Journal Club: Metabolic Overdrive in Bipolar Disorder | The Metabolic Link Ep.51

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In this journal club episode of The Metabolic Link, we explore the "Metabolic Overdrive Hypothesis" with Dr. Dominic D'Agostino, Dr. Angela Poff, and Victoria Field, diving into the brain’s energy dysregulation in bipolar disorder. The featured paper, "The Metabolic Overdrive Hypothesis: Hyperglycolysis and Glutaminolysis in Bipolar Mania", by authors Dr. Iain Campbell and Dr. Harry Campbell, proposes that mitochondrial dysfunction forces the brain into a hypermetabolic state, leading to manic episodes.
We discuss how this groundbreaking research links bipolar disorder to epilepsy and how therapeutic ketosis-through diet or supplementation-might restore energy balance, reduce manic episodes, and complement traditional medications.
With the potential to reshape psychiatric treatment, you won't want to miss this paper or journal club episode! Read the full paper here: www.nature.com...
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In every episode of The Metabolic Link, we'll uncover the very latest research on metabolic health and therapy. If you like this episode, please share it, subscribe, follow, and leave us a comment or review on whichever platform you use to tune in!

[@dyaneharwood2023]

This is a fascinating analysis, and I learned something new about glutamate!! As someone who has postpartum bipolar and has done a vegan ketogenic diet for two years, I’m so happy that you chose this topic.

[@rayannecharlie9593]

Thanks guys! I am grateful for the information and am gaining valuable insights for myself, my family and my community. Many blessings to you!

[@dyaneharwood2023]

I think the well-formulated vegan ketogenic diet I’ve been practicing complements the lithium and the MAOI tranylcypromine I’ve been taking since 2013. I was interviewed about my experience by Dr. Iain Campbell and Matt Baszucki on episode #23 of the Keto Bipolar (formerly Bipolarcast) podcast on TH-cam.