Sodium Borohydride in Organic Chemistry | NaBh4 Details| Explained by IITian | Mains, Advanced| NEET
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- เผยแพร่เมื่อ 24 ก.ย. 2024
- Hello guys, In this lecture we are going to discuss a very important, selective and versatile reagent for IIT Jee Mains, Advance, NEET, AIIMS and Chemistry Olympiads, it’s non other than NaBH4.
Sodium borohydride is a good reducing agent. Although not as powerful as lithium aluminum hydride (LiAlH4), it is very effective for the reduction of aldehydes and ketones to alcohols. By itself, it will generally not reduce esters, carboxylic acids, or amides (although it will reduce acyl chlorides to alcohols). It is also used in the second step of the oxymercuration reaction to replace mercury (Hg) with H.
lithium aluminum hydride (LiAlH4) although less reactive. For our purposes, sodium borohydride is really useful for one thing: it will reduce aldehydes and ketones. In this sense it traverses one rung on the oxidation ladder.
The mechanism of the reaction of sodium borohydride with aldehydes and ketones proceeds in two steps. In the first step, H(-) detaches from the BH4(-) and adds to the carbonyl carbon (an example of [1,2]-addition). This forms the C-H bond, and breaks the C-O bond, resulting in a new lone pair on the oxygen, which makes the oxygen negatively charged (FYI: we call these negatively charged oxygens alkoxides, as they are deprotonated alcohols). In the second step, a proton from water (or an acid such as NH4Cl) is added to the alkoxide to make the alcohol. This is performed at the end of the reaction, a step referred to as the workup.
I suppose I should also mention that NaBH4 will reduce acyl halides to alcohols, but things are a little lengthy here already.I also won’t go into the detailed arrow pushing for NaBH4 in the oxymercuration reaction. But the key point is that the carbon-mercury bond is broken, and a new carbon hydrogen bond is formed, and it is NaBH4 which performs this reaction.
In this Lecture, Many important functional groups have been reduced by NabH4:-
Reduction of aldehydes with NaBH4
Reduction of Ketones with NaBH4
Reduction of acid Chloride with NaBH4
Reduction of ester by NaBH4
Reduction of imide with NaBH4
Reduction of dihydrouridine with NaBH4
Reduction of c=n with NaBH4
Reduction of imine with NaBH4
Reduction of ozonides with NaBH4
Reduction of azides with NaBH4
And many more functional groups with detail mechanism has been discussed in this session by MKA Sir.
Some other great reducing agents for Jee and NEET.
LiAlH4 in One Shot | Concept Booster | Explained by IITian | Mains, Advanced | NEET | AIIMS
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DIBAL-H in Organic Chemistry || Explained by IITian || Jee Mains | Advance | NEET | AIIMS
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MKA Sir
I don't know, why people dislikes such a beautiful content for jee and neet.
Being an University professor, i can say, this is the best content on Sodium borohydride.
Good going champ, MKA Sir.
Thank you Sir.
😊
Actually sir , they might be in opposite party.
They might be from Dushyant Kumar side(paisa )
They are bots.
They are Commerce Students 😂😂
*my whole jee life i thought of the reason of nabh4 in OMDM :)*
Kehna kya chahte ho 🤡👉👈
To demercurate by Hydride ion in the second step
The greatest online educator we have. Blessed that we have a teacher like you. Crystal clear concepts! Sir like akhil said pls make a video pn sn1 vs sn2 vs e1 vs e2.. 🙏 Also more videos on inorganic
True
God of Chemistry...
How you know this much depth of everything.. 😎
Shaandaar....Jaandaar 🤗
He is man like others not a God minded, stupid.
Thanks.
But, I am the guy like you. 😊
@@IITianexplains but sir ur work and affords are awesome
@@Musayyab_Ali. That complement was just to praise the level of MKA sir teaching organic . Don't get too much religious , try to be religious in your study
when after spending lacs in coaching you come on this free platform seeking QUALITY content.....
THANK YOU GURUJI.
You’re welcome Sarvesh 🙂
*SIR CAN U PLEASE MAKE A VIDEO ON SN1 VS E1 AND SN2 VS E2 , it really confuses us alotttttt, i have scored alot negative marks by this please make a video on comparison* !! Pls sir
Like it guys if u also want!
Yep, Those Concepts are Tough To Understand But Waiting For IITIAN Explains Lecture
go to physics wallah , acha h wahan bhi
Yes,it is good.
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I want that as well
One of the Best content on TH-cam
Sir aap ki smile bhut achi lgti hai. .plz comment padhte padhte smile dijea
Sir please after completion of reagent series...make 1 video on all reagents' typical questions..so that it becomes crystal clear
Yes
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Amazing sir, no one else has covered NaBH4 in this depth and detail! Thank you very much!!
This type of content are not delivered by most educator even after paying money and U are giving it for free.
Dil se shukriya sir ji❤️❤️
Sir ....apki class dekhte dekhte 200 page ki 2 copy Bana li maine..🙏🙌 🙌
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I improved my organic from 0% to 75% because of you...and trying to make it...to 99%🙌🙌🙌🙌
Dhanyavad guruji.....
Ur efforts mean a lot sir...thank you from the bottom of my heart 😊
Sir please make video on ring expansion...
Thanku sir. Mujhe DIBAL-H ka question aaya tha 9 jan ko thanks sir pls continue your series ..👍
Hm apke video ka wait krte h plzzz upload krte rhe hma bhala ho rha h Or thanku so muchh sir love you 😘
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Thnx
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Yahi ek chanel pe mujhe laga h ki Sahi adv. Level ka padhaya gaya. We love you sir. need more
Love from West Bengal 🇮🇳🕉️
The Best Video on NBH on yt. Thank you sir for your efforts.
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Sir
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Asalamualikum sir
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See in solomons organic chem book
Never experienced such a great teaching. Hats off sir
Ek common video of LiAlH4 vs Dibal H vs NaBH4.
SO THAT WE CAN GET SIMILARITY AND DIFFERENCES AMONG THEM
👇👇LIKE👍👍👍👍
teeno ke video bana diya hai, khud se compare nahi kar sakta kya?
Not needed at all
Not needed
@@ritwikgupta1288 kiske paas teno lambi videos dekhne ka time hai.
Maine to ek bhi nahi dekh
I just commemted here,not even seen this one.
@Shaunak Deshpande yes its true.
guruji apke jaisa teacher mil jaye phir iit kya mit pahuch jayenge thank you sir blessed with your videos
Best organic chemistry teacher
🙏❤️
Also , NaBH4 can reduce double bonds conjugated to cyclic ketones ( double bond present in ring).
Example : cylcopent-2-enone On reduction with NaBh4 gives cyclopentanol in 100% yield.
This reduction goes via Michael addition or conjugate addition.
Bro which book i want to know the refrence.. I think you are right as i have read somewhere
@@Motired08 Clayden or John March. It's in both
That's a different case. 😊
Physical parameters and solvent plays a great role in reduction.
We will try to make such auxiliary videos on Michael reductions, Luche reduction etc..
MKA Sir
@@IITianexplains I studied all these for Incho so maybe didn't look so much into physical conditions. Thanks!
OUTSTANDING LECTURE ,, SALUTE TO YOUR MIND BLOWING CONCEPTS ,,, SIR.THANK YOU
I have never seen this type of study guruji mujhe bhi aapke Jaise banna hai mujhe blessings de guruji mujhe aashirwad de gurudev
Sir at 38:12 for reduction of acid halide actually methanol solvent is not used because methanol reacts with acid halide first and forms an ester. So it cannot be reduced after that. Instead diglyme solvent is used.
Aap super se b uper hn Sir ❤❤a lots of love to you Sir thank you Sir 😊😊
In local coachings NaBH4 reagent ONE REACTION......IN IITIAN EXPLAINS NaBH4 ONE HOUR.....thats the speciality of MKA SIR.....INDIA IS REALLY LUCKY TO HAVE A TEACHER LIKE U....TH-cam IS LUCKY TO HAVE a channel like IITIAN EXPLAINS...
We are very fortunate to have a mentor like you.............SIR CAN YOU MAKE VIDEOS ON ALL TYPES OF SN REACTIONS......LIKE SN1, 2, SN Ar etc....... so that our basics get almost cleared.......
The most fabulous and contented lecture on NaBh4... 🙏
U are the Einstein of chemistry
Padte rahengay aage badte rahengay 😁
Thanks to mka sir
Thank you so much sir. In the same way pls make videos on solving advanced level questions
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Sir can u make a video on Fenton's reagent??
Thanks sir ...please make video on NaOH also ...
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never any book can explain as you(sir)
Sir Complete This Series On Reagents For JEE ADVANCED 💜💙
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If my school teacher had even have 10 % of your knowledge I would not have skip a single class of her.
Thanks for your help and love sir for the children like me who are not having good content
that trick of omdm WAS SO FUNNY ..wt an AMAZING TRICK .. OVERALL WHOLE LECTURE WAS FULL OF CONCEPT AND KNOWLEDGE.THANKS FOR THIS PRECIOUS EFFORT SIR.
Thank you sir we will wait next reagent
sir amazing
pls makr a video on clemmensn reduction
Thank you sir plzz try to make more vedios according to January mains
Sir!! Your lectures increase my love towards organic
Your detailed concept make me so strong at organic
First view and like
Thanks sir
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Sir why B- IS MORE STABLE THAN Al-
Jabki F- IS LESS STABLE THAN I- ???????
And also al ki electron gain enthalpy > B ki electron gain enthalpy 🤔🤔🤔🤔🤔🤔🤔
Same doubt 😢😢
Bro aluminium is metal, why will it be stable with negative charge?
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I am preparing net/slet/gate sir
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thank you sir ......
Keep going on....
I am preparing in home and i am following you day by day
*Sir why smaller the cation better the RA* ?
ab iske bad wala aap kya coordination chem per denge ?
Thanks guru ji.
Great sir
no one can give content like you sir...
superb...
Doesn't LiAlH4 reduce ozonides??
Yes, they do.
Sir please make video on stereochemistry
From basic to advanced level
And concept booster questions from stereo
Please sir🙏
Sir kal sai wait kar raha tha viedo ka
Sir goc karva dijiye
Great personality with huge knowledge.....You rocks....😘😘
49:00 Weirdly enough, if you form aldehydes by the ozonolysis of Alkenes and perform NaBH4 on them, final results will be the same.
In all EXAMPLES!!
Sir , i was very weak in this reagents concept , But because of u ,now i am able to solve any problems related to this concept
thank you sir
Thank u sir for making videos next by next in series it helps me much
Sir H2 as reducing agent ka video pls banaiye, bahut confusion rehta hai kab Palladium ke saath kya hota hai Nickel ke saath kya hota hai
Sir u r the best teacher in the world thank you very much
U r my favourite sir
After giving JEE mains January , I had lost all hope for organic chem as I was not able to solve any questions of JEE but now after watching so many quality videos of MKA sir , I really am feeling confident for Aprils exam .
I cant just thank you enough for all your efforts!
Sir could you possibly make a vidoe on all tests like Lucas test,azo dye test, Fehling soln, 2,4Dnp test,idoform test etc please sir
Thank you a lot sir,waiting for it video
Nabh4 aaj khud reduce hogya 😇
sir board bharne ke baad 1 baar samne se completely hat jaya kijiye, notes likhne me problem hoti h.
wese aapki videos me itna kuch hota h ki kya baat h, thanku sir, ise ppart time nhi full time bna lo
I learn something new in sodium borohydride but we missed it's stereochemistry
Please sir also add the stereochemistry of reagents .these lecture help very much in preparation of jee advanced thank you sir for guiding self study student who read at its home
Sir Thank you so much.....u my only one online favourite sir....Apki teaching meri purri career Mei yaad rahega Thank you a lottery Sir .
At last I understand nabh4
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Sir how we remember characterstics of all organic reagent and sir which book will be the best book for organic chemistry for jee main and advance
Sir plzzzz make a series of vidio on natrul product and photochemistry
This is very helpful to us ......thank u
Realy u are Superman of chemistry