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- เผยแพร่เมื่อ 8 ต.ค. 2024
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👀 Your visual system is astounding down at the molecular level-because the photoreceptor cells in your retina maintain an incredible balance of proteins that allows for an incredible visual range. Let’s meet rhodopsin, the molecular worker at the core of your visual system. We’ll discover how light physically touches and changes you every time you perceive just about anything.
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Clockwork is produced using real molecular data thanks to the brilliant Molecular Nodes extension for Blender:
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🦠 Pigment Epithelium layer made using procedural assets by Viczie: vizcie.gumroad...
If you want to better understand these systems, the videos made by @KerryKim are an incredible resource: • Phototransduction: Ho...
🧬 Primary Structures Cited:
1azt
1gp2
1iku
1jsa
1u0h
2194
2r2i
2w01
3fsn
3jab
4j2q
6zwj
6oya
7rhh
7zbc
7zbe
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![[Live] : ONE FIGHT NIGHT 25 วันนี้!! "อเล็กซิส vs รีเกียน"](http://i.ytimg.com/vi/suVr9a6BM2g/mqdefault.jpg)
this video is insane! I love the quality and clarity of this content. Never stop. You are doing humanity a favor.
This machine only moves faster
This one REALLY should have been split into two videos -- but how do y'all feel about 30-minute episodes on here?
Next video is short, punchy, and releasing in three weeks. NO MORE LONG UPLOAD GAPS.
channels like yours have great potential to cover things in a lot of detail. shorter videos is not good for detail. the amount of times I have been Blue balled by channels covering complex topics in a approachable way and then they go on to make 10-minute videos that only scratch the surface. please make 2 hour long videos.
@@Clockworkbio I didn’t even realize it was 30 minutes!
It was great! I have no issue with longer videos. But I have one little suggestion - during the video, there's a lot of "meta"-talk, including unnecessary preamps ("buckle up", "now we're going to analyze X and Y and Z"), a little bit of mild fearmongering (like in the GPCR bit - "ooh boy", or a sigh during the explanation of phosphodiesterase - literally all enzymes are named in this manner, so making it seem difficult to pronounce or remember is counterproductive). Maybe I'm extra sensitive to it, since coming from a chemistry background I've seen so many people scared of complexity, while in reality this anxiety only makes learning more difficult for some. Please don't take it as mindless criticism! I enjoy your videos a lot, sometimes I just wish there was more content going deeply into the biochemistry (for example - you could have explained how photons cause a cis-trans isomerization in retinal, which would also make remembering retinoid isomerase simpler).
Thank you for your work!
I have no problem with long episodes. No everything can be well explain in a few minutes. This is why we have Novels,Movies, Documentries,etc.
@@Valgween 2 hours is too much, but 30 minutes is better.
Isn’t it amazing how your rod cells mutated into cone type cells however many millions of years ago and your brain was able to exploit this an evolve to interpret this as color, and how it specifically centralizes these at the center of vision and uses them less frequently than rods? It’s the whole point of this channel but god biology is more sublime than anything I’ve seen in physics
Our Creator has made us a most magnificent creature!
@@beamshooterlol
@@beamshooter 😂
@@beamshooterI promise u don’t actually die and all ur family members still exist 😉
@@beamshooterWe can't even see infrared or ultra violet.. what's so magnificent exactly?
This explains why I see optical illusions when in a totally dark room, like my bathroom with the lights off. The chemistry with the calcium and the mechanism for turning that chemistry into nerve signals is what's making those patterns appear.
you mean you are seeing stuff (like dots maybe?) when there isn't any light in the room?
Noise signals, basically, I think.
Visual static. Sometimes in low light settings your eyes can trick your brain which is attempting to trying to determine objects. Depending on where you think you are and what you think you're seeing. Most of the time it's just blotchy static
The brain actually hallucinates stimuli in these cases, as no input of signals coming rom the eyes are non desirable and the brain will create a "screensaver" image in place of the lack of signal input. These can quite literally be shadowy figures or things moving outside your peripheral vision, so whenever you get startled by these sots of things its your brain that is to blame
I genuinely love you man. I cant properly say how much these videos make me truly appreciate life and how amazing every little tiny biological function behaves.
I send your videos to every friend and family member I can that can truly appreciate this.
You speak with the same wonder I would if I specialized in your field. Your amazement it's matched by all of us. Please keep up the incredible work ❤
This channel deserves so much more! It's beautiful to observe the complexity of evolution and life.
30+ minute videos are AWESOME! Plus all the information you have in them make them worth it. I'd say longer tbh
Thanks so much for "shedding some light" on the biochemistry of eyesight! Really enjoyed the animations, as always!
Awesome as always, the 30 minute videos are thought provoking and insightful
Fantastic video, explanations and animations! The depth and width of coverage is great and packs an amazing amount into a half hour. And thank you for the mention!
I knew I had to bring in the maximum effort possible if I was going to keep producing videos in the same place as one of the greats! Your comment means the world to me. Thank you so much for taking the time to watch! Can't wait for more videos from you.
This channel deserves more views. This stuff is so great - entertaining enough for people like me who aren't particularly interested in biology but informative enough to be worth watching
This could have been a 6 week long video and I would watch every single second.
We've been told that in the future we'll have nanomachines repairing our bodies, but our bodies were nanomachines all along
I might have to watch this a dozen times before half of it sticks, it's so dense!
Love the style of explanation and visuals. Makes things very clear
1. I love the longer format.
2. KEEP THE PUMPS RUNNING!
Today is a good day. I get 30 minutes' worth of new Clockwork content.
The quality of this video is almost as mind-boggling as the biology it talks about. Thank you!!
Loving the videos and the wonderful commentary!
Oh, and I love coastal redwood trees. :)
this channel is so underrated. i binged all the videos as soon as i found the channel. ill definitely get the curiosity box if they aren't sold out in 2 days, i want that deck of cards and i dont care about any of the other things in the box- yet.
The signal reduction prior to transmission to the brain is not a problem to get around; it is the initial image processing itself! Things like edge detection happen long before the brain gets it.
monkey see snake
Not many creators I sub to without watching at least a first video to the end. I just know I needed to with this one bro. A1
My primary hobby is robotics and using the Robot Operating System. Seeing bio engines, actuators, pumps, event systems is wild. I really appreciate your teaching skills. Not long after I finished reading Nick Lane's The Vital Question and Ed Yong's The Multitudes Within, I discovered your channel. Like robotics, I'm learning these new things in layers of time. So fascinating!
MAN I wish this kind of visualization was available when I was studying this stuff in college. This was some sci-fi stuff back then!
I can't describe how much I love your content, I recently discovered your channel and the fact that you started working on it again is absolutely amazing. Keep that up🎉
Not only keeping it up, but pushing the pace now as well! Glad you're here. Even gladder that I didn't make you wait 3 years like so many other folks.
I was just thinking I wanted to look into exactly this!! And then one of my favorite channels, definitely favorite nano scale channel, uploads this
CGump is going into textbooks. You are ahead of your time.
KEEP THE PUMPS RUNNING!
Absolutely one of the best videos i have seen om This topic - you should be very proud of yourself❤️
Dude... This is the first time I have come across your channel and all I can say is holy shit! The quality of this video is nuts! 36k subscribers is a tragedy. You're going to take off. I already know it. You even have great personality in narration.
Can’t thank you enough for this, this is exactly what I needed and wanted to binge on and watch. Please keep up the fantastic work
On it! Thanks so much for spending your time here!
My favorite trees are the ones I can see! Right now they’re turning yellow and red around here, which is molecularly neat!
"All of our senses are really touch." Such a fascinating idea!
I learned about these concepts in biology class, but to see the proteins and molecules and kinetics responsible for vision allows for a transcendent physical chemical understanding of our awareness. I deeply appreciate the work that goes into these videos.
amazing video. hopefully the algorithm picks these up and they get the viewership they deserve. thirty minute videos are just fine!
Absolutely every single particle of the universe is absolutely stunning and amazing. Which includes us of course.
I have no problems with longer episodes, you do you.
If only my physiology lectureur explained stuff like you do... you make everything so clear and understandable, AND WITH THE IMMACULATE VISUALS everything just clicks
Thank you for the work effort and love you put into your vids
The complex beauty of it all is staggering
Your work moves me to tears every time
The quality of the animations in this video is insane!
This is one of the most fascinating graphical visualizations of the processes happening inside your body. i never knew biochemistry was this complicated (but Awesome!) to look at, but you made it much much easier to understand.
Makes me wonder how, or where in the sequences, visual hallucinations work, and how they can be superimposed over actual visual information.
Your channel honestly deserves more attention. I hope you get to 1M subscribers soon.
Amazing explanation 👌
I always thought there's just a protein that deforms when stimulated with light, which then gets picked up as a signal... But the actual process is (from a design standpoint) waaaay to freaking unnecessarily complicated.
But life just ran with whatever works
It is indeed a protein that deforms when stimulated, plus some extra stuff to make electrical signals using chemical soup
new clockwork video! just in time to learn something not covered by the syllabus in detail to force it into my answer to a slightly related HSC question(the photosynthesis videos wouldve come in clutch if i did the 2018 hsc)
26:50 fav tree: binary tree. very useful. definitely the kind of tree he was talking about
Owls rhodopsin must be goin on whole another level!! Giving more scotopic vision....🦉
it's all the same rhodopsin actually! Certain owl species simply have way more rod cells (and in the Great Horned Owl they are thinner and packed more together) and a reflective membrane at the very back of the retina that helps them pick up on a LOT more detail in the dark!
This channel is just amazing. The content is high quality and the delivery is espetacular.
This is the most interesting channel i've seen on the whole youtube for a fair amount of years. The beauty of these molecular, well, literally mechanisms is astounding.
Thanks for the hard work😊
Another incredible video. Good job, man. The detail you include in your videos is very much appreciated, thank you.
Just a tiny part in this video but the fact the membrane bound proteins can move freely in the cell membrane is what amazed me most. Didn’t learn that anywhere before..
It really is!
Some are not free to move. An obvious example is membrane proteins like spectrin that get linked to the cytoskeleton. they are responsible for the erythrocyte shapes in animals.
Love that this video came onto my feed randomly! Love that you made this video 58 minutes ago! Thank You! I miss in depth, so detailed, and easy to consume content like this! Great work!
Thanks for the video! Been tired from the long hard day, and just in 30 minutes of the most satisfying video and now I feel ready to climb mountains🤩
I was considering going blind before watching this. But now i realize i have been taking my sight for granted
speedrunning the anatomy - spoken like a true cell & molecular biologist
ITS SO BORING THO. ANATOMISTS GO HOME.
Incredible work! I wonder, what's the mechanism that occurs in retinal overexposure? Does it have to do with cGMP depletion or some related effect of PDE overactivation?
Hey ! This was a great video ! Really enjoyed the animation and the detail, also very philosophical topic. As a chemist I think it would be cool to also include the molecular structure of the molecules (like for cGMP). Also as the molecular structures are just sticks and static 2D , it could be an opportunity to animate them into something more visually pleasing ? And a question: What song do you think would best fit the folding of a protein into its final structure ? Thanks !
My brain is fried. I literally habe no background required to understand this but still watch anyways.
All hands to the pumps!
The production value is fantastic.
I was looking for something like this and a channel like this. I’m adding you to my biology channel list
Color vision is the most wild thing i've ever come across... Like its a complete mental fabrication yet every human can *see* it
I think i would have mentioned that heat also causes rods to misfire, which is the cause of some visual hallucinations you see in the dark!
This video was great, I didn't even notice it was 30 minutes until i saw your comment, and answered many questions I've always had and many i didn't know i had. If i can make just one note, the beginning of the video had lots of interjections, "oh isnt this name wacky" and "y'alls" that didn't really add much but interrupted the flow (brain is too tiny to parse protein chemistry and jokes at the same time)
Mentioning something and specifying that you're gonna cover it later instead is very useful. Doesn't distract me from the current explanation by wondering about the missing step
Sandalwood tree! Also I love the long format episodes, because I can grab a meal while I watch.
loving the new visuals
Thank you for this brilliant video
my favorite tree is the manchineel tree, i love your videos and im all for super long videos, the way you animate all the physical processes and explain all the electromagnetic processes is just wonderful for actually understanding how a biological reaction occurs and not just why. the only thing i found myself wishing for a deeper explaination to is the protien movements, i would love a more focused depiction of the actual change in shape of a protien when its activated and how that allows the subsequent step to occur. but honestly dude all your videos are so mind blowingly amazing that i cant wait to see how the rest of my senses work on such a fundamental level. thank you for the obvious hard work.
in the opening it's mentioned that we can see better than a regular camera in the dark
wow cant believe he is back!
Woohoo! New Clockwork video!!!
Amazing video!
I have a question that bothers me for about 3 years now:
Regarding color vision, have you noticed that when looking at UV light, it appears to be purple-ish (for UV A) and it can make sense from one perspective, as the wavelength of red light is roughly twice. Is it the second harmonic?
Same thing with UV C, it appears as a beautiful pale blue with a hint of green. That can be also explained with the second harmonic.
Another theory could be that the UV light is absorbed by some fluorescent stuff on its way to the retina and gets re emitted as visible light.
So what is the molecular difference between opsins in cone cells? And how is the light interacting with that little twisted vitamin a molecule?
Or am I just stupid and it's all about activation energy?
Rainbow eucalyptus! 😜 first clockwork episode ever! Instant subscriber! Engaging Binge commencement drives 🤓
I like extra long clockwork videos but more uploads makes more sense
my favourite tree is elder (it mostly grows as shrubs but can be a tree so it counts)
wow this is fantastic this is just like i imagined one way how alphafold will help!!!
Your videos are amazing and I will watch every video you make no matter the subject, but I would love a video about celular respiration. You are greate, and I would love to see your chanel grow, and with this much quality I am sure it will
The really wild thing is that, where human engineering would tend to use fixed wiring, this process basically has everything free-floating and the signal is transmitted by chance collisions.
2:22 My gf says those cones look like knotted toys... I just googled it and yeah 😂 pretty much bang on
I love this, It makes me want to study biochemestry instead of biomedicine. It honestly astonishme how you made it so digestible. O and my favorite tres is the pirul.
I enjoyed this a lot! It's such a crazy convoluted process, I was expecting it to be more like wiring. It seems like this would be way too slow/indirect/blurry for our amazing vision.
Wait, youre back?
YOUR BACK??!!
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So inspiring thank you
Cool. Thanks for sharing.
what an amazing channel
Bro, how am I just now finding this channel??????
Love your work.
Hell yeah my goat posted🙏🙌
Shagbark hickory for sure
I like how in this animation the membrane layers in the rod cell look a lot like grana in the thylakoid of chloroplasts. I guess membrane stacks are just good at catching lots of light!
I literally wished for this exact video
I do what I can!
He’s pushing the limit of molecular nodes for real eh?
even though I'm never going to use it thank you for telling me this exists.
I love learning about something I have no knowledge of but a lot of fascination with like bio chem
I'm loving the upgraded animation style in these new releases, but I have one request/suggestion if you wouldn't mind considering... In future could you please tone down the Brownian motion a little bit? Particularly for the background molecules like the phospholipids at 0:55, 1:51 and 5:37 for example. I know it's to better simulate the reality of the motion but it's so much movement that it's hard for my eyes to focus on the important proteins we're meant to be focussing on!
3:00 is a good example too - the ion pump is moving quite fluidly, but the phospholipids are kind of like stop motion and it's hurting my brain haha.
If you go to 7:20 of your hearing video, it's the older style of animation but the movement of the phospholipids is (less realistic, but) less distracting, if that makes sense? I'm sure there's a happy compromise somewhere in the middle which I would leave to your better judgement.
Only meant as friendly constructive suggestion, it's okay if you ignore it too - keep it up with the mind-blowing productions either way 👍
I agree :)
3:28 the foreshadowing for guanosine is complete!
SOMEONE NOTICED
New drop, let's go!
22:14 Long story short, you can't see a single photon because, being warm blooded, you need to filter out thermal noise (every once in a while, rhodopsin gets activated by bumping into another molecule in the wrong way instead of by light, which happens more at high temperatures), and so the neurons connected to the rods only pass the signal on if they receive a strong signal from one rod or a weak signal from multiple rods.
Frogs, being cold blooded, don't have this circuitry and can see a single photon, but the price they pay is that their vision gets staticky on a hot, dark night.
I Fcking love your videos! I liked the videos from iBiology for it's scientificness but your animations are way nicer. Maybe there is a colab waiting to be done :D
fantastic video man! The animation is top notch, great script, fantastic knowledge and a nice teacher voice! I had a question, i hope you can help me out or possible make a video about it but why does nature use ATP as an energy molecule? Why didn't other molecules past the test? And why is cholesterol considered the ultimate chemical of all animal life? Thanks!
At the fundamental level, things just spin and kick things around