A Biological Switch that Drives Obesity, Diabetes, and Dementia | The Metabolic Link Ep. 39
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- เผยแพร่เมื่อ 22 เม.ย. 2024
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In this episode, recorded at Metabolic Health Summit 2024, Dr. Richard Johnson dives into the groundbreaking research that has uncovered the central role of fructose in driving the epidemics of obesity, diabetes, and a wide range of other metabolic diseases.
Dr. Johnson presents compelling evidence that fructose, a seemingly innocuous sugar, is in fact a key trigger for activating a powerful biological survival switch. This switch, evolved in nature to help animals prepare for times of scarcity, is now being inadvertently activated in humans by our modern high-carbohydrate, high-sugar diets.
Through detailed scientific explanation and insightful case studies, Dr. Johnson illuminates how fructose's unique metabolic effects - including its ability to lower ATP levels, induce leptin resistance, and promote fat storage - are the driving forces behind the rise of metabolic syndrome and its associated conditions.
Equally important, Dr. Johnson offers practical dietary recommendations and strategies to help individuals navigate this complex landscape, emphasizing the importance of reducing sugar, refined carbs, and processed foods, while embracing a low-carb, nutrient-dense approach.
This eye-opening episode is a must-listen for anyone seeking to understand the root causes of the metabolic health crisis and learn evidence-based solutions to reclaim their wellbeing.
Special thanks to our sponsors of this episode:
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Good presentation. However, I must disagree with one thing. It is possible to be completely satisfied on a zero carb diet. I'm almost one year carnivore, and don't see myself ever switching back.
It's great not being run by cravings. I wish I had known sooner. I am never going back to carbs. It's hard to believe that desserts no longer interest me at all when I was a sugar addict my entire life!
Great to hear about your success with carnivore!
82
All the glycogen from meat is gone?
If you run into problems down the road, look into Dr. Barry Sears and his Zone Diet as a potential high end of low glycemic, nutrient-dense, natural carbs once your mitochondria’s carb processing mechanism recovers a bit.
Processed carb overload is demonic.
Morley Robbins and Dr. Chris Knobbe have good info as well.
What a loooong introduction ... jump to @6:54 , here is where Professor started the talk
Thanks
Thank you
Thank you, wish all videos on yt had a "skip intro" option.
@@DessicatedCadaver That's an excellent point indeed
Thank you so much.
I've been studying low carb and carnivore for 6 years now, learning from all the best people, but I have to say that this is one of the most comprehensive presentations that I've ever seen. It really brings all the factors together in one overarching theory. Brilliant !
Around 15 years ago I read Gary Taubes’ view that people who ate traditional diets didn’t get our diseases until they started importing sugar, flour, and seed oils.
This scientific presentation deserves all the gratitude and reverence because it is at a similar level of human endeavor, reflecting the same level of dedication, intelligence, passion, brilliance, and excellence as the artworks of Picasso, Leonardo da Vinci, Michelangelo, Antoni Gaudí, Johann Sebastian Bach, Vivaldi, Chopin, etc. We live in wonderful times.
I'd love to see a discussion with Dr Johnson and Dr Seyfried. It would be interesting.
I loved Dr Johnson's book, and I loved this presentation, and the thing that I love most is his evolutionary reasoning. We, and other animals are what we are because we developed internal processes that gave us a survival advantage. One of the main points, to my mind, is that we developed fuel storage from Fructose (like bears) to get our stores up to get us through the Winter. The big problem for us is that we are getting Fructose all the year round. A bit from fruit, but mainly from Colas, Sodas and UPF including breakfast cereal. Anything with Sucrose in it.
HFCS, honey, agave syrup, maple syrup, molasses, etc. Ultimate storage form of food is fat. Our body doesn't store proteins nor amino acids, and the high nitrogen content also means high uric acid levels and stress on the kidneys!!!
Dr Johnson hit a grand slam here. I have tried to watch ALL his presentations - he is so earnest and knowledgeable. Here, more so than any other video, he has tied it (almost) all together. It would be fabulous to see his"extended" version where he addresses all the other pswitch triggers, especially alcohol (probably tying in Dr Lustig's Sugar, A Bitter Truth masterpiece). His team's research, the explanation of our pathways, and the ties to our evolution give a believable big picture of what the heck is going wonky with obesity. Thank you for posting this, MHS.
Absolutely excellent. His narrative is complemented by slides with enough info and easy to absorb. This is how technical stories should be told.
This was amazing & eye-opening…. When I first got Long Covid, I put on 30 pounds seemingly overnight, as well as extreme thirst (despite drinking 2 liters+daily) and craving salt…. Fascinating tie-in to mitochondrial dysfunction, and oxygen deficiency due to micro clots. Thank you for this informative presentation.!
Thank you for sharing! We hope you're feeling better.
Intriguing, but I think seed oils are the main cause. Sugar intake has been dropping for years, yet obesity rises
Thank you for making this lecture available! ❤❤❤
Thanks so much for watching!
I believe in humane outreach. Carefully chosen, people can be moved to consider a new way of thinking.
The problem here is that people love the taste.
Some people love the taste, and think that's the reason they eat it so much. We know better, but yes, we love the taste. How to convince someone that life can be worth living without the constant taste of sugar? One approach is to say "no, it's not a matter of never. Once you get stabilized after the initial fast some weeks, you will be healthier, you will feel the difference, but still want to have some sugar. Fine. Once a week, like people used to do in the old days, Sabbath meal, for example. You're healthy now. All you have to do is make sure it's rare and moderate." That's not a bad approach. It's actually worked for me.
Richard Johnson deserves a Nobel Price
I just eat red meat and berries once in a while. I have dropped 80+ lbs, got off T2D meds, and the ones associated with obesity. I went from 42 waist to 32, and there's NO going back for me! Lol
Do your own N=1 and see what works for you.
Personally, I quit all man made foods, including veggies and fruits. They are not the same as they were when I was younger....cheers, and good luck!
I am wondering what you eat, if you only eat red meat and berries once in a while and no man made foods including fruit and veg?
@@janeabbotts The OP said what they eat . . red meat and berries. Red meat is pretty much any ruminant, and berries are, well, berries. I tend to eat mostly blueberries, but occasionally dip into strawberries, lingon berries, etc, whatever seems to be available at the store when I go looking. And, the berries should be organic only. Apparently berries absorb pesticides, etc, very easily into their skins.
@@ChromeForDays They said..'I just eat red meat and berries once in a while'. Period. Then they went on to say how much weight they have lost etc. Then they went on to say they have quit all manmade food including fruits and veg. So as they have written it they only eat 'Red meat and berries once in a while' and eat nothing else. Perhaps the 'once in a while' was not intended/true. I just read it as it was written.
@@janeabbotts More than likely the "once in a while" just means they do some form of intermittent fasting/time restricted feeding. Usually when folks start eating this way they naturally begin to spread meals out more as they're just not hungry. It's not uncommon for me to not eat for a day or two.
@@ChromeForDays I was commenting on what was written, not what may have been meant. Thank you for your replies. Cheers.
Well, it's as people used to do in the old days: pies and cakes, etc, were for Sabbath meals only. Looking forward to the Sabbath was to look forward to the food you weren't eating during the week. Festival Foods. Sugar is fine once in a while. Even Dr. Lustig says that. It's all about the chronic load.
is this the Unified field theory of metabolism?
Thank you for this content. We have an epidemic of metabolic diseases. And we are fed a dangerous industrial diet.
Outstanding presentation.
Excellent presentation. I’m going to watch again
Refined Salt, BAD.
Unrefined Salt, GOOD!
Excellent presentation, thanks!
We're glad you enjoyed it!
Very good presentation! It was very informative of novel data and mind-blowing at the same time!! Great job, everyone!
We're so glad you enjoyed the lecture!
Fascinating: I've started adding MSG to my keto foods to be able to eat more of what I'm supposed to be eating. Often I can't get enough to keep my hunger/cravings under control. I don't put MSG to anything else.
Also adding allulose in higher amounts to anything I can sneak it in to sauces, yogurt, berries, even stir fry. It has an almost immediately noticeable effect on satiety.
These talks have had real life impact on those of us doing n=1 nutritional studies on ourselves!
This was one of the most informative presentations I've ever seen. Thank you.
Skip forward to 5:57 to dodge the long-winded ads.
So, finally we are there. Very nice, great lecture for itself, great content, thanks for uploading. As a biologist in the health business I appreciate it very much. new for me: the role of salt.
fructose is a fascinating piece of matter, as it serves as a messenger, linking plants, their ecology and animals up to their behavior and deep metabolic regulation. so its more like an information matter. it provides a completely new perspective onto all the ecosystems biology.
It could be interesting in this regards, however, to take a closer look to orang utans. They forage figs, which appear highly clumped = tree wise, all year over. And so, orang utans clump on those trees.... feasting, yet, they stay lean, very lean indeed.
about us humans: We urgently need to create GMO plants that produce more oleic acid, instead of O6. If you calculate the number of calories consumed worldwide as bad oils, and carbs, you will find that there is by far not enough such that everyone could eat healthy. And I don't like GMO at all...
Allulose put me in the hospital with serious liver attacks. It can be an absolute poison for some people. It will take time for people to realize
What a wonderful and comprehensive presentation! Thank you Dr Johnson.
Thank you ! 😊
So interesting!!! Thank you
Incredible presentation, low carb moderate protein seems like the way forward
Fantastic,!!!
I like prof. Tim Noakes' model of human metabolism. We primarily run on fat and ketones leaving glucose for tissues that need it exlusively.
Great informations regarding all the evils of modern ill health, bundled in just one lecture by Prof. Richard Johnson. Thank you.
Amazing presentation. So useful in understanding obesity.
Fascinating
I am NOT worried about fruit supplying sugar I AM WORRIED ABOUT CHEMICALS
Gonna stay worried a loooong time
I too will listen to this again, so packed with information, and in a very understandable way. So many mechanisms at play rooted in survival that in our world of abundance turn to excessive behaviors in humans.
But that’s why we have a brain, we can make informed choices, whereas animals are just working on instinct .
So interesting! Thank you.
His take on lowering salt intake was confusing to me. I believe he said that salt would not cause you to get fat if you were on a low carb or carnivore diet. In other words, salt, in the absence of sugar, was not a problem. So, if you're on a carnivore diet for instance, can you eat all the salt you want or should it still be minimized.
So if I stop eating carbs and fructose then salt has no effect, but we still blame the salt and should reduce it? Doctors have a strange habit of coming to opposite conclusions from their own data. Salt is a required nutrient, carbs and fructose are not. Your heart will literally stop beating from hyponatremia.
I have an ice cream machine that I haven't used in a long time because I stay away from sweet things since carnivore, but I will now use it once in a while with allulose as the sweetener, since both cream and allulose are healthy.
38:40 How do you reconcile the "salt = bad" statement with your LMNT endorsement?
His presentation in about the effects of carbohydrates in the diet. At 38:40 He's talking about how salt can trigger the process for carbohydrates to be stored as fat (and other effects,) with examples of salted carbohydrates as 'bad foods'. Salt is essential for us to function, and if someone is on a consistent low carb diet they will likely retain less salt in their body (than someone with higher insulin levels,) and will need more salt in their diet, LMNT could be an appropriate supplement.
The suggestion that elopement behavior by those with Alzheimer's is induced by fructose is fascinating. That it is, in effect, foraging behavior with risk taking.
Excellent presentation! I do not agree with Dr Johnson trying to create a way to disable what fructose does so we can continue to eat too much of it. Haven't we learned that we shouldnt muck around with nature using pharmaceuticals?
Eating sweet tasting foods drives the craving for more. After 60 years of being a sugarholic, and now 2 years Carnivore, I no longer crave sweets at all and do not feel like I am missing anything. I do use Dr Berg's electrolyte powder which has a small amount of organic stevia ( no aftertaste). I do not find this to trigger cravings.
Dr Johnson is addicted to sweet taste and should come out and admit it. He hasnt even tried Carnivore, so he doesn't know how good you can feel. That is why so many people on Carnivore never go back to Carb eating.
I don't think that Dr Johnson is advocating a drug to turn off this process but rather making the necessary changes to your diet in order to turn off the switch.
It seems that a ketogenic diet is the most efficient tool along with carnivore
What the? This is a game changer. Get use to different.
First error detected: Fructose doesn't block ATP formation but rather uses up ATP twice as fast. Fructose is 100% metabolized by the liver and after absorption Fructose disappeares from blood extremely fast. These observations point to the fact that Fructose is phosphorylated very fast resulting in rapid accumulation of ADP, then AMP, then IMP and then uric acid. Glucose however is utilized by all cells of the body and only 20% handled by the liver. The liver preferentially converts the glucose into glycogen which it can hold as much as 100g. It takes much higher and faster intake of glucose to match the detrimental effect of fructose in elevating uric acid levels.
The later metabolic path also overwhelmes the citric acid cycle (also knon as the tricarboxylic acid cycle) so that citric acid escapes from the mitochondrium and be converted into saturated fatty acid. Dr. Robert Lustig said about 30% of fructose will be converted into fat. This is how fructose can cause fatty liver and obesity.
There are several counteractive hormones to raise blood glucose but not blood fructose.
Not good to be carnivore with kidney issues, any experience or expertise or suggestions?
I like when we see something that ties us back to our environment. I have long thought that in temperate climates, fruit is only available towards the end of summer/early autumn and would make an ideal way to fatten up for the winter months when food is in a much less plentiful supply. Bears are an extreme example in that they hibernate, but pre-agricultural man would have needed extra fat to last out the winter. The fact that our bodies evolved to latch on to fructose as being a ‘store as much as you can’ signal makes perfect sense.
It would be interesting to set this down against populations in tropical climates where fruit is readily available 365 days per year. We can see that Asians were (and to an extent still are) typically skinnier than Caucasians even though they would have a higher fructose diet all year wrong. We know that for example, many Asians have trouble metabolizing alcohol as they lack an enzyme used by the liver. It is highly likely that there would be other metabolic differences given that for hundreds of thousands of years they lived in a different climate and thus were exposed to different foods than most westerners. Incidentally, obesity is now a massive problem in Asia and if you go to the average supermarket in Asia, the aisles are full of the same ultra processed garbage as those in the west. Equally, they cook with seed oils now (which is of course a more recent thing as it is for the west). Not to mention sugar sweetened beverages etc!
Put the ads in later in the video
We appreciate the feedback!
This is interesting - I see PTSD symptoms are also exacerbated due to its ADHD-like symptoms in many of us. Not being sugar orientated I notice that my medication makes me crave huge bags of crisps, and then I suddenly fancy of sugary rounding off of the snack-fest. Roll on the day when the medication options cease mess up your metabolism. Anybody else notice that medication is always the unaddressed element though, on presentations on metabolic health.
Carb is not a food group
Yes it is. All grains, legumes, fruit and veg
All the bad eating habits mentioned 12:26 are true concomitantly!
For me, LMNT really helps reduce nighttime muscle cramps. But if I have too many anti-nutrients (the tannins in chocolate, coffee, & green tea, etc.), then LMNT only limits them 😢
I couldn't handle the excessively salty and stevia aftertaste of LMNT. I use Dr Berg's electrolyte powder. This brand has more potassium and he uses a form of organism stevia that doesn't have an aftertaste.
Great to hear it's been helpful with your cramping!
I just add citrates of potassium, magnesium and calcium to my distilled drinking/cooking water. Always enough electrolyte throughout the day.
WFPB 4 LIFE. All leg issues will disappear.
@@WFPBFORLIFE?
Drama @ home can reck a diet , make u eat to much or to little, make u want strong drink 🍸 or something else but it effects a diet !
It's called Coritsol and yes it's triggered by streess/drama. A death in the family and boom 30 pounds came rushing back. It's all cortisol and now coming off again.
We were exercise nuts & even still , y were skinny, no meds , 💝🚴♀️🎶🎶🎶🎶🎶
Perform a SKIN PICH TEST on the back of ur hand, if it tents then u r dehydrated. If ur urine is clear u r dehydrated. After urinating have a glass of water. Things the doctors should have told us.
Actually clear urine is from having an abundance of water. Dark yellow and strong smelling urine is concentrated from dehydration
5:51
I’m not sure I can watch long enough to get through the ads. At least get me interested first. Think I’ll move on
He say at 18:56 that the animal starts eating "more than it should". This has to be fundamentally incorrect, nature does not work that way. The animal starts eating "just as it should" to increase fat to be ready for the coming season when food will not be available.
Also, by not adhering to this natural rhythm - humans in the modern world no longer spend their winters eating less/moving less, we have to work/socialize, etc - are we fundamentally f'ing with how we should be living? I find all of this so interesting.
@@kimberlyf4888well, it can be argued that no matter what one does, it is what one should be doing. In the end, “should is just a concept. Take it out of the sentence and you’d have me something like: the animal eats more. The “should” is meaningless.
👏
34:00 I don't doubt this gentleman is extremely learned and educated about his topic but I do object to one of his conclusions; that salt is bad for humans. We've been down this road before. If you eat natural raw mostly unprocessed salt I believe you'll be absolutely fine, in fact you'll be extremely healthy.
Over-processed and relatively dead table salt may be an issue for some salt-sensitive individuals but the body needs its electrolytes. It needs its healthy salts. The body can go into cardiac arrest or have other severe health complications if the body becomes too depleted in electrolytes and salts. Just like we do best, in my opinion, on a high natural healthy fat diet and I believe that people experience complications when they go into an extremely low fat consumption pattern, I feel a similar thing is true regarding salt intake.
So I feel that it would behoove the average listener, who may just starting to educate themselves about basic health and nutrition, to differentiate between the incredible health benefits in my opinion of full-spectrum natural unprocessed mineral-containing salts and their importance in our bloodstream, and highly processed commercialized table salt.
I feel this is a pretty crucial distinction. It's like the difference between highly commercialized, adulterated, industrial-produced and processed pasteurized milk from a typical high-capacity commercial dairy, versus raw unprocessed dairy and milk straight from a healthy animal. One is extremely nourishing and healthy, and the other as far as I'm concerned is just inert.
I really want to hear this. But I've been listening for 20 minutes and I'm only 6 minutes into the talk... the rest is advertisements. I'm trying to listen while cleaning, so I'm not near the "skip" button. Irritating.
Shut The Front Door!! Salt!?
If fructose makes you fat explain all the skinny fruitarians and if starch makes you fat explain all those on ‘The Starch Solution’ who are leaner than the speaker.
If you eat high fat and high fructose then the liver is processing all the fructose and fat will be stored. This is my understanding, feel free to correct.
That is why fruitarians are skinny - no fat.
I like to add some, not a lot, miso in some foods and it is said to be good for your gut; but Dr. Johnson does not favor umami flavor.
I had fibromyalgia, IBS, chronic anemia, depression and brain fog for over 30 years. When I went on Carnivore WOE all of it went away. The fibromyalgia was caused by eating oxalates in the veg and nuts. The IBS was caused by the fiber and lectins.
My gut microbiome gets fed directly from the butyrate in my bloodstream .
We are not able to absorb the form of iron that is in plants, that is whu I was anemic on a plant based diet.
Plants also do not contain B12 and essential fatty acids in bioavailable forms. Meat is rich in all of the B vitamins.
Also, the beta carotene in plants is not vitamin A. It must be converted to the active form of retinol. Over 40% of people lack the gene to convert any. The rest can only convert a very small percentage.
A diet without meat is not biologically appropriate for humans. We can only get the nutrition we need from animal meat and fat unless supplements are taken. What other animals in nature has to take supplements to be optimally healthy?
Modern fruit is very high in sugar/ fructose. The body processes it as it does all carbohydrates. It raises insulin and the fructose is converted to fat and uric acid causing the problems Dr Johnson described.
not possible. You are dreaming
he sez watching tv is associated with obesity...you could dd adementia too...🤡...lots of water is best with appropriate trace minerals
Damn, I bought The Fat Switch, and I gave it to Dr. Adam Nally...
Mmm several minutes in still advertising. Need summary. No time
I agree I thought it was a bait and switch. You have to skip the first 6 minutes to get to the talk. if I wanted to watch ads I wouldn't be paying for premium. Did she steal this video?
@@CP59FITthis video wasn't stolen. The host in this episode is one of the organizers of the conference that invited Dr. Johnson to give this presentation and provide it to the public for free. Our podcast partners help us make this type of free content possible. Our premium content is ad-free and some of it is CME eligible. You can find it on our medical education platform, The Metabolic Initiative, here: membership.metabolicinitiative.com
American healthcare, quite disgraceful. Life’s too short. Switch off and grateful for the NHS UK.
I pay TH-cam premium, I do not expect to be bombarded by ad.
Can you get your tests without a Dr... Cause my Dr won't sign off on anything. He won't even test my glucose and insulin.
Meat meat meat only for me oh and salt lots of it heaps of fat I've never felt better lost a ton of weight too😂
Interesting discussion but like so many of these talks they don't explain why Americans are fatter than the French or why our grandparents were not obese. They all ate Jam and tarts and pastries every day. Afternoon tea always came with a cake or biscuits. Noone was obese and noone had diabetes. Cancer was rare, as was heart disease. Malnutrition and contaminated water were their only worries. When is someone going to talk about the negative impact of vaccines? They correlate with the rise in all these diseases.
If I eliminated milk (products), eggs, meat, and cheese as some suggest, I would surely die within a couple of months if not sooner. I might make it past a month with hymalayan salt and water. I do not think starving to death is a wise or sustainable choice to maintain great health let alone extend health span and Longevity.
I would seriously suggest wearing way less makeup... that can't be good for your health
Disgusting pre talk sales pitch
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Why do people as clever as this guy still thinks it’s calories. WE DON’T EAT CALORIES
This is a very good presentation. You might want to listen again. There’s a lot here. I’m going to listen to it about 4 times to make sure I understand it all, it’s very dense with information. This is complicated!
He did not say that. I think you did not watch the vídeo. His main topic was fructose how it affects the metabolism.
@@rodolfocoelhodesouza3306 I watched the whole thing, he made conclusion for all theories saying they all play a part and all partially correct then said the instigator is fructose in all these cases. Which means he agrees calories are a thing.
Because he knows that excess energy has to go somewhere...
@@danielpincus221 calories are a measurement of heat in a closed system the human body does not change its heat as a closed system
You are what you eat. Your diet impacts your health.
Lower stress, reduce obesity, get enough sleep and more exercise are key to a healthy life.
Obesity in children and adults is rising across the world.
Fast food and sugary drinks including fruit juices are contributing to the problem of poor health and obesity.
Eat a healthy plant based diet and exercise regularly.
Reduce or ELIMINATE cows milk, eggs, cheese and meat. Eat more salad greens, beans, fruit and vegetables. Eliminate fast food, snacks like cookies, cakes, chips, and sugary drinks and juices.
Every adult and child should own a bicycle and ride it regularly.
Regular exercise will help you sleep better. Yoga is a great stress reducer.
Obesity is all too common today. Get off the couch. Get off the phone, ipad or video game.
A variety of stretching and other exercises help with increased mobility.
Ride to work, ride to school, ride for fun.
Every city should be a bicycle city.
Speak up for bicycles in your community
You started with, you are what you eat. Then, proceeded to say people should eat greens, fruits, beans, and veggies? People are made of meat, fat, and water.
Haha joker. Clearly didn't watch the video.
If I eliminated milk (products), eggs, meat, and cheese as you suggest, I would surely die within a couple of months if not sooner. I might make it past a month with hymalayan salt and water. I do not think starving to death is a wise or sustainable choice to maintain great health let alone extend health span and Longevity.
BS advice. Listen to what this doctor taught. Who are you? Do not come here to preach what you belief.
@@Santa-ny1yp wrong
too much makeup
It’s staring you right in the face. It’s the seed oils!