So they're not just the little kidney bean energy factories that I learned about 50 years ago. So cool to see how both they and our understanding of them have evolved.
Thanks for the video, just an interested person in science in general. Seems we have plenty to keep us busy investigating and discovering in the future.
Awesome Video, thx, if Back in school days you thought me biology, I Might have been interested enough to remember This stuff after 40 years...thx again
I studied Biology at school (many years ago, 1962 to 65 or so), so a bit late for me to study mitochondria) and I knew about them as producing ADP (adenine diphosophate) and that they were on the endoplasmic reticulum...what great words. I think I just liked the pictures and the words of things and so on but I don't think anyone knew much about them having DNA, there own. Yesterday I would have laughed if someone had said there is DNA in the mitochondria. 'No, DNA is in (most) cells, in the nucleus...But I was reading a book by David Reich about how (where we come from etc) and mitochondria were mentioned versus a Y chromosome so I was assuming he was talking about mitochondrial DNA meaning the genes in say the X Chromosome or wherever or a part determined at 'genesis' by the nucleus (DNA) of the ova, a gene that "made" the mitochondria. At least it was informative. Everywhere (or, all the very naive ones which are good for people in a hurry I suppose) else they just say 'M-DNA is DNA inherited from the maternal....' But either my hearing (when I was in my late 30s in a Comms lab someone made an audio freq oscillator and (I wasn't surprised) my hearing cut off about 20Khz. I suppose as I am nearly as old if older than Trump my hearing is worse so I had to re-run a lot of this. Her accent sounded sometimes like she was talking in German or French...something like that. Bad diction a lot of English and American people have, or bad for me...perhaps it is a special dialect from some place in the US no one has heard of or I am even more deaf to those high frequencies... I find, for some reason, this to be fascinating, but it is also terrifying and reminds me of death.
During mitosis.....what happens to mitochondria ? Do they divide first, then get shared by the two daughter cells? Do they multiply once in the daughter cells ? What is the mechanism of their survival during cell division ?
mitochondria can multiply thru fission and can combine to fix dna damaged in the mitochondria thru fusion, mitophagy (breaking down of mitochondria) is a benefit if the mitochondria become very inefficient, preventing of consumption of ADP that could be used by more efficient healthier motochondria. so when the the cell goes thru mitosis, the number of mitochondria are shared, not sure what percentage. As the cell requires more energy, it triggers mitochondria to perform fission, and as a person becomes more sedentary, the mitochondria being so efficient, perform fusion, thus repairing any damaged motochondria and killing off some mitochondria that have become overly inefficient. I am not a biologist, but i did stay in a Holiday Inn Express once, as a child
bellissima lezione - i mitocondri hanno diverse analogie con i batteri: Contengono cardiolipina, possiedono un DNA circolare tutto loro; esprimo 13 proteine che contengono FORMIL-METIONINA, proprio come le proteine batteriche, producono melatonina "proprio come il batterio viola Rodhospirillum Rubrum, hanno una doppia membrana, sono anche in grado di metabolizzare piccole quantità di solfuro di idrogeno, uno dei primi substrati energetici dei batteri primordiali, e vengono riconosciuti come antigeni batterici dal sistema immunitario.
Thank you for your wonderful presentation! What have you learned in relationship to the role that the ancient molecule melatonin plays within the mitochondria? -- Audrey
As you mentioned that mitochondria in eukaryotic cell has different properties from the bacteria ,so how do we know the current mitochondria is from ancient bacteria ?
Wow . Very well presented on Mitocondria in humans ! I am interested in finding opportunities for Clinical Studies for developing immune therapeutics for older americans. Examiing now links between Mytocondira Cross Talk with Gut Based Immune Cells. Any ideas for a Clinical Study Design coming out of Nunnari Lab ??
great talk...i take pqq for increased mitochondrial performance and energy production...i know i don't get enough sleep..., but what other health hacks do you have? i saw nad and nadh on your chart... i think i've heard it mentioned in other mitochondrial videos..... maybe some more citric acid to boost up/have available for the citric acid cycle
Hi Jodi what happens, if you isolate people and poison their mitochondria with e.g. fluoroquinolones in respirators.... and the person doesnt have a chance to come in contact with other people and their mitochondria, so that they can exchange each other and repair mitochondrial damage... just like bacteria do it if harmed with transcription and stuff like this...? Thank you for this wonderful presentation.
There are other ways of generating energy - anaerobic, based on sulfur or iron - which bacteria use until today and thrive. However, iirc, ATP is the most efficient method.
The mitochondria is indeed fascinating. But it's ironic to hear such a strong sales pitch for evolution using the organelle that so clearly demonstrates intelligent design. For example, consider the proteins. There are a *_lot_* of different proteins in the mitochondria. Proteins must fold correctly to be useful and they have to form the right shape and expose the right amino acids at the right places to perform their task. Did all of those proteins evolve? If not, where'd they come from? If they did, then surely there are a fair percentage that aren't quite done evolving yet, that don't fold compactly yet, or that don't fit together neatly with the other proteins components. What percentage of proteins in the mitochondria aren't done evolving? Many proteins have no value apart from being a component in a complex or machine. As the various proteins evolved, why did natural selection conserve them until the other components of the complex completed their evolution? Did natural selection see the evolving purpose? And as each complex in the electron transport chain evolved to functional completion, why did natural selection conserve the whole complex before ATP synthase had evolved into place? The fascination comes from the wealth of molecular machines and their protein components that all function so smoothly to perform such complex chemical processes and even proton pumping. The whole thing is amazingly well designed.
You're such a piss poor salesman for pimping creationism. Nothing you just said is incompatible with endosymbiotic theory. Go back to apologetics Sunday school.
@@patldennis Wow! To me, evolution seems to be the religion. Occam's Razor tells me an intelligent agent designed this insanely complex machinery. Scary, right?
@@itsReallyLou Direct observation (an aspect of Occam's razor) tells me that the intelligent things that intelligent agents do are also always the consequence of physical brains. Occam's razor doesn't really lend itself to the invocation of supernatural agents anyway, so you might want to rethink that. Psst.. complexity can accumulate incidentally, and when people design things "for reasons" the complexity usually isn't a selling point but instead a necessary "it is what it is" consequence of having to juggle and compromise btwn various demands from within and without. It's almost as if declarations of complexity are Inadvertent admissions that "the designer" was constrained by aspects of its own creation. I guess that's why dogs can only sweat near their paw pads.
Not all fatty acids are equal in energy production.Saturated animal fat produces 100% efficiency, mono saturated fat 115% due to the bond opening in the center is a easy snip, now you have 2 smaller sable saturated fats.PUFA's (polyunsaturated fatty acids) are highly oxidative and in metabolizing them produce toxic by-products.Omega 6/ linoleic acid has a 60% efficiency and Omega 3/linolenic acid has 24% efficiency. These heart healthy fats are anything but.Seed oils are damaging energy production from the mitochondria watch TH-cam video's of Dr Cate Shanahan, Dr Michael R Eades, Dr Chris Knobbe, Nina Teicholz, Dr Paul Saladino
Take a week off. Get online and order 4 things. A playstation 2 - a memory card for it - the game called Parasite Eve - the guide book to Parasite Eve. Then take some time and play this game. I promise you that you will love it.
iBiology should remove this video. It is rambling and almost pointless. The presenter night have accomplished good science, but speaking coherent English sentences in front of a camera is a challenge for her.
what an awesome woman. how lucky her students are to have her as an instructor.
So they're not just the little kidney bean energy factories that I learned about 50 years ago. So cool to see how both they and our understanding of them have evolved.
Thanks for the video, just an interested person in science in general. Seems we have plenty to keep us busy investigating and discovering in the future.
I learnt so much from such a well delivered talk. Thank you.
Great talk!
You really get taken into the subject by her enthousiasm!
What a dynamic and essential organelle!!
Awesome Video, thx, if Back in school days you thought me biology, I Might have been interested enough to remember This stuff after 40 years...thx again
Very well explained, thank you.
Outstanding -- I am not at all an expert in this field -- but read all four Nick Lane's book
Very interesting. Thank you.
NO PROBLEM
Thanks for your amazing lecture gives us so informative knowledge
Thank you so much for this easy to understand and visually rich teaching presentation! 💚
Quite interesting talk. Thank you.
Very good information !
Thank you very much for sharing
She is a wealth of information.
I studied Biology at school (many years ago, 1962 to 65 or so), so a bit late for me to study mitochondria) and I knew about them as producing ADP (adenine diphosophate) and that they were on the endoplasmic reticulum...what great words. I think I just liked the pictures and the words of things and so on but I don't think anyone knew much about them having DNA, there own. Yesterday I would have laughed if someone had said there is DNA in the mitochondria. 'No, DNA is in (most) cells, in the nucleus...But I was reading a book by David Reich about how (where we come from etc) and mitochondria were mentioned versus a Y chromosome so I was assuming he was talking about mitochondrial DNA meaning the genes in say the X Chromosome or wherever or a part determined at 'genesis' by the nucleus (DNA) of the ova, a gene that "made" the mitochondria. At least it was informative. Everywhere (or, all the very naive ones which are good for people in a hurry I suppose) else they just say 'M-DNA is DNA inherited from the maternal....' But either my hearing (when I was in my late 30s in a Comms lab someone made an audio freq oscillator and (I wasn't surprised) my hearing cut off about 20Khz. I suppose as I am nearly as old if older than Trump my hearing is worse so I had to re-run a lot of this. Her accent sounded sometimes like she was talking in German or French...something like that. Bad diction a lot of English and American people have, or bad for me...perhaps it is a special dialect from some place in the US no one has heard of or I am even more deaf to those high frequencies... I find, for some reason, this to be fascinating, but it is also terrifying and reminds me of death.
Finally! A TH-cam channel for Kreb's cycle enthusiasts!
I assume that there is a rhythm to their action that is concordant to breath. If so, then how one breathes affects their action.
During mitosis.....what happens to mitochondria ? Do they divide first, then get shared by the two daughter cells? Do they multiply once in the daughter cells ? What is the mechanism of their survival during cell division ?
mitochondria can multiply thru fission and can combine to fix dna damaged in the mitochondria thru fusion, mitophagy (breaking down of mitochondria) is a benefit if the mitochondria become very inefficient, preventing of consumption of ADP that could be used by more efficient healthier motochondria. so when the the cell goes thru mitosis, the number of mitochondria are shared, not sure what percentage. As the cell requires more energy, it triggers mitochondria to perform fission, and as a person becomes more sedentary, the mitochondria being so efficient, perform fusion, thus repairing any damaged motochondria and killing off some mitochondria that have become overly inefficient. I am not a biologist, but i did stay in a Holiday Inn Express once, as a child
bellissima lezione - i mitocondri hanno diverse analogie con i batteri: Contengono cardiolipina, possiedono un DNA circolare tutto loro; esprimo 13 proteine che contengono FORMIL-METIONINA, proprio come le proteine batteriche, producono melatonina "proprio come il batterio viola Rodhospirillum Rubrum, hanno una doppia membrana, sono anche in grado di metabolizzare piccole quantità di solfuro di idrogeno, uno dei primi substrati energetici dei batteri primordiali, e vengono riconosciuti come antigeni batterici dal sistema immunitario.
Love it 🔥
Wow! How about in plants? Do they form this reticulum?
Thank you for your wonderful presentation! What have you learned in relationship to the role that the ancient molecule melatonin plays within the mitochondria? -- Audrey
As you mentioned that mitochondria in eukaryotic cell has different properties from the bacteria ,so how do we know the current mitochondria is from ancient bacteria ?
You very well convenienced us and I want a next level video on this from you..
Wow . Very well presented on Mitocondria in humans ! I am interested in finding opportunities for Clinical Studies for developing immune therapeutics for older americans. Examiing now links between Mytocondira Cross Talk with Gut Based Immune Cells. Any ideas for a Clinical Study Design coming out of Nunnari Lab ??
Only 'older Americans '?
Why not people?
great talk...i take pqq for increased mitochondrial performance and energy production...i know i don't get enough sleep..., but what other health hacks do you have? i saw nad and nadh on your chart... i think i've heard it mentioned in other mitochondrial videos..... maybe some more citric acid to boost up/have available for the citric acid cycle
Great job
this "schematic"...linking al the metabolisms, is that available somewhere?
www.sigmaaldrich.com/technical-documents/articles/biology/interactive-metabolic-pathways-map.html Similar one.
For an interactive version of this see www.brenda-enzymes.org/pathway_index.php.
Hi Jodi
what happens, if you isolate people and poison their mitochondria with e.g. fluoroquinolones in respirators.... and the person doesnt have a chance to come in contact with other people and their mitochondria, so that they can exchange each other and repair mitochondrial damage... just like bacteria do it if harmed with transcription and stuff like this...?
Thank you for this wonderful presentation.
Are these little critters aided by red or near infrared light?
21:15 What are the yellow dots?
Mitochondria are colonized: like workers in a corporation, the perks make it worthwhile to specialize, however, the tools to be independent are lost.
That's what I was thinking as well!!
Molecular machines and these guys are the machinists
mitochondria is the powerhouse of the cell
Might-o- chondria
How could the ancient cells live without mithocondria before they ate(!) one?
There are other ways of generating energy - anaerobic, based on sulfur or iron - which bacteria use until today and thrive. However, iirc, ATP is the most efficient method.
@@stefanhensel8611 ATP can be generated by glycolysis - it is a product not a method
I have mitochondria is there a way to keep from passing it on to my kids you know since it can cause dementia
The mitochondria is indeed fascinating. But it's ironic to hear such a strong sales pitch for evolution using the organelle that so clearly demonstrates intelligent design. For example, consider the proteins.
There are a *_lot_* of different proteins in the mitochondria. Proteins must fold correctly to be useful and they have to form the right shape and expose the right amino acids at the right places to perform their task.
Did all of those proteins evolve? If not, where'd they come from? If they did, then surely there are a fair percentage that aren't quite done evolving yet, that don't fold compactly yet, or that don't fit together neatly with the other proteins components. What percentage of proteins in the mitochondria aren't done evolving?
Many proteins have no value apart from being a component in a complex or machine. As the various proteins evolved, why did natural selection conserve them until the other components of the complex completed their evolution? Did natural selection see the evolving purpose? And as each complex in the electron transport chain evolved to functional completion, why did natural selection conserve the whole complex before ATP synthase had evolved into place?
The fascination comes from the wealth of molecular machines and their protein components that all function so smoothly to perform such complex chemical processes and even proton pumping. The whole thing is amazingly well designed.
You're such a piss poor salesman for pimping creationism. Nothing you just said is incompatible with endosymbiotic theory. Go back to apologetics Sunday school.
@@patldennis Wow! To me, evolution seems to be the religion. Occam's Razor tells me an intelligent agent designed this insanely complex machinery. Scary, right?
@@itsReallyLou Direct observation (an aspect of Occam's razor) tells me that the intelligent things that intelligent agents do are also always the consequence of physical brains. Occam's razor doesn't really lend itself to the invocation of supernatural agents anyway, so you might want to rethink that. Psst.. complexity can accumulate incidentally, and when people design things "for reasons" the complexity usually isn't a selling point but instead a necessary "it is what it is" consequence of having to juggle and compromise btwn various demands from within and without. It's almost as if declarations of complexity are Inadvertent admissions that "the designer" was constrained by aspects of its own creation. I guess that's why dogs can only sweat near their paw pads.
Of the eucariots only mammalian mitochondria exhibit maternal inheritance; nonmammalian mitochondria are not maternally so bound. I wonder why???
🤔 interesting thanks for that bit
Find it hard to conceive we 'consume our body weight in ATP every day'
That's 50g per min (ten teaspoons of atp) for a person weighing 150 pounds. Probably an active person?
Appreciated,
Looks like Jodi could use a few more mitochondria
Love One Another
Not all fatty acids are equal in energy production.Saturated animal fat produces 100% efficiency, mono saturated fat 115% due to the bond opening in the center is a easy snip, now you have 2 smaller sable saturated fats.PUFA's (polyunsaturated fatty acids) are highly oxidative and in metabolizing them produce toxic by-products.Omega 6/ linoleic acid has a 60% efficiency and Omega 3/linolenic acid has 24% efficiency. These heart healthy fats are anything but.Seed oils are damaging energy production from the mitochondria watch TH-cam video's of Dr Cate Shanahan, Dr Michael R Eades, Dr Chris Knobbe, Nina Teicholz, Dr Paul Saladino
Pls subtitle indo
So, Mitochondrias are like midi-chlorians at «the Force»?
Hey guys, do you want to train «the Force»?
Learn about the mitochondria.
I learned you can't talk about mitochondria without invaginated, must mean folds
An invagenation is a pocket.
Take a week off. Get online and order 4 things. A playstation 2 - a memory card for it - the game called Parasite Eve - the guide book to Parasite Eve. Then take some time and play this game. I promise you that you will love it.
So all by chance...........?!!!!!!!!!!!!!!!!!!!!!
👏👏👏👍🇧🇷
iBiology should remove this video. It is rambling and almost pointless. The presenter night have accomplished good science, but speaking coherent English sentences in front of a camera is a challenge for her.
...cross your eyes ?...
I assume it's a reference to 3d magic pictures.
Elon Musk wants to create the Borg on Mars
and evolutionists believe all this came from ...?
very generic talk, and mostly about evolution, which is not certain science and un proven, not very useful video indeed
We didn't evolve
🤣 bs A mathematical impossibility. Call me for an education.