I am a PHD in Immunology. My educated guess would be that the flood supercell instantly detects and mimics the cell surface marker complement of the nearest host cells to it. Basically like a foreign spy putting on the uniform of a target army. In doing so the supercell would be completely invisible to both the innate and adaptive immune system. It could also continuously change its cell surface markers in order to stay one step ahead of the immunr system. This is known as antigen shedding. Both single cell and parasitic organism infections are known to use these techniques irl, though never with 100% effectiveness.
@@RoanokeGaming HIV would be inside a T-cell, hiding, hijacking, and hindering the immune system itself. It sounds like the flood wouldn't hide in an immune cell, though it is possible (kinda like how tuberculosis hides in macrophages when the mac's try to phagocytose it), but rather it would mimic the cells of the host in the presence of immune cells, making it so the IS can't "see" it. If this is the case then the IS wouldn't think there was anything there to fight, allowing the supercell to sneak attack all the host's cells with little to no retaliation. Unless it mimics a cell that the host has an autoimmune reaction to, then ya know, HA! Gottem!
The reason for low/none immune response for Flood infestation could be that they first target the organs responsible for producing the immune system, the bone marrow and such. Then since it provides the white blood cells, it's easy pickings from there. Also explains how the Master Chief can take health damage from them without turning into one of them, because his unbreakable bones can't be broken open to be infested, thus his immune system is never compromised. (I'm assuming your immune system could fight it off just by the single scratch, but, a deep bite on a bone, directly infecting the marrow...yeah...)
@Roanoke Gaming You probably got Stephen King's _It_ mixed up with John Carpenters _The Thing._ You used the right name, but the similar titles seem to have crossed some wires regarding the attribution. A lot of people mix up which movie is which in my experience.
Small nitpick, Stephen King didn't write The Thing. The original novel was written by John W. Campbell and the 1982 film was directed by John Carpenter and written by Bill Lancaster. Keep up the good videos, though. You deserve way more subs and views than you get.
As far as I know, no. Not the original novel, the 1951 film, the 1982 film, or the 2011 film. I get why you'd think that though, it totally sounds like something King would come up with. And yeah, you clearly put a lot of effort into your videos, you generally speak pretty clearly and articulately, and I like that you actually have outside knowledge you can apply to the things you talk about and make them a bit more understandable and easier to relate to real life.
Thanks for that compliment bro! I appreciate you saying that, my videos appear to have been struggling as of late so thats really cool to hear! I will try to keep that coming and hopefully, get even better in the future
Rome wasn't built in a day, man. I know it sucks getting only double or triple digit view counts, but keep at it. You really do put out interesting stuff and I think you have potential.
@@RoanokeGaming though, if you have any fungus, bacteria, or anything, growing there... the flood can infect that, and then infect you. If it infects alien cells, then it's basically a no brainer that it can infect other diseases too. Also, if you recently shaved or anything, that could expose live skin cells, that the flood can then infect. Also... i think the flood can use dead cells. Maybe not as efficiently as live cells, but all the material is essentially still there. So it could probably eat away the dead cells, and get to your live cells anyway. I mean, if it can casually speak in Iambic Heptameter, then it can probably figure out all the ways it could infect you.
In Halo The Flood, there is a scene where Master Chief is penetrated by a flood infection form but he yanked it off before it could hijack his nervous system. Whether or not that was helped by supposed Spartan immunity due to their neural augmentations I don’t know. In the Halo Evolutions story Mona Lisa, a human Combat form bites an unfortunate marine. That marine was then shot by one of his comrades and reanimated as a feral Flood form. I can understand if these and numerous other curious examples have to be chalked up to mistakes in continuity but I want to know if it’s legitimate inconsistency or if I just don’t know the Flood as well as I thought.
Clyde Marshall If I'm right, the chief's shields kill the infection form. As for the spartan immunity, they aren't immune just resistant. I have no clue on the Mona Lisa though. Oni was experimenting on the flood so perhaps they made it able to spread via bite. I don't know but there's my two cents.
Supposedly Sergeant Johnson was able to survive the Flood because of his Spartan I augmentations. They allegedly made him immune. Perhaps Spartan IIs don't have the same benefit as a result of their augmentations but I thought it was something that would be related at the very least. As for Flood infection, I hypothesize and maintain that while Flood infection via cellular contact or inhalation or internalization of spores is possible I do think that direct infection via the Flood Infection Form is probably much more reliable and effective. I posit that in order for infection via spores to work with any major degree of effectiveness the concentration must be quite high. Regarding cellular contact, it seems clear to me that simple physical touch likely is not inherently dangerous but bites and lacerations do have the capacity to infect. Unfortunately, none of that speculation offers much in the way of a real explanation for why the Arbiter Thel 'Vadam was able to explore Flood infested areas with evidently minimal risk of infection. The only explanation besides plot hole that I can readily think of is that maybe his energy shields provided some protection. The user of an energy shield can breath so obviously the shield does allow the free movement of air particles. But perhaps Flood Spores are too large to go through an energy shield.
The reason chief wasn't infected was because cortana used the suits energy and sent an electrical shock to the infected area which killed all cells there and saved the chief but there were still cells in his body but they are dead.
Roanoke Gaming Jesus Christ congrats. Hope you keep growing as quickly as you are right now. You bring some really interesting ideas to the table and I would really love to see more content!
I hope I do as well! Currently this grow is quite explosive so I honestly don't know how sustainable it really is, but I am also cool with steady growth as well haha And believe me, there is no end on the lore front!
When they say a single spore can destroy a whole planet, they're completely right. When I first heard this, I thought maybe it meant one infected creature could carefully take over and spread. I didn't guess that it could actually be like a virus, hiding and spreading far, before infecting everywhere. They put a lot of good research into those games.
What music do you use in the backgrounds of your videos? Some of it is really cool. Also, love your videos. I hope this channel becomes mega popular. 💜
The flood supercell is known to be extremely large compared to other cells so my guess is white blood cells can't envelop it or the supercell does get attacked but has a really good protective coating that defends against it being digested by the white blood cell
My best bet on why the immune system doesn't respond or isn't able to respond fast enough for flood spores, is that usually once that process has truly begun to start, the species information is already within the interconnected flood consciousness. Meaning it already at the least, DNA to mimic that of a native cell to bypass the defenses. Because at least within what we see in the first three games, the flood are comparatively slow to convert or reanimate hosts. But by Halo 3 we see infection forms causing rapid, active mutation and take over of humans in particular. Meaning that either the flood super cell has mutated and evolved to include human DNA into itself to quickly bypass internal defense, or has mutated to be too powerful over overwhelming for any internal defenses. We also know via books that the Chief was briefly stuck by an infection form on installation 04, only for a second or two, but the fact that he was not infected lends credence to the need for flood super cells to adapt to each potential host species before it can cause real damage. As otherwise it is highly reliant on it's most basic 'creature' form, the infection form, to highjack a host's nervous system through the spine and brain stem directly.
2:15-2:51 made me think. In one of the novels, Halo: The Flood, an infection form actually pierced Chief's Mjolnir armor and his neck but Cortana killed it by using Chief's energy shields by electrocuting it and thus popping it. Why did Chief not get infected by the super cell? I'd assume it would have something to do with his biological augmentations, what do you think?
The only way I can figure is the electrical shock from the shields probably was powerful enough to fry the cells in direct connection with the flood pod. So chief's cells were killed as well but it also killed the flood cells
The original flood was considerably devastating but since Halo Wars 2: Awakening the Nightmare, it seems that the atmospheric conversion no longer infects creatures breathing the spores, but just makes it easier for the flood to survive the atmospheric conditions while increasing the chances of other organisms to suffocate or encounter infection forms from nests, which means the Halo firing in Halo 3 altered their genetic composition so badly that now it creates more effective contact forms because it has lost the extreme effectivety of the spore, going as far as making airborne and land dwelling forms that are designed to engulf the drivers of vehicles and control the vehicle for effective decimation of armies, heck, even the regular infection forms have become bigger while a new type of walking colony has been created which constantly seeks population centers and release infection forms, can´t wait to see how this changes their lore in the future.
Actually, it could just be that the Brutes have a really strong immune system, and the spores aren't enough. They do come from an extremely hostile environment, so i wouldn't be surprised if that's the case. Yeah. I think it is... they can still infect brutes, but the brute would need to be constantly breathing a LOT of spores, and for a lengthy period of time.
Very interesting! I never considered that the Flood Super Cell (henceforth referred to as “FSC”) might be similar to a global cell. I personally always assumed the FSC would be akin to the ultimate undifferentiated cell.
I ain't sure if the "bite/scratch turning you into Flood" is canon. We only saw it in one short, spin-off story, and it kinda of takes the point out of infectors - not to mention apparently contradicting what we see in most flood combat scenarios on other sources. My theory is: is the answer to your "immune sistem" problem. It actually takes a massive ingestion of flood supercells (either from an infection form attaching to you or from constant spore breathing) to overwhelm your natural defenses.
I can think of a few ways the flood super cell could overcome any defenses but have one that I feel is most probable: they are a hybrid. The cells themselves behave like zooids but are also infectious. My thought is that within each super cell there's a few pockets that contain a viral component of the flood, capsid and all. The supercell sends a distress signal to the pockest activating them, in turn converting the white blood cell. With the new host cell's membrane it could pass as a native cell, allowing it to continuously produce more of the virtual forms. Each new infected cell wouldn't be recognized as an intruder and with some internal modification it could last nearly indefinitely. The new cells could then revert to an undifferentiated cell and become part of the nearest tissue. Also, with full access the the genome the viruses could be tailored to the individual bypassing the autoimmune response all together. Just a thought.
No. Roanoke is usually super on point but he’s really misinformed about what toxoplasmosis does in humans, and that’s maddeningly disappointing considering he is supposed to have some authoritative background in this topic. This parasite does NOT cause humans to seek out more cats, because we are not part of the parasite’s actual intended host cycle. We are dead-ends for the parasites and usually our immune system just keeps it in check. Now, if it gets into the human brain, studies HAVE shown it has a potential link with the risk for developing schizophrenia, a slight decrease in reaction time, and a few other small effects, but it does not hijack the human brain or affect our behavior in any way comparable to what it does in rodents
Funny that you referenced toxo, as my personal theory is that it is able to use multiple methods to avoid detection similar to another parasite :- Plasmodium falciparum. for example when entering the body the ability to "shift" it's proteins for protein homology with the host also perhaps antigen polymorphism.
Latent toxoplasmosis is incredibly common, by the way. A rule of thumb I heard of was that your chance of being infected is about as large as your age. If you're ten, about 10%, fifty years old then 50%, and so on. But that might not apply to where you happen to live: According to the CDC, some populations have infection rates of 95%, while others are obviously far lower. How relevant that infection is to human behaviour is unclear at this point, as far as I know. I mostly know of it as a dangerous re-activation in people with severely impaired immune systems, such as HIV/AIDS.
I mean given that we've seen someone take a bite from someone infected and within two or three minutes succumbing to infection themselves, I think it works way too fast for the immune system to even realize something's wrong except for maybe the briefest of moments.
So my theory is that at the exact time when the flood supercell and the human cell are being converted, the flood supercell has a protein that allows it to bypass a certain function of our own cell’s used to alert white blood cells of a viral infection
Roanoke Gaming flood are from Precursors, so they pretty much have an inherited understandings of Neural physics. So it would be easier to infect pretty much everything sinse half of the species created in the galaxy came from the Precursors
I've always wondered if the spore infected people. Cause in the games you have to have one of the infection forms latch onto you in order to begin changing you. Adleast that what it seems like. I don't know if I've ever seen a in game scene where the spore or a scratch was enough to start an infection that would transform you.
The infection is litterrally spreading too fast for the white blood cells to respond effectivelly and by the time they do its not enough. Then the cells that attack after the white blood cells believe that the infected cells are healthy and are yours.( i cant explain better and if you can please do)
Roanoke Gaming i know some things abiut the immune system because i wondered how a normal one works cause mine is really strong compared to a nirmal one.( i am a mutant :-) )
@@RoanokeGaming it's more of a mix of your theory, and this guy's theory. It's just too fast, and it ends up absorbing the white blood cells, before they can absorb the FSCs. Kinda like a guy with a gun, vs a guy with a gun. The one who shoots first, is the one who wins. And the FSC, is "faster on the draw".
The Arbiter lacks a rebreather of any sort and yet he moves through heavily contaminated areas where the Flood have started blasting spores into the air.
Like I said, could be continuity errors or I might be right that the infection rate is significantly reduced when employing methods other than infection forms.
It doesn’t. He’s dead wrong about that fact but it’s a really pervasive myth in media, so I can give him a pass. In humans, toxoplasmosis can contribute to the risk of developing schizophrenia or a small loss in reaction time, and maybe even make people more likely to take on minor risks, but there is absolutely no evidence to support the idea that it can alter human behavior in a way similar to what it does in rats and mice. Humans are not a target host for the parasite and more people who come into contact with the parasite never even develop symptoms at all
I think the only closest thing Humanity had to "natural" defenses against infection was SGT Johnson's fucked up nervous system but then again that was due to Human experimentation in the Spartan I project. Also, still it just makes him appear as old leftovers to the flood still food just not as tasty as regular stuff.
Fun fact: The Flood need biomass to survive and can only control creatures with a nervous system. The Necrons from Warhammer 40k have neither, so they'd be immune to the Flood.
Wouldn't any inbody fighting of the infection result in some sort of feeling of sickness? what if it mimics that of maybe the common cold or something? honestly I'm not sure if that would be correct at all or not. I didn't go to school for a lot of this like you guys did, and i'm just giving my very uneducated thoughts, but hell i thought i'd throw it in anyway :)
There is! and slugs, but if you want a creepier version, I had to give a presentation in my immunology class, their is a parasite called toxoplasmosis that infects mice. It drives them to go above ground and become lost and also become attracted to the smell of cat urine. They get eaten by cats and this is where the parasite completes its life cycle. It can infect humans and actually drive us to want more cats around us. So crazy cat ladies are really just infected with that parasite
Roanoke Gaming makes me feel that parasite could potentially a cat invented weapon intended to conquer the world XD. Think about it leaves their prey vulnerable. Causes the other dominant species to be attracted to them despite being psychopathic furballs. And does little to harm them. Coincidence? I think probably but its still pretty suspicious.
You’re using BillsChannel’s music copyright and also the flood can bend reality if they took over the whole universe I think the flood and the thing should fight each other
I honestly wish that I didn’t watch your videos on the flood and how they work because when I was like 10 playing halo 3 and the flood first being encountered. I used to think of the the flood as a monster that just made you look different not turn you into a zombie and I didn’t realize that they posed this much of a danger to anything really I just thought those little things that jump on the body it not cells that get into your body and infect making you die slowly and when you where talking about how the flood change the body were they break all your bones and liquefy organs scare the every living crap out of me
Roanoke Gaming late reply, you might have already done this, but Bioshock has the Big Daddy's and Little Sisters, which would be awesome to get your perspective on.
Roanoke Gaming I know it's meant to be this unstoppable force, but perhaps an aggressive autoimmune disorder could be the best hope for a vaccine (that's ignoring the likely mortality of such a disorder)
A possibility, but the main issue I see is any auto immune disorder that is strong enough to kill the food. Would probably kill the host as well. But the maybe a vaccine for a flood super cell? Would the immune system be strong enough? Very interesting line of though, I wonder if it is possible though
I heard that something to this effect was achieved by sergeant johnson. He was formerly a spartan 1 and the modifications to his body jacked it up enough that the flood had difficulty infecting him.
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If y'all liked the video don't forget to sub it up! Helping the channel grow would be totally bro of you
Awesome vids Roanoke Gaming. I'd like to see Nicole Brennan explained from Dead Space 2 rather the apparition of her.
thanks for the compliment bro! I can probably make a quick video on that, but it would be a short 3 minute video haha
Just did and The Thing is from John Carpenter's film
Evil Xero true! I was totally wrong Haha I could have sworn it was Stephen king but meh, more research next time!
No problem Roanoke Gaming. We all make mistakes. So are you going to make a video/presentation on the Nicole apparition from DS2?
I am a PHD in Immunology. My educated guess would be that the flood supercell instantly detects and mimics the cell surface marker complement of the nearest host cells to it. Basically like a foreign spy putting on the uniform of a target army. In doing so the supercell would be completely invisible to both the innate and adaptive immune system.
It could also continuously change its cell surface markers in order to stay one step ahead of the immunr system. This is known as antigen shedding. Both single cell and parasitic organism infections are known to use these techniques irl, though never with 100% effectiveness.
Very interesting! Honestly it sounds like HIV in some aspects, the body is never able to keep up fighting as it can identify it. Makes sense to me
@@RoanokeGaming HIV would be inside a T-cell, hiding, hijacking, and hindering the immune system itself. It sounds like the flood wouldn't hide in an immune cell, though it is possible (kinda like how tuberculosis hides in macrophages when the mac's try to phagocytose it), but rather it would mimic the cells of the host in the presence of immune cells, making it so the IS can't "see" it. If this is the case then the IS wouldn't think there was anything there to fight, allowing the supercell to sneak attack all the host's cells with little to no retaliation. Unless it mimics a cell that the host has an autoimmune reaction to, then ya know, HA! Gottem!
"Not if I absorb it first!" - *Flood supercell*
*mumbling*(not if I burn it first) - the pyro TF2
@@thearkitect4254*the flood does the move (adaptation)*
*is effective*
The reason for low/none immune response for Flood infestation could be that they first target the organs responsible for producing the immune system, the bone marrow and such. Then since it provides the white blood cells, it's easy pickings from there. Also explains how the Master Chief can take health damage from them without turning into one of them, because his unbreakable bones can't be broken open to be infested, thus his immune system is never compromised. (I'm assuming your immune system could fight it off just by the single scratch, but, a deep bite on a bone, directly infecting the marrow...yeah...)
A part of me died when you said Stephen kings the thing.
Yaaahhh, it was brought to my attention a few days after I posted lol last time I watched I was a kid and was so sure Stephen king wrote it
@Roanoke Gaming
You probably got Stephen King's _It_ mixed up with John Carpenters _The Thing._ You used the right name, but the similar titles seem to have crossed some wires regarding the attribution. A lot of people mix up which movie is which in my experience.
Small nitpick, Stephen King didn't write The Thing. The original novel was written by John W. Campbell and the 1982 film was directed by John Carpenter and written by Bill Lancaster.
Keep up the good videos, though. You deserve way more subs and views than you get.
interesting, so you're basically saying that Stephen King had nothing to do with it? that actually blows my mind haha thanks for the compliment bro!
As far as I know, no. Not the original novel, the 1951 film, the 1982 film, or the 2011 film. I get why you'd think that though, it totally sounds like something King would come up with.
And yeah, you clearly put a lot of effort into your videos, you generally speak pretty clearly and articulately, and I like that you actually have outside knowledge you can apply to the things you talk about and make them a bit more understandable and easier to relate to real life.
Thanks for that compliment bro! I appreciate you saying that, my videos appear to have been struggling as of late so thats really cool to hear! I will try to keep that coming and hopefully, get even better in the future
Rome wasn't built in a day, man. I know it sucks getting only double or triple digit view counts, but keep at it. You really do put out interesting stuff and I think you have potential.
thanks dude! One day, hopefully within the next year or two haha
"non flood infected people" I will have you know I am a planetary gravemind
Sam Boyd We will have him know we are actually Zerg.
Sam Boyd
Keymind*
Wouldn't shooting the flood also release the spores
I'm fairly certain it would, but as long as you don't breathe in your skin should provide a barrier against it as all the top layers of skin are dead
@@RoanokeGaming though, if you have any fungus, bacteria, or anything, growing there... the flood can infect that, and then infect you. If it infects alien cells, then it's basically a no brainer that it can infect other diseases too. Also, if you recently shaved or anything, that could expose live skin cells, that the flood can then infect.
Also... i think the flood can use dead cells. Maybe not as efficiently as live cells, but all the material is essentially still there. So it could probably eat away the dead cells, and get to your live cells anyway.
I mean, if it can casually speak in Iambic Heptameter, then it can probably figure out all the ways it could infect you.
In Halo The Flood, there is a scene where Master Chief is penetrated by a flood infection form but he yanked it off before it could hijack his nervous system.
Whether or not that was helped by supposed Spartan immunity due to their neural augmentations I don’t know.
In the Halo Evolutions story Mona Lisa, a human Combat form bites an unfortunate marine. That marine was then shot by one of his comrades and reanimated as a feral Flood form.
I can understand if these and numerous other curious examples have to be chalked up to mistakes in continuity but I want to know if it’s legitimate inconsistency or if I just don’t know the Flood as well as I thought.
I believe when it almost kills chief he is saved by the suits shields killing the flood infection form
Clyde Marshall
If I'm right, the chief's shields kill the infection form.
As for the spartan immunity, they aren't immune just resistant.
I have no clue on the Mona Lisa though. Oni was experimenting on the flood so perhaps they made it able to spread via bite. I don't know but there's my two cents.
Supposedly Sergeant Johnson was able to survive the Flood because of his Spartan I augmentations. They allegedly made him immune. Perhaps Spartan IIs don't have the same benefit as a result of their augmentations but I thought it was something that would be related at the very least.
As for Flood infection, I hypothesize and maintain that while Flood infection via cellular contact or inhalation or internalization of spores is possible I do think that direct infection via the Flood Infection Form is probably much more reliable and effective.
I posit that in order for infection via spores to work with any major degree of effectiveness the concentration must be quite high. Regarding cellular contact, it seems clear to me that simple physical touch likely is not inherently dangerous but bites and lacerations do have the capacity to infect.
Unfortunately, none of that speculation offers much in the way of a real explanation for why the Arbiter Thel 'Vadam was able to explore Flood infested areas with evidently minimal risk of infection.
The only explanation besides plot hole that I can readily think of is that maybe his energy shields provided some protection. The user of an energy shield can breath so obviously the shield does allow the free movement of air particles. But perhaps Flood Spores are too large to go through an energy shield.
The reason chief wasn't infected was because cortana used the suits energy and sent an electrical shock to the infected area which killed all cells there and saved the chief but there were still cells in his body but they are dead.
You're talking about a pretty severe burn. I'm not sure I recall that being in the book.
I find it fascinating how the Flood super cell is essentially the ultimate form of an undifferentiated cell.
You've got a very enjoyable video style. I've been binging your stuff all day. You should have more subs.
That is great to hear! I cringe at my own voice but I am glad not everyone does haha one day ill get more!
FRESH
This content is amazing! I hope you keep making videos like this because you deserve lots of recognition.
Hopefully one day but until then thanks for the compliment bro!
Over the past few hours your sub count has gone up from 8.5 to 8.7. Those are some real gains.
I am exceedingly lucky to have gotten discovered! 12 days ago I was at 600 subs haha
Roanoke Gaming Jesus Christ congrats. Hope you keep growing as quickly as you are right now. You bring some really interesting ideas to the table and I would really love to see more content!
I hope I do as well! Currently this grow is quite explosive so I honestly don't know how sustainable it really is, but I am also cool with steady growth as well haha And believe me, there is no end on the lore front!
When they say a single spore can destroy a whole planet, they're completely right. When I first heard this, I thought maybe it meant one infected creature could carefully take over and spread. I didn't guess that it could actually be like a virus, hiding and spreading far, before infecting everywhere. They put a lot of good research into those games.
Really good stuff. I enjoy biology so the scientific explanations in your videos are really cool to me. Keep it up man! ^.^
thanks brah!
What music do you use in the backgrounds of your videos? Some of it is really cool. Also, love your videos. I hope this channel becomes mega popular. 💜
The flood supercell is known to be extremely large compared to other cells so my guess is white blood cells can't envelop it or the supercell does get attacked but has a really good protective coating that defends against it being digested by the white blood cell
My best bet on why the immune system doesn't respond or isn't able to respond fast enough for flood spores, is that usually once that process has truly begun to start, the species information is already within the interconnected flood consciousness. Meaning it already at the least, DNA to mimic that of a native cell to bypass the defenses. Because at least within what we see in the first three games, the flood are comparatively slow to convert or reanimate hosts. But by Halo 3 we see infection forms causing rapid, active mutation and take over of humans in particular. Meaning that either the flood super cell has mutated and evolved to include human DNA into itself to quickly bypass internal defense, or has mutated to be too powerful over overwhelming for any internal defenses. We also know via books that the Chief was briefly stuck by an infection form on installation 04, only for a second or two, but the fact that he was not infected lends credence to the need for flood super cells to adapt to each potential host species before it can cause real damage. As otherwise it is highly reliant on it's most basic 'creature' form, the infection form, to highjack a host's nervous system through the spine and brain stem directly.
2:15-2:51 made me think. In one of the novels, Halo: The Flood, an infection form actually pierced Chief's Mjolnir armor and his neck but Cortana killed it by using Chief's energy shields by electrocuting it and thus popping it. Why did Chief not get infected by the super cell? I'd assume it would have something to do with his biological augmentations, what do you think?
The only way I can figure is the electrical shock from the shields probably was powerful enough to fry the cells in direct connection with the flood pod. So chief's cells were killed as well but it also killed the flood cells
Thanks for the reply, awesome channel by the way. Just found out about it on reddit yesterday.
Thanks bro! I appreciate the sub as well! Hopefully I can maintain the trajectory of awesome haha
I'm super glad I found someone who is just as curious about things like this as I am.
For sure bro! I love the biology of games!
The original flood was considerably devastating but since Halo Wars 2: Awakening the Nightmare, it seems that the atmospheric conversion no longer infects creatures breathing the spores, but just makes it easier for the flood to survive the atmospheric conditions while increasing the chances of other organisms to suffocate or encounter infection forms from nests, which means the Halo firing in Halo 3 altered their genetic composition so badly that now it creates more effective contact forms because it has lost the extreme effectivety of the spore, going as far as making airborne and land dwelling forms that are designed to engulf the drivers of vehicles and control the vehicle for effective decimation of armies, heck, even the regular infection forms have become bigger while a new type of walking colony has been created which constantly seeks population centers and release infection forms, can´t wait to see how this changes their lore in the future.
Actually, it could just be that the Brutes have a really strong immune system, and the spores aren't enough. They do come from an extremely hostile environment, so i wouldn't be surprised if that's the case.
Yeah. I think it is... they can still infect brutes, but the brute would need to be constantly breathing a LOT of spores, and for a lengthy period of time.
I thought the flood were terrifying enough
There’s no way Roanoke doesn’t have toxoplasmosis gondi with how much he likes cats. Crazy cat man
Very interesting! I never considered that the Flood Super Cell (henceforth referred to as “FSC”) might be similar to a global cell. I personally always assumed the FSC would be akin to the ultimate undifferentiated cell.
Great channel love the videos keep them coming !!
Thanks bro! glad you like them!
I ain't sure if the "bite/scratch turning you into Flood" is canon. We only saw it in one short, spin-off story, and it kinda of takes the point out of infectors - not to mention apparently contradicting what we see in most flood combat scenarios on other sources.
My theory is: is the answer to your "immune sistem" problem. It actually takes a massive ingestion of flood supercells (either from an infection form attaching to you or from constant spore breathing) to overwhelm your natural defenses.
Can you do an episode about Zerg biology? Thanks!
I can think of a few ways the flood super cell could overcome any defenses but have one that I feel is most probable: they are a hybrid. The cells themselves behave like zooids but are also infectious. My thought is that within each super cell there's a few pockets that contain a viral component of the flood, capsid and all. The supercell sends a distress signal to the pockest activating them, in turn converting the white blood cell. With the new host cell's membrane it could pass as a native cell, allowing it to continuously produce more of the virtual forms. Each new infected cell wouldn't be recognized as an intruder and with some internal modification it could last nearly indefinitely.
The new cells could then revert to an undifferentiated cell and become part of the nearest tissue. Also, with full access the the genome the viruses could be tailored to the individual bypassing the autoimmune response all together.
Just a thought.
Woah wait what? There's a crazy cat Person infection? That's insane.
No. Roanoke is usually super on point but he’s really misinformed about what toxoplasmosis does in humans, and that’s maddeningly disappointing considering he is supposed to have some authoritative background in this topic.
This parasite does NOT cause humans to seek out more cats, because we are not part of the parasite’s actual intended host cycle. We are dead-ends for the parasites and usually our immune system just keeps it in check. Now, if it gets into the human brain, studies HAVE shown it has a potential link with the risk for developing schizophrenia, a slight decrease in reaction time, and a few other small effects, but it does not hijack the human brain or affect our behavior in any way comparable to what it does in rodents
Well I’m hooked now.
The plan worked! haha
Funny that you referenced toxo, as my personal theory is that it is able to use multiple methods to avoid detection similar to another parasite :- Plasmodium falciparum.
for example when entering the body the ability to "shift" it's proteins for protein homology with the host also perhaps antigen polymorphism.
Latent toxoplasmosis is incredibly common, by the way. A rule of thumb I heard of was that your chance of being infected is about as large as your age. If you're ten, about 10%, fifty years old then 50%, and so on. But that might not apply to where you happen to live: According to the CDC, some populations have infection rates of 95%, while others are obviously far lower. How relevant that infection is to human behaviour is unclear at this point, as far as I know. I mostly know of it as a dangerous re-activation in people with severely impaired immune systems, such as HIV/AIDS.
For information about the flood that is accurate I'd recommend HiddenXpperia's lore videos on the flood.
What’s inaccurate about this lmao
I mean given that we've seen someone take a bite from someone infected and within two or three minutes succumbing to infection themselves, I think it works way too fast for the immune system to even realize something's wrong except for maybe the briefest of moments.
Damn flood you scary
Extra spoopy!
I am a big fan, nice videos
Thanks bro I am glad you like them!
So my theory is that at the exact time when the flood supercell and the human cell are being converted, the flood supercell has a protein that allows it to bypass a certain function of our own cell’s used to alert white blood cells of a viral infection
Things that i like :floating light bulbs
Now that I am thinking about it, I am so curious to see how the nanites of the nanosuit from crysis 2-3 react when they encounter flood supercells
bold of you to assume I'm not flood infected.
It reminds me a lot of how infectors in dead space infect people and the corpses to reanimate them into necromorphs
You would think how advanced the forerunner would've had nanomachines to deal with the flood
you would think but whos to say the flood couldnt have overcome those nanites and basically used them against the forerunners?
Roanoke Gaming flood are from Precursors, so they pretty much have an inherited understandings of Neural physics. So it would be easier to infect pretty much everything sinse half of the species created in the galaxy came from the Precursors
I've always wondered if the spore infected people. Cause in the games you have to have one of the infection forms latch onto you in order to begin changing you. Adleast that what it seems like. I don't know if I've ever seen a in game scene where the spore or a scratch was enough to start an infection that would transform you.
The infection is litterrally spreading too fast for the white blood cells to respond effectivelly and by the time they do its not enough. Then the cells that attack after the white blood cells believe that the infected cells are healthy and are yours.( i cant explain better and if you can please do)
I could see that being the case
Roanoke Gaming i know some things abiut the immune system because i wondered how a normal one works cause mine is really strong compared to a nirmal one.( i am a mutant :-) )
@@RoanokeGaming it's more of a mix of your theory, and this guy's theory. It's just too fast, and it ends up absorbing the white blood cells, before they can absorb the FSCs. Kinda like a guy with a gun, vs a guy with a gun. The one who shoots first, is the one who wins.
And the FSC, is "faster on the draw".
Subbed, that was a great video and I don't know anything about Biology, most science I did was Physics in High School.
Jordon Pollock glad you liked it man! The biology aspect to me is almost as interesting as the flood themselves, I'm glad you think to!
The Arbiter lacks a rebreather of any sort and yet he moves through heavily contaminated areas where the Flood have started blasting spores into the air.
very strange, but the spores are a sited thing to cause infection! maybe a plot hole or something lol
Like I said, could be continuity errors or I might be right that the infection rate is significantly reduced when employing methods other than infection forms.
Oh wait, that cat parasite can actually drive humans to get more cats? I've heard a lot about that parasite, but never that fact before.
It doesn’t. He’s dead wrong about that fact but it’s a really pervasive myth in media, so I can give him a pass. In humans, toxoplasmosis can contribute to the risk of developing schizophrenia or a small loss in reaction time, and maybe even make people more likely to take on minor risks, but there is absolutely no evidence to support the idea that it can alter human behavior in a way similar to what it does in rats and mice. Humans are not a target host for the parasite and more people who come into contact with the parasite never even develop symptoms at all
I think the only closest thing Humanity had to "natural" defenses against infection was SGT Johnson's fucked up nervous system but then again that was due to Human experimentation in the Spartan I project. Also, still it just makes him appear as old leftovers to the flood still food just not as tasty as regular stuff.
The flood is an........interesting creature in halo ce original graphics for the fllod look pretty scary compared to the new flood btw awsome
Fun fact: The Flood need biomass to survive and can only control creatures with a nervous system. The Necrons from Warhammer 40k have neither, so they'd be immune to the Flood.
They be immune to tyranid infection and the thing super cell too? Hmm
You guys ever spent hours trying to save the marines?
The Thing: It`s not human yet.
but eventually you might not be able to tell!
Maybe the human body simply has no ability to defend itself from the flood
Did you assume my infection?
Perhaps
Wouldn't any inbody fighting of the infection result in some sort of feeling of sickness? what if it mimics that of maybe the common cold or something? honestly I'm not sure if that would be correct at all or not. I didn't go to school for a lot of this like you guys did, and i'm just giving my very uneducated thoughts, but hell i thought i'd throw it in anyway :)
Isn't there a fungi that attacks ants and uses the infected host ant as a way to get into the colony?
There is! and slugs, but if you want a creepier version, I had to give a presentation in my immunology class, their is a parasite called toxoplasmosis that infects mice. It drives them to go above ground and become lost and also become attracted to the smell of cat urine. They get eaten by cats and this is where the parasite completes its life cycle. It can infect humans and actually drive us to want more cats around us. So crazy cat ladies are really just infected with that parasite
Roanoke Gaming Very interesting. Keep up to good work! Glad to see a scientist who likes games!
Thanks for the compliment bro! and science and games are my jam!
Roanoke Gaming have you ever thought about the Pacific Rim movie seris for a video?
Roanoke Gaming
My girlfriend is obessed with cats . . . ._.
Do a video about guyver..
Finding old Roanoke is odd.
could anyone please tell me what the music is?
Reminds me that worm from the slither film
So toxo plasma gondi basically makes people easy sniper targets
well, it makes rats, for humans it just makes us want cats lol
Roanoke Gaming makes me feel that parasite could potentially a cat invented weapon intended to conquer the world XD.
Think about it leaves their prey vulnerable.
Causes the other dominant species to be attracted to them despite being psychopathic furballs. And does little to harm them.
Coincidence? I think probably but its still pretty suspicious.
Do the Elites' shields act as a defense mechanism to the spores?
If so, why don't they fall infected when their shields are down?
I believe they do, it covers their face
The skin would also be infected as we have all seen the flood infect the dead in halo 3.
Flood cells are tryanid and zerg if not even the xenomorph in the micro world
"Stephen King's The Thing"? Pretty sure that was written long before he came along.
It would be amazing if they made a metro 2033 style halo game
But do u do side lore of halo like novels and such
Steph King's the thing? Come on man, that's almost inexcusable but I forgive you.
You’re using BillsChannel’s music copyright and also the flood can bend reality if they took over the whole universe I think the flood and the thing should fight each other
Billschannel's? Then hes using the same source as me which is youtube audio I believe
Roanoke Gaming may sorry for accusing you of copy right then also wouldn’t you love to see the thing and flood fight each other ?
I wonder who would convert who considering they are creatures that are very similar! Perhaps at that point it would really come down to virulence!
Roanoke Gaming yeah it would be a mad battle but what’s verluince ?
@@RoanokeGaming they probably form a symbiotic relationship
I honestly wish that I didn’t watch your videos on the flood and how they work because when I was like 10 playing halo 3 and the flood first being encountered. I used to think of the the flood as a monster that just made you look different not turn you into a zombie and I didn’t realize that they posed this much of a danger to anything really I just thought those little things that jump on the body it not cells that get into your body and infect making you die slowly and when you where talking about how the flood change the body were they break all your bones and liquefy organs scare the every living crap out of me
They are very brutal!
They are very brutal indeed
Ebola has some ways to bypass the immune system as well right ?
that it does! But its more viral so it hides in plain sight, inside your cells, but an actual cell attacking should be attacked such as with bacteria
Just had this idea that the flood super cell might do this as well, not sure convergent evolution would apply though.
Do you play bioshock?
I do have it, gotta suggestion?
Roanoke Gaming late reply, you might have already done this, but Bioshock has the Big Daddy's and Little Sisters, which would be awesome to get your perspective on.
Roanoke Gaming do you at me to make more thumbnails for you?
The Thing was a novel?!
Indeed it was! By Alan Dean Folster! not Stephen King like how I totally messed that up lol
If the Forerunners couldn't solve it, neither can we.
Try 40 k universe it has a lot biological diversity
I have been looking into 40k as I type this!
Try the hive fleet is more like flood life form
You should do vids about the creatures of warhammer 40k!!!!
Couldnt get into warhammer like I hoped unfortunately
Hmm so the only possible resistance could be autoimmune disorders
That's a good point, however if the disorder isn't killing you, I do not believe it would be able to stop he flood cell infection
Roanoke Gaming I know it's meant to be this unstoppable force, but perhaps an aggressive autoimmune disorder could be the best hope for a vaccine (that's ignoring the likely mortality of such a disorder)
A possibility, but the main issue I see is any auto immune disorder that is strong enough to kill the food. Would probably kill the host as well. But the maybe a vaccine for a flood super cell? Would the immune system be strong enough? Very interesting line of though, I wonder if it is possible though
I heard that something to this effect was achieved by sergeant johnson. He was formerly a spartan 1 and the modifications to his body jacked it up enough that the flood had difficulty infecting him.
Stephen King's "The Thing"? Bruh...😅
That music right before the outro. What is it. Its glorious
Herpes
Imagine a flood whale
GOOOOOOOD Lord thats a big flood form lol
@@RoanokeGaming I'm pretty sure it was the base of a cut flood form that shot the infection forms at enemies or worked like a flood warthog
>74k subs
FUCK WHY DIDNT I STAY SUBBED FOR BRAGGING RIGHTS
YOU TRAITOR. You are actually mentioned in my 50,000 sub special haha I was pretty sure you had died
You fucked up with that thing mess up
wat
God I hate that they added in this bullshit supercell crap