Improvement of the capacity for physical exertion thanks to Kaftrio

Joan Llobera, owner of "Físic, espai de salut integral" and physical educator of the Respiralia Group, tells us about the effects on the improvement of the capacity of physical exertion thanks to Kaftrio.
Before the arrival of this new drug, the users of the Endurance training program had already noticed an increase in their lung capacity and in their ability to perform daily activities that require physical effort more easily.
We are talking about some users over 45 years of age who achieved an increase of up to 4%, although it is true that the intensity of the exercises was limited.
Once Kaftrio began to be administered in April 2022 in the Balearic Islands, Joan tells us about the feeling of bewilderment he experienced, since in a period of one or two weeks, the users were no longer coughing, did not cough up mucus every 10 minutes and did not have oxygen desaturation in the blood. In fact, they even reached 97-98% saturation during physical exercise.
We are talking about strength exercises, with which we had to be careful because many of the users had back pain. After a slow but continuous process, they can now lift weights of about 25 kg in squat or dead weight, for example, without reaching fatigue or having back pain, whereas before with 8 kg they would reach fatigue immediately.
The Respiralia Group's stress Endurance training program is based on re-educating the body so that it can withstand the effort of certain daily activities, not to achieve sports records.
Joan tells us that each person trains to achieve certain goals in his/her life. In the case of people with a pathology such as Cystic Fibrosis, their goals may be to go shopping and carry a sack of potatoes or a bottle of water, climb stairs, etc.
Therefore, the Endurance training program becomes more important with the arrival of Kaftrio, since with its effects the secretions of the upper and middle airways disappear, so that the performance can increase a lot. It is true that we still have to work the peripheral airways with Autogenous Drainage, since now it will be easier to reach them than when there were accumulated secretions in the first airways.
Before, during the sessions, cardiovascular fatigue was reached before muscular fatigue, which prevented us from providing a stimulus at the muscle level because oxygen was lacking. Now it is the other way around, since it is possible to give a high quality stimulus to the muscle because the limit is not set by the cardiovascular system.
Joan and the Respiralia Foundation are very optimistic about the possibilities offered by this new drug and the clinical trial that is being carried out to see if Kaftrio can be applied to people with mutations other than F508del.
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