Bartonella tracks/non-conventional striae with Dr. Marna Ericson | biofilms, microscopy
ฝัง
- เผยแพร่เมื่อ 21 ก.ค. 2024
- 0:00 Intro
3:27 Bartonella in skin, collagen, biofilms
7:55 Bartonella in lesional vs. non-lesional skin
8:20 Bartonella tracks/non-conventional striae distensae vs. typical striae distensae (stretch marks)
10:42 Color of Bartonella tracks/non-conventional striae distensae
11:59 Features of typical stretch marks: color, age, genetics, potential inflammation
15:37 Origin of term “Bartonella tracks”
16:24 Interplay of Bartonella plus skin stretching
17:38 Unilateral vs. bilateral
20:25 Biofilm research
24:59 How skin biopsies are looked at with confocal laser microscopy
26:03 Bartonella, lymphatic vessels, blood vessels, nerves, hemangiomas
27:58 Interaction b/w melanoma, Bartonella, VEGFC
34:09 Association b/w small fiber neuropathy and Bartonella
35:39 Hyperalgesia in mice w/ Bartonella
37:55 Sickle cell disease & Bartonella
39:26 Liver transplants, blood transfusions, Babesia & Bartonella in blood banks
47:08 Dr. Ericson’s journey with her son
49:53 Cosmetic concerns of striae
51:58 Upcoming research: oncogenics, deep-sequencing, host response
55:41 Why isn't VEGF elevated in more patients?
56:53 Pitfalls of testing, lab transparency, what makes good science and good communication
59:56 Understanding microscopy: can’t find Bartonella with bright-field microscopy, RNA FISH
1:12:25 Marna’s words of encouragement!
1:13:52 Mom "helping me prepare" lol
Dr. Mozayeni's webinar: • Clinical spectrum of p...
Saliva transmission: • Can Bartonella be tran...
Refs
1. Atwal, G. S. S., et al. "Striae gravidarum in primiparae." British Journal of Dermatology 155.5 (2006): 965-969.
2. Chang, A. L. S., Agredano, Y. Z., & Kimball, A. B. (2004). Risk factors associated with striae gravidarum. Journal of the American Academy of Dermatology, 51(6), 881-885.
3. Sheu, H. M., Yu, H. S., & Chang, C. H. (1991). Mast cell degranulation and elastolysis in the early stage of striae distensae. Journal of cutaneous pathology, 18(6), 410-416.
4. www.aad.org/dw/dw-insights-an...
5. Hall-Stoodley, L., Costerton, J. W., & Stoodley, P. (2004). Bacterial biofilms: from the natural environment to infectious diseases. Nature reviews microbiology, 2(2), 95-108.
6. Ericson, Marna E., et al. "Bartonella henselae Detected in Malignant Melanoma, a Preliminary Study." Pathogens 10.3 (2021): 326.
7. Hu, Huanrong, et al. "Antibiotic drug tigecycline inhibits melanoma progression and metastasis in a p21CIP1/Waf1-dependent manner." Oncotarget 7.3 (2016): 3171.
8. Kalaora, Shelly, et al. "Identification of bacteria-derived HLA-bound peptides in melanoma." Nature 592.7852 (2021): 138-143.
9. Lynch, Jessica L., et al. "Analysis of nociception, sex and peripheral nerve innervation in the TMEV animal model of multiple sclerosis." Pain 136.3 (2008): 293-304.
10. Wacnik, Paul W., et al. "Tumor-induced mechanical hyperalgesia involves CGRP receptors and altered innervation and vascularization of DsRed2 fluorescent hindpaw tumors." Pain 115.1-2 (2005): 95-106.
11. Vieira-Damiani, Gislaine, et al. "Bartonella henselae infection induces a persistent mechanical hypersensitivity in mice." Revista do Instituto de Medicina Tropical de São Paulo 62 (2020).
12. De Almeida, Amanda R., et al. "Bartonella henselae infection in sickle cell disease mice is associated with hyperalgesia." Vector-Borne and Zoonotic Diseases 19.2 (2019): 102-105.
13. Soares, Tânia Cristina Benetti, et al. "Prevalence of Bartonella spp. Infection in Patients with Sickle Cell Disease." Vector-Borne and Zoonotic Diseases 20.7 (2020): 509-512.
14A. Velho, P. E. N. F. "Blood transfusion as an alternative bartonellosis transmission in a pediatric liver transplant." Transplant infectious disease: an official journal of the Transplantation Society 11.5 (2009): 474.
14B. Eduardo, P., Velho, F., & Ericson, M. E. (2012). Cryptogenic hepatitis and bartonellosis. Digestive diseases and sciences, 57(4), 1107.
15A. Moritz, Erin D., et al. "Screening for Babesia microti in the US blood supply." New England Journal of Medicine 375.23 (2016): 2236-2245.
15B. Silva, Marilene Neves, et al. "Bartonella henselae transmission by blood transfusion in mice." Transfusion 56.6pt2 (2016): 1556-1559.
16. Pitassi, Luiza Helena Urso, et al. "Bartonella spp. bacteremia in blood donors from Campinas, Brazil." PLoS neglected tropical diseases 9.1 (2015): e0003467.
17. Breitschwerdt, Edward B., et al. "Bartonella henselae bloodstream infection in a boy with pediatric acute-onset neuropsychiatric syndrome." Journal of central nervous system disease 11 (2019): 1179573519832014.
18. Maggi, Ricardo G., et al. "Co-infection with Anaplasma platys, Bartonella henselae and Candidatus Mycoplasma haematoparvum in a veterinarian." Parasites & vectors 6.1 (2013): 1-10.
19. Gadila, Shiva Kumar Goud, et al. "Detecting Borrelia Spirochetes: A Case Study With Validation Among Autopsy Specimens." Frontiers in Neurology 12 (2021): 707.
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SO interesting about biofilms. Fascinating!
You rock! Great job as always! :)
Thank you!! ❤️ Marna made it easy too
very rude of youtube to not put this on my sub page. glad I saw instagram!! I really enjoyed dr. ericson's perspective since I've had quite an ordeal with bart and skin reactions
SO RUDE! Make sure you're still subbed because apparently YT just unsubs people? I had such a good time chatting with her. Looking forward to learning more about biofilms from her and others soon!
As always the time, effort and research you put in to each video is appreciated. Keep up the good work! I now have info to take to my dermatologist for my next skin cancer exam. Melanoma InSitu surgery 2 yrs ago and I had wondered if it was connected to TBD. Thank you Jake & Dr Ericson!
Thank you so much for your comment Lisa! Will be interesting to see what your derm says
Yay! Watching now :)
The end was hilarious!
So much WOW!!
Yay Jake you rock!!
Thank you!! ❤️ And so does Marna! ☺️
Holy moley I think I have this
Do you need to have the tracks or stretch marks?
Hey Jake did I miss the section where you two discuss the duration of these tracks? Can they come and go quickly within an hour or so or do they generally last longer and for how long usually? Days? Weeks? Months?
Hi Rob! The Bartonella associated stretch marks are very controversial. You will see in case reports that say that the marks “go away“ but these case reports aren’t very specific on what that means. Some people define go away as become less red and Fade into a skin color or a silver color along with indentation marks because the collagen is damaged underneath and that is what accounts for the indentations. This is what stretch marks do over time regardless of whether they were caused or exacerbated by Bartonella. There are anecdotal reports of people having very superficial marks that look like stretch marks and these can go away completely. And when I say completely it means that there is no indentation or visible traces whatsoever. This can also happen with really superficial stretch marks. The more superficial ones, once again anecdotally, can appear and disappear rather quickly. The deeper and more severe ones appear and then technically last forever because they have permanently damaged the tissue like scar tissue
@@BartonellaBabe Ugh, its never easy with this bs :(
Thanks for the reply and all the vids. :)
I've been to dermatologists and talked to two different infect. disease centers here in North Texas and I can't find anyone that can help me with bartonella, should I just keep searching for a lyme specialist? I'm at my wits end would love a suggestion from a bartonella buddy
Hi James! The best way to get support is through our Facebook group called Breaking Down Bartonella. One of our admin keeps a list of practitioners and other people may be able to suggest a doc in your area. Infectious disease doctors won’t be able to help you. So just add yourself to the group and make sure to answer all the questions and then you will be admitted!
Serapettase for scars