzaterry7768]

Great video. Thank you for make it so simple

[@NursingSchoolExplained]

Glad it was helpful!

[@em-bj4rm]

Hi. i wanted to ask about the peak levels if they were high. We know this could lead to toxicity, and PK factors could have influenced it. But is it correct to say that the trough conc also could have influenced the peak to be high, meaning the trough conc was higher than the appropriate range

[@NursingSchoolExplained]

There is no general answer to this question as both also depend on the half life of medications and individual patient factors such as age, kidney function etc.

[@mohammadrezarezaei5401]

Thank you very much

[@NursingSchoolExplained]

You are welcome!

[@BushyHairedStranger]

So peak & trough test shows drug concentrations in specific tested organs? Or is this test showing amount of the active drug working physiologically-pharmacologically in serum levels in specific organs? It’s not indicative of effect on perception at any time?

[@NursingSchoolExplained]

Peak and through measure the serum concentration of a specific drug to determine steady state, dosing, and metabolism of that specific drug in a person's body.
Hope this helps!

[@leannebaker823]

Might be a crazy question, So how do you know if it has reached the toxic effect?

[@NursingSchoolExplained]

The patient will exhibit signs and symptoms of toxicity plus their peak levels will be high.
Hope this helps!

[@marianb2530]

So if a medication was given 4 hours ago, what would be the peak and trough level? Thank you so much!😊

[@NursingSchoolExplained]

The peak would be measured right after the infusion is complete and the trough right before the next dose is due.
Hope this helps!

[@dio.ahmed3]

Thanks, you are awesome

[@NursingSchoolExplained]

Happy to help!

[@shadabkhan4811]

Great Job!

[@NursingSchoolExplained]

Thank you!