Ron Vale (UCSF, HHMI) 1: Molecular Motor Proteins
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- เผยแพร่เมื่อ 30 พ.ค. 2024
- www.ibiology.org/cell-biology...
Molecular motor proteins are fascinating enzymes that power much of the movement performed by living organisms. In this introductory lecture, I will provide an overview of the motors that move along cytoskeletal tracks (kinesin and dynein which move along microtubules and myosin which moves along actin). The talk first describes the broad spectrum of biological roles that kinesin, dynein and myosin play in cells. The talk then discusses how these nanoscale proteins convert energy from ATP hydrolysis into unidirectional motion and force production, and compares common principles of kinesin and myosin. The talk concludes by discussing the role of motor proteins in disease and how drugs that modulate motor protein activity can treat human disease.
Part 2 discusses recent work from the Vale laboratory and other groups, on the mechanism of movement by dynein, a microtubule motor that is less well understood than kinesin and myosin. The lecture discusses the unusual properties of dynein stepping along microtubules, which have been uncovered using single molecule techniques. The nucleotide-driven structural changes in the dynein motor domain (elucidated by X-ray crystallography and electron microscopy) are also described. A model for dynein movement in the form of an animation is presented. However, much remains to be done in order to understand how this motor works and to test which elements of this model are correct.
The third (last) part of the lecture explains how the movement of mammalian dynein is regulated by other proteins such dynactin and adapter proteins. It also describes the effect of post-translational modifications of tubulin on dynein motility. This talk features the use of single molecule imaging techniques and biochemical reconstitution to study these problems. Unanswered questions on dynein regulation are also presented.
Speaker Biography:
Ron Vale is a Professor of Cellular and Molecular Pharmacology at the University of California, San Francisco and an Investigator of the Howard Hughes Medical Institute. He is also the founder of the iBiology project.
Vale received a B.A. degree in biology and chemistry from the University of California, Santa Barbara, and a Ph.D. degree in neuroscience from Stanford University. His graduate and postdoctoral studies at the Marine Biological Laboratory led to the discovery of kinesin, a microtubule-based motor protein.
Dr. Vale’s honors include the Pfizer Award in enzyme chemistry, the Lasker Award for Basic Medical Research, and elections to the National Academy of Sciences, National Academy of Medicine, and the American Academy of Arts and Sciences. Besides studying the mechanism of motor proteins, Vale’s laboratory studies mitosis, RNA biology, and the mechanism of T cell signaling. - วิทยาศาสตร์และเทคโนโลยี
Whoever designed these molecular machines was a genius
Nature is a genius, yes
Almost God like design.. ex nihilo nihil fit
Evolution comes up with some cool shit huh
I remember learning that the inside of cells was just a "chemical soup" where everything just mixed together.
But no, it is a much more ordered and organized system full of paths, rails, and active transport. Cells are much more "machine" than we used to think.
our teachers were idiots teaching us from books written by idiots
That's because they were designed!! No fluke.
Yes! It's called the intelligent design by a Divine Creator.
@St. Clair Dancing Agree!
When did you learn about cells? 1899?
the graphics are killer. explanation atop! thank you.
It's amazing how complex even a single cell can be.
We have a hard time understanding what the atom is really made of, what its structure really is, and how it really works.
Humans have about 100 billion neurons per brain, and each neuron has on average 5 *_quadrillion_* atoms (thanks google).
That makes for a larger number of atoms per thinking cortex than I can understand, and even our best brains can't properly "see" what a single atom actually is and how it functions.
TLDR: Thou shall never expect to understand "even a single cell".
@@azka1912 doesnt that indicate Intelligent Design?
@@platzhirsch4275 If you used any level of proper logic, you wouldn't even ask such retarded questions.
@@azka1912 says who? You? You have intelligent logic? You! Then explain to me how a single cell could possible arrange itself by chance and then start multiplying itself too. Tell me with all your great wisdom.
@@platzhirsch4275 It takes a *life-time* to understand many things about the universe around oneself. To get some gut-feeling of how things work that are too small for your eyes to even see. To make connections between a hundred different domains of knowledge, to try and picture the whole elephant after listening to all the blind reports you can.
These are things I've been after all my life. Unlike all bible pushers, I didn't reach the ultimate truth. I'm not finished learning about things, and will never be.
Sadly for you, I am not here to educate you. This is your own path and your own effort -- if you are honestly looking to get there.
Otherwise, feel free to choke on a cloud of holy pink lies and die a complete idiot, like so many others before you.
Thank you for incredibly clear presentation on molecular motors. It is great to hear about these wonders of life from someone who is actually working on them.
(13:20) It's incredible to think that such a tiny motor protein can transport the entire cell nucleus. I mean, tug boats are pretty impressive when you see them helping to move large ships around but with these tiny proteins it's like pulling a Panamax ship with a rowboat.
I'd be curious to know what the force of 7pN would be scaled up to our size.
@@CaptApril123 it would be like pushing a navy ship full speed through an ocean of cement (I forgot the exact parameters of model and speed but I've read this metaphor.)
A fascinating presentation by an expert lecturer. Very didactic, recent examples, gorgeous and appropriate illustrations and open-ended questions. I wish ALL my professors were that good when I was in grad school! Well done Ron !! Thanks ! More please...
Great video smart man. Horrible lecturer. He says uh, and um entirely too much. It's better than "like"..... but it's also just as horrible. Also he is monotonous. He needs to throw in a question in there here and there, a pause, and relatable connection to what he is saying. His PowerPoint needs to be changed as well. You don't have to teach using death by slide. He should have the ability to write on the screen drawing arrows, etc. What he is doing is regurgitating, and that is literally bad lecturing 101.
@@taniabk28 I liked the flow and structure of the presentation so much I did not pay attention to the small problems, if any. I really like cogency more than any aesthetic presentational value, and "this guy" (He's a Nobel Laureate) is pretty cogent
whenever i watch these kind of cellular machinery videos, there always comes a point in the video where i'll just be sitting here half-asleep and then i see something where the sheer complexity of life clicks in my head and the realization leaves me almost falling out of my seat, pulse racing,
Those motor proteins that change their direction in response to blue light are amazing! I can't believe that's possible! It's almost like the light is taking the place of a catalyst. Really cool!
th-cam.com/video/TDPQEXa7S3I/w-d-xo.html
@@nickkrug8157 Tour is a synthetic chemical engineer but does he work on this project?
@@patldennis tour is butt slapped by professor dave...
@@jackyjack9660 the creationist I was addressing must have deleted his comment and bravely run away..
We truly are little machines! Awe inspiring and beautifully presented. Thank you. My mother died from heart failure. It was a hard way to go. It is so exciting to see such fundamental progress moving towards the treatment of that and so many other diseases. My hat is off to the scientists and their students who work so hard to "light a candle in the darkness". I feel fortunate to be able to see these things taking shape in my lifetime.
Thank you, Ron, for the very interesting and engaging talk. exceptionally clear and I loved the animations and movies you included.
This is the best explanation of molecular proteins I have seen or read! Thank you for making this clear and presenting it so well!
Although little I know about biology, I understood this lecture. Thank you Ron Vale!
So do I, I have been fascinated with our DNA, proteins and transitional metals. I've been watching Roger Spurr from the Mudfossil University channel and now I can not get enough. 😁 I think I love biology.❤️
Dear Prof. Dr. Ron Vale, this is one of the best lectures I saw since a long time. As a physicist I am really deeply impressed how concrete molecules works. Furthermore, as you told by showing the medical treatment examples, it shows what tremendous possibilities molecular-nanotech-engeneering contains. Thank you very much, Sir.
This is gotta be one of my favorite of iBiology's lectures
The real footage of molecules in motion are so cool!
I’ve always been amazed by motor proteins. This was an excellent, concise introduction to them! Thank you!
beautiful illustration of wonderful science! Thanks!
Incredible course, what a formidable instructor!
This is the guy that discovered Kenesin? Amazing! learnt so much.
Animations were really helpful and fluorescent microscopy is just such a gamechanger. Thank you for the comprehensive lecture
What a beautifully complex designed system showing a intelligence that is very creative. The complexity tells us something of the Designer’s ingenuity. To believe this complex system came about by random chance ignores the obvious.
...please...
This is about science, facts of reality, don't abuse science to belittle or even humiliate people who prefer to know
Believers never knew that we even have cells, god did not tell them about it.
We know about it because we do not accept god as the obvious explanation.
And the complexity of reality tells us a lot about how ignorant gods are.
Even mighty Thor did not know much about Molecular Motor Proteins.
It is one of the most interesting lecture I ever have learnt! I gives me at least several answers for my child questions I put in biology lessons in school times (~1975). Thank you!!!
This is the best thing ive seen all day! Thank you so much ive now subscribed to your channel!!!!
I have read some of the papers on this topic but never really 'got it' until I listened to Prof. Vale's lectures. Fantastic... and you know, no pay wall!
This is by far the best lecture I have had on motor proteins
an excellent lecture. i look forward to part 2. a big thankyou to ibiology for making great presentations such as this one freely available.
This is so different from traditional school teaching. Elites teaches like a package, connecting dots, fascinating and fantastic. This will definitely transform the average people
Exquisite, superbly complex, stunning engineering.
By a process as clumsy as evolution?
Yeah right!
Scientists today are rejecting the silly story of evolution.
@@danminer5343
True.
I'm sure there is a lot of truth in it, but the clumsy mechanism do go anywhere near explaining the stupendous engineering marvels and supreme artistry you see in nature.
@@thinkislamcheckmychannel Yes, the only reason people try to believe in the story of evolution is to falsely claim that there is no God to be accountable to.
@@danminer5343
Yes. I think it's indoctrination as well.
The mainstream view is that evolution is true and explains all life and that there is no God.
Most people but into that without checking things out in greater detail.
And those that are experts are cultured into that view.
It's a firm of cult/belief system
in the sense that
dissent and alternative views,
and a willingness to question the mainstream narrative
is absent.
@@thinkislamcheckmychannel - Yes. The only way to change what is in dogma is for the old scientists to die off (who are trying to protect their career/reputation) and for young scientists to take over.
Just discovered this high quality biology channel. Absolutely killer!
Best illustration. This lecture is essential and a good clue for molecular electronics, microchips, biochips, and bioelectronics. Thanks!
This is amaizing! I am so glad that I found this channel.
This is a fascinating topic. Great presentation.
one of the best documentary i have ever seen. clear and not boring
Absolutely amazing introduction with fantastic explanations and demonstrations. It opens up a new world in modern biology. Thank you!
I'm amazed the cells don't just get messed up and die instantly. This is so cool.
th-cam.com/video/TDPQEXa7S3I/w-d-xo.html
You are right. The cell could not slowly adapt and mutate into the miraculous machines they are today. Too many things had to exist at the same time and instantly. No time to slowly acquire functions or they would instantly die. The cell has no foreknowledge on what it even needs and if it did it had no ability to create what it needs to survive. We know its not even possible for 1 single protein to form by accident to build a cell. We know information comes from intelligence. The cell is filled with information that is needed to instantly exist to instruct the cell on how to function. th-cam.com/video/qxhuxg3WRfg/w-d-xo.html
@@Mark777Tube Can you provide sources for any of your assertions from the relevant scientific literature?
@@Mark777Tube why the fuck would an intelligent designer make such a messy and inefficient design? They're either dumb as a bundle of sticks or it arose due to natural processes.
@@subject8332 I was thinking the professor should provide us with sources for his assertions. If I recall about 3 times when he is explaining something so mindboggling remarkable when your mind thinks to itself that function seems impossible to accidentally come into existence by accident. He then as if intentionally each time tells us I better say to them it was evolutions because I know they are thinning how is this possible and they just might not believe evolution is viable.
The cell builds a temporary track so that Kinesins can walk and carry cargo to repair a damaged area of a cell. Actually traveling faster than a automobile in comparison. So then kinesins are actually running down a track to repair damages faster than a car. They are like a handyman (8:43) After the cargo reaches its needed destination the track is disassembled. As you said it is amazing that a cell would get messed up and die instantly if it did not from the very formation of the first cell have a track that appears out of nowhere constructing a road for Kinesin to run down with to with various and the exact repair material to keep it from dying.
How do these molecules construct such complex all these complex motors that a cell needs to function? World-renowned synthetic organic chemist James Tour says it is impossible. James Tour has built the world’s fastest nanocar a car so small you can fit 40,000 on the width of a hair. You need enzymes to build a cell you the problem is only a cell can build enzymes. Where did all the components of a cell come from? We know it is impossible for a protein accidentally forms if even more absurd that motorized molecular machines accidentally formed or a cell that houses all this miraculous machinery along with massive amounts of information that is in DNA. Where did this information come from? Repeated observation science reveals information only comes from an intelligent mind. Our human body has so much information in it that if we could print the DNA code in one person it we would fill the entire Grand Canyon with papers.
Science can even explain how 1 single protein formed by accident
Here are relevant scientific sources explaining the impossibility
This short video explains the imposable odds of a protein accidentally forming. The odds are way longer than the stated age of the universe.
th-cam.com/video/aA-FcnLsF1g/w-d-xo.html
James Tour explain a cell cant form by accident
th-cam.com/video/zU7Lww-sBPg/w-d-xo.html
fantastic lecture, it greatly helped my understanding of intracellular motion and my development as a teacher :)
This presentation was superbly delivered. The facts were easily captured because of the simple explanations of the necessary details coupled with perfect graphic application; a great teaching tool.
Understandable presentation on a really complex subject. Really great, thanks!
Fantastic video, explanation and discussion. The use of animation allows an understanding of the conclusions of a staggering number of biochemical and molecular biology studies and hours of laboratory work. Ron Vale gives a very lucid explanation of the concepts.
But who made it all? Random attraction of molecules forming ONE protein cell is 10 to the power 164.
@@Toncor12 Then it obviously didn't happen in one step. Proteins are different sizes (so by the way your number is applicable to proteins of a certain size but not others); a mutation in DNA can add to the length of the protein; clearly our ancestors, WAY back, had shorter proteins. So what's the simplest possible protein? How about a dipeptide?
@@rodschmidt8952 - my point is that nothing random results in an intelligent design. Only intelligence results in an intelligent design. The fact that these small building blocks have formed functioning sentient beings is simply impossible without a designer to put it together. Break your laptop down to minute parts and see how long it takes to form itself into a computer again. Evolution is completely pathetic.
@@Toncor12 who said anything about random?
@@zhou_sei - as I said, if it does not happen randomly then it has been organized and organization = intelligence. Whose intelligence? God perhaps?
This stuff is utterly breath-taking. I humbly ask that opponents of Intelligent Design grant that ID enthusiasts, like me, have come to that conclusion as a very reasonable assessment of what we see here. I have never once heard an ID proponent declare, "It is Intelligently Designed. Let us stop all research." No, our very souls cry out, "Let's go deeper!". If you will, it's like the SETI project aiming in the opposite direction of cosmic zoom. Yes! Show more! The Motors and Medicine section of this video is most encouraging.
I agree wholeheartedly. Some evolutionists think we're anti-science when nothing could be further from the truth.
I have nothing against the idea that things might have been designed but the problem is it's a hypothesis at best. How would you go about proving it? How do you teach Intelligent Design?
@@zfoxfire Is it even a hypothesis? I mean, how can it be a hypothesis if there's no way of testing it?
@@zfoxfire So how does abiogenesis/evolution get past the *MULTIPLE LEVELS OF EXTREME COMPLEXITIES ?*
@@zfoxfire And how are Bible prophesies made 1900 to 2500 years ago, being fulfilled after 1948 (the reformation of Israel !) ???
Great Lesson to supplement reading of Molecular Biology of THE CELL. Very good presentation. Thank you, Ron Vale.
One of the best explanations of such a technical topic I have seen. Many thanks. I'm now subscribed.
Amazing progress in our understanding of molecular motor proteins.
Much of this was new to me. Thank you for preparing and posting this video.
Amazing, awesome, mind blowing! To have gained such a studied understanding of the intricacy of cellular mechanics is truly an accomplishment. From my view, I appreciate it when I see not just the human effort of coming to know about something, but the application of that learning, as you have for medical purposes, or to otherwise combine that knowledge with other knowledge to improve our understanding of the world around us. While this knowledge is sincerely laudable, I find your references to evolution as the mother of these wonders, to be profoundly detracting. Your is but one study, of the thousands of likewise miraculous intricacies of the world and universe around us, and to distill the little that we do know into an accident of time, or the learning over time of non-thinking bio chemical interactions, is simply disingenuous and insulting to a reasoning mind. All the more so when every single one of these amazing discoveries, including the amazing fact that you live, and breath and can comprehend these things, is literally screaming DESIGN! Why not simply present your incredible knowledge without the profoundly detracting attribution to evolution? Inasmuch as you know a thousand times more about the bio mechanics you can observe than you do about the genesis of those miracles, why do you say you "have much more to learn about cell mechanics", then, in the second breath, you present the unequivocal yet unlearned conclusion that these miracles find their genesis in evolution? That conclusion and assertion seems to me to be far beneath you.
You are exactly correct. Just inserting comments like "Evolution did it" or "It learned how to do this or that" as if it knew you to create itself without a Master Designer" is a total waste of words as only results in deceiving others into a false world view.
Bravo 👏 well said. I thought this was about science and was very disheartened to realize it was a lesson in his religion 😏
Thank you for accurately articulating my mind on this matter.
Its so astounding how complex biology is. In one cell and all these cells make up your body. And how you think of yourself as one being yet you are only made possible by all this complex action of these cells going on inside you all the time..
A wonderful lecture. I'm not a biologist, but I found the concepts explored here christal clear and fascinating. Thank you.
It's a wonderful video! Thank you very much, I'll be watching more of them. :) :) :)
I don't understand why we can't resist the urge to use phrases like "Evolution learned", "evolution designed" and so forth.
This use of language is very common, but it might sound a bit anthropomorphic. Using such language can be confusing, even misleading, because it attributes evolution the ability to "get knowledge or skill in a new subject or activity"(learn) and/or to "1) conceive and plan out in the mind, 2) have a purpose or intend, or 3) devise [form in the mind] for a specific function or end" (design).
We don't use that language in relation to other forces or processes. We would not say "gravity learned/designed...", or "evaporation learned/designed".
If we attribute to evolution the ability to learn and design we might have to change its definition.
Imo learned is not that bad because there are genetic algorithms that you can use to learn solutions to optimization problems and they work the same as evolution
@@paulcurry8383 I see what you mean. But again, if we compare evolution to a computer that can learn what are we really saying? A computer is not a process like we say evolution is. It’s a machine that has been designed, it uses a binary machine code (genetic code is quaternary [please, I’m not english, forgive me if I make mistakes hehe]), that code allows humans to interact with it and obtain results, one of them machine learning, which is awesome 😃
@@titotan5298 Important to note an algorithm is separate from a computer, it is a mathematical concept, can be conducted in any base. All I mean to say is that the word "learn" can be used to describe the mathematical operation of fitting to a complex function given experience/data, since evolution can be thought of as fitting a complex function- fitness via experience, I think that semantically evolution can "learn", and it could serve good educational purpose to couple these two ideas with a common word. But at the end of the day, like all language, it's subjective.
@@paulcurry8383 Ok 😃 thanks for sharing your thoughts! One way or the other, the processes in the video are amazingly complex and a delight to see and study
One issue is that it is just verbal shorthand. He's here to intro motor proteins structure and function and it's getting too much into the weeds to use language that describes the evolution of them accurately. a talk that actually discusses about their evolution would have the room to do that.
One question was burning my mind during this great video... How the HELL did the scientists study all that!? How who!? Man!
Awesome lecture! Killer graphics, crystal clear explanations. I also loved the ending, how better understanding a small molecular phenomenon, can help improve the lives of humans.
Covered everything I need to know for my biochem II exam next week, so thankful I found this video as well as your channel. You are now my biochem lifeline.
Thank you 🙏🏻
I was waiting for an explanation about how the stuff get inside and outside the cells. Now I understood there are tubes and motor proteins to take the cargo. At school I always thought it was unlikely to food floating around the cytoplasm will get inside the nucleus. Now make sense with these cargo lifters. Now I have question how they are repaired as well as the tubes in the case they are damage, maybe the cell just dies and is substituted by a new one.
So what happens to a motor protein when it gets to the end of a microtuble? Is there a mechanism in place that lets it turn around and head back in the other direction, or does it die?
I believe the tube disassembles and the motor protein detaches and all the components "float" around until called into service again where everything reassembles to be used again.
It gets a call from its dispatcher to pick up another load where it travels through Omaha..... OMAHA!?!?!
It isn't actually alive.
@@johnwaynebadass1586 Hmm, kind of like a computer isn't actually alive. I get that.
It’s a molecule, it doesn’t live or die in the conventional sense. It’s chemical/electrical interaction
Didn’t even watch the entire video but gained information that I put to memory. Great job!
Superb lecture:O
I've always been scared of diving into the details of these protein nano-motors😅
There is a Creator that fearfully and wonderfully made us!
...and not Quadzillions of years, several explosions, and one lighting bolt?
Yup you are correct.
We're extremely complex machines.
extremely
Ultra Extremely Highly Complex.
i get surprised more how these precious videos are made than the subject matter thank you .
One of the few instances where I don’t care when someone messes up a word - this is pretty cool content, I love learning about it
Cool video. But I still don't understand how binding of ATP causes movement
Have a look at "conformational change" in biochemistry texts - it's a general process of ligand binding causing molecular flexing due to charge repulsion and attraction.
excellent video. Would be even better if you could add subtitles
Wow! Thank you so much for helping me to understand and envision how the motor proteins move! So much to absorb! Will watch a few more times! I wish videos like this, were around when I was studying for my Biology degree!
Such an outstanding presentation on molecular motors and organelle motility!
How can anyone who has learned so many details of the awe-inspiring design of these incredible machines still maintain his faith in evolution?
Because evolution is a series of incremental superficial changes being slowly compiled atop successive tiers of fundamental similarities and it is an observed empirical fact of phylogeny, so anyone's faith and emotion driven personal opinion on empirical data is quite irrelevant.
en.wikipedia.org/wiki/Evidence_of_common_descent
"series of incremental superficial changes being slowly compiled atop successive tiers of fundamental similarities"@@subject8332 It's not the form of the beaks of the finches we are talking about here.. This is a fundamentals ov live organisms. The Chicken and Egg problem. None of these tiny machines has a function separately, they only work in unison. It's a very fine-tuned and thought out system. People choose to be blind to the inevitable conclusion that Life is designed by an intelligent Creator.
@@oswaldcobblebot Please, can you provide sources and references for your assertions from the relevant peer reviewed scientific literature?
Because evolution doesn't rely on faith. It relies on observation and the scientific method. Don't confuse science with your myth.
@@subject8332 someone's been watching Aron Ra videos.. lol. Awesome I like him too.
I love how he says, “Evolution has learned...” hahahha. Even as we begin to unravel the mysteries of biological systems we feel bound to mindless descriptors. Nature just ‘figured out’ how to build, maintain, program and duplicate the most complex systems we know of in the universe and we talk about it like it’s just mindless chance. Fascinating video!
It's not "mindless chance". You are just one of the many people who don't understand the concept of geological timescales and its implications. A billion years isn't just some number, it's a huge, HUGE amount of time and it's time for you and the many others who spew out the same thing over and over again to do some research on that. A simple system can, with time, develop into a very complex system. Computer simulations show that, using very basic rules. The real world is vastly more complex and the timescales are unimaginably large. This is why you have such complex systems and not due to "mindless chance".
We have a tendency to describe things in terms of ourselves.
I believe its called "analogy of intention" or something along those lines
People don’t like the implications of an intelligent Creator.
Theos Tragonidis Wow, don’t know how I missed your reply. I watched this video 5 months ago and recall it being polemical and not very useful. As to you imploring geologic timescales to evolutionary systems, I’m afraid your equally polemical. A billion years is not a “HUGE” amount of time when you consider the tasks claimed to have been accomplished. I know because I have spent a great deal of time looking at time scales and organism development.
I know of no computer simulations which credibly predict the evolution of biological systems represented among the extinct or extant taxonomic rank on this planet. In fact, many credible arguments exist within accepted evolutionary circles highlighting this very problem. Hence the need for a more refined theory of the process of evolution.
This isn’t some tired refrain of “God did it”, but, rather, an understanding that mechanisms this complex (even if guided by natural selection) are not likely to have formed under random mutation. Random mutation would require, according to many credible sources, far more time than has been allotted to creation on this planet.
My current theory of favor is James Shapiros “Natural Genetic Engineering”. I have heard few arguments against it and those that I have found were either weak on substance or purely subjective complaints.
David Richards in a modern world they have been trained to reject such notions. Pitiable really, as it limits investigation. Thanks for replying, it helped me notice an oversight in an earlier reply.
I'm speechless. What additional knowledge will we gain in 10, 100, 1000 years.
The efficiency of these little guys!!! Unreal!
It's amazing to see that each machine has an inherantly designed task, and so many pefectly exicuted consecutive steps are required for the construction of the DNA into the many components of a fully formed healthy organism.
If an amino acid connects to another acid, that is "chance" due to the approximation of the two chems, yet fully functional "working machines" are in no way associated to the word "chance." Each element in the highly complex structure has a proper address, and each machine can access the proper address without any additional motivational stimulant than that for which it was specifically designed.
Without the direct intervention of an intelligent biologist, the existence of any working machine, let alone self built over any length of time, is a joke from any mouth. To say that all these atoms could have ever been constructed into any "working complex structure" "which interacts with any other working structure" "to the fulfillment of the DNA's grand plant without each part containing knowledge of the full plan" "all working directly against entropy" again, without intervention or guidance, is absolutly absurd in the upmost degree to any stretch of the imagination(even for an evolutionist's non-scientific opinion).
Every part of the Universe is Life, Source, Love, God, Whatever you want to call It. It's sole (soul?) purpose is to become more and more aware of Itself. Through more and more complex forms of matter and biology.
Why is it so difficult for people to realize that both evolution and creation are one and the same? Why is it so difficult for people to accept that both can be true and not take away from their idea of an Intelligent Designer? Evolution IS creation. To me, it's more amazing that life, the universe as it is today, can form from just a couple of elements that coalesced and fused into more and more complex elements that dispersed and coalesced again into biological elements, that through the eons, coalesced and formed into even more complex biological systems, eventually becoming what we know today.
How in the fuck does this take away from Intelligent Design?! Come on!! Wake up!! This IS how God expresses Itself, or more to the point: THIS IS HOW YOU ARE EXPRESSING YOURSELF RIGHT NOW! In all ways! As the universe, trying to wake yourself up.
Wake up.
1.Evolution from an egg/sperm, etc, to a full grown organism, or from one capasity of a gene pool to another, which is all dependent on pre-existing forms of rna/genes/cells/ribosomes/etc: these processes are called metamorphosis, or adaption which is gene lose, gene damage, genes switched, etc. It is misrepresented as "Evolution" which gives the unobserved connotation that chemicals are self-forming, self-guided, self-manipulating, etc. Metamorphosis, and adaption in an organism's genes are both observable.
2. Evolution of chemicals into "working machines" by means of abiogenesis, and mutated(damaged sequences) rna developing into a the working codes needed to reform any existing body form into another(fish to frog etc) is an idea that is not founded on reality, nor observable on this planet according to any group of peer reviewed scientists.
If it were possible to prove God exists, we have not yet done so, that is His priority, not ours.
If it were possible to attribute evolution to any part of this world, we have not done so as of yet, we could say we have evidence of that conjecture.
Ignorant people look at design, and declare it "self-forming" yet every chemical seeks equilibrium with other chemicals. Every force seeks equilibrium with other forces. Every energy seeks equilibrium with those places where energy is absent. Every device of this universal machine seeks rest however long it takes to attain this rest. This rest we call entropy.
Life is the obstinate working force against entropy, and this life must needs a reason for doing so as that is the nature of the force of life. Order is an attribute of intelligence, and only intelligence can recognize the idea of order. Order does not come from disorder, as order is the resulted outcome of challenging disorder. Working structures are built in order to function for a specific purpose outside of it's own understanding, and within the perameters of the intelligent being's will. This is seen in every laboratory, in every facet of observed existing evidence.
Only an intelligent being gives reason to existence. An intelligent being gave reason to life, and life to built structures resulting in the operation of said structures. It is our fault if we choose not to observe the intelligent being charged with the creation of our existence.
People love to dwell in the self-perpetuated euphoria of their selfrighteousness, believing that they know something of this world, or even the universe that they didn't even get to choose to exist in. They are unwilling to remember that the extent of their understanding is very puny, and most of their gained intelligence is subject to change, yet they seem to thrive in this hallucination however far from wisdom they choose to flee. Somehow, they think that a phrase like "wake up," or words like "scientific" somehow give them argumentative authority over the sound mind of others. Who, with a sound mind, could believe in any part of a hysterical hyperbolic conjecture that entropic, unintelligent existing chemicals could choose to form any "working" protein machine capable of devising it's own structure working in harmony with other miraculously "self-formed" strands of intellectual data, and "self-formed" cells to bring about a team build project of any capacity with out even "OBSERVING" any part of this imaginative conundrum. The answer is that no self respecting scientist can say that any part of the delirium of chemicals forming them selves by means of any evolutionary processes has been observed, or believed to be observed in the future. This is why they stack on "billions of years" in order to create the objectionable mythical circumstances needed along with the unknown conjectured time spans of unobserved history in order to orchestrate the misconception that anything, given enough time, can happen by chance. The whole "LIE" of evolution is contingent upon bias towards the conjecture of evolution.
If I don't see it, or observe it, then it doesn't exist. If I were to believe that evolution is a workmanship of a god/God/gods, then I could believe it only after observing the process no matter how small, but evolution is absent of evidentiary preponderance.
Daniel Cage 100% agree with you. "Evolutionners " have a belief that all that is random so...by chance! But no proof at all it is just a belief like the religious one have in their six days earth made by a God!
You could do yourself a favour and actualy try and learn biology. But then again, this would hard kill all the misconceptions you've reposted here from science freaks forums, so you won't do so.
@@jean-marclamothe8859 The six days is more accurately translated and understood as "Epochs" of time. An undetermined amount of time split more or less in phases deemed "days". No sense in jettisoning science, our discovery of what is. The people who believe in a literal six 24hr days are on the fringe.
Thanks for compiling a logical description of these processes that could be used in a course. It is disconcerting though that you assume with no evidence that evolution has built these molecular engines. These things are good examples of irreducible complexity which better fits an intelligent design rather than any kind of random changes where the thing won't work unless all parts are in place. Better to just say that they exist, rather than that they "learned" (via evolution apparently...) or that they "evolved into...". Your bias for evolution is no longer shared by a growing number of scientists. Just give the facts please, not your unsubstantiated assumptions. Otherwise great, useful and appreciated work!!
The process of how things work in life or even within our bodies is no indication that chance (Evolution) has even the remotest possibility to create, control, and operate towards a greater end these molecular engines, nor anything related to life. Funny, that these professors cannot identify, directly study, nor capture the entity they call Evolution that is responsible for the creation and sustainability of life. They can see change, they can monitor process, they can identity parts but they are only watching the designed processes and functions created by a much higher intelligent being who designed, created and set all of life in motion. Life is not chance created nor maintained. I concur with you m c.
@Juno Donat The video depicting intelligent design is already in front of us, Science is slowly unraveling it for our observation.
There is no identifiable source (power) that we can capture called Evolution. In the above sentence, I'm asking about what Evolution is as a particle or a force...not as a process. We cannot capture gravity, but we understand it's source (the bending of space/time due to mass), we know gravity well enough to use it and can now, recently, detect it from merging black holes. Other scientific studies have produced the identity, capture and testing of molecules, atoms, electrons, protons, neutrons, quarks, etc.., but no where can we capture nor use Evolution, the force that is responsible for creation (evidently in some people's mind).
Evolution, as I understand it, is not an originating creation force, but an inherent process (allowed variance) BUILT into the DNA/RNA code of living things. Some DNA code allows a greater operational variance, prior to mutation (errors in DNA transcription, the death knell) than other DNA code, this allows the host to have greater/lesser adaptation to forces outside itself.
I absolutely believe in Evolution as an inherent allowed variation in the pre-written code of DNA , of which all but some creatures are dependant upon. There are plenty of non-creation based biology studies here on TH-cam that describe the almost indescribable complexity within even small processes that support other process that support greater processes that support life...etc..This is not by chance, chaos or random pools of warm water. This is all coded with the DNA. Even DNA cannot create itself and needs a host of separate processes outside itself to read, duplicate, correct and create what the DNA code holds. What coded the first DNA....of each species, of life in any form? I definitely see an intelligence much greater than any possible human behind all this...the question is who?
@Juno Donat I don't know of your God of the gaps theory. I'm not concerned with that, I'm focusing on the complex intelligent processes that cannot self create without prior existing DNA (in things that have DNA). DNA is the pre-written code that describes, the creation of, birth, living process and death of living things. Science has finally discovered it, and the variance allowed within the code. Just like the programming code we humans create, (although not even close as complex), our code is pre-written, has a purpose and accomplishes that purpose plus it allows variance within the processes it creates depending on what the codes purpose is.
What you are describing as Evolution is the inherent allowed variance (processes) with DNA.
@Juno Donat I would like to see the same video or be present too !!
The best we have though, is use our intelligence to investigate, document and understand the world without and within us, and try to see the beauty, complexity and sheer intelligence written in creation.
Thanks Juno.
@Juno Donat As a side note about interesting things, I was watching a Particle Physics video recently that noted that every atom, proton, electron, neutron, quark, photon, every packet of energy is perfectly and absolutely exact, whether in a star, a gas or in our bodies. The non-creationist video went on to say somehow creation has a factory that kicks out perfect uncontaminated particles that form the basis of larger objects. By itself I found that interesting.
Proteins are amazing. These little automatons are mind blowing.
Dr. Vale, you are not only a great educator but a first class scientist! My hat off to you (I don't wear hats, but if I did...)
it's nearly magical. simply amazing.
It is magical I agree so is our God
@@martingleeson2362 your God doesn't exist. Deal with it.
Shade How one can watch this and come away with the conclusion that there is no God is beyond me.
@@Sjolden98 because all of these phenomena obey the laws of physics. They require matter, gene expression energy input etc. Nothing supernatural about them
@@patldennis Do you know about the multiple complexities evolution would need for a new body part ?
Like say a new limb (arm or leg): first the genetic would have to be formed !
at that time, evolution would need to form the muscular system, the skeletal system, nervous system, the endocrine system, the circulatory system, lymphatic system *AND MORE!* (TO MUCH TO ACCOMPLISH WITHOUT A DESIGNER !)
Its just si amazing. just think every cell in your body has come and gone and your basically a clone of yourself. only your conciousness is consistant from birth till death.
And what does it mean to say that consciousness is consistent?
@@rodschmidt8952 it might mean that your Consciousness is actually who You are and the material is just part of the machine. The question becomes more interesting when you start thinking about dimensional mindsets.
@Shaun Welch Depends on your definition of consciousness - . In the Vedic cultures, consciousness is sharply discerned from intellect
@@rodschmidt8952 I can’t speak for anyone else, but personally when I say that consciousness is consistent I mean that consciousness is consistent.
15:47 : The ONLY even somewhat satisfying explanation I’ve EVER gotten (not due to lack of searching!) for how I’m even able to yank the strings of this puppet AT ALL. THANK YOU
Awe inspiring details and engineering.
Awe inspiring ability of humans to have been able to develop the means to peer into this world.
Such sophisticated complexity at a molecular level staggers the mind, and yet the scientist who know of this still insist that it developed through chance mutations in an evolutionary process, even though the same scientists have proven that mutations only result from a *degradation* of the genome, not the addition of new information and complexity.
You can see by the way I use my walk I'm a motor protein...
It's amazing what you and your colleagues are discovering. But I can't understand that when confronted with such a mechanism that works so good and whit zero errors you attribute the design and development to the evolution. It's crazy how people can get so blind despite being so inteligent.
That's definitely one of the coolest presentations i"ve seen. Incredible logistics ..
It seems to me that evolution has run out of time. How long would it take to evolve this level of complexity by chance? Intelligent design makes more sense to me.
These proteins were without a doubt present during the Cambrian period and probably earlier. Therefire 4.5 billion years is obviously more than enough time
Supernatural magic makes more sense to you?
That's. My line some one stole my motor protein down there and now it won't work! They took my little catalytic converter and so we are going to Rob the Bank of Mejico? Come on men! Let take it out of there ass
Why would ID makes mor sense seeing this, the potential is here for ever and what you see with your capacity is just a random necessity.
its no chance its shaped and influenced by the enviroment
Excellent presentation. However, similarities in structure can be indicative of a common Creator.
And the 1000+ different sequences for kinesins throughout biology would indicate 1000 designers
@@patldennis God did say "let US make man" and that the Angels were eye witnesses.
@@senseijuan3230 some man said that God said that...
@@patldennis but science overwhelmingly indicates there must be a God, a designer !
Stupid comments about “gods” - nature is infinitely more interesting and impressive than comments of village idiots 😇
Wow !!! What a video clip, gorgeous graphics, always wanted to watch something like this, explanation is wonderful. Subscribed to the channel !
Well done sir. I truly appreciate you sharing your knowledge with us.
The idea that all this could spontaneously emerge from some “warm little pond” is preposterous.
Whoa whoa whoa, I think you meant to say “prebiotic” soup...
It is completely unacceptable for a scientist, in all his pride, to acknowledge God in any way. They just WILL NOT give credit to God! Their hearts are darkened in the extreme.
"The idea that all this could spontaneously emerge from some “warm little pond” is preposterous."
I agree, this why only creatards claim such stupid things. They claim it is impossible that life could spontaneously emerge from some 'warm little pond', instead they suggest that life spontaneously emerged from some 'warm little pond (mud)' because it was spoken into existence by a magic spell!
If you are interested in what is actually being considered by scientists:
en.wikipedia.org/wiki/Abiogenesis
@@jbooks888 Or you are simply stupid and have been fooled pretty badly by talking snakes and bushes.
Proteins like this are the result of evolution. They probably weren't a direct result of abiogenesis
Nice pants. Great fit 😉
Ron Vale is a stud
That's what she said...
Thanks to people like this for passing on human knowledge.
Excellent presentation! I've gained several new understandings.
“The eternal mystery of the world is its comprehensibility … The fact that it is comprehensible is a miracle.” --- Albert Einstein, 1936
Amazing! This is much too complex to be because of evolution! This is definitely intelligent design
How so? these proteins were around long before humans and humans evolved from non human apes. The human versions of them are just human sequence versions of previous antecedents
@@patldennis That doesn't really counter my point of it being too complex to be because of evolution. Protein has and does now exist in almost everything.
@@david50028 they weren't the same proteins. Comparative genomics shows that. Therefore evolution
@@patldennis I didn't say they were the same proteins. I said your point doesn't sufficiently counter my point. This is too complex to be done by "slow, gradual processes" (a direct quote from Darwin).
@@david50028 a direct quote mine by Darwin.. I can show you using tools available online that the sequence for the proteins under discussion is evolvable and thus evolved.
How do you measure complexity in this case? What units do you use? What is the quantitative cutoff for complexity which demarcates evolvable vs too complex to have evolved? What non evolved system and evolved systems did you compare in order to discover this? What was your p value?
What a fascinating presentation. It is humbling to know these things are functioning to make us what we are.
Things that exist have properties. Humans exist, thereforethey have properties. It's fascinating and compelling to be sure, don't know about humbling. Humbling to whom or what?
AMAZING design of the cell.
27:42 "now evolution has learned" seems like he is cracking a half smile when saying that. It's hard saying that with a straight face.
And evolution must have simultaneously learned how to make theses tubules for no apparent reason at the same time. Why would there be a need for the motor without the tubule? Why would there be a need for the tubule without the motor? Why would the motor bind to a specific cargo if it had no way of transporting it without the tubule? Why would it be taking it anywhere in the first place? None of these molecular machines have any reason for wanting to do any of these things nor do they have the intellect to do so. None of this is logical within a framework of evolution. This bears no similarity to a female bird choosing mates with colorful tail feathers. None at all. Look at these complex tiny machines! They built themselves by accident! Dumb.
Really? You're really that desperate that you cling on to that as if it proves your goddidit?
its 2020. Are there still people that dont understand evolution? Lack of education? Is it religious upbringing?
@@karlakarl3715 When I was in high school I read a lot of Scientific American magazines, and I got the impression that this debate happened and was over 150 years ago. Apparently its echoes are still happening outside the scientific community.
@@rehoboth_farm Because you can not visualise a more or less stepless evolutionary regression back to the first proteins that were capable of self replication, which started out as one protein being formed after a serendipitous complex chemical reaction (There is much evidence the base molecules for this came from outer space - PansPermia). there are trillions of steps, evolutionary speaking. and in the first billions of steps, cells did not even exist. Just bunches of replicating proteins.Hard to wrap your head around. It's like trying to visualise a googolplex, or graham's number. You just can't do it in your mind.
It is amazing that after explaining such complexity it is said that this was a evolutionary chance 😓
Is not chance !!! Is a wonderfull Inteligence that is behind this beautiful complexity. That is reasonable and sceintific. Yet only an hypotesis.
Life has had billions of years to develop into this level of complexity. Covid has had 1 year and there are already strains that have evolved into more transmissible forms. Random code mutation combined with natural selection is an extremely powerful process that should not be underestimated.
That being said, there are some structures that are generally good for survival- like eyes, so there is a lot of convergent evolution. Those arn’t so much “chance” as they are an inevitable development.
And for what it’s worth, none of the above is predicated on there being or not being a God.
Trillions of life forms died without reproducing for the end result that’s lead to what we’re measuring today. That’s a lot of suffering. Also most of those deaths were at the hands of another organisms mouth. Most living thing die a very gruesome death.
If you see love and intelligence in this systems design, I prey to the god I don’t believe in that you are never involved in government.
@@vadude23 - You fail to realize that every kind of life form is irreducibly complex. Nothing could live while being built a piece at a time.
@@vadude23 In the beginning there was no death, not until man sinned and ruined the creation. Even today we find cooperation within all ecosystems.
This Educational tool is a wonderful and well descriptive example of Molecular biology; its mechanical and chemical interactions are also impressive. I look forward to more.
RD McGahee ISA, CLES
Sr.Engineer Bio-Clinical Laboratory
I really like the animations . It makes it easy to follow
This is obviously chemical engineering at a level far beyond anything we can possibly conceive of doing today. Why not just admit it?
Because there is no reason to admit or even think that.Lightning and fire were equally inspiring to prehistoric people.
@@patldennis I'm sure that prehistoric people would also be amazed by a jet airplane or a wrist watch as well. That doesn't mean jet aircraft evolved from a pool of slime. Of course a 747 pales in terms complexity to the mechanics of a single human skin cell. The silliness involved in the belief that life must be ubiquitous in the universe whenever a handful of elements are present is only compounded by the fact that within our observable sphere we find exactly ZERO examples of life springing ex-nihlo from the mud under our feet today. If it were so there would be an abundance of new life in various stages of development, diverse in lineage, with multituedes of novel molecular systems appart from the system of DNA that we share with ALL other life on the planet. Is that what we find? No. We find exactly one set of tinker toys arranged in a very similar fashion. Yes, a human being is 99% genetically similar to a chimpanzee. It is also about 35% the same as a daffodil. When it comes to genetics, cellular biology, etc. human beings are children running with sissors. We have no idea how all of these things actually work. We are a bunch of fools screwing around with systems which are orders of magnitudes more complex than we even understand. Go and deliberately make a single living cell from raw inorganic elements and then get back to me about beliving in magic accidents.
@@rehoboth_farm jet engines and wrist watches aren't genetic entities that reproduce and are not a part of nature. I don't understand your attempt to conflate them with living things. Unless you forgot that I don't share your presupposition that the latter were designed???
Your comments about abiogenesis are superfluois and irrelevant to the necessity of genetics, observed natural history eg. the first vertebrates being fish, fish preceding terrestrial tetrapods (fins->limbs) etc. Just stahhp with flak bs. Besides why would we expect life to be constantly forming in our modern oxidizing atmosphere that is already niche occupied with existing life?. either you are dumb as to the dynamics of planet formation (earth then totally unlike Earth now) or are just making a strawman. Again, just stahhppp!
Yes lineage divergence would expect that daffodils would be less conserved at any particular locus than chimps because animals and plants diverged from a common eukaryote ancestor much longer ago than chimps and humans you've just cited a confirmation of a testable verified prediction of gebetics/evolution as a problem. That is truly pathetically retarded.. The fact that humans and plants share a core set of genes that can be compared in the first place doesn't phase your dense head though, does it?
Mutation and sequence divergence is an intrinsic necessary aspect of DNA, not an accident. It is a tangible molecule that can be seen, and has properties that can be measured unlike your invisible God, who has supposed magical powers that many have claimed but no one has ever witnessed being demonstrated.
@@patldennis
"Lightning and fire were equally inspiring to prehistoric people."
Which one of these is alive?
If happy, magical, unicorn accidents abiotically produce life then a smart guy like you should certianly be able to crank out a single living cell with no problem. Just go bang one out for me to look at. Document your process so that it can be replicated independently. So... by noon? Next week? Either that or admit that people are no more capable of doing so than chimps.
@@rehoboth_farm we understand the series of events involved in the progressive fusion of H nuclei, and ejecting packets (quanta) of energy that occur in stars that produces elements heavier than H and that also provides energy. To do so in a controlled manner would revolutionize energy production but we cannot. I suppose by your logic that is still a supernatural phenomenon but it is really just matter of technological ability and knowledge.
Likewise the lack of what is now trivial knowledge about the phenomena of fire and lightning to prehistoric people caused them to find meaning and explanation in wrong supernatural conjectures. Your point about whipping into the lab and reproducing life abiogenically is refuted.
Someone roll the dice, i might create a lamborgini....
Go for it, you've got 500 million years and a billion trillion dice, and you only have to make a toy unicycle that barely rolls and you can go from there. By the way, nobody designs a car from scratch (until the Cybertruck); each car design is a variation on previous designs, so the Lamborghini evolved.
@@rodschmidt8952 and here we are billions of years later, we had to make an intelligent creature to actually make a lamborghini XD
My favorite teacher as an undergrad at UC Berkeley was Donald Mazia. His research interest was cell division in sea urchin eggs and his presentations would have been made even more compelling than they already were with overhead projectors if he had this technology in 1970. Microtubule self-assembly, centromere-microtubule interaction, actin-myosin energy generation, ATP energy coupling, cAMP regulation of slime molds all came alive with his delicate, humorous, detailed presentation.
iBiology is aamaaazing!! the lecture was very lucid, simple and helpful. Thanks !!!
Ron, you talked about evolution as a person with learning ability. This "evolution" is God.
Evolution is a series of incremental superficial changes being slowly compiled atop successive tiers of fundamental similarities, and it is an observed empirical fact of phylogeny and population genetics, encompassed by the theory of evolution, which is our only scientific theory explaining biodiversity, while god is the main fictional character of an ancient book compiled from ancient myths found on papyrus rolls and it was scribbled by some iron age sand dwelling desert tribes about talking snakes and bushes, dragons, a man living in a whale, dragons, magic spells and a reanimated transcendent zombie magician.
en.wikipedia.org/wiki/Evidence_of_common_descent
Fantastic! And all that have appeared by chance if we believe in evolution theory!!!
Are we lucky or not???
I am impressed by the 26:00 explanation for how muscles work I feel like I am a little ant 🐜 on a big tv 📺 unable to understand how such tiny movements can result in muscular contraction...
Thank you. I found it fascinating and immensely instructive.