That was my first thought when I discovered this channel. My first (video) was the ATP machinery one, and every single one after has reaffirmed this thought.
@@ClockworkbioWould u consider creating a video of how graphene would travel in the body when it is injected ... as well as inhaled, skin exposure, drink, and inhaled into the sinus. Please consider.
This one REALLY should have been split into two videos -- but how do y'all feel about 30-minute episodes on here? Next video is short, punchy, and releasing in three weeks. NO MORE LONG UPLOAD GAPS.
channels like yours have great potential to cover things in a lot of detail. shorter videos is not good for detail. the amount of times I have been Blue balled by channels covering complex topics in a approachable way and then they go on to make 10-minute videos that only scratch the surface. please make 2 hour long videos.
It was great! I have no issue with longer videos. But I have one little suggestion - during the video, there's a lot of "meta"-talk, including unnecessary preamps ("buckle up", "now we're going to analyze X and Y and Z"), a little bit of mild fearmongering (like in the GPCR bit - "ooh boy", or a sigh during the explanation of phosphodiesterase - literally all enzymes are named in this manner, so making it seem difficult to pronounce or remember is counterproductive). Maybe I'm extra sensitive to it, since coming from a chemistry background I've seen so many people scared of complexity, while in reality this anxiety only makes learning more difficult for some. Please don't take it as mindless criticism! I enjoy your videos a lot, sometimes I just wish there was more content going deeply into the biochemistry (for example - you could have explained how photons cause a cis-trans isomerization in retinal, which would also make remembering retinoid isomerase simpler). Thank you for your work!
Isn’t it amazing how your rod cells mutated into cone type cells however many millions of years ago and your brain was able to exploit this an evolve to interpret this as color, and how it specifically centralizes these at the center of vision and uses them less frequently than rods? It’s the whole point of this channel but god biology is more sublime than anything I’ve seen in physics
This explains why I see optical illusions when in a totally dark room, like my bathroom with the lights off. The chemistry with the calcium and the mechanism for turning that chemistry into nerve signals is what's making those patterns appear.
Visual static. Sometimes in low light settings your eyes can trick your brain which is attempting to trying to determine objects. Depending on where you think you are and what you think you're seeing. Most of the time it's just blotchy static
The brain actually hallucinates stimuli in these cases, as no input of signals coming rom the eyes are non desirable and the brain will create a "screensaver" image in place of the lack of signal input. These can quite literally be shadowy figures or things moving outside your peripheral vision, so whenever you get startled by these sots of things its your brain that is to blame
Probably not. Photo receptors hyperpolerize in light, meaning they release less neurotransmitter onto target neurons, and depolarize in dark, meaning they release more neurotransmitter in dark. The neurotransmitter is glutamate and it inhibits its target neuron. With that said, a visual sensation occurs when cells of the visual cortex are stimulated to threshold. The visual cortex does get input from other sensory paths. This is why a visual target is easier to see if it is also accompanied by a sound. The energy from each pathway add to increase activity in the visual cortex. It’s basically a crude form of synesthesia where one sense can activate sensation in another sensory modality. And it exists on a continuum, more to less in adults. More common in children than adults. I’m the dark, sound powerfully causes me to experience visual sensations. Folks with high levels of synesthesia often have very very good memories. I’ve had professors accuse me of stealing their notes because I reproduced what they said in lectures word for word. I can also read and the recite near verbatim what I’ve read hours later, like I can recreate the page in my mind to reread.
I genuinely love you man. I cant properly say how much these videos make me truly appreciate life and how amazing every little tiny biological function behaves. I send your videos to every friend and family member I can that can truly appreciate this. You speak with the same wonder I would if I specialized in your field. Your amazement it's matched by all of us. Please keep up the incredible work ❤
I just found this channel, but I’ve fallen down the rabbit hole of binging every video. The narratives are so compelling, and the biochemical insights are genuinely astounding. Plus the graphics are so charming, and the 3D style is incredible! It really shows how much time and effort go into these videos, looking forward to whatever you have in store next!
This channel deserves more views. This stuff is so great - entertaining enough for people like me who aren't particularly interested in biology but informative enough to be worth watching
The fact that we can percieve photons that have been traveling thru space for thousands of light years is absolutely mind blowing, Nature is a master builder of function and form.
I just stumbled across your channel. I found myself literally subscribing to it in less than two minutes. That's how impressed I was with your channel! Awesome!
You got to hand it to the biochemical scientists who worked out all these biochemical reactions. Me takes me hat off to ye! Trained as a biochemist years ago, and this stuff still leaves me in awe!!!
This channel is absolutely amazing. I am so fascinated with cellular biology, and when you said biochemistry probably isn’t why you’re here, I laughed because it so was. Keep up this amazing content, I love the intricacies you explain.
Oh my God I'm crying this is so beautiful 😭 Sight is a sense of touch... oh god all senses are touch?! 😳 All of my molecules are being touched 😱 ...... Can I feel all of my molecules? Surely every process is connected... But they can't be aware of each other... molecules aren't conscious... But molecules performing human processes create consciousness... Fuck. It's all random... Like, fire is a chemical process. Fire isn't aware of its own combustion.. each molecule of fuel being drained of its energy and converting it to carbon... The fire does not know it processes molecules or that it transforms them... In the same way, human processes don't know they are transforming molecules... They just do, because the processes which are in motion demand it be so.... and somehow, underlying all of this, DNA creates a language that transfers real survival knowledge from generation to generation. Babies born knowing how to eat, how to drink, preprogrammed from conception to partake in these self sustaining processes... Fuck. Fuck you've broken my brain...... Fuck man.. wtf even are we??? 😳
I feel the same, that overwhelming astonishment at life's complexity and beauty. Lately, at age 68, I no longer see "myself" as someone or something separate from everything else. It's all one great unfolding, and we're all temporary manifestations, or antennas, of awareness. Maybe that's why we don't feel older as the body ages, because we're always here in some sense.
Fantastic video, explanations and animations! The depth and width of coverage is great and packs an amazing amount into a half hour. And thank you for the mention!
I knew I had to bring in the maximum effort possible if I was going to keep producing videos in the same place as one of the greats! Your comment means the world to me. Thank you so much for taking the time to watch! Can't wait for more videos from you.
I can't describe how much I love your content, I recently discovered your channel and the fact that you started working on it again is absolutely amazing. Keep that up🎉
This is such an amazing way to explain such a complex process. I mean, I didn't absorb all the information, but I understood the amazing principles behind how we see from a molecular standpoint. Your narration is so passionate that I think I felt what teenagers would feel when they have crushes on their profs
My primary hobby is robotics and using the Robot Operating System. Seeing bio engines, actuators, pumps, event systems is wild. I really appreciate your teaching skills. Not long after I finished reading Nick Lane's The Vital Question and Ed Yong's The Multitudes Within, I discovered your channel. Like robotics, I'm learning these new things in layers of time. So fascinating!
Absolutely amazing. I've drifted my career off biology and biochemistry into something seemingly unrelated as urban planning, but these processes are still so cool to me... For a long time during the video I'd question how does retinal goes back to its original shape, but you showed how it's continually replaced with fresh ones. That makes a lot of sense on why we call it Vitamin A, being vitamins nutrients we can't produce ourselves. But now I need other answers! How does the replacement process happen? How does the cell makes retinal readily available in order to feed rhodopsin(?) in real time?? Questions on how the system turns back to basal states are always on my mind, and you've answered a lot of them. Some feedback for the future: dude, chill a bit, your videos are great, you don't have to feel rushed to present them. People who are here are because they love the subject. If you rush it too much, it may even lower the quality of the content, and that's a huge boomer, considering that's what you have best to offer.
Love that this video came onto my feed randomly! Love that you made this video 58 minutes ago! Thank You! I miss in depth, so detailed, and easy to consume content like this! Great work!
Amazing in-depth breakdown. I love that you mentioned nucleotides are used as energy because it's one of my favorite facts. In a way it means our genetic information is stored in the energy currency of the cell. Sort of analog pseudo digital feel if you think about it.
This is the most interesting channel i've seen on the whole youtube for a fair amount of years. The beauty of these molecular, well, literally mechanisms is astounding.
this channel is so underrated. i binged all the videos as soon as i found the channel. ill definitely get the curiosity box if they aren't sold out in 2 days, i want that deck of cards and i dont care about any of the other things in the box- yet.
Dude... This is the first time I have come across your channel and all I can say is holy shit! The quality of this video is nuts! 36k subscribers is a tragedy. You're going to take off. I already know it. You even have great personality in narration.
If only my physiology lectureur explained stuff like you do... you make everything so clear and understandable, AND WITH THE IMMACULATE VISUALS everything just clicks Thank you for the work effort and love you put into your vids
1 minute shorts, 10 minutes, 30 minutes, anything--just keep bringing me this level of quality! Also, basic Southern Californian here so I gotta go with palm trees
Thank you for this. I learned a ton from this video and now have a richer appreciation for my sense of vision. I quite like the perspective of it being a sort of touch of a tiny fragment of stars. It's pretty remarkable how much this biomolecular dance has allowed us to learn about our universe from afar. Also if anyone is ever trying to flirt with a biochemist that specializes in phototransduction you can ask: "Did your retinal absorb a photon or are you just happy to see me?"
The signal reduction prior to transmission to the brain is not a problem to get around; it is the initial image processing itself! Things like edge detection happen long before the brain gets it.
Hi. Thanks for beautiful journey thru vision. I have XLRP so it was really cool to find what is genetically broken in my body. It would be quite nice and interesting to see your work on this disseas. Maybe some day 😎Once more - thanks for all. 🍻
I'm loving the upgraded animation style in these new releases, but I have one request/suggestion if you wouldn't mind considering... In future could you please tone down the Brownian motion a little bit? Particularly for the background molecules like the phospholipids at 0:55, 1:51 and 5:37 for example. I know it's to better simulate the reality of the motion but it's so much movement that it's hard for my eyes to focus on the important proteins we're meant to be focussing on! 3:00 is a good example too - the ion pump is moving quite fluidly, but the phospholipids are kind of like stop motion and it's hurting my brain haha. If you go to 7:20 of your hearing video, it's the older style of animation but the movement of the phospholipids is (less realistic, but) less distracting, if that makes sense? I'm sure there's a happy compromise somewhere in the middle which I would leave to your better judgement. Only meant as friendly constructive suggestion, it's okay if you ignore it too - keep it up with the mind-blowing productions either way 👍
The really wild thing is that, where human engineering would tend to use fixed wiring, this process basically has everything free-floating and the signal is transmitted by chance collisions.
it's all the same rhodopsin actually! Certain owl species simply have way more rod cells (and in the Great Horned Owl they are thinner and packed more together) and a reflective membrane at the very back of the retina that helps them pick up on a LOT more detail in the dark!
This is truly mind blowing stuff. The fact that we have figured out how some of this stuff works is also incredible. Makes our own human built machines look so pathetically simple. If I could do it all over again I think I might study biochemistry, it's fascinating! I love your videos and your narration style, long videos like this are GREAT.
Amazing explanation 👌 I always thought there's just a protein that deforms when stimulated with light, which then gets picked up as a signal... But the actual process is (from a design standpoint) waaaay to freaking unnecessarily complicated. But life just ran with whatever works
This is one of the most fascinating graphical visualizations of the processes happening inside your body. i never knew biochemistry was this complicated (but Awesome!) to look at, but you made it much much easier to understand.
I learned about these concepts in biology class, but to see the proteins and molecules and kinetics responsible for vision allows for a transcendent physical chemical understanding of our awareness. I deeply appreciate the work that goes into these videos.
I just discovered this channel- I love science content and this is just fantastic. So good. I love it so much. Thinking about biological systems from the physics on up fills me with awe and wonder. The speed at which these reactions are happening. The sheer number of molecules, the complexity of proteins. I get goosebumps from the feelings of awe this inspires. I thought I had subscribed to every science channel on TH-cam, and have been a science enthusiast for more than 50 years, and I have to say this is my new favourite TH-cam channel. I can’t wait to watch the rest of your content!
Just a tiny part in this video but the fact the membrane bound proteins can move freely in the cell membrane is what amazed me most. Didn’t learn that anywhere before..
It really is! Some are not free to move. An obvious example is membrane proteins like spectrin that get linked to the cytoskeleton. they are responsible for the erythrocyte shapes in animals.
My iPhone 14pro’s long exposure feature recently outperformed my eyes to view the comet in the night sky. As a long time photographer this is nothing new, but for a phone to do it is just incredible. No tripod, no setup, just an automatic 3 second exposure and boom comet and stars visible that my eyes could hardly make out. Amazing.
It was so funny to hastily make this joke during this video-only to turn around and do the EXACT SAME THING for both the aurora that hit North America and the comet. Great way to enhance stargazing-and an even greater reminder that I need to put more thought into the half-baked jokes I write. The 3 second exposure is great-but I’m jealous of new iPhone folks who have access to 10 second. Those shots look wild.
And thank you for making my day with this beautiful and profound glimpse to the inner workings of life. Excitement for the coolness of the whole process and tears for an overwhelming feeling of connection to the universe, moved by your starting and ending poetry verses.
speedrunning the anatomy - spoken like a true cell & molecular biologist
ITS SO BORING THO. ANATOMISTS GO HOME.
Never expected the two channel I watch are here.
We've been told that in the future we'll have nanomachines repairing our bodies, but our bodies were nanomachines all along
any sufficiently advanced nanomachine is indistinguishable from biology
That was my first thought when I discovered this channel. My first (video) was the ATP machinery one, and every single one after has reaffirmed this thought.
That's why riding a bike is better than driving a car - just because you don't understand the technology doesn't mean it's not better
this video is insane! I love the quality and clarity of this content. Never stop. You are doing humanity a favor.
This machine only moves faster
@@ClockworkbioWould u consider creating a video of how graphene would travel in the body when it is injected ... as well as inhaled, skin exposure, drink, and inhaled into the sinus. Please consider.
This one REALLY should have been split into two videos -- but how do y'all feel about 30-minute episodes on here?
Next video is short, punchy, and releasing in three weeks. NO MORE LONG UPLOAD GAPS.
channels like yours have great potential to cover things in a lot of detail. shorter videos is not good for detail. the amount of times I have been Blue balled by channels covering complex topics in a approachable way and then they go on to make 10-minute videos that only scratch the surface. please make 2 hour long videos.
@@Clockworkbio I didn’t even realize it was 30 minutes!
It was great! I have no issue with longer videos. But I have one little suggestion - during the video, there's a lot of "meta"-talk, including unnecessary preamps ("buckle up", "now we're going to analyze X and Y and Z"), a little bit of mild fearmongering (like in the GPCR bit - "ooh boy", or a sigh during the explanation of phosphodiesterase - literally all enzymes are named in this manner, so making it seem difficult to pronounce or remember is counterproductive). Maybe I'm extra sensitive to it, since coming from a chemistry background I've seen so many people scared of complexity, while in reality this anxiety only makes learning more difficult for some. Please don't take it as mindless criticism! I enjoy your videos a lot, sometimes I just wish there was more content going deeply into the biochemistry (for example - you could have explained how photons cause a cis-trans isomerization in retinal, which would also make remembering retinoid isomerase simpler).
Thank you for your work!
I have no problem with long episodes. No everything can be well explain in a few minutes. This is why we have Novels,Movies, Documentries,etc.
@@Valgween 2 hours is too much, but 30 minutes is better.
Just feeding the algorithm because it's just ridiculous that the algorithm isn't amplifying a channel of this quality.
Isn’t it amazing how your rod cells mutated into cone type cells however many millions of years ago and your brain was able to exploit this an evolve to interpret this as color, and how it specifically centralizes these at the center of vision and uses them less frequently than rods? It’s the whole point of this channel but god biology is more sublime than anything I’ve seen in physics
@@beamshooterlol
@@beamshooter 😂
@@beamshooterI promise u don’t actually die and all ur family members still exist 😉
@@beamshooterWe can't even see infrared or ultra violet.. what's so magnificent exactly?
@@beamshooter If you think we need a creator then who created the creator?
This explains why I see optical illusions when in a totally dark room, like my bathroom with the lights off. The chemistry with the calcium and the mechanism for turning that chemistry into nerve signals is what's making those patterns appear.
you mean you are seeing stuff (like dots maybe?) when there isn't any light in the room?
Noise signals, basically, I think.
Visual static. Sometimes in low light settings your eyes can trick your brain which is attempting to trying to determine objects. Depending on where you think you are and what you think you're seeing. Most of the time it's just blotchy static
The brain actually hallucinates stimuli in these cases, as no input of signals coming rom the eyes are non desirable and the brain will create a "screensaver" image in place of the lack of signal input. These can quite literally be shadowy figures or things moving outside your peripheral vision, so whenever you get startled by these sots of things its your brain that is to blame
Probably not. Photo receptors hyperpolerize in light, meaning they release less neurotransmitter onto target neurons, and depolarize in dark, meaning they release more neurotransmitter in dark. The neurotransmitter is glutamate and it inhibits its target neuron. With that said, a visual sensation occurs when cells of the visual cortex are stimulated to threshold. The visual cortex does get input from other sensory paths. This is why a visual target is easier to see if it is also accompanied by a sound. The energy from each pathway add to increase activity in the visual cortex. It’s basically a crude form of synesthesia where one sense can activate sensation in another sensory modality. And it exists on a continuum, more to less in adults. More common in children than adults. I’m the dark, sound powerfully causes me to experience visual sensations. Folks with high levels of synesthesia often have very very good memories. I’ve had professors accuse me of stealing their notes because I reproduced what they said in lectures word for word. I can also read and the recite near verbatim what I’ve read hours later, like I can recreate the page in my mind to reread.
30+ minute videos are AWESOME! Plus all the information you have in them make them worth it. I'd say longer tbh
I genuinely love you man. I cant properly say how much these videos make me truly appreciate life and how amazing every little tiny biological function behaves.
I send your videos to every friend and family member I can that can truly appreciate this.
You speak with the same wonder I would if I specialized in your field. Your amazement it's matched by all of us. Please keep up the incredible work ❤
I just found this channel, but I’ve fallen down the rabbit hole of binging every video. The narratives are so compelling, and the biochemical insights are genuinely astounding. Plus the graphics are so charming, and the 3D style is incredible!
It really shows how much time and effort go into these videos, looking forward to whatever you have in store next!
This channel deserves so much more! It's beautiful to observe the complexity of evolution and life.
This channel deserves more views. This stuff is so great - entertaining enough for people like me who aren't particularly interested in biology but informative enough to be worth watching
Awesome as always, the 30 minute videos are thought provoking and insightful
The fact that we can percieve photons that have been traveling thru space for thousands of light years is absolutely mind blowing, Nature is a master builder of function and form.
Thanks so much for "shedding some light" on the biochemistry of eyesight! Really enjoyed the animations, as always!
I just stumbled across your channel. I found myself literally subscribing to it in less than two minutes. That's how impressed I was with your channel! Awesome!
Same.
Absolutely every single particle of the universe is absolutely stunning and amazing. Which includes us of course.
You got to hand it to the biochemical scientists who worked out all these biochemical reactions. Me takes me hat off to ye! Trained as a biochemist years ago, and this stuff still leaves me in awe!!!
This channel is absolutely amazing. I am so fascinated with cellular biology, and when you said biochemistry probably isn’t why you’re here, I laughed because it so was. Keep up this amazing content, I love the intricacies you explain.
The quality of this video is almost as mind-boggling as the biology it talks about. Thank you!!
Oh my God I'm crying this is so beautiful 😭 Sight is a sense of touch... oh god all senses are touch?! 😳 All of my molecules are being touched 😱 ...... Can I feel all of my molecules? Surely every process is connected... But they can't be aware of each other... molecules aren't conscious... But molecules performing human processes create consciousness... Fuck. It's all random... Like, fire is a chemical process. Fire isn't aware of its own combustion.. each molecule of fuel being drained of its energy and converting it to carbon... The fire does not know it processes molecules or that it transforms them... In the same way, human processes don't know they are transforming molecules... They just do, because the processes which are in motion demand it be so.... and somehow, underlying all of this, DNA creates a language that transfers real survival knowledge from generation to generation. Babies born knowing how to eat, how to drink, preprogrammed from conception to partake in these self sustaining processes... Fuck. Fuck you've broken my brain...... Fuck man.. wtf even are we??? 😳
I feel the same, that overwhelming astonishment at life's complexity and beauty. Lately, at age 68, I no longer see "myself" as someone or something separate from everything else. It's all one great unfolding, and we're all temporary manifestations, or antennas, of awareness. Maybe that's why we don't feel older as the body ages, because we're always here in some sense.
KEEP THE PUMPS RUNNING!
Fantastic video, explanations and animations! The depth and width of coverage is great and packs an amazing amount into a half hour. And thank you for the mention!
I knew I had to bring in the maximum effort possible if I was going to keep producing videos in the same place as one of the greats! Your comment means the world to me. Thank you so much for taking the time to watch! Can't wait for more videos from you.
I can't describe how much I love your content, I recently discovered your channel and the fact that you started working on it again is absolutely amazing. Keep that up🎉
Not only keeping it up, but pushing the pace now as well! Glad you're here. Even gladder that I didn't make you wait 3 years like so many other folks.
Today is a good day. I get 30 minutes' worth of new Clockwork content.
This is such an amazing way to explain such a complex process. I mean, I didn't absorb all the information, but I understood the amazing principles behind how we see from a molecular standpoint. Your narration is so passionate that I think I felt what teenagers would feel when they have crushes on their profs
My primary hobby is robotics and using the Robot Operating System. Seeing bio engines, actuators, pumps, event systems is wild. I really appreciate your teaching skills. Not long after I finished reading Nick Lane's The Vital Question and Ed Yong's The Multitudes Within, I discovered your channel. Like robotics, I'm learning these new things in layers of time. So fascinating!
Just stumbled upon this video and your channel. I love it!
Great to have you, thanks so much! Really excited you're here at this phase since we've got some WILD topics on the horizon.
This is such an underrated channel. May the YT algorithm gods bless you
Trying hard here -- thanks so much for taking the time!
Absolutely amazing. I've drifted my career off biology and biochemistry into something seemingly unrelated as urban planning, but these processes are still so cool to me...
For a long time during the video I'd question how does retinal goes back to its original shape, but you showed how it's continually replaced with fresh ones. That makes a lot of sense on why we call it Vitamin A, being vitamins nutrients we can't produce ourselves.
But now I need other answers! How does the replacement process happen? How does the cell makes retinal readily available in order to feed rhodopsin(?) in real time?? Questions on how the system turns back to basal states are always on my mind, and you've answered a lot of them.
Some feedback for the future: dude, chill a bit, your videos are great, you don't have to feel rushed to present them. People who are here are because they love the subject. If you rush it too much, it may even lower the quality of the content, and that's a huge boomer, considering that's what you have best to offer.
Loving the videos and the wonderful commentary!
Oh, and I love coastal redwood trees. :)
Love that this video came onto my feed randomly! Love that you made this video 58 minutes ago! Thank You! I miss in depth, so detailed, and easy to consume content like this! Great work!
I like the long form videos!
MAN I wish this kind of visualization was available when I was studying this stuff in college. This was some sci-fi stuff back then!
This could have been a 6 week long video and I would watch every single second.
The photon recepticle must, at one time, had cubic miles of vulcanic cristals as its back ground, as ancestor..amazing, as: in it's wake.
The quality of the animations in this video is insane!
I might have to watch this a dozen times before half of it sticks, it's so dense!
Love the style of explanation and visuals. Makes things very clear
Amazing in-depth breakdown. I love that you mentioned nucleotides are used as energy because it's one of my favorite facts. In a way it means our genetic information is stored in the energy currency of the cell. Sort of analog pseudo digital feel if you think about it.
Bogle minded
This is the most interesting channel i've seen on the whole youtube for a fair amount of years. The beauty of these molecular, well, literally mechanisms is astounding.
There is so much more this channel deserves! The intricacy of life and evolution is stunning to witness.
1. I love the longer format.
2. KEEP THE PUMPS RUNNING!
this channel is so underrated. i binged all the videos as soon as i found the channel. ill definitely get the curiosity box if they aren't sold out in 2 days, i want that deck of cards and i dont care about any of the other things in the box- yet.
My brain is fried. I literally habe no background required to understand this but still watch anyways.
Dude... This is the first time I have come across your channel and all I can say is holy shit! The quality of this video is nuts! 36k subscribers is a tragedy. You're going to take off. I already know it. You even have great personality in narration.
Well now I get why getting hit with a bright flash of light takes a minute to fade away from your view.
If only my physiology lectureur explained stuff like you do... you make everything so clear and understandable, AND WITH THE IMMACULATE VISUALS everything just clicks
Thank you for the work effort and love you put into your vids
Can’t thank you enough for this, this is exactly what I needed and wanted to binge on and watch. Please keep up the fantastic work
On it! Thanks so much for spending your time here!
Absolutely one of the best videos i have seen om This topic - you should be very proud of yourself❤️
Not many creators I sub to without watching at least a first video to the end. I just know I needed to with this one bro. A1
1 minute shorts, 10 minutes, 30 minutes, anything--just keep bringing me this level of quality! Also, basic Southern Californian here so I gotta go with palm trees
After living in SoCal for a bit I’m shocked you didn’t go with Jacaranda!
I was just thinking I wanted to look into exactly this!! And then one of my favorite channels, definitely favorite nano scale channel, uploads this
Thank you for this. I learned a ton from this video and now have a richer appreciation for my sense of vision. I quite like the perspective of it being a sort of touch of a tiny fragment of stars. It's pretty remarkable how much this biomolecular dance has allowed us to learn about our universe from afar.
Also if anyone is ever trying to flirt with a biochemist that specializes in phototransduction you can ask: "Did your retinal absorb a photon or are you just happy to see me?"
The signal reduction prior to transmission to the brain is not a problem to get around; it is the initial image processing itself! Things like edge detection happen long before the brain gets it.
monkey see snake
CGump is going into textbooks. You are ahead of your time.
I have no problems with longer episodes, you do you.
Its stunning how much we have learned in just the last few years to understand these mechanisms. Fantastic explanation. Keep the pumps going.
The production value is fantastic.
Hi. Thanks for beautiful journey thru vision. I have XLRP so it was really cool to find what is genetically broken in my body. It would be quite nice and interesting to see your work on this disseas. Maybe some day 😎Once more - thanks for all. 🍻
man i love science
I know right? It only gets cooler all the time.
I'm loving the upgraded animation style in these new releases, but I have one request/suggestion if you wouldn't mind considering... In future could you please tone down the Brownian motion a little bit? Particularly for the background molecules like the phospholipids at 0:55, 1:51 and 5:37 for example. I know it's to better simulate the reality of the motion but it's so much movement that it's hard for my eyes to focus on the important proteins we're meant to be focussing on!
3:00 is a good example too - the ion pump is moving quite fluidly, but the phospholipids are kind of like stop motion and it's hurting my brain haha.
If you go to 7:20 of your hearing video, it's the older style of animation but the movement of the phospholipids is (less realistic, but) less distracting, if that makes sense? I'm sure there's a happy compromise somewhere in the middle which I would leave to your better judgement.
Only meant as friendly constructive suggestion, it's okay if you ignore it too - keep it up with the mind-blowing productions either way 👍
I agree :)
This is phenomenal, thank you so much for creating this. Learning from you is such a joy. Glad you're back at it!
amazing video. hopefully the algorithm picks these up and they get the viewership they deserve. thirty minute videos are just fine!
The really wild thing is that, where human engineering would tend to use fixed wiring, this process basically has everything free-floating and the signal is transmitted by chance collisions.
Thank you so, so much for repeating and re-summarizing things! This was a fascinating video, and so well put together
Color vision is the most wild thing i've ever come across... Like its a complete mental fabrication yet every human can *see* it
6:10 It's got electrolytes!
Owls rhodopsin must be goin on whole another level!! Giving more scotopic vision....🦉
it's all the same rhodopsin actually! Certain owl species simply have way more rod cells (and in the Great Horned Owl they are thinner and packed more together) and a reflective membrane at the very back of the retina that helps them pick up on a LOT more detail in the dark!
This is truly mind blowing stuff. The fact that we have figured out how some of this stuff works is also incredible. Makes our own human built machines look so pathetically simple. If I could do it all over again I think I might study biochemistry, it's fascinating! I love your videos and your narration style, long videos like this are GREAT.
Amazing explanation 👌
I always thought there's just a protein that deforms when stimulated with light, which then gets picked up as a signal... But the actual process is (from a design standpoint) waaaay to freaking unnecessarily complicated.
But life just ran with whatever works
It is indeed a protein that deforms when stimulated, plus some extra stuff to make electrical signals using chemical soup
This is one of the most fascinating graphical visualizations of the processes happening inside your body. i never knew biochemistry was this complicated (but Awesome!) to look at, but you made it much much easier to understand.
The complex beauty of it all is staggering
26:50 fav tree: binary tree. very useful. definitely the kind of tree he was talking about
11:38 XD ... OMG! I've been reading chapter 12 of Lehninger all this time without realizing it
I learned about these concepts in biology class, but to see the proteins and molecules and kinetics responsible for vision allows for a transcendent physical chemical understanding of our awareness. I deeply appreciate the work that goes into these videos.
loving the new visuals
"All of our senses are really touch." Such a fascinating idea!
… wonderful Explantation. I got all the way toto my Favorite tree.
I love learning about something I have no knowledge of but a lot of fascination with like bio chem
in the opening it's mentioned that we can see better than a regular camera in the dark
I was considering going blind before watching this. But now i realize i have been taking my sight for granted
This has an excellent level of detail and memes. Just wonderful!
I'm speechless. So much beauty and complexity.
I just discovered this channel- I love science content and this is just fantastic. So good. I love it so much. Thinking about biological systems from the physics on up fills me with awe and wonder. The speed at which these reactions are happening. The sheer number of molecules, the complexity of proteins. I get goosebumps from the feelings of awe this inspires. I thought I had subscribed to every science channel on TH-cam, and have been a science enthusiast for more than 50 years, and I have to say this is my new favourite TH-cam channel. I can’t wait to watch the rest of your content!
Thanks for the video! Been tired from the long hard day, and just in 30 minutes of the most satisfying video and now I feel ready to climb mountains🤩
Your work moves me to tears every time
My favorite trees are the ones I can see! Right now they’re turning yellow and red around here, which is molecularly neat!
Woohoo! New Clockwork video!!!
Another incredible video. Good job, man. The detail you include in your videos is very much appreciated, thank you.
Just a tiny part in this video but the fact the membrane bound proteins can move freely in the cell membrane is what amazed me most. Didn’t learn that anywhere before..
It really is!
Some are not free to move. An obvious example is membrane proteins like spectrin that get linked to the cytoskeleton. they are responsible for the erythrocyte shapes in animals.
Thanks for the hard work😊
Couldn't stop watching. Shared. Thanks.
Your channel honestly deserves more attention. I hope you get to 1M subscribers soon.
The ions must flow.
Oh my god THATS A MUCH BETTER LINE
This channel is just amazing. The content is high quality and the delivery is espetacular.
It's mind boggling how fast all this has to happen.
I'm a maple man myself - fantastic video! you really make
me think
My iPhone 14pro’s long exposure feature recently outperformed my eyes to view the comet in the night sky. As a long time photographer this is nothing new, but for a phone to do it is just incredible. No tripod, no setup, just an automatic 3 second exposure and boom comet and stars visible that my eyes could hardly make out. Amazing.
It was so funny to hastily make this joke during this video-only to turn around and do the EXACT SAME THING for both the aurora that hit North America and the comet. Great way to enhance stargazing-and an even greater reminder that I need to put more thought into the half-baked jokes I write. The 3 second exposure is great-but I’m jealous of new iPhone folks who have access to 10 second. Those shots look wild.
And thank you for making my day with this beautiful and profound glimpse to the inner workings of life.
Excitement for the coolness of the whole process and tears for an overwhelming feeling of connection to the universe, moved by your starting and ending poetry verses.
Amazing! Keep making these videos. Awesome for my IB and AP students.
Great to hear! Let me know if there are any topics they keep getting stuck on that I can prioritize in my editorial calendar!