Simply eating beef can boost your mitochondria as stearic acid from beef and taurine have amazing benefits for mitochondria, but nothing is going to help with your mitochondria and help prevent cancer more than doing some fasting! The many benefits of occasional extended fasting and lowering dietary carbs: Your body recycles up to 1/3 of all immune bodies in a 72h fast, rejuvenating your entire immune system. This helps with autoimmune disease, cancers and cytokine storm. Fasting stimulates phagocytosis, the ingestion growths pathogens and plaques by macrophages and other immune cells. This will remove spikes quicker, whether natural or unnatural in origin! Fasting and low carb help with POTS, which is driven by high insulin and blood sugar. Clotting and fibrin are inhibited, stopping any 'unusual' clots. Fibrosis aka scarring is reversed over time, including in the heart, lungs and clots. When insulin is high, vit D stays locked in the blood cells but fasting quickly lowers it. Vitamin D plasma levels are increased as fasting improves metabolic health, and vitamin D in turn increases autophagy. Fasting restores NAD+ and increases nitric oxide release to open blood vessels. Reflexes and short term memory are increased. Fasts from 36-96 h increase metabolic rate due to norepinephrine release!. Blood sugar and insulin are lowered when fasting, reducing inflammation and allowing the immune bodies to move freely through the body. T cells and T reg cells are vital in fighting cancer, autoimmune disease and infections. With age, the thymus stops making as many of them but fasting releases stem cells, which then can become new T cells. It also releases growth hormone, which regenerates the thymus itself! Fasting increases anti-aging Yamanaka factors and increases average telomere length in stem cell pools. Fasting can help with MS, Depression, BPD, Autism and seizures. When you move out of MTOR your body shuts down the building blocks of the cell required for viruses to replicate. The hunger hormone ghrelin also lowers with extended fasting and rises from dieting. What breaks a fast? Anything with protein or carbohydrates in it will break a fast but most teas and herbs are OK. Supplements and meds often break ketosis directly or contain a filler that will. Many meds are dangerous to take while fasting. Does fasting lower testosterone? No, it raises it when the fast is broken by increasing lutenizing hormone. Fasting also increases insulin sensitivity, which helps with muscle building. Fasting activates autophagy (literally self eating), which causes cells to recycle damaged proteins and foreign matter such as viruses. Lowering insulin via fasting virtually eliminates chronic inflammation in the body. Weight loss from daily caloric restriction has 1/4 to 1/3 of the weight lost as lean tissue while many studies show fat loss from 36 h fasts without losing any lean tissue! The obese will lose loose skin while fasting, but the frail will have increased growth hormone release, which helps to make more lean tissue and reduce frailness. Fasts of 36-96 will not affect short term female fertility or affect menstrual cycle. They also may increase long term fertility for some women. It increases mitochondrial function and repairs mitochondrial DNA. Good mitochondrial function also has the added benefit of increasing your metabolism, fighting infection and cancer prevention! 24h of fasting can cut your leptin levels in half! This reduces leptin resistance, which impairs immune function. Your brain prefers to burn ketones at a rate of around 2.5 to 1 when they are available in equal measure to glucose. Except for brief periods of very intense exercise, your body mainly burns fats in the form of free fatty acids. Fasting increases telomere length, negating some of the effects of aging at a cellular level. Fasting releases BDNF and NGF in the blood. This stimulates new nerve and brain cell growth, which can help a great deal with diseases like MS, peripheral neuropathy and Alzheimers. When not in ketosis, the brain can only burn carbohydrate, which produces a great deal of damaging ROS the brain has to deal with. Fasting stimulates apoptosis in senescent or genetically damaged cells, destroying them. Senescent cells are responsible for many of the effects of aging and are a root cause of the development of cancer. A fasting mimicking diet for 3-5 days in a row provides many of the same benefits as water fasting. FMD usually has 200-800 calories, under 18 g of protein and extremely low carbs. Exogenous ketones can aid with fasting, allowing some people with specific issues to fast in spite of them without worrying as much about hypoglycemia. They also help with dementia and many other issues even if you take them while not fasting! Glycine and trimethylglycine can also be useful supplements while fasting that won't break ketosis and have many benefits. Children, pregnant or nursing women should not fast for periods longer than 16 hours. People with pancreatic tumors that excrete insulin or certain rare forms of hypoglycemia generally cannot fast at all or only with doctor supervision. Type 1 diabetics can also fast but it is more complicated and should be approached with caution as it could lead to ketoacidosis and done under doctor supervision. If you experience extreme symptoms of some kind, especially dizziness or tremors, then simply break the fast with a low carb meal. Resources: www.nia.nih.gov/news/research-intermittent-fasting-shows-health-benefits pubmed.ncbi.nlm.nih.gov/31890243/ www.sciencedirect.com/science/article/pii/S0005272806000223 www.ncbi.nlm.nih.gov/pubmed/23876457 www.sciencedirect.com/science/article/pii/S1931312809002832 www.ncbi.nlm.nih.gov/pubmed/10859646 www.ncbi.nlm.nih.gov/pmc/articles/PMC7093158/ www.ncbi.nlm.nih.gov/pmc/articles/PMC5895342/ www.cell.com/cell-metabolism/abstract/S1550-4131(15)00224-7 pubmed.ncbi.nlm.nih.gov/2518860/ www.ncbi.nlm.nih.gov/pubmed/24905167 www.nejm.org/doi/full/10.1056/NEJMc2001176 pubmed.ncbi.nlm.nih.gov/31877297/ www.ncbi.nlm.nih.gov/gene/25712 www.ahajournals.org/doi/10.1161/HYPERTENSIONAHA.121.17852 www.clinicaltrials.gov/ct2/show/NCT04375657 pubmed.ncbi.nlm.nih.gov/20102774/ n.neurology.org/content/88/16_Supplement/P3.090 pubmed.ncbi.nlm.nih.gov/6859089/ repository.upenn.edu/cgi/viewcontent.cgi?article=1537&context=edissertations www.ncbi.nlm.nih.gov/pmc/articles/PMC1779438/ www.ncbi.nlm.nih.gov/pmc/articles/PMC6407435/ www.cell.com/molecular-cell/fulltext/S1097-2765(18)30605-1?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1097276518306051%3Fshowall%3Dtrue pubmed.ncbi.nlm.nih.gov/28235195/ www.ncbi.nlm.nih.gov/pmc/articles/PMC2815756/ medicalxpress.com/news/2022-10-treatment-pulmonary-fibrosis-focus-telomeres.html www.cell.com/cell/fulltext/S0092-8674(19)30849-9 clinical.diabetesjournals.org/content/36/3/217 www.ncbi.nlm.nih.gov/pubmed/25686106 onlinelibrary.wiley.com/doi/full/10.1111/j.1365-2265.2005.02288.x academic.oup.com/ajcn/article/81/1/69/4607679 www.amjmedsci.org/article/S0002-9629%2815%2900027-0/fulltext www.collective-evolution.com/2017/05/16/study-shows-how-fasting-for-3-days-can-regenerate-your-entire-immune-system/ pubmed.ncbi.nlm.nih.gov/7714088/ www.nejm.org/doi/full/10.1056/NEJMoa012908 www.ncbi.nlm.nih.gov/pmc/articles/PMC6141719/ www.arcjournals.org/pdfs/ijrsb/v3-i11/7.pdf pubmed.ncbi.nlm.nih.gov/27569118/ pubmed.ncbi.nlm.nih.gov/23408502/ faseb.onlinelibrary.wiley.com/doi/abs/10.1096/fasebj.2019.33.1_supplement.819.10 www.ncbi.nlm.nih.gov/pmc/articles/PMC3017674/ www.ncbi.nlm.nih.gov/pmc/articles/PMC6526871/ pubmed.ncbi.nlm.nih.gov/23707514/ pubmed.ncbi.nlm.nih.gov/20921964/ pubmed.ncbi.nlm.nih.gov/29727683/ pubmed.ncbi.nlm.nih.gov/15522942/ www.ncbi.nlm.nih.gov/pmc/articles/PMC7607739/ pubmed.ncbi.nlm.nih.gov/33530881/ www.biorxiv.org/node/93305.full www.health.harvard.edu/heart-health/abundance-of-fructose-not-good-for-the-liver-heart pubmed.ncbi.nlm.nih.gov/25909219/ www.ncbi.nlm.nih.gov/pmc/articles/PMC5783752/ www.ncbi.nlm.nih.gov/pmc/articles/PMC1413655/ www.ncbi.nlm.nih.gov/pmc/articles/PMC5783752/www.ncbi.nlm.nih.gov/pmc/articles/PMC8470960/ europepmc.org/article/MED/22402737?javascript_support=no www.ncbi.nlm.nih.gov/pubmed/10232622 pubmed.ncbi.nlm.nih.gov/21410865/ This list compiled over years of research by the user known as Pottenger's Human on youtube. Feel free to copy and paste this anywhere you like, no accreditation needed!
All cows are fed grass until harvested. Yes, the cows on feed lots for the last few months of their lives are fed grass. Yes they are fed corn. The corn is that 6’ tall plant that holds the (1) ear of corn. It is harvested as silage. Calves, baby cows, are not raised on feed lots. They are born on a ranch. They drink milk from their mother. Then after ~ 14 months are sold to a feed lot. They get harvested after ~ 4 months.
One of the byproducts from making apt, energy, by the mitochondria is low deuterium water ...this is easily produced eating animal products ...that's why a diet with meat will always be the healthiest.....high deuterium water is a growth promoter, say hello cancer
Great video. Just a few comments, from my experience suffering from cronic fatigue due to Ross River fever. Viruses also damage mitochondria. I did take the supplements of CoQ10, l-carnitine, ala, etc, but they only helped so much. The best thing I did was intermittent fasting.Twice a month for four or five months, anywhere between 36 to 48 hours. I could see the results within 3 days of fasting each time. I don't need to fast anymore. I'm very healthy. I'm 57 and I don't take any prescription medication. If any of my symptoms come back, the only thing I will do is intermittent fasting. Of course I always eat healthy too.
That’s great advice, and I agree that viruses can certainly damage mitochondria. Have you looked into methylene blue? My video on this topic will come out tomorrow. Methylene blue can greatly improve mitochondrial health and is also an anti-microbial agent.
I suffer with chronic fatigue, but I cannot fast 😂😂 I have tried and tried and it’s just so so hard. I know fasting is the best thing one can do to improve general health, but this eating little and often, it’s worked years ago, not it’s a habit that’s hard to shift.
@@aluna_m888 Try doing 12 hours only at first. Then increase to 16 hours, and so on. The body will adjust over time. For example, every Saturday, fast for12 hours. After one month, fast for 16 hours. You only have to do one 36 hour fast per month to see the results. This is the only way nature has designed our body to recycle and heal itself. The power to fast is in your mind.
@@JonasKuehneMDThanks so much for this video. I'm suffering from long Covid since 2020 followed by vaccine injury. I'm finding B1 benfotiemne at 900mg a day extremely helped cognitive impairments ( brain fog) This was very noticeable within a few days... Theory being it's helping mitocondria process gulcoses 🤷🏼♂️ I started on methylene blue yesterday also 👍🏼
@@Ezpize626 May I ask what brand of methylene blue you've purchased? I want to try it in hopes it'll help with my chronic fatigue. I also hope you'll report back shortly on your dosing and results. Best of luck. TIA
@monnoo8221 they didn't have trouble rushing the food pyramid into the mainstream and schools without evidence. It's _possible_ something else is happening
@@monnoo8221 Some of this may be "new" as you say, but if you practice it, it's possible that you may appear dangerously unhealthy to many mainstream doctors. At age 70, I was extremely healthy. I was even knowledgeable enough to point out, in some detail, the conflict between supposed risk factors for cardiovascular disease: high HDL versus good lipid ratios. TG/HDL ratio of .69. Total cholesterol 325.
Thanks. To reduce toxin exposure, I switched from carpet to hard wood floors. Previously, when I vacuumed, the vacuum cleaner just filled up way to quickly. Now keeping things clean is much easier.
My primary healthcare provider knows i practice Fasting ( 9 months now). She was initilially slightly horrified and bemused. At the outset of my last visit she asked outright " am i still doing it?" I replied in the affirmative that yes i am and feel great. I did not go into any detail whatsoever but mentioned Weightloss, inflammation and that i am a believer in autophagy. She has no idea what autophagy meant. Still pushing Statins but will not have my fasting insulin tested. Oh 🇨🇦 !!!
I am sorry to hear that. A lot of physicians are very ignorant about nonpharmacologic medicine. Good for you that you are taking measures to improve your health!
Fasting insulin isnt even a public funded test in new zealand...let alone recomended lab. There are a lot of other blood tests i get which my doctor did not request. I did
Oh talking to a primary care doc who prescribed a drug that they didn’t know in the first place would hurt our mitochondria is always a good idea. I n my experience in this life I do not trust very few WM doctors with any chronic illness or disease. Peace
Excellent program on such an important topic as Dr. Kuehne explains this so well. Pithy, succinct with great takeaways. For mitochondria, the type of exercise I have learned from my CPT and Advanced Senior Fitnesss Training was Zone 2 cardio. Resistance training is critical as well and for the myokines and helping with metabolic health. Would love for you to explore exercise and its effect on health markers. Thank you - will pass on.
HI JONNAS, it's a great pleasure to meet YOU, I am 69 and been swimming from 51 , I Also love Bioquemistry and follow some great Doctors in USA who practice functional Medicine, I do intermitent fasting for 2 years now and I feel great, have more energy and mental clarity plus inteligence 18-6. As to mythocondria I would Say that doing high intensive excercises let's Say for a minute and resting for 70 seconds is a good way to go, and if You can do it during fasting is much better. As to good foods there is soybeans or Tofu organic, rosted chocolate seeds or dark chocolate, cocoa, Resveratrol capsules, and beets . It's good to exchange information for attaining better Health, allá the Best from Perú.
Thank you for your comment and hi to beautiful Peru. It looks like you have a great workout, fasting, and nutrition schedule. I am very impressed with your healthy lifestyle. Wishing you continued great health and fitness.
Interesting information. From my personal experience i agree with your take on autophagy, even because e can combine exercise and fasting in a way to trigger autophagy.
Thank you for your feedback. Yes, the benefits of autophagy, mitophagy, and improved insulin resistance can be seen with regular intermittent fasting and even modest 14 to 18 hour fasting windows. I find this very encouraging and motivating to someone with impaired glucose tolerance or early diabetes.
@@liberty8424 Making high intensity/low intensity exercises (i guess this is how it's called) and also respiratory and chi-gong style exercises while you are fasting it's like increasing the number of hours of fasting, thus triggering autophagy quicker, at least this is the way this works on me. Another good thing that i used to do more in the summer it's taking a shower of icy water. I connect a water hose directly to the well, and the water comes out from 30 meters deep around 10Cº or less, taking that jet of water is a miracle after putting up with a day of 35 to 40Cº, it's rejuvenating. It's well known for boosting mitochondria. Taking a cold shower after going for a run is also a good strategy. Basically, anyhting that burns a lot of energy, you don't need to go on 24h fastings (or more) to trigger autophagy, like a lot of people do, specially if you don't need to lose weight. I hope this helps, it's all simple things that anyone can do, no big deal!
It's worth mentioning that 1/3rd of the body weight is entirely mitochondria and by simply checking one's body temperature will let you know how efficient their working (closer to 98.6 the better). It's said that mitochondria make 15 degrees more heat than the ambient temp around them. Yes that's right, we get hot when we exercise because our mighty mitochondria are hard at work.
Dr. Ben Bickman also pointed out that metformin damages mitochondria. I take the max dose. I am angry because my endocrinologist considers metformin harmless and wants me to continue using it. But here I am, a diabetic that eats almost no glucose, fighting cancer, that is working very hard to make my body as hostile to that cancer as possible.
One advantage is that metformin decreases the uptake of glutamine, which is one of the fuels for cancer cells. This is a good function that it has. Together with supplements like EGCG and berberine it can be very helpful. Yes, at higher doses it can cause some mitochondrial problems. Given your current diagnosis of cancer, ketogenic diet would be the second aspect of metabolic therapy as outlined by Dr. Seyfried. This is also an option to decrease your left glucose levels significantly. I recommend to discuss any of these changes with your treating physician, of course.
Nice summary. Perfect for sharing. Finding the right balance when post menopausal is hard. Aiming for prevention of mitochondrial damage rather than weight loss may be more motivational when you feel like an alien has taken over your body. I’m going to try that. Thank you.
Good evening! Thank you very much for sharing your knowledge. I llike your videos , they re short , informative, to the point, clear speech and no bubbling. Greetings from Greece
Of course, you are aware that coq10 Ubiquinol is far more bio-available that regular COQ10 - Ubiquinone. Vitamin E- Tocopherols versus regular vitamin E and for vitamin K2 - MK7 is recommended as best. Anyone taking statins should be made aware that the statin also inhibits the liver's production of the COQ10 enzyme thus requiring supplementation.
I think that health, longevity, and muscle growth can go hand-in-hand. A low carb high protein diet, optimizing body fat can achieve these goals. I will do a more detailed video on this at some point.
@@JonasKuehneMDbut doesn’t a higher protein diet stimulate IGF hence promoting cancer and reducing life expectancy? Wouldn’t balancing MTOR and the AMPK energy pathways be more suitable for longevity?
@@jimking6484 point is that you should not indulge in feasting all the time, regardless of the macro composition. A 15/18 to 9/6 feeding window allows insulin and IGF coming down. The "high" in high proteni diet is relative... compared to the RDA, whch is propagated as default, but is too low for muscle maintenance.
If I may ask please if you could answer or if someone can let me know where to get this question to you... Mastering Diabetes is composed of 2 men one doctor. They're young and very intelligent. They believe that insulin resistant is caused because of an accumulation of fat in the cells which thus reject insulin obviously causing insulin resistance. They put their clients on fruit and vegetable diets and all of their A1Cs drop. I'm dyingggg to know your thoughts. I do extensive studying on my own as much as I can. I believe mitochondrial health will be the next trend in the next 5 yrs. Thank you so much for sharing this invaluable information 🙏🏽
Excellent, Dr. Jonas. Quite comprehensive. You are so close to the truth I hope you live in EU where you'll find greater support. You talk about mitochondria recovery (near IR) and replacement (fasting), but perhaps you could enlarge this and include diets that actually boost mitochondria besides going to a gym (or dunking in ice water). My question: If a person transitions to high-and-good fat with low carbs diet and doing it suddenly, would you expect a dramatic Omega 6/3 change that may need some guidelines? A very enjoyable presentation.
Thank you very kindly. Seed oils buildup overtime and it may take several years to decrease their levels significantly after we largely cut them out of our diet. Remember that omega six fats are also in small amounts in saturated fats, but the main issues are with the seed oils that have an exorbitant amount of them. so your benefits after cutting out omega six fats will happen overtime, but will require some patience.
Thank you Dr Kuehne for spreading the word for what has been coined as the metabolic approach. This approach has been extolled by Dr Thomas Seyfried (if the reader is unfamiliar with his work a search on TH-cam will unearth many entertaining interviews with this gentleman) and before him the winner of the 1931 Nobel Prize in Physiology, Otto Warburg.
@@JonasKuehneMD Can you post the references that demonstrate seed oils being unhealthy? Recent studies, not something done 50 years ago. What I see is study after study showing that either inflamation is reduced or not affected at all with increased seed oil consumption and also a link to less heart disease and cardiac events. So what is the basis for the claim that these oils are unhealthy?
The Budwig Protocol also optimizes mitochondria function It involves mixing electron-rich flaxseed oil with sulfur-rich cottage cheese. This combination allows the flax oil to bind with the sulfur proteins in the cottage cheese, making the fats more water-soluble. This process enhances the absorption of essential omega-3 fatty acids into your cells, providing significant anti-inflammatory and cancer-fighting benefits. It’s a powerful way to boost your mitochondrial health naturally! I found that talking the Budwig flax oil cottage cheese mix with olive leaf extract capsules 20% oleuropein and mixing 95 percent curcuminoids directly into the mixture significantly boost energy levels. Johanna Budwig's research still holds up. Budwig mix is just 8 tablespoons of cottage cheese or quark if you're in the U.K mixed with 4 tablespoons of flax seed oil. Mix with spoon then immersion blender. Consume within 20 minutes..
I read somthing about taking methylene Methylene blue with niacin increases NADH or NAD several fold it was an increase up there with intravenous NAD therapy
I have a question: why does the fermentation method of cell energy production exist? I've been told it's a relic of the way cells used to create energy before animals started using ATP and it isn't normally used any more, but that has to be wrong because mutations to our DNA that are associated with the fermentation process would be harmless; instead everyone still has a functioning ferment energy process (presumably mutations here are fatal). Why? When do our cells ferment anything apart from when we have cancer? Edit: I just pasted the above into ChatGPT and I now know the answer. Fascinating!
Fermentation helps cells to produce energy in the absence of oxygen. We see this frequently when people exercise and cannot sufficiently oxygenate muscle tissue.
H Doctor, my 18 yr old daughter was been diagnosed with some Mitochondria problem but they haven’t explained why or what to do in order to help her. She is been having lots of medical issues, mostly mental related. Can you please advise on this!!
@@JonasKuehneMD No, we been looking for answers for a little over 5 years . We look into Endocrinology, Neurology, Psychology and genetics and nothing. Around five months ago she had a skin biopsy but until now we haven’t heard anything from doctors. She is currently beeen seen under Seattle Children Hospital Research Center and no answer yet!, but all I can say is the worse part is the mental health which is very disability for her most of the time. Lack of attention, concentración and mood changes
@@PlimsollHero to a large extent, yes... packaged fish in olive oil is almost ok, or cheese. A rest of convenience for me is packaged natural yoghurt, or rare treats like gyozas, proschiuto...
It’s a great antibacterial/antiviral medication, and can also improve mitochondrial health by directly impacting the electron transport chain. Also has antioxidant and anti-inflammatory properties.
I Totally agree and i tried to tell the Oncologist that was treating my dads cancer. I say because Otto Warburg effect The Warburg Effect causes alterations in mitochondrial redox potential, ultimately changing ROS generation [18]. An important determinant of redox potential in cells is the NADH that is available in the mitochondria for electron transport.Jan 5, 2016 The Warburg Effect: How Does it Benefit Cancer Cells? - PMC - NCBI Also the other important aspect is the Proton Pump Health. Lastly what are the best way to test the Mitochondria ?
Unlimited appreciation for the inclusive and yet simple presention of this integral topic which greatly added to my search of the components of preventing and treating ailments. I was diagnosed with stage 4 breast carcinoma and been in search of knowledge. How can i reach u personally Dr. Kuehne ??
Thank you for your informative video. Confused about Near IR that heals the mitochondria. Your diagram @1.30 shows a picture of what happens with the nucleus, but the mitochondria is not part of the nucleus So, are you saying that if you somehow can alter the mitochondria in cancer cells via Near IR, then the cell can turn into non-cancerous cell. Also which wavelengths are effective for Near IR. Thank you.
Thank you for your feedback. No, cancer cells have malfunctioning mitochondria that can only ferment. The positive effect of NIR is on healthy cells. Here, you are correct it is penetrating into the mitochondria where it increases the production of melatonin. This improves the health of the cell. The video may have been confusing here.
I've read that using a sauna (dry not steam)is beneficial to your mitochondria. Could you comment on what temperature would be too high for someone with lupus?
Yes, a regular sauna through heat stress can increase mitochondrial function. an infrared sauna that has near infrared as part of its wavelength spectrum can also directly stimulate mitochondrial health and function. Auto immune disorders like lupus increase inflammation. I am not sure whether or not that can be an issue. Cold therapy in the form of whole body cryotherapy has been shown to be extremely anti-inflammatory for autoimmune disorders.
This needs to be discussed with the treating oncologist of course, but a ketogenic diet with added supplements like EGCG and berberine helps to decrease the fuels available to cancer cells and may be very beneficial here.
Very balanced video. However can we measure the health of the mitochondria just like we test many organs or lipids. I already do all the things you have mentioned and my blood results are all very well especially BMI, tg/hdl of 0.5, CRP 0.3, vo2 max at 60, grip strength, etc…
You're really scaring me, Jonas. Should i now worry about having cancer? I had it 10 yrs ago, but luckily, i needed no chemo or radiation. As far as i know i do not have cancer now, but your mentioning all those horrible diseases linked to mito dysfunction is truly unsettling...ALS, OMG! No way! And i dont have heart disease or diabetes. Lifelong STRESS is the cause of my mito dys. Add to that my age, 70+
It looks like your functional MD is following you on these parameters. The best preventive strategy is to keep your HG A1c, low by decreasing total carbohydrate intake and eat clean foods free from herbicides, pesticides, seed oil and additives. You can ask your functional MD about regular high dose intravenous vitamin C drips. Every 2 to 3 months on the order of 25,000 to 50,000 mg.
Been thru hell...was diagnosed with adrenal fatigue (hpa axis dysregulation) by ND. Then after much research and tests, i self- diagnosed mito dys. There really isn't a reliable test for mito...it is a process of elimination.
Mitochondrial dysfunction is going hand-in-hand with inflammatory processes in the body, which we can sometimes identify with Labs like CRP. Anti-inflammatory strategies can also include NIR/red light panels, cryotherapy, pemf, and an anti-inflammatory diet.
I find limiting to 50 carbs per day is easily achievable and facilitates weight loss and maintained the loss with an 18 hour fasting window. Easy peasy
Your information is ok BUT incomplete. You have left off light, sunlight to be exact, and the importance of circadian rhythm. Please check out Dr. Jack Kruse’s work. Light, water (building exclusion zone water) and magnetism these come first THEN comes food and exercise.
So you are saying that eating a ketogenic diet is great if you have cancer and it will help a person heal from that disease? So what diet do you recommend after healing one’s self after healing cancer after eating a keto diet? Are you leaning to go back to eat a high carb diet that got us sick in the first place? Please explain what you mean? Peace
A person being treated for cancer or recovering from cancer should continue on a ketogenic or at least very low-carb diet. In my opinion. It is always important to check with their oncologist or primary care doctor to ensure that levels of minerals and other labs are within range. They should also continue with supplements to decrease the uptake of glutamine, like EGCG, and berberine.
I just discovered that i have Hashimoto's. Already gone Paleo and taking numerous supplements. For mitochondria I take Ubiquinol, PQQ, creatine, NAC and magnesium citrate (speeds peristalsis). I also have a small near-infrared panel although I'm hoping to get a more modern one with a broader spectrum. My recovery from exercise is already improving so I know that it is working.
Yes, dietary changes are very important here. I would strongly recommend to cut out all gluten, which is easily achievable on a Paleo diet. I did a video about gluten a few days ago, and the research was fascinating. None of us can digest gluten completely, and it triggers an immune response with hydrates inflammation in the small intestine in everyone. For some people, this is very mild and goes unnoticed more profound with symptoms. This inflammation increases zonulin causing a widening of tight, junctions in the small intestine and a leaky gut. This allows antibodies and gluten particles to enter the bloodstream and contributes to auto immune disorders like Hashimoto’s thyroiditis.
What can we do when we've been prescribed a statin, have been advised by all our doctors to take it, and have would up with a mitochondrial disease that we did not have before?
Not medical advice, but I would ask about the reason for the statin. If HDL is high, triglycerides low, then LDL is secondary in my opinion. If there is heart disease or a previous MI, then a statin can be given preventively and may be useful. How much a statin contributes to mitochondrial dysfunction is difficult to estimate. It is one of the medications that can contribute, but is not necessarily on its own.
@@Statinstories Statins inhibit body production of CoQ10, Vitamin K2, and selenoproteins. Statins stimulate atherosclerosis and heart failure. Make diet changes and take a lot of vitamin C and lysine as recommended by Linus Pauling. "Vitamin C supplementation lowers serum low-density lipoprotein cholesterol and triglycerides: a meta-analysis of 13 randomized controlled trials." "Dietary l-Lysine Prevents Arterial Calcification in Adenine-Induced Uremic Rats"
Hi doc, I loved this info. and have subbed you. I'd like to let you know that i'm CMV positive and unable to gain weight. Could you please make a video on this virus which not many people are aware about yet majority of population harbour this virus in them that may produce complications in later life. What type of diet you would recommend to healthy sedentary adults who are CMV +ve and want to gain healthy weight and keep the virus latent as long as possible?
Thank you for your feedback. That sounds like a very important topic and I will definitely look into it. Are you currently taking methylene blue? It can greatly improve mitochondrial health and is also acting as an antiviral. Maybe a topic you could discuss with your primary care doctor.
These are sugars that are immediately available, so not bound in long chains of carbohydrates. Examples are of course, candy, fruit,sucrose, high fructose corn syrup, etc.
Hi doctor a have a comment here there are a lot of studies that show cancers also metabolize fatty acids mainly pancreatic one maybe pubmed it too I wouldnlike tonlearn more
I need to research this more. In general, the two fuels for cancer cells are glucose and glutamine. If cancer cells can entirely live of fat is questionable. I will look into the research.
@JonasKuehneMD not sure if entirely but when I ask perplexity ai it was able to give me a lot of studies showing certain cancers can metabolize fatty acides and also there are some metabolic drugs that stop fatty acid metabolism for those
Supplements with preformed ketones can help to get into ketosis faster. I do not believe that they have a major positive influence on the mitochondria, however, a ketogenic diet in itself can be beneficial.
@@JonasKuehneMD thanks. So theyre pretty useless on their own..with ketogenic diet.,or fasting. I cant do either of those dietery changes, unfortunately, cos of hypoglycaemia issues.. I dont know whats causing it, and its forcing me to have to eat hidious load of Sugar and carbs, on regular basis. Its the bane of my life..i know my body doesnt have a chance to get healthy, whilst eating that cr*p, to say the least. If u have suggestions about this issue, i would appreciate any advice.
@@JonasKuehneMD ok thanks. I ask cos im in a situ, with poorly health issues, where im not always able to exercise regularly. But also, just to boost muscles anyway.
You mentioned that IR from the sun is good for us. What about when you live someplace like AZ or CA? We’re told to avoid the sun to prevent skin cancer if we’re Caucasian. I believe that advice is sound in extreme UV climates. I wait for the sun to go down before running or run in the morning sun to keep UV exposure at a minimum.
Too much exposure to UV radiation certainly contributes to skin cancer and skin aging. However, we are spending only about 7% as much time outdoors in sunlight today then we did about 150 years ago. Early morning and late afternoon sun will have sufficient NIR while not having as much UV radiation. 10 to 20 minutes per day is already beneficial. Also, if we change our nutrition to exclude seed oils, we can improve mitochondrial function in our skin, which helps to decrease the risk of sunburns and skin damage from UV radiation.
I never seen anyone mentioning vision and hearing changes. According to my optometrist, i have esodeviations...never seen a case like mine. 😢 Five examinations, five different results. My eye muscles are too weak to focus..ever heard of it, Jonas?
I have heard of esodeviation due to miss alignment or weakness of extraocular muscles. I am not sure if Methylene blue would be helpful in this case. What advice has your ophthalmologist given you?
@@JonasKuehneMD he told me I can leave it as is if not too bothersome, or get very long and expensive therapy that may or may not work. Prescr. glasses didn't work. Up close no problem...distance is the problem. I had five examinations this year, and each and everyone was different than the one before...so, seems intermittent. Opt told me he had never seen this before...made me feel like a freak. ☹️
When I told my GP I have Mito dysfunction, he replied "every elderly person has that, and there is no treatment for it...it's called Aging," which confuses me bc I'm 70+ but surely, not every senior feels this terrible!
@@JonasKuehneMD I don't think anyone is able to avoid processed foods entirely, but I'm doing pretty well keeping it to a minimum. Have I told you how miserable this condition is? Having to take so many supplements, and not being able to eat what I want feels like HUGE punishment. I just can't get excited about a salad...it isn't strawberry cheesecake, is it?☹️
@natalie8518 well, then, all allopaths are bozos bc they don't treat Mito dysfunction...not profitable. I take coQ10 daily, plus a handful of other supplements.
the mighty dwarfs (more than 7) in the background (and behind the mountains).... fascinating, absolutely. I have a question, and probably the mitos offe a solution to it. Consider a body that is in a quite good shape. CVD markers 0, BF 12%, Vo2max 48, fasted glucose 87, fasted insulin 2.4, Tg/HDL 0.6, ALT/AST 30, RBC parameters fine and the better end of the ref range, hsCRP 0.04/dL, leuco 7k, eosinophils however outside or reference range bacause of airbourne plant allergy since 56y, no glasses. All acceptable. However, hba1c indicating that my average glucose is 115..120. Even after 18h std fast, no carbs for 24 hours, glucose is 95..100. I have to work out fasted, and add another 12h fasting, iaw, depleting glycogen completely, then the glucose is at 87. I am on a high fat regimen and have no problem to cut carbs to 50g. The question: are damaged mitochondria able or the possibly the cause for driving blood glucose high if there is any carb, even glycogen, in the system?
Your lab values are excellent. An average blood glucose of 115 is not terrible. I would not blame the mitochondria for this. In some instances after prolonged fasting glucose may spike. Your fasting insulin is great. I would just keep following yourHB A1c. As long as you stay below 5.6 you should be fine. I would expect it to be a bit lower given your very low carb diet.
Very much appreciating the quality of your video. At 6:21 you mention the link between obesity and cancer. I am just perplexed by something. Wouldn’t it be relatively easy to simply measure categories of body fat composition against cancer rates? Body fat is super easy to check. Cancer is not exactly but close to binary (you have a malignancy or not). Then…. At different ages, different types of cancer, etc you just determine: is there a large statistical difference between, let’s say,
Great question. They have been a lot of studies to prove the relationship between obesity and cancer. They even describe the percent increase. www.hindawi.com/journals/isrn/2013/680536/ nyaspubs.onlinelibrary.wiley.com/doi/full/10.1111/j.1749-6632.2012.06750.x
Im in a hypoglycaemia nightmare...where im forced to eat hidious amounts of sugar and carbs ..ti control hidious symptoms...its been goin on for years.i know how bad it is fir health, but cant i dont know what to do about it...havnt found the answr yet. Any suggestions, please?
Why would you need to do this? What happens if you stop eating carbs? Try slowly reducing the amount of carbs. You body will slowly seitch over to burning fats (ketones). At that point, you will no longer need to worry about your blood sugar. Your liver will produce all the glucose required even if you don't consume any carbs at all.
@@davepeterschmidt5818 i dont know whats causing the hypoglycaemia, but the symptoms can get too severe, if i dont eat sugary food. I get brain fog, anxiety from the adrenaline, sometimes angina..symptoms that i cant ignore. I know other people who have similar..in terms of hypo symptoms, and have to eat often.
There’s some speculation that red light therapy might be bad, I’d be cautious It’s fine naturally from the sun but recreation of it may not be all it’s cracked up to be and may actually lead to unfavorable outcomes
@@napua5217 the classic: speculation vs science. So, if the speculation is based on a couple of anecdotal evidence, these need to be investigaetd thorougly. Doo you knw them? then please share. Yet you are partially right regarding the brain... if the NIR comes from lasers. yet, LEDs are not lasers, so, no issue regarding red light panels
Doctor please confirm my understanding. Near Infrared Radiation to make Melatonin - does not require naked skin - goes through clothing. UV rays to initiate vit D3 production - requires naked skin (and time limit etc.) .
Do not take vitamin e without consulting a doctor. Aside from D and K, fat soluble vitamins can be very dangerous (those two as well, but generally the risk is much lower at normal doses)
I am not aware that we can significantly influence glutamine production, but we can decrease glutamine uptake via supplements like EGCG or intermittently block with medications like DON.
@@ccaselli7 the ea behind that? it is non-essential, meaning the body can produce it easily and in quantities. It is also contained in any protein. Maybe you meant glycin?
Cancer cells have defective mitochondria and will not benefit from the supplements. They are often referred to as ‘ghost mitochondria’, and can only ferment the substrates glucose and glutamine.
@@JonasKuehneMD I hope that is the case. However, in this article, "Ivermectin, a potential anticancer drug derived from an antiparasitic drug" This paper tried to define the theoretical mechanisms of ivermectin including apoptosis, autophagy, pyrotosis (programmed cell death) based on previous studies. It noted that the presence of the mitochondrial fuel acetyl-L-carnitine (ALCAR), and the antioxidant N-acetyl-L-cysteine (NAC), could reverse IVM-induced inhibition.
Actually, there is work being done on long-term ketosis, and even carnivore! And it looks like all the warnings were just wrong or made up! Standby for published papers!
Humans definitely do well longterm ketosis. Just look at us. With out it humans would not exist. Anyone that thinks longterm ketosis is anything other than natural state of human 🤔 🙄 they don't know how to think.
I followed a ketogenic diet for over two years and did great on it. There were a few drawbacks in terms of minerals and nutrients that I should have addressed differently in retrospect. I think some people can definitely thrive on this for long periods of time, while for others it could be a short-term start into a better metabolic state.
Good advice. After transplant, they put me on immune depression + statin + baby aspirin + blood pressure med. I don't think they'll lower the dose just because I want better mitochondria. They're ok with supplements as they "don't affect treatment". I've also hypothyroidism, so still tired in spite of following your list.
Thank you for your comment. I am not sure how methylene blue would interact with immunosuppressive medications. I have not found any literature on this. You are correct though that you still want healthy mitochondria, just enough immune suppression to prevent from rejecting the transplant.
Simply eating beef can boost your mitochondria as stearic acid from beef and taurine have amazing benefits for mitochondria, but nothing is going to help with your mitochondria and help prevent cancer more than doing some fasting! The many benefits of occasional extended fasting and lowering dietary carbs:
Your body recycles up to 1/3 of all immune bodies in a 72h fast, rejuvenating your entire immune system. This helps with autoimmune disease, cancers and cytokine storm.
Fasting stimulates phagocytosis, the ingestion growths pathogens and plaques by macrophages and other immune cells. This will remove spikes quicker, whether natural or unnatural in origin!
Fasting and low carb help with POTS, which is driven by high insulin and blood sugar.
Clotting and fibrin are inhibited, stopping any 'unusual' clots.
Fibrosis aka scarring is reversed over time, including in the heart, lungs and clots.
When insulin is high, vit D stays locked in the blood cells but fasting quickly lowers it. Vitamin D plasma levels are increased as fasting improves metabolic health, and vitamin D in turn increases autophagy.
Fasting restores NAD+ and increases nitric oxide release to open blood vessels.
Reflexes and short term memory are increased.
Fasts from 36-96 h increase metabolic rate due to norepinephrine release!.
Blood sugar and insulin are lowered when fasting, reducing inflammation and allowing the immune bodies to move freely through the body.
T cells and T reg cells are vital in fighting cancer, autoimmune disease and infections. With age, the thymus stops making as many of them but fasting releases stem cells, which then can become new T cells. It also releases growth hormone, which regenerates the thymus itself!
Fasting increases anti-aging Yamanaka factors and increases average telomere length in stem cell pools.
Fasting can help with MS, Depression, BPD, Autism and seizures.
When you move out of MTOR your body shuts down the building blocks of the cell required for viruses to replicate.
The hunger hormone ghrelin also lowers with extended fasting and rises from dieting.
What breaks a fast? Anything with protein or carbohydrates in it will break a fast but most teas and herbs are OK. Supplements and meds often break ketosis directly or contain a filler that will. Many meds are dangerous to take while fasting.
Does fasting lower testosterone? No, it raises it when the fast is broken by increasing lutenizing hormone. Fasting also increases insulin sensitivity, which helps with muscle building.
Fasting activates autophagy (literally self eating), which causes cells to recycle damaged proteins and foreign matter such as viruses.
Lowering insulin via fasting virtually eliminates chronic inflammation in the body.
Weight loss from daily caloric restriction has 1/4 to 1/3 of the weight lost as lean tissue while many studies show fat loss from 36 h fasts without losing any lean tissue!
The obese will lose loose skin while fasting, but the frail will have increased growth hormone release, which helps to make more lean tissue and reduce frailness.
Fasts of 36-96 will not affect short term female fertility or affect menstrual cycle. They also may increase long term fertility for some women.
It increases mitochondrial function and repairs mitochondrial DNA. Good mitochondrial function also has the added benefit of increasing your metabolism, fighting infection and cancer prevention!
24h of fasting can cut your leptin levels in half! This reduces leptin resistance, which impairs immune function.
Your brain prefers to burn ketones at a rate of around 2.5 to 1 when they are available in equal measure to glucose. Except for brief periods of very intense exercise, your body mainly burns fats in the form of free fatty acids.
Fasting increases telomere length, negating some of the effects of aging at a cellular level.
Fasting releases BDNF and NGF in the blood. This stimulates new nerve and brain cell growth, which can help a great deal with diseases like MS, peripheral neuropathy and Alzheimers.
When not in ketosis, the brain can only burn carbohydrate, which produces a great deal of damaging ROS the brain has to deal with.
Fasting stimulates apoptosis in senescent or genetically damaged cells, destroying them. Senescent cells are responsible for many of the effects of aging and are a root cause of the development of cancer.
A fasting mimicking diet for 3-5 days in a row provides many of the same benefits as water fasting. FMD usually has 200-800 calories, under 18 g of protein and extremely low carbs.
Exogenous ketones can aid with fasting, allowing some people with specific issues to fast in spite of them without worrying as much about hypoglycemia. They also help with dementia and many other issues even if you take them while not fasting!
Glycine and trimethylglycine can also be useful supplements while fasting that won't break ketosis and have many benefits.
Children, pregnant or nursing women should not fast for periods longer than 16 hours. People with pancreatic tumors that excrete insulin or certain rare forms of hypoglycemia generally cannot fast at all or only with doctor supervision. Type 1 diabetics can also fast but it is more complicated and should be approached with caution as it could lead to ketoacidosis and done under doctor supervision. If you experience extreme symptoms of some kind, especially dizziness or tremors, then simply break the fast with a low carb meal.
Resources:
www.nia.nih.gov/news/research-intermittent-fasting-shows-health-benefits
pubmed.ncbi.nlm.nih.gov/31890243/
www.sciencedirect.com/science/article/pii/S0005272806000223
www.ncbi.nlm.nih.gov/pubmed/23876457
www.sciencedirect.com/science/article/pii/S1931312809002832
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www.ncbi.nlm.nih.gov/pmc/articles/PMC7093158/
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www.cell.com/cell-metabolism/abstract/S1550-4131(15)00224-7
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www.ncbi.nlm.nih.gov/pubmed/24905167
www.nejm.org/doi/full/10.1056/NEJMc2001176
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www.ncbi.nlm.nih.gov/gene/25712
www.ahajournals.org/doi/10.1161/HYPERTENSIONAHA.121.17852
www.clinicaltrials.gov/ct2/show/NCT04375657
pubmed.ncbi.nlm.nih.gov/20102774/
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pubmed.ncbi.nlm.nih.gov/6859089/
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www.ncbi.nlm.nih.gov/pmc/articles/PMC1779438/
www.ncbi.nlm.nih.gov/pmc/articles/PMC6407435/
www.cell.com/molecular-cell/fulltext/S1097-2765(18)30605-1?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1097276518306051%3Fshowall%3Dtrue
pubmed.ncbi.nlm.nih.gov/28235195/
www.ncbi.nlm.nih.gov/pmc/articles/PMC2815756/
medicalxpress.com/news/2022-10-treatment-pulmonary-fibrosis-focus-telomeres.html
www.cell.com/cell/fulltext/S0092-8674(19)30849-9
clinical.diabetesjournals.org/content/36/3/217
www.ncbi.nlm.nih.gov/pubmed/25686106
onlinelibrary.wiley.com/doi/full/10.1111/j.1365-2265.2005.02288.x
academic.oup.com/ajcn/article/81/1/69/4607679
www.amjmedsci.org/article/S0002-9629%2815%2900027-0/fulltext
www.collective-evolution.com/2017/05/16/study-shows-how-fasting-for-3-days-can-regenerate-your-entire-immune-system/
pubmed.ncbi.nlm.nih.gov/7714088/
www.nejm.org/doi/full/10.1056/NEJMoa012908
www.ncbi.nlm.nih.gov/pmc/articles/PMC6141719/
www.arcjournals.org/pdfs/ijrsb/v3-i11/7.pdf
pubmed.ncbi.nlm.nih.gov/27569118/
pubmed.ncbi.nlm.nih.gov/23408502/
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This list compiled over years of research by the user known as Pottenger's Human on youtube. Feel free to copy and paste this anywhere you like, no accreditation needed!
If it is grass fed beef
World full of soon to be dead experts. Google college light undergraduates featuring youtube university students
All cows are fed grass until harvested.
Yes, the cows on feed lots for the last few months of their lives are fed grass. Yes they are fed corn. The corn is that 6’ tall plant that holds the (1) ear of corn. It is harvested as silage.
Calves, baby cows, are not raised on feed lots. They are born on a ranch. They drink milk from their mother. Then after ~ 14 months are sold to a feed lot. They get harvested after ~ 4 months.
One of the byproducts from making apt, energy, by the mitochondria is low deuterium water ...this is easily produced eating animal products ...that's why a diet with meat will always be the healthiest.....high deuterium water is a growth promoter, say hello cancer
How often to fast and for how long,??
Great video. Just a few comments, from my experience suffering from cronic fatigue due to Ross River fever. Viruses also damage mitochondria. I did take the supplements of CoQ10, l-carnitine, ala, etc, but they only helped so much. The best thing I did was intermittent fasting.Twice a month for four or five months, anywhere between 36 to 48 hours. I could see the results within 3 days of fasting each time. I don't need to fast anymore. I'm very healthy. I'm 57 and I don't take any prescription medication. If any of my symptoms come back, the only thing I will do is intermittent fasting. Of course I always eat healthy too.
That’s great advice, and I agree that viruses can certainly damage mitochondria. Have you looked into methylene blue? My video on this topic will come out tomorrow. Methylene blue can greatly improve mitochondrial health and is also an anti-microbial agent.
I suffer with chronic fatigue, but I cannot fast 😂😂 I have tried and tried and it’s just so so hard. I know fasting is the best thing one can do to improve general health, but this eating little and often, it’s worked years ago, not it’s a habit that’s hard to shift.
@@aluna_m888 Try doing 12 hours only at first. Then increase to 16 hours, and so on. The body will adjust over time. For example, every Saturday, fast for12 hours. After one month, fast for 16 hours. You only have to do one 36 hour fast per month to see the results. This is the only way nature has designed our body to recycle and heal itself. The power to fast is in your mind.
@@JonasKuehneMDThanks so much for this video. I'm suffering from long Covid since 2020 followed by vaccine injury.
I'm finding B1 benfotiemne at 900mg a day extremely helped cognitive impairments ( brain fog)
This was very noticeable within a few days... Theory being it's helping mitocondria process gulcoses 🤷🏼♂️
I started on methylene blue yesterday also 👍🏼
@@Ezpize626
May I ask what brand of methylene blue you've purchased? I want to try it in hopes it'll help with my chronic fatigue.
I also hope you'll report back shortly on your dosing and results. Best of luck. TIA
stuff like this should be taught in school and pushed out to the public. it would help keep people healthy and drive down health insurance cost
stuff like this is NEW... until it will make its way into the curriculum... 2034? time until insurance costs come down... 2048?
Thank you, I agree. Maybe that is why it is not taught … 😳😁
It won't because the industry will not benefit from it. Doctors to this day only focus on LDL
@monnoo8221 they didn't have trouble rushing the food pyramid into the mainstream and schools without evidence. It's _possible_ something else is happening
@@monnoo8221 Some of this may be "new" as you say, but if you practice it, it's possible that you may appear dangerously unhealthy to many mainstream doctors. At age 70, I was extremely healthy. I was even knowledgeable enough to point out, in some detail, the conflict between supposed risk factors for cardiovascular disease: high HDL versus good lipid ratios. TG/HDL ratio of .69. Total cholesterol 325.
This dovetails right into Dr Thomas Seyfried's research and 150 papers on the metabolic origins and usefulness in the treatment of cancer.
It appears to be taken right out of Thomas Seyfried's research.
@@nickseccombe1357who is Thomas S?
Thanks. To reduce toxin exposure, I switched from carpet to hard wood floors. Previously, when I vacuumed, the vacuum cleaner just filled up way to quickly. Now keeping things clean is much easier.
same
My primary healthcare provider knows i practice Fasting ( 9 months now). She was initilially slightly horrified and bemused.
At the outset of my last visit she asked outright " am i still doing it?"
I replied in the affirmative that yes i am and feel great. I did not go into any detail whatsoever but mentioned Weightloss, inflammation and that i am a believer in autophagy.
She has no idea what autophagy meant.
Still pushing Statins but will not have my fasting insulin tested. Oh 🇨🇦 !!!
I am sorry to hear that. A lot of physicians are very ignorant about nonpharmacologic medicine. Good for you that you are taking measures to improve your health!
How many hours does your fast last?
@@versewriter8123 the links are directly above in the comment section👆
Fasting insulin isnt even a public funded test in new zealand...let alone recomended lab. There are a lot of other blood tests i get which my doctor did not request. I did
The fasting u mentioned mean no drinking at all or some water is fine ?@@JonasKuehneMD
I really like your vids, Jonas...no background music, no nonsense!! Straight to the point. 👍
Thank you very much! 🙏❤️
Oh talking to a primary care doc who prescribed a drug that they didn’t know in the first place would hurt our mitochondria is always a good idea. I n my experience in this life I do not trust very few WM doctors with any chronic illness or disease. Peace
Definitely a contradiction. As the person whose body I alone experience, who better to decide what works and what doesn’t for that body?
What makes u think docs don't know the drugs they prescribe?
Excellent program on such an important topic as Dr. Kuehne explains this so well. Pithy, succinct with great takeaways. For mitochondria, the type of exercise I have learned from my CPT and Advanced Senior Fitnesss Training was Zone 2 cardio. Resistance training is critical as well and for the myokines and helping with metabolic health. Would love for you to explore exercise and its effect on health markers. Thank you - will pass on.
Thank you. I think that’s an excellent idea.
HI JONNAS, it's a great pleasure to meet YOU, I am 69 and been swimming from 51 , I Also love Bioquemistry and follow some great Doctors in USA who practice functional Medicine, I do intermitent fasting for 2 years now and I feel great, have more energy and mental clarity plus inteligence 18-6.
As to mythocondria I would Say that doing high intensive excercises let's Say for a minute and resting for 70 seconds is a good way to go, and if You can do it during fasting is much better.
As to good foods there is soybeans or Tofu organic, rosted chocolate seeds or dark chocolate, cocoa, Resveratrol capsules, and beets . It's good to exchange information for attaining better Health, allá the Best from Perú.
Thank you for your comment and hi to beautiful Peru. It looks like you have a great workout, fasting, and nutrition schedule. I am very impressed with your healthy lifestyle. Wishing you continued great health and fitness.
@@JonasKuehneMDI worked for 20 years in the Health food industry, developed on My own a couple of energetic & a suplement for sports.
Thank you
Congratulations on your videos. Are excellent.
Thank you! Much appreciated!
Interesting information. From my personal experience i agree with your take on autophagy, even because e can combine exercise and fasting in a way to trigger autophagy.
Thank you for your feedback. Yes, the benefits of autophagy, mitophagy, and improved insulin resistance can be seen with regular intermittent fasting and even modest 14 to 18 hour fasting windows. I find this very encouraging and motivating to someone with impaired glucose tolerance or early diabetes.
How?
@@liberty8424 Making high intensity/low intensity exercises (i guess this is how it's called) and also respiratory and chi-gong style exercises while you are fasting it's like increasing the number of hours of fasting, thus triggering autophagy quicker, at least this is the way this works on me.
Another good thing that i used to do more in the summer it's taking a shower of icy water. I connect a water hose directly to the well, and the water comes out from 30 meters deep around 10Cº or less, taking that jet of water is a miracle after putting up with a day of 35 to 40Cº, it's rejuvenating. It's well known for boosting mitochondria.
Taking a cold shower after going for a run is also a good strategy. Basically, anyhting that burns a lot of energy, you don't need to go on 24h fastings (or more) to trigger autophagy, like a lot of people do, specially if you don't need to lose weight.
I hope this helps, it's all simple things that anyone can do, no big deal!
@@liberty8424 both stimulate autophagy, so if you do both together (i.e. exercise while fasted) the overall effect/stimulation is stronger.
Hello,respected sir very nice suggestions for Gut health issues with Gallbladder chronic cystitis issues and huge bloating issues
It's worth mentioning that 1/3rd of the body weight is entirely mitochondria and by simply checking one's body temperature will let you know how efficient their working (closer to 98.6 the better). It's said that mitochondria make 15 degrees more heat than the ambient temp around them. Yes that's right, we get hot when we exercise because our mighty mitochondria are hard at work.
Thank you. Great input!
Interesting! I never heard that before
Accurately 10% of your body weight is mitochondria but that is still a crazy amount.
Everything you mentioned has great for mitochondria but generic also plays a big role in longevity
Do you mean genetic?
This was very well put together! Thank you for the information
Thank you for your kind words. Much appreciated.
Seasonal diet makes the most sense from an evolutionary perspective. The shock from switching also helps the microbiota.
👍
Dr. Ben Bickman also pointed out that metformin damages mitochondria. I take the max dose. I am angry because my endocrinologist considers metformin harmless and wants me to continue using it. But here I am, a diabetic that eats almost no glucose, fighting cancer, that is working very hard to make my body as hostile to that cancer as possible.
One advantage is that metformin decreases the uptake of glutamine, which is one of the fuels for cancer cells. This is a good function that it has. Together with supplements like EGCG and berberine it can be very helpful. Yes, at higher doses it can cause some mitochondrial problems. Given your current diagnosis of cancer, ketogenic diet would be the second aspect of metabolic therapy as outlined by Dr. Seyfried. This is also an option to decrease your left glucose levels significantly. I recommend to discuss any of these changes with your treating physician, of course.
Excellent info - PQQ is also good for mitochondrial health
Yes, great point! I was going to do a video specifically about PQQ as many people do not know about this molecule.
I take Coq10 with PQQ. It's 85$ a month. But worth it.
What is Pqq ?
@@25rara
A powerful antioxidant
@@25rarait repairs the Mitochondrial cell walls
Nice summary. Perfect for sharing. Finding the right balance when post menopausal is hard. Aiming for prevention of mitochondrial damage rather than weight loss may be more motivational when you feel like an alien has taken over your body. I’m going to try that. Thank you.
I agree... excellent summary of recent research highlights in layman's terms, perfectvfor sharing.
Good evening! Thank you very much for sharing your knowledge. I llike your videos , they re short , informative, to the point, clear speech and no bubbling. Greetings from Greece
Thank you very kindly.
Greece, huh?
Of course, you are aware that coq10 Ubiquinol is far more bio-available that regular COQ10 - Ubiquinone. Vitamin E- Tocopherols versus regular vitamin E and for vitamin K2 - MK7 is recommended as best. Anyone taking statins should be made aware that the statin also inhibits the liver's production of the COQ10 enzyme thus requiring supplementation.
Thank you.
Thanks
I have yet to encounter a PC Dr. who is interested in or knowledgeable about nutrition.
You are sadly correct. I am hoping that this will change.
Thank you for this info and for the visuals.
Glad it was helpful!
There seems to be a trade off between longevity & cancer prevention vs muscle growth.
Can you talk about how to optimize/ balance both?
TYIA!
I think that health, longevity, and muscle growth can go hand-in-hand. A low carb high protein diet, optimizing body fat can achieve these goals. I will do a more detailed video on this at some point.
@@JonasKuehneMD Okay, good to know! Looking forward to the video!
@@JonasKuehneMDbut doesn’t a higher protein diet stimulate IGF hence promoting cancer and reducing life expectancy? Wouldn’t balancing MTOR and the AMPK energy pathways be more suitable for longevity?
@@jimking6484 point is that you should not indulge in feasting all the time, regardless of the macro composition. A 15/18 to 9/6 feeding window allows insulin and IGF coming down. The "high" in high proteni diet is relative... compared to the RDA, whch is propagated as default, but is too low for muscle maintenance.
I will show this to my doctor🙂thank you, Jonas!
If I may ask please if you could answer or if someone can let me know where to get this question to you... Mastering Diabetes is composed of 2 men one doctor. They're young and very intelligent. They believe that insulin resistant is caused because of an accumulation of fat in the cells which thus reject insulin obviously causing insulin resistance.
They put their clients on fruit and vegetable diets and all of their A1Cs drop.
I'm dyingggg to know your thoughts. I do extensive studying on my own as much as I can. I believe mitochondrial health will be the next trend in the next 5 yrs.
Thank you so much for sharing this invaluable information 🙏🏽
Excellent, Dr. Jonas. Quite comprehensive. You are so close to the truth I hope you live in EU where you'll find greater support. You talk about mitochondria recovery (near IR) and replacement (fasting), but perhaps you could enlarge this and include diets that actually boost mitochondria besides going to a gym (or dunking in ice water). My question: If a person transitions to high-and-good fat with low carbs diet and doing it suddenly, would you expect a dramatic Omega 6/3 change that may need some guidelines?
A very enjoyable presentation.
Thank you very kindly. Seed oils buildup overtime and it may take several years to decrease their levels significantly after we largely cut them out of our diet. Remember that omega six fats are also in small amounts in saturated fats, but the main issues are with the seed oils that have an exorbitant amount of them. so your benefits after cutting out omega six fats will happen overtime, but will require some patience.
Great narrative! Subbed!
Thank you!
very good , thank you very much Dr Kuehne 👍
You are very welcome
Thank you Dr Kuehne for spreading the word for what has been coined as the metabolic approach. This approach has been extolled by Dr Thomas Seyfried (if the reader is unfamiliar with his work a search on TH-cam will unearth many entertaining interviews with this gentleman) and before him the winner of the 1931 Nobel Prize in Physiology, Otto Warburg.
Well said!
I shall look this information up.. many thanks 🙏🏼
I would say sunshine can charge those mitochondria like charging your phone overnight. Failing that go for the NIR, which is just a subset of sunlight
Yes, great advice!
@@JonasKuehneMD Thx and great channel you run, by the way
Such great info.
Thanks for watching!
@@JonasKuehneMD Can you post the references that demonstrate seed oils being unhealthy? Recent studies, not something done 50 years ago. What I see is study after study showing that either inflamation is reduced or not affected at all with increased seed oil consumption and also a link to less heart disease and cardiac events. So what is the basis for the claim that these oils are unhealthy?
@@JonasKuehneMD could you do video on ivermectin as used for cancer? And even aspirin...
@@cyberfunk3793The trials you want will never be held. Who will pay?
Good info!
Well presented! Great information that is easy to follow along with and encourages me to stay on this path. You got a new subscriber!!
Thank you! Very much appreciated!
Fantastic video...Key were the 7 ways .
👍🔮🙏
Thank you! 😃
The Budwig Protocol also optimizes mitochondria function It involves mixing electron-rich flaxseed oil with sulfur-rich cottage cheese. This combination allows the flax oil to bind with the sulfur proteins in the cottage cheese, making the fats more water-soluble. This process enhances the absorption of essential omega-3 fatty acids into your cells, providing significant anti-inflammatory and cancer-fighting benefits. It’s a powerful way to boost your mitochondrial health naturally! I found that talking the Budwig flax oil cottage cheese mix with olive leaf extract capsules 20% oleuropein and mixing 95 percent curcuminoids directly into the mixture significantly boost energy levels. Johanna Budwig's research still holds up. Budwig mix is just 8 tablespoons of cottage cheese or quark if you're in the U.K mixed with 4 tablespoons of flax seed oil. Mix with spoon then immersion blender. Consume within 20 minutes..
This is very interesting, thank you for sharing.
voodoo is similar.
"electron-rich flaxseed oil" ???
ever heard about bile? about lipoproteins?
I read somthing about taking methylene Methylene blue with niacin increases NADH or NAD several fold it was an increase up there with intravenous NAD therapy
Thank you for Such Great Infos!🙏
I have a question: why does the fermentation method of cell energy production exist? I've been told it's a relic of the way cells used to create energy before animals started using ATP and it isn't normally used any more, but that has to be wrong because mutations to our DNA that are associated with the fermentation process would be harmless; instead everyone still has a functioning ferment energy process (presumably mutations here are fatal). Why? When do our cells ferment anything apart from when we have cancer?
Edit: I just pasted the above into ChatGPT and I now know the answer. Fascinating!
Fermentation helps cells to produce energy in the absence of oxygen. We see this frequently when people exercise and cannot sufficiently oxygenate muscle tissue.
Very clear and helpful, thank you very much!
🙏
H Doctor, my 18 yr old daughter was been diagnosed with some Mitochondria problem but they haven’t explained why or what to do in order to help her.
She is been having lots of medical issues, mostly mental related.
Can you please advise on this!!
I’m sorry to hear that. Do you know what diagnosis she has received? There are different types of mitochondrial diseases.
@@JonasKuehneMD No, we been looking for answers for a little over 5 years . We look into Endocrinology, Neurology, Psychology and genetics and nothing. Around five months ago she had a skin biopsy but until now we haven’t heard anything from doctors. She is currently beeen seen under Seattle Children Hospital Research Center and no answer yet!, but all I can say is the worse part is the mental health which is very disability for her most of the time. Lack of attention, concentración and mood changes
I hate that sunflower oil is in too many things.
And sugar
My consumption of sunflower oil etc = 0
From which follows that there are lot of things without it... Just try
@@monnoo8221I guess that means giving up packaged food that’s what you mean
@@PlimsollHero to a large extent, yes... packaged fish in olive oil is almost ok, or cheese. A rest of convenience for me is packaged natural yoghurt, or rare treats like gyozas, proschiuto...
Corn, soy, and canola is much worse than sunflower oil. And most of the time it is gmo.
Very nice video 👍🏽
Thank you kindly!
Thoughts on methylene blue
It’s a great antibacterial/antiviral medication, and can also improve mitochondrial health by directly impacting the electron transport chain. Also has antioxidant and anti-inflammatory properties.
@@JonasKuehneMD awesome thank you so much great video!
I Totally agree and i tried to tell the Oncologist that was treating my dads cancer. I say because Otto Warburg effect
The Warburg Effect causes alterations in mitochondrial redox potential, ultimately changing ROS generation [18]. An important determinant of redox potential in cells is the NADH that is available in the mitochondria for electron transport.Jan 5, 2016
The Warburg Effect: How Does it Benefit Cancer Cells? - PMC - NCBI
Also the other important aspect is the Proton Pump Health.
Lastly what are the best way to test the Mitochondria ?
You can test your mitochondrial DNA, however, testing the general metabolic health of mitochondria is difficult.
@@JonasKuehneMD like testing the MPK or the Proton Pump as 2 examples. what is difficult is sometimes just as important as easy test
Unlimited appreciation for the inclusive and yet simple presention of this integral topic which greatly added to my search of the components of preventing and treating ailments.
I was diagnosed with stage 4 breast carcinoma and been in search of knowledge.
How can i reach u personally Dr. Kuehne ??
Thank you for your kind words. You can send me an email to frontdesk@cryohealthcare.com. Please address to Dr. Kuehne.
Yet another youtube university student
Dr Greger made the point that co-enzyme Q10 could be made within the body if you ate leafy greens and sat in the sunshine.
With good nutrition and light exposure you need less supplements.
Not for the people who are on statins.
Dr Gregor should eat more beef
is a quack, distorted by ideology, mixing bad lies int his videos.
Ater some fact checking I blocked every channel where he appears.
Thank you for your informative video. Confused about Near IR that heals the mitochondria. Your diagram @1.30 shows a picture of what happens with the nucleus, but the mitochondria is not part of the nucleus So, are you saying that if you somehow can alter the mitochondria in cancer cells via Near IR, then the cell can turn into non-cancerous cell. Also which wavelengths are effective for Near IR. Thank you.
Thank you for your feedback. No, cancer cells have malfunctioning mitochondria that can only ferment. The positive effect of NIR is on healthy cells. Here, you are correct it is penetrating into the mitochondria where it increases the production of melatonin. This improves the health of the cell. The video may have been confusing here.
Thank you for this great video!
Wow ! Great stuff !
Thanks!
I've read that using a sauna (dry not steam)is beneficial to your mitochondria. Could you comment on what temperature would be too high for someone with lupus?
Yes, a regular sauna through heat stress can increase mitochondrial function. an infrared sauna that has near infrared as part of its wavelength spectrum can also directly stimulate mitochondrial health and function.
Auto immune disorders like lupus increase inflammation. I am not sure whether or not that can be an issue. Cold therapy in the form of whole body cryotherapy has been shown to be extremely anti-inflammatory for autoimmune disorders.
th-cam.com/video/btl1y9rMVbY/w-d-xo.htmlsi=cNJAvviZSuijEcGh talks about biohack that can get inside an inflamed cell.
What do you recommend to a Mytiple Myeloma patient in terms of diet.
Metabolic Therapy - treating cancer by reducing glucose and glutamine
th-cam.com/video/wugzz0YcdHU/w-d-xo.html
This needs to be discussed with the treating oncologist of course, but a ketogenic diet with added supplements like EGCG and berberine helps to decrease the fuels available to cancer cells and may be very beneficial here.
Very balanced video. However can we measure the health of the mitochondria just like we test many organs or lipids. I already do all the things you have mentioned and my blood results are all very well especially BMI, tg/hdl of 0.5, CRP 0.3, vo2 max at 60, grip strength, etc…
👍
I guess the lipids and other tests are showing a proxy for that
I wonder if NIR could account for a lot of the reputed benefits of the sauna.
Many Saunas use far infrared, but some do have near infrared wavelengths as well. This is certainly therapeutic beyond the heat.
You're really scaring me, Jonas. Should i now worry about having cancer? I had it 10 yrs ago, but luckily, i needed no chemo or radiation. As far as i know i do not have cancer now, but your mentioning all those horrible diseases linked to mito dysfunction is truly unsettling...ALS, OMG! No way! And i dont have heart disease or diabetes. Lifelong STRESS is the cause of my mito dys. Add to that my age, 70+
It looks like your functional MD is following you on these parameters. The best preventive strategy is to keep your HG A1c, low by decreasing total carbohydrate intake and eat clean foods free from herbicides, pesticides, seed oil and additives. You can ask your functional MD about regular high dose intravenous vitamin C drips. Every 2 to 3 months on the order of 25,000 to 50,000 mg.
@@JonasKuehneMD thank you, will do.
Been thru hell...was diagnosed with adrenal fatigue (hpa axis dysregulation) by ND. Then after much research and tests, i self- diagnosed mito dys. There really isn't a reliable test for mito...it is a process of elimination.
Mitochondrial dysfunction is going hand-in-hand with inflammatory processes in the body, which we can sometimes identify with Labs like CRP. Anti-inflammatory strategies can also include NIR/red light panels, cryotherapy, pemf, and an anti-inflammatory diet.
@@JonasKuehneMD Thanks
I find limiting to 50 carbs per day is easily achievable and facilitates weight loss and maintained the loss with an 18 hour fasting window. Easy peasy
👍
Time stamps would have been useful 😊🙏👍
Very good!
Thanks!
Your information is ok BUT incomplete. You have left off light, sunlight to be exact, and the importance of circadian rhythm. Please check out Dr. Jack Kruse’s work. Light, water (building exclusion zone water) and magnetism these come first THEN comes food and exercise.
So you are saying that eating a ketogenic diet is great if you have cancer and it will help a person heal from that disease? So what diet do you recommend after healing one’s self after healing cancer after eating a keto diet? Are you leaning to go back to eat a high carb diet that got us sick in the first place? Please explain what you mean? Peace
A person being treated for cancer or recovering from cancer should continue on a ketogenic or at least very low-carb diet. In my opinion. It is always important to check with their oncologist or primary care doctor to ensure that levels of minerals and other labs are within range. They should also continue with supplements to decrease the uptake of glutamine, like EGCG, and berberine.
If we could just stop them useless wasting from cancer tho. It's beyond horrible
Muscle wasting *
I just discovered that i have Hashimoto's. Already gone Paleo and taking numerous supplements. For mitochondria I take Ubiquinol, PQQ, creatine, NAC and magnesium citrate (speeds peristalsis). I also have a small near-infrared panel although I'm hoping to get a more modern one with a broader spectrum. My recovery from exercise is already improving so I know that it is working.
Yes, dietary changes are very important here. I would strongly recommend to cut out all gluten, which is easily achievable on a Paleo diet. I did a video about gluten a few days ago, and the research was fascinating. None of us can digest gluten completely, and it triggers an immune response with hydrates inflammation in the small intestine in everyone. For some people, this is very mild and goes unnoticed more profound with symptoms. This inflammation increases zonulin causing a widening of tight, junctions in the small intestine and a leaky gut. This allows antibodies and gluten particles to enter the bloodstream and contributes to auto immune disorders like Hashimoto’s thyroiditis.
Oh wow this is very interesting, I've developed autoimmune after " preventive medication" I'll need to look into gluten free @@JonasKuehneMD
Thank you Dr. Brad Pitt!
Haha, thank you, but you owe Brad Pitt an apology. Unless we are talking about the first 30 minutes of Benjamin Button… 😂
@JonasKuehneMD oh no! You are really good looking! Better than unhealthy looking Brad. 😉
@@JonasKuehneMDhumble and witty. Miss my European friends!
Good video bro,, no no excellent video🎉🎉
Thank you so much 😀
What can we do when we've been prescribed a statin, have been advised by all our doctors to take it, and have would up with a mitochondrial disease that we did not have before?
Stop taking it? Explore natural methods such as red yeast rice & the amino acid Taurine
Not medical advice, but I would ask about the reason for the statin. If HDL is high, triglycerides low, then LDL is secondary in my opinion. If there is heart disease or a previous MI, then a statin can be given preventively and may be useful.
How much a statin contributes to mitochondrial dysfunction is difficult to estimate. It is one of the medications that can contribute, but is not necessarily on its own.
@@Statinstories Statins inhibit body production of CoQ10, Vitamin K2, and selenoproteins. Statins stimulate atherosclerosis and heart failure.
Make diet changes and take a lot of vitamin C and lysine as recommended by Linus Pauling.
"Vitamin C supplementation lowers serum low-density lipoprotein cholesterol and triglycerides: a meta-analysis of 13 randomized controlled trials."
"Dietary l-Lysine Prevents Arterial Calcification in Adenine-Induced Uremic Rats"
@@Statinstories "Statins stimulate atherosclerosis and heart failure: pharmacological mechanisms" Harumi Okuyama et al. Expert Rev Clin Pharmacol. 2015 Mar.
Hi doc, I loved this info. and have subbed you. I'd like to let you know that i'm CMV positive and unable to gain weight.
Could you please make a video on this virus which not many people are aware about yet majority of population harbour this virus in them that may produce complications in later life.
What type of diet you would recommend to healthy sedentary adults who are CMV +ve and want to gain healthy weight and keep the virus latent as long as possible?
Thank you for your feedback. That sounds like a very important topic and I will definitely look into it. Are you currently taking methylene blue? It can greatly improve mitochondrial health and is also acting as an antiviral. Maybe a topic you could discuss with your primary care doctor.
@@JonasKuehneMD Thank you so much for your response. Cannot wait for your next video on this topic.
And, surely i'll consult with my doctor on MB.
Iodine lowers your weight!!! High doses like 10-50 mg daily!
Hello. What are simple sugars?
These are sugars that are immediately available, so not bound in long chains of carbohydrates. Examples are of course, candy, fruit,sucrose, high fructose corn syrup, etc.
Hi doctor a have a comment here there are a lot of studies that show cancers also metabolize fatty acids mainly pancreatic one maybe pubmed it too I wouldnlike tonlearn more
I need to research this more. In general, the two fuels for cancer cells are glucose and glutamine. If cancer cells can entirely live of fat is questionable. I will look into the research.
@JonasKuehneMD not sure if entirely but when I ask perplexity ai it was able to give me a lot of studies showing certain cancers can metabolize fatty acides and also there are some metabolic drugs that stop fatty acid metabolism for those
What about raspberry ketones supplement ...will it help mitochondria
Supplements with preformed ketones can help to get into ketosis faster. I do not believe that they have a major positive influence on the mitochondria, however, a ketogenic diet in itself can be beneficial.
@@JonasKuehneMD thanks. So theyre pretty useless on their own..with ketogenic diet.,or fasting.
I cant do either of those dietery changes, unfortunately, cos of hypoglycaemia issues.. I dont know whats causing it, and its forcing me to have to eat hidious load of Sugar and carbs, on regular basis. Its the bane of my life..i know my body doesnt have a chance to get healthy, whilst eating that cr*p, to say the least. If u have suggestions about this issue, i would appreciate any advice.
What do u think about taking spirulina to boost muscle strength? Ive heard it does that..even without exercise..
I am not familiar with studies on this topic, but I will look into it.
@@JonasKuehneMD ok thanks.
I ask cos im in a situ, with poorly health issues, where im not always able to exercise regularly. But also, just to boost muscles anyway.
You mentioned that IR from the sun is good for us. What about when you live someplace like AZ or CA? We’re told to avoid the sun to prevent skin cancer if we’re Caucasian. I believe that advice is sound in extreme UV climates. I wait for the sun to go down before running or run in the morning sun to keep UV exposure at a minimum.
Too much exposure to UV radiation certainly contributes to skin cancer and skin aging. However, we are spending only about 7% as much time outdoors in sunlight today then we did about 150 years ago. Early morning and late afternoon sun will have sufficient NIR while not having as much UV radiation. 10 to 20 minutes per day is already beneficial. Also, if we change our nutrition to exclude seed oils, we can improve mitochondrial function in our skin, which helps to decrease the risk of sunburns and skin damage from UV radiation.
Hi, Jonas, dont you worry about the phtalates and plasticisers uses in softgel pills like omega 3 and vitamin D3 ??
I wait for your answer😊😊
I never seen anyone mentioning vision and hearing changes. According to my optometrist, i have esodeviations...never seen a case like mine. 😢 Five examinations, five different results. My eye muscles are too weak to focus..ever heard of it, Jonas?
I have heard of esodeviation due to miss alignment or weakness of extraocular muscles. I am not sure if Methylene blue would be helpful in this case. What advice has your ophthalmologist given you?
@@JonasKuehneMD he told me I can leave it as is if not too bothersome, or get very long and expensive therapy that may or may not work. Prescr. glasses didn't work. Up close no problem...distance is the problem. I had five examinations this year, and each and everyone was different than the one before...so, seems intermittent. Opt told me he had never seen this before...made me feel like a freak. ☹️
@@JonasKuehneMD there are no exercises to strengthen eye muscles bc eyes turn inward...seems I'm stuck with it ☹️ thanks for reply, Jonas.
On fasting 16 hrs, one variable is the amount of calories intake. I assume the fasting depends if one had 3000 or 1500 calories for the day.
When I told my GP I have Mito dysfunction, he replied "every elderly person has that, and there is no treatment for it...it's called Aging," which confuses me bc I'm 70+ but surely, not every senior feels this terrible!
Our processed food diet and decreased exposure to NIR have greatly contributed to this situation.
@@JonasKuehneMD I don't think anyone is able to avoid processed foods entirely, but I'm doing pretty well keeping it to a minimum. Have I told you how miserable this condition is? Having to take so many supplements, and not being able to eat what I want feels like HUGE punishment. I just can't get excited about a salad...it isn't strawberry cheesecake, is it?☹️
Your doc is a bozo...I take thiamine co q 10 b vits and mag for my mitochindria and they love me for it
@natalie8518 well, then, all allopaths are bozos bc they don't treat Mito dysfunction...not profitable. I take coQ10 daily, plus a handful of other supplements.
Actually, it's true: Mito dysfunction is a sign of old age.@@natalie8518
You said, “Sh1tty!” 😂😂 I love it!
😁
What about NR and NMN supplements? Do they really work with mitochondria?
Those are precursors for NAD+, Which is needed for healthy mitochondrial function.
They have shown in studies to increase NAD+ levels.
@@JonasKuehneMDdoes B3 have the same benefits?
Best form of coenzyme Q10 is Uniquinol. Most easily absorbed and bioavailabil
You mean ubiquinol, right?
@@donnajean9805 lol! Yes!
the mighty dwarfs (more than 7) in the background (and behind the mountains)....
fascinating, absolutely.
I have a question, and probably the mitos offe a solution to it.
Consider a body that is in a quite good shape. CVD markers 0, BF 12%, Vo2max 48, fasted glucose 87, fasted insulin 2.4, Tg/HDL 0.6, ALT/AST 30, RBC parameters fine and the better end of the ref range, hsCRP 0.04/dL, leuco 7k, eosinophils however outside or reference range bacause of airbourne plant allergy since 56y, no glasses. All acceptable.
However, hba1c indicating that my average glucose is 115..120. Even after 18h std fast, no carbs for 24 hours, glucose is 95..100. I have to work out fasted, and add another 12h fasting, iaw, depleting glycogen completely, then the glucose is at 87. I am on a high fat regimen and have no problem to cut carbs to 50g.
The question: are damaged mitochondria able or the possibly the cause for driving blood glucose high if there is any carb, even glycogen, in the system?
Your lab values are excellent. An average blood glucose of 115 is not terrible. I would not blame the mitochondria for this. In some instances after prolonged fasting glucose may spike. Your fasting insulin is great. I would just keep following yourHB A1c. As long as you stay below 5.6 you should be fine. I would expect it to be a bit lower given your very low carb diet.
Never heard of dr. Kuhne.
Very much appreciating the quality of your video. At 6:21 you mention the link between obesity and cancer.
I am just perplexed by something. Wouldn’t it be relatively easy to simply measure categories of body fat composition against cancer rates? Body fat is super easy to check. Cancer is not exactly but close to binary (you have a malignancy or not).
Then…. At different ages, different types of cancer, etc you just determine: is there a large statistical difference between, let’s say,
Great question. They have been a lot of studies to prove the relationship between obesity and cancer. They even describe the percent increase.
www.hindawi.com/journals/isrn/2013/680536/
nyaspubs.onlinelibrary.wiley.com/doi/full/10.1111/j.1749-6632.2012.06750.x
Obesity isn't the whole picture. There's many thin/unobese people with a lot of visceral fat, which is arguably way worse. It's like a hidden killer
Im in a hypoglycaemia nightmare...where im forced to eat hidious amounts of sugar and carbs ..ti control hidious symptoms...its been goin on for years.i know how bad it is fir health, but cant i dont know what to do about it...havnt found the answr yet. Any suggestions, please?
Why would you need to do this? What happens if you stop eating carbs? Try slowly reducing the amount of carbs. You body will slowly seitch over to burning fats (ketones). At that point, you will no longer need to worry about your blood sugar. Your liver will produce all the glucose required even if you don't consume any carbs at all.
@@davepeterschmidt5818 i dont know whats causing the hypoglycaemia, but the symptoms can get too severe, if i dont eat sugary food. I get brain fog, anxiety from the adrenaline, sometimes angina..symptoms that i cant ignore.
I know other people who have similar..in terms of hypo symptoms, and have to eat often.
Use a continuous glucose meter to check your insulin response
I used red/NIR LED panel for 20 minutes on the naked body before daily morning shower.
It goes through clothes
There’s some speculation that red light therapy might be bad, I’d be cautious
It’s fine naturally from the sun but recreation of it may not be all it’s cracked up to be and may actually lead to unfavorable outcomes
@@napua5217
Are you sure about that, Son?
@@ianstuart5660 ? What do you want?
@@napua5217 the classic: speculation vs science. So, if the speculation is based on a couple of anecdotal evidence, these need to be investigaetd thorougly. Doo you knw them? then please share.
Yet you are partially right regarding the brain... if the NIR comes from lasers. yet, LEDs are not lasers, so, no issue regarding red light panels
Doctor please confirm my understanding.
Near Infrared Radiation to make Melatonin - does not require naked skin - goes through clothing.
UV rays to initiate vit D3 production - requires naked skin (and time limit etc.)
.
Yes, that is correct. If the clothing is too thick, then the infrared radiation maybe shielded to some extent from reaching the skin.
C.F.S/M.E should also be included as its the mitochondria that have been damaged & not hypochondria
you should switch the thumbnail at 10:50 to the definition of CoQ10 slide bro, that shit would be cash.
Any info on the supplement l-carnitine?
I have not done a video on L-carnitine yet.
Thank you. I was just wondering if l carnitine can improve mitochondrial health can it be part of a supplement arsenal for melanoma cancer?
How about sesame seed oil? Is that ok?
It is a seed oil, so I would consume it in moderation. Much better than soybean oil though.
Do not take vitamin e without consulting a doctor. Aside from D and K, fat soluble vitamins can be very dangerous (those two as well, but generally the risk is much lower at normal doses)
What can be done for glutamine production?
I am not aware that we can significantly influence glutamine production, but we can decrease glutamine uptake via supplements like EGCG or intermittently block with medications like DON.
So not a good idea to take glutamine supplement? 😁
@@ccaselli7 the ea behind that? it is non-essential, meaning the body can produce it easily and in quantities. It is also contained in any protein. Maybe you meant glycin?
Can all these supplements also help the cancer cell mitochondria?
Cancer cells have defective mitochondria and will not benefit from the supplements. They are often referred to as ‘ghost mitochondria’, and can only ferment the substrates glucose and glutamine.
@@JonasKuehneMD I hope that is the case. However, in this article,
"Ivermectin, a potential anticancer drug derived from an antiparasitic drug"
This paper tried to define the theoretical mechanisms of ivermectin including apoptosis, autophagy, pyrotosis (programmed cell death) based on previous studies. It noted that the presence of the mitochondrial fuel acetyl-L-carnitine (ALCAR), and the antioxidant N-acetyl-L-cysteine (NAC), could reverse IVM-induced inhibition.
And all the while, we have a Medical community that ignores this proven we think, way of avoiding the poison given that is known to kill you!
Actually, there is work being done on long-term ketosis, and even carnivore! And it looks like all the warnings were just wrong or made up! Standby for published papers!
Yes! Every Human being is born IN KETOSIS.
Humans definitely do well longterm ketosis. Just look at us. With out it humans would not exist. Anyone that thinks longterm ketosis is anything other than natural state of human 🤔 🙄 they don't know how to think.
I followed a ketogenic diet for over two years and did great on it. There were a few drawbacks in terms of minerals and nutrients that I should have addressed differently in retrospect. I think some people can definitely thrive on this for long periods of time, while for others it could be a short-term start into a better metabolic state.
@@JonasKuehneMDcan you explain which mineral and nutrients are missing on a keto or carnivore diet?
@@napua5217dr sten ekberg has a good video on it 🎉
Subbed, doc!
🙏
Actually, cancer can mutate to use keep bodies. Only after you remove other fuel sources though and not efficiently.
❤ from INDIA......Thanks.
Nobody mentions chronic stress...i suffered severe childhood trauma, which i believe caused my mito dys.
Yes, that can certainly contribute.
Good advice. After transplant, they put me on immune depression + statin + baby aspirin + blood pressure med. I don't think they'll lower the dose just because I want better mitochondria. They're ok with supplements as they "don't affect treatment". I've also hypothyroidism, so still tired in spite of following your list.
Thank you for your comment. I am not sure how methylene blue would interact with immunosuppressive medications. I have not found any literature on this. You are correct though that you still want healthy mitochondria, just enough immune suppression to prevent from rejecting the transplant.
@@JonasKuehneMD yes, it's a balance and they check it every 3 months.
Statins inhibit the production of CoQ10, selenoproteins, and vitamin K2.