Migraine Medications
ฝัง
- เผยแพร่เมื่อ 6 ก.ค. 2024
- Official Ninja Nerd Website: ninjanerd.org
Ninja Nerds!
In this lecture Professor Zach Murphy will be presenting on migraine medications. This lecture will begin by discussing the pathophysiology of migraine and how migraines are typically triggered. We will then transition into the mechanism of action of migraine medications and look at the cellular level where these drugs exert their effects. We then talk about the most common names of migraine medications and the general classes they fall within. We conclude this lecture with a discussion on adverse drug reactions and contraindications to migraine medications. We hope you enjoy this lecture and be sure to support us below!
Table of Contents:
0:00 Lab
0:08 Migraine Medications Introduction
0:29 Pathophysiology of Migraines
13:02 Mechanism of Action and Migraine Medication Names
27:19 Adverse Effects and Contraindications
40:45 Outro: As Always, Until Next Time
40:54 Comment, Like, SUBSCRIBE!
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I've had migraines for 15 years. It's hell. I've researched a lot on how to stop them and this is by far the most expertly concise thing I've ever seen on migraine. Well done.
You are right, my elder sister is suffering from migraine for 30 years, develops renal disease as a of intake of vasoconstricting drugs and analgesics ... finally I asked her to take proper rest and sleep and apply cold ice packs around neck and head..
After 7 years of headaches and visiting way over 10 doctors, finally I got triptans, ergots and anti-seizure for trial last week for the first time. I wanted to understand how they work and found this video. Now I am just angry how come no doctor gave me such basic magraine medicine for 7 freaking years.
Amazing, clear content - love it!
If I end up graduating pharmacy school, I owe it 100% to you and your amazing videos. You have taught me more and better than any professor I've ever had. You are the only reason I've gotten through these last 3 years and the second I get an actual adult job one of the first things I'm going to do is financially contribute to this channel because you deserve so much for everyone you've helped and for how fantastic of a teacher you are!!! Thank you so much for everything and especially for the time and energy you've put into these videos!!!
I suffered from migraines for over 40 years, 2 to 5 severe migraine episodes per week. People that suffered from migraines can relate to chronic excruciating pain, nausea, vomiting & loneliness. I had to stay in a pitch dark room alone, quiet & cool due to sensitivity to lights, smell, alcohol, noise and many forbidden foods.
I'm glad to get more information from Ninja🙂
I was the same for 25 years, then I discovered cannabis oil, 1 drop at night and occasionally another if one is coming.. they've dropped about 75% and are much milder, no vomiting.
@@ellendurkee5444 I love cannabis too so very much, of course, obviously ✌🏻
How did you heal them
I was the same since I can remember, then I did an elimination diet. When I eliminated instant ramen noodles for 3 months, I did not get migraine. I tried other food with MSG and it came back. I realized its the MSG that triggers my horrible migraine. I grew up with it in almost all our food. These days whenever i crave instant ramen I limit it to 1 a month and I’m ok.
I swear to God, and I mean this in the nicest way possible, I'd want him as my husband. This man is so knowledgeable and he continues to give us these high quality, clear and detailed videos for free. He does not sell out, or get greedy and he has been doing this for years! My silly comment in the beginning is just to drive home how valuable he is, I know he is married :D
Haha he would not accept you, Zach is a god, he deserves a goodess
Godess
@@uweraandrew2426 chill out man, clearly she was joking no need to become so defensive
I thought it was cute and funny.
@@uweraandrew2426relax dude, no need to be rude
These vids are great. I send them to patients to watch. As a physician who is also a migraine sufferer, it grates on my nerves when people describe headaches as migraines when they're clearly not. "I got a full-blown migraine at the concert but I stayed anyway bc it was such a great show," or, "I have a migraine right now, but I still have to run a bunch of errands, so I'll just push myself." When I hear people say these kinds of things, it's clear that what they're experiencing is not a migraine. I worked at a university and had the school's policy's changed; their rules and regulations once read, "Minor illnesses are not acceptable reasons to miss an exam, for eg. colds, food poisoning, migraine headaches." Can you imagine sitting an exam with a migraine? Or with food poisoning? It's challenging to suffer with something so common, yet so misunderstood.
sure, I'll go to my exam. I'm sure no one will mind when I sit there puking.
It’s nice that you changed it one time in one place, but it seems to me the root of the problem is that there are no legal consequences for that kind of stupendously dumb policy.
@@jackthompson6296 It has to start somewhere. The point is that the policy was made based on ignorance, not really dumbness - though I know what you mean. And legal consequences aren't really the answer; the school admin needed to be challenged by someone more expert than, say, an admin person - and again, it's people casually referring to a mild headache as "a migraine" that's done this.
@@Lionforaday at a minimum it’s a violation of dignity and personal safety to force someone with an illness to work/take an exam while incapacitated, which risks exacerbating their condition and/or an outbreak. If the law can’t protect basic human rights then what good is it?
@@jackthompson6296 while I agree with you philosophically, I doubt it's an actual law. Maybe that will change - here in Canadian grade schools, kids can scan barcodes in school hallways to "file human rights complaints," which is a bit nutty considering that there's no education provided to these kids on what their human rights even are (never mind what a violation of them would be). It's easy to say, "what good is the law?" but it has to exist before it can be enforced.
Thank you so much for these videos! I'm a nursing student and you've helped me so much! I also have suffered from chronic migraines for nearly 15 years and it's great to finally understand the pathophysiology behind the migraines and the medications I take. Thanks!
Thank you so much for this video. I am not in med school or pharmacology school. I newly suffer from chronic migraines and I found this so helpful in understanding whats going on inside my body and what my possible solutions are. I'm so grateful that this information is available for people who want to educate themselves about their condition.
I love your videos! They help me so much. I study pharmacy, but i had to take a break due to another severe major depression episode. This time, one of my symptoms was forgetting almost all I learned about drugs :( and many other things. Your videos are so helpful, you can't even imagine!! THANK YOU! 💛💚💙
i am extremely eager to know that which was the first video ninja nerd uploaded on youtube.
And that day must be celebrated by medical student
stay alive until this universe collapse
Your videos are just out standing & so easy to go. I'm a pharmacy student & trust me this video was really helpful. Hoping to watch more videos on pharmacology.
I don't know......why there is only few million subscribers.
u deserve the best youtuber tag with lots of subscribers for ur awesome videos and effort which ensures our effortless learning.😉
god bless uh.
As a doctor, Your videos are super helpful in revising imp concepts. Thank you ninja nerd
My first pay check will go to you once I become a doctor!
You deserve the world
Thank you so much
Whhooo baby...... I've been getting migraines with Aura since i was 13 years old.... I'm now 62. I have not, in 49 years, found anything that completely...100% takes away the migraine pain.😢
I topped my post graduation in biochemistry.. thankyou sooo much Ninja nerd, we need more people like you to motivate us. 💪
i am obsessed with youuu. you save life by teaching literally
I had biggest doubt about migraine medication and damnn ur video helped me to solve that🙌🥺I searched everywhere for that doubt but when u dropped this video I was like hell yeah now it will gonna solve for sure ❤️
Thank you so much for making migraine medications so easy to remember. As someone who expreinces migraine quite often this video gave me insight into the pathophysiology so easily as eating a cake. Thank you again. Looking forward to see a lot more videos in future. You are a saviour😇❤️
Thank you so much 🙏 for doing videos on much required topics for clinical practice...
Ninza Sir.... Please teach microbiology... There is not even a single good microbiology channel on youtube
Excellent! The best and most detailed headache lesson I’ve ever heard!!!! Bravo!
it gives such a joy to watch and learn from your video just because you enjoy while giving lectures AWESOME
Excellent content! Migraine HAs therapy can be complicated- and you made it simple! Thanks so much!
You guys rock 🤘🏻 excited to dive back into some of your content after my board exams to keep myself in the game
You’re doing amazing work! 🙌🏻
Thanks for this video, fantastic work!
thank you. can't explain how helpful that was.
Thank you so much for teaching so easily!
I really enjoy your videos, they helped me during paramedic class.
For me the ONLY thing that works is a cup of strong SASSAFRAS ROOT TEA. It has to be brewed with the Real root. Boil 1/2 oz. of chopped root for 30 minutes until water turns reddish. Tastes like root beer since this is how root beer was flavored for the first 300 years ever since the American Indians taught us Europeans about SASSAFRAS ROOT TEA. One thing Native Americans recommended SASSAFRAS ROOT TEA for was HEADACHES! It was WILDLY popular with migraine headache sufferers in Europe from 1687 to 1965 when artificial SASSAFRAS ROOT TEA was brought on the market. Since highly concentrated SASSAFRAS ROOT TEA is a mild hallucinogen and "tripping" was a big thing in the 1960's the FDA had to say something bad about SASSAFRAS ROOT TEA so after 300 years they called it "cancer causing" without any study but they needed some reason other than "Stopping people from having too much fun" which is not a legal reason. SASSAFRAS ROOT TEA is also the precursor to the street drug Molly or Ecstasy but it takes about 50 highly technical steps to super concentrate it to the level call MDNA.
In any case SASSAFRAS ROOT TEA was how they discovered Imatrix. It amplifies serotonin in the brain very rapidly unlike SSRI's which require weeks of use to increase serotonin levels.
You can legally buy Sassafras root cutting for planting trees on ebay or amazon. Its easy to tell if you got the real thing. Scratch root cutting with a knife and a strong rootbeer smell will come off. Also once cleaned and boiled in hot water it will turn the water red and has a strong rootbeer taste. Hard to fake and lets face it there is no need to fake it, there are billions of Sassafras trees growing wild and on private property in the Eastern USA from Michigan to Texas. Everyone who has tried real home brewed Sassafras root tea for ending a migraine has told me it works like nothing else can. Ginger root ALSO amplifies serotonin in the brain but not to the same degree Sassafras tea does.
Thank you Ninja Nerd team! Your videos are very helpful.
YOU ARE A GREAT HUMAN BEING.
Outstanding sir....!!!! Thank you
Lots of respect for you sir 🙌🙌
Thank you guys... U deserve more attention
I Plan to watch all your videos this summer
I love that my Professors link us to your content instead of giving us lectures. They must know you do it best!
i'm a medical student, and your video really helps me so much, thank you :"
Thanks a lot. I don't speak inglish but i can underestand every things your talking about and it helps me very much. Just going on as usual, you relly born for this. 👍
Amazing lecture thank you Zach ☺️
Could you make a pharmacology video like this for endocrine problems? That would be sick.
Buy a cefaly. Which is a trigeminal nerve stimulator worn on the forehead. I use it for 20 minutes a day everyday. It's gotten rid of the both the pain and the severity of my migraine attacks. You can also use it on the hour long abort setting if you have a migraine.
Hey you are a great teacher.
gracias, muchas gracias, eres el mejor explicando estos temas. 🥰
Thanks for great presentation
you really do a great job
Thank you!
Thanks for the lessons
Very good! TKS!
You help us alot, choose topics that are complicated.
Awesome stuff!
I have a migraine problem since I was teen age n I keep getting headaches frequently.. but I recently started to consume bioiron which contains iron. Vitamin c. Folic acid and b12 all in 1 supplement... I noticed past 1 month didn't even have 1 headache it's a wonder for me... Specially I get before n after my period but this time was shocking for me not to have migraine even once... Thank god
I believe our body vitamins deficiency and tensions can cause headaches.
Where can you buy this product? Thanks.
@@southbound5968 you can get it in any pharmacy.
Great video! 🔥
This is awesome!
Thanks a lot doctor
As someone currently with a migraine. This I'd interesting but imma have to revisit this later lol
So so smart guy!!!!
Love it 💞
I love your educational videos 🤩
They're informative and interesting in the same time!
Stay blessed sir...
Thank you
The only teacher i love so match♥
Honestly I enjoy your lessons, you are good at this ✊🏿👍
Great lecture 👌
Thank you very much
Great teacher highly talented
Thank you so very much. Angel sent
I love your videos! Thank you so much.
Metoprolol is a selektiv inhibitor of Beta 1 receptor. In this Video you say metoprolol is bindig to beta 2 receptors.
Yes,
Even i notice that.
Beta 2 act on lungs and breathing pattern. While beta 1 act on vessels and beats.
@@letsmakeit9710 For me the ONLY thing that works is a cup of strong SASSAFRAS ROOT TEA. It has to be brewed with the Real root. Boil 1/2 oz. of chopped root for 30 minutes until water turns reddish. Tastes like root beer since this is how root beer was flavored for the first 300 years ever since the American Indians taught us Europeans about SASSAFRAS ROOT TEA. One thing Native Americans recommended SASSAFRAS ROOT TEA for was HEADACHES! It was WILDLY popular with migraine headache sufferers in Europe from 1687 to 1965 when artificial SASSAFRAS ROOT TEA was brought on the market. Since highly concentrated SASSAFRAS ROOT TEA is a mild hallucinogen and "tripping" was a big thing in the 1960's the FDA had to say something bad about SASSAFRAS ROOT TEA so after 300 years they called it "cancer causing" without any study but they needed some reason other than "Stopping people from having too much fun" which is not a legal reason. SASSAFRAS ROOT TEA is also the precursor to the street drug Molly or Ecstasy but it takes about 50 highly technical steps to super concentrate it to the level call MDNA.
In any case SASSAFRAS ROOT TEA was how they discovered Imatrix. It amplifies serotonin in the brain very rapidly unlike SSRI's which require weeks of use to increase serotonin levels.
You can legally buy Sassafras root cutting for planting trees on ebay or amazon. Its easy to tell if you got the real thing. Scratch root cutting with a knife and a strong rootbeer smell will come off. Also once cleaned and boiled in hot water it will turn the water red and has a strong rootbeer taste. Hard to fake and lets face it there is no need to fake it, there are billions of Sassafras trees growing wild and on private property in the Eastern USA from Michigan to Texas. Everyone who has tried real home brewed Sassafras root tea for ending a migraine has told me it works like nothing else can. Ginger root ALSO amplifies serotonin in the brain but not to the same degree Sassafras tea does.
thank you
You are the best!❤
Thank You
Thankyou so much sir ❤❤❤
can't thank you enough really
Thanks dr
INCIDENTALLY, which book would you recommend for freshman and sophomore students who are eager to learn anatomy and physiology?
I would recommend Moore's anatomy textbook for anatomy and kaplan physiology
Vishram Singh for anatomy and Guyton for physiology
Vishram Singh for anatomy and ganong or guyton for physiology
Thanx a bunch
Content aside, cause its always amazing, I just gotta point out that your sleeve is DOPE! I haven't noticed it so I'm assuming its relatively new.
Hats off to you 👍
Oh it is very nice to this zach
Well, that was much better than what we got in medical school, which was basically “just throw drugs at everyone until you reach toxicity“
I have migraine and Sumatriptan works for me in 20 minutes on empty stomach. I also take Atenolol which helps reduce the frequency.
Very good
Thanks your the best keep going
Zach please make more neuro pharmacology lectures like cardiovascular
I’ve suffered since the age of 9 . I was placed on PTU . As a teen I couldn’t stand bright lights nor some days but as I got older it died down a bit . From 2013 ( Fiorcet helped until no more migraines , do not take no more than 10 pills in a week)I didn’t suffer and lately 2020 to present 😳oh God 👀 . Can’t seem to get them anymore and don’t like taking any meds especially if I don’t know how it works. Ugh
Please make more videos on pathology
Great 👍🩺❤️
Dear Dr. Ninja, I have a question please, Could the long term use of my 'triptans' /often weekly, and Ibruprofen more frequently contribute to osteoporosis? I'm suspecting the interference with CGRP. I'd be so grateful for your feedback. Julie RN
Lot of love.
Pls more vedios on pathalogy
It would be nice to know what all the migraine sufferers who commented under this post ... 1. What treatment they tried. 2. Was it successful for them and 3, Are they still taking it.
Omg 😱 you’re awesome 👏🏻
Anyone know if there’s a specific lesson on the CTZ (Chemo Trigger Zone)?
I got a question to ask about metoprolol, on the prophylaxis part it acts on beta 2 receptor for this case or ? Because I know it is a beta 1 receptor blocker
Sir sufficient intake of caffeine is supportable for the treatment of migraine because it block the formation of prostaglandin e.
God bless you, I love you
If you have hypermobility syndrome, and/or are over 6 ft tall, and/or have ever had an epidural of any kind, and have watched this because you have mystery headaches, fatigue, chronic confusion, or POTS, or think you might have fibromyalgia, you should also watch “The Mystery Headache: Migraine, positional Headache, Spinal Fluid Leak?” By Dr Ian Carroll at Stanford. The last few minutes include an invitation to contact him and his email is supplied.
best channel
can you please make full detailed video on meanure's disease
What about the use of triptans in hemeplegic migraine? I found out it was contraindicated with this type of migraine. I guess it is because of the severity of the vasoconstriction in the aura phase of the migraine? Are all medications with a vasoconstrictive effect contraindicated in this case, including porpanolol or other beta blockers? What options are there then? Nsaids are certainly not as effective as triptans in my experience. Botox?
happy about it
Can you please upload other CNS pharmacology videos
Antipsychotics
Antidepressants etc
(These videos are very useful for me to remeber hard theories)