Clockwork
Clockwork
  • 13
  • 497 292
The Incredible Mechanics That Make You Hear
Support the channel by joining our newsletter: bit.ly/watchclockwork
How does sound actually get inside your head? How can little vibrations in the air turn into nerve impulses? Let's meet the 100 nanometers of protein that connect you to sound
Sources are cited in this ever-growing Twitter thread: bit.ly/cadherin
This channel is created with the support of all our patrons on Patreon: www.patreon.com/clockworkshow
Support the channel directly with a one time donation: www.paypal.me/clockworkshow
This channel is dedicated to sparking your curiosity about biochemistry, not to being a definitive resource. To help you continue you biochem journey, I'm really excited to partner with Biocord , a Discord server dedicated to bringing together biologists from around the globe! Join the conversation with over a thousand life sciences professionals and enthusiasts here:- discord.gg/kwsVbfC
All music is by Jeremy Blake(th-cam.com/users/redmeansrecording), released on the TH-cam Audio Library.
Intro music: Let's Go Home (bit.ly/rmrlgh)
Outro music: Lost and Found (bit.ly/rmrlnf)
The style of this video was largely developed based on tutorials by Ben Marriot: (bit.ly/posterizethis)
Consciousness is super weird--how do we take all these signals from the outside world and make them make sense enough to like...be alive?
However--if you examine hearing from a molecular perspective--you’ll begin to see how simple and elegant it is as a sense. We’re traveling deep into your cochlea to meet your inner ear cells and the stereocilia that make it possible for you to hear. Here, you’ll discover that hearing is just a hundred nanometers of protein tugging on a membrane. It is such a small and simple process with incredibly complex consequences.
มุมมอง: 53 637

วีดีโอ

How Plants Turned Air Into Civilization |The Calvin Cycle
มุมมอง 19K3 ปีที่แล้ว
Support the channel by joining our newsletter: bit.ly/watchclockwork The Calvin Cycle is how we transform carbon dioxide into well everything. By making carbon biologically useful, our biosphere has managed to transform CO2, Sunlight and water into basically the entire world around you. Does that sound hyperbolic? Watch to find out just how much of an understatement that really is. This channel...
This Protein Hugs Ice Crystals to Death
มุมมอง 27K3 ปีที่แล้ว
Support the channel by joining our newsletter: bit.ly/watchclockwork Join Biocord here: discord.gg/kwsVbfC If liquid water is an absolute requirement for life how on earth does ANYTHING survive in Earth's polar regions? What should be a frozen wasteland is a thriving ecosystem. Let's look at ice structuring proteins and discover how they literally bind to ice crystals as they form giving the sm...
The Most Underrated Chemical Process on Earth|Nitrogen Fixing
มุมมอง 53K3 ปีที่แล้ว
Support the channel by joining our newsletter: bit.ly/watchclockwork Why aren't more people talking about how cool Nitrogen is? Almost every single compound that makes you requires Nitrogen. And without organisms that take in nitrogen from our atmosphere and make it useful all the complexity of life on earth wouldn't be possible. Let's take a look at the nitrogenase enzyme and discover how it b...
The 7,800 RPM Motor that Powers Everything You Do|ATP Synthase
มุมมอง 164K3 ปีที่แล้ว
Support the channel by joining our newsletter: bit.ly/watchclockwork ATP Synthase is one of the most important and fundamental machines that gives life it's incredible powers. Looking at it from the chemical level will give you even more respect for just how much work it takes for you to even read these words right now. Sources are cited in this ever-growing Twitter thread: bit.ly/synthasesourc...
What turns sunlight into chemical energy?
มุมมอง 18K3 ปีที่แล้ว
Support the channel by joining our newsletter: bit.ly/watchclockwork So, we know that plants use sunlight to make food. That’s kind of one of the most important facts in our ecosystem. Plants and photosynthetic bacteria form the bedrock of our food chain and are one of the most important forces making Earth a habitable planet. But how do we transition from solar energy to chemical energy? How e...
So, what's the deal with phosphine?
มุมมอง 8K3 ปีที่แล้ว
This channel is created with the support of all our patrons on Patreon: www.patreon.com/clockworkshow By now you've heard about the detection of phosphine on Venus, and how this may indicate there is life in the upper clouds of the Venusian atmosphere. But what *IS* phosphine? What kind of life on earth produces this gas and what kind of life would make it in the extremely acidic clouds of our ...
WAY More than a Powerhouse: The Incredible Roles Mitochondria Play
มุมมอง 17K3 ปีที่แล้ว
We all know Mitochondria are the powerhouse of the cell. But is that ALL they do? This video provides a really broad introduction to the incredibly mutlifacted roles mitochondria play in everyday cell life. A review video like this will gloss over lots of important details though. Corrections, clarifications and sources are here: bit.ly/clockworkep5 Fact checking for this episode was generously...
Why Do You Lose DNA Every Time Your Cells Divide?
มุมมอง 26K3 ปีที่แล้ว
Support the channel by joining our newsletter: bit.ly/watchclockwork How does your DNA contribute to aging? This video provides a really broad introduction to the end replication problem, telomeres and senescence. but can't hit all the important details. Corrections, clarifications and sources are here: bit.ly/clockworkep4 Fact-checking for this episode was generously donated by the BRILLIANT @...
This Chemical Steals Sunlight to Power All Life on Earth: Photosystem II
มุมมอง 34K3 ปีที่แล้ว
Photosynthesis is an immense, mind-blowing process. This video covers the complex that starts it off: Photosystem II. This video provides a solid introduction to photosystem II and photosynthesis, but can't hit all the important details. Corrections, clarifications and sources are here: bit.ly/clockworkep3 Sources are cited in this ever-growing twitter thread: bit.ly/psiisources This channel is...
How Does Fluoride Change Your Teeth?
มุมมอง 54K4 ปีที่แล้ว
Support the channel by joining our newsletter: bit.ly/watchclockwork Let's talk about how fluoride ions straight-up change the chemistry of your teeth. This video provides a solid introduction to this topic, but can't hit all the important details. Corrections, clarifications and sources are here: bit.ly/clockworkep2 This channel is created with the support of all our patrons on Patreon: www.pa...
The Gorgeous Symmetry in Your Blood Chemistry
มุมมอง 21K4 ปีที่แล้ว
How does your blood know where to deliver oxygen in your body? Let's explore the basics of how hemoglobin works and how it serves as an awesome intro to biochemistry. Ultimately, this video simplifies a lot of the details of the processes that help hemoglobin pick up and release oxygen. I go over that in some more detail here: bit.ly/clockworkep1 This channel is created with the support of all ...

ความคิดเห็น

  • @navinsingh1730
    @navinsingh1730 ชั่วโมงที่ผ่านมา

    If P680 acts on only the 680nm light, what about the blue light, and other wavelengths?

  • @dreamyrhodes
    @dreamyrhodes 6 ชั่วโมงที่ผ่านมา

    I enjoyed this however I would strongly disagree that 78% Nitrogen is useless for life. You don't want a 100% or even 70% Oxygen atmosphere, that would be a disaster, everything would constantly oxidize and go up in flames, not to mention all the radicals that would be formed and mess with our biology... Therefore having an huge amount of an inert gas in the atmosphere is actually quite useful.

  • @seanjustg5425
    @seanjustg5425 12 ชั่วโมงที่ผ่านมา

    Neat stuff to say the least...thankz for sharing❤

  • @robertunderwood1011
    @robertunderwood1011 วันที่ผ่านมา

    Tobias ERB has found a way to synthesize sugars from carbon dioxide and sunlight, without chlorophyll. The process is much faster. Cai, Sun , and Mu. Have recently done the same thing with starches We’re gonna need an update

  • @robertunderwood1011
    @robertunderwood1011 วันที่ผ่านมา

    I’m so glad I ran into this channel. we are in the early morning of the golden age of biotechnology and nitrogen. Fixation has been the holy Grail for about the past hundred years. I’m getting excited I think we are close to learning the whole process What an incredibly important discovery that will be! I’m keeping a watchful eye on corporations, like deep branch, and Novo nutrients 😅 People should be dancing on the streets already because Tobias

    • @robertunderwood1011
      @robertunderwood1011 วันที่ผ่านมา

      Tobias Erb has synthesized sugar from carbon dioxide at a much higher rate than any plant can produce it. In the past four years. The Chinese chemists Cai, Sun and Mu Have synthesized starch from carbon dioxide at a much higher rate than plants can produce it So this opens the question : Will we be able to do nitrogen fixation as a low temperature low pressure chemical process without reliance on plants? Will we be able to do protein synthesis from carbon dioxide? Such a process allows us to find a use for a greenhouse gas and provides human nutrition, without dependence on seasons, weather, or the mechanics of farming, land water, and all the related chemistry of insecticides, pesticides, herbicides, and there many problems Speed of production will be the main issue

  • @lyhongleft3676
    @lyhongleft3676 วันที่ผ่านมา

    What if you don't eat carbs and eat lets say, meat instead?

  • @Dr.Kraig_Ren
    @Dr.Kraig_Ren วันที่ผ่านมา

    Amazing video. I'm Excited for season 2. 😊

  • @CaptivaLP
    @CaptivaLP วันที่ผ่านมา

    I really hope this channel will come back. The videos are amazing

  • @jameshopkins3541
    @jameshopkins3541 2 วันที่ผ่านมา

    Where is the photon????

  • @pelegshalev7359
    @pelegshalev7359 2 วันที่ผ่านมา

    please come back making videos

  • @matteomezzetti8277
    @matteomezzetti8277 2 วันที่ผ่านมา

    Thanks

  • @pierrevillemaire-brooks4247
    @pierrevillemaire-brooks4247 2 วันที่ผ่านมา

    I was left to believe that hydrogen doesn't float around our body and cells freely , but that it was rather hydronium (H30) that carried around that extra proton to toss it wherever it was most needed or welcomed.

    • @blaineburns4325
      @blaineburns4325 2 วันที่ผ่านมา

      It does stick around water, in fact it usually complexes between the oxygens of multiple water molecules forming something like (H2O)2H+, but the end result of the chemistry is still the same. any time the "proton goes somewhere", it's just the proton being transferred from the water complex to protonate some other molecule.

  • @Aizemiyo
    @Aizemiyo 2 วันที่ผ่านมา

    I need to know how to boost that F0 motor. Need to increase my 0.3hp to 1.3hp. Do we have biological-equivalent to a NOS or turbocharger? Gotta spin it to 20000rpm for moarr powahh

  • @mattBLACKpunk
    @mattBLACKpunk 3 วันที่ผ่านมา

    For real though, why is your website not archived? All of this high quality work, lost to the world? If it was a paid service I'll buy it but omg don't let it get lost

    • @Clockworkbio
      @Clockworkbio 3 วันที่ผ่านมา

      Woah my bad-moved the website to watch clockwork.com and forgot to re-up this domain!

  • @davidlamb2430
    @davidlamb2430 3 วันที่ผ่านมา

    Boggles the brain to think how something like this evolved, like what was the first accidental protein that got together to form the first part of the engine. And actually worked in concert with all the other systems. Equally mind boggling is how anyone worked out all this stuff, like how would they know what’s happening at molecular level in such detail without being able to see it in action in a live cell.

  • @opabinnier
    @opabinnier 3 วันที่ผ่านมา

    Never seen your stuff before, Mr C Lockwork, so: I like your animation here- nicely illustrating a tricky process AND satisfying to watch endlessly. WELL DONE! Ah ATP synthesis... at school we did cover basic organic chemistry and I was caught by its glamour: the shapes and structures and logic of giant molecules: wow! Sadly when choosing exam courses for O Level I had to make a CHOICE and so dropped all 3 sciences to make room for all the subjects where I was sure of high marks. But always stayed a science freak in my bones!

  • @Chad-Giga.
    @Chad-Giga. 3 วันที่ผ่านมา

    ❤bio so much

  • @decro4945
    @decro4945 3 วันที่ผ่านมา

    Varsha gut

  • @TojiFushigoroWasTaken
    @TojiFushigoroWasTaken 4 วันที่ผ่านมา

    I randomly discovered this channel and every video blew my mind. It's seriously insane how random molecules fit together and make extremely specific tasks work so well....it kind of redefines the definition of consciousness to a whole another level As a kid i was so obsessed with science that i used to wake up till 3 in the morning just to catch an episode of curiosity by Neil d tyson. The videos in your channel awakens that same childlike fascination in me 🥰

  • @johnpowell9174
    @johnpowell9174 4 วันที่ผ่านมา

    Nearly all life, as you mention, there are some chemotrophs. Also, physicists have given up on conservation of energy.

  • @FutureAIDev2015
    @FutureAIDev2015 4 วันที่ผ่านมา

    Could you add a little explanation for the smooth brain conspiracy theorists who think the government is trying to poison them with fluoride?

  • @saraholmes4221
    @saraholmes4221 4 วันที่ผ่านมา

    Just found your channel and I’m in love! Thank you for what you do!

  • @nobody.of.importance
    @nobody.of.importance 5 วันที่ผ่านมา

    The same power plants that run our video games also run hospitals and water purification, without which our society would almost definitely collapse. Even if you're just watching this video, you can still appreciate that it's there to give you the energy for what *ever* you need it for. <3

  • @jameshopkins3541
    @jameshopkins3541 5 วันที่ผ่านมา

    I DO NOT UNDERSTAND ANY THING

  • @jameshopkins3541
    @jameshopkins3541 5 วันที่ผ่านมา

    CAN YOU EXPLAY SOMETHING????

  • @eduardomanrique400
    @eduardomanrique400 5 วันที่ผ่านมา

    Not me crying. Thank you for these videos.

  • @perfectman3077
    @perfectman3077 5 วันที่ผ่านมา

    I wonder what our atomic composition is on a dry basis

  • @philipd8868
    @philipd8868 5 วันที่ผ่านมา

    Thank you for the description and explanation of the amazing ATP machine. I too find it awe inspiring, and brilliant design comes to mind. This is where the quiet awe is meant to lead us. Billions of years would never explain something like this, and there are many such nano machines. Ask the chicken or egg questions ... this is where it should lead us. A nano machine would never ask the questions 🙂 Further to your point at the end, the One who designed us cares about us because He is much more than we are ... the Great I Am. Check Him out.

  • @memberwhen22
    @memberwhen22 5 วันที่ผ่านมา

    it's just absolutely incredible how a bunch of hydrogen gas gathered to form the first stars and those stars created all the heavier elements and then those elements ended up in planets and then this planet absolutely absurd amounts of conditions had to be met for life to even begin, and then to get from single celled organisms to people, and then the people getting smart enough to figure that all out. wow.

  • @jameshopkins3541
    @jameshopkins3541 6 วันที่ผ่านมา

    REDOIT. COME AGAIN BUT EXPLAINING ARE YOU TA TELLOMERES?

  • @Pomali1029
    @Pomali1029 6 วันที่ผ่านมา

    I am so glad I found you

  • @deltachange6204
    @deltachange6204 6 วันที่ผ่านมา

    So I tried to Google and was unsuccessful. Where does adp initially come from in the cells? Like yes it comes when the phosphate group is split. But where did the original adp come from to be made into atp?

  • @gregorysagegreene
    @gregorysagegreene 7 วันที่ผ่านมา

    I just need one more life? ... now, I can get it right this time. Telomerase me!

  • @GenomeNinjaScience
    @GenomeNinjaScience 7 วันที่ผ่านมา

    Hi @Clockwork! Your content is awesome. I find it engaging and informative! I also really like the animations you use in your video. I was curious, What software do you use to make them? Thank you for any time and attention that is provided to this comment!

  • @adamwu4565
    @adamwu4565 7 วันที่ผ่านมา

    This whole issue of DNA replication being unable to copy that last bit of the chromosome ultimately exists because we eukaryotes have linear chromosomes. Prokaryotes have circular chromosomes, and in a circular chromosome there is no problem, as there will always be leading DNA for those RNA primers to stick to. DNA replication almost certainly first evolved in proto-prokaryotes with circular chromosomes, so this issue of DNA loss with replication would not have come up. When the first eukaryotes emerged after their two bacterial and archaean ancestor prokaryotes merged, somehow the original prokaryotic circular chromosome got chopped up into multiple lineage chromosomes, giving rise to this problem. The whole system with telomeres and telomerase was a kluge that early eukaryotes came up with to deal with the new problem. This may also be one of the reasons Eukaryotes have a lot of junk DNA, while Prokaryotes don't. Because telomeres are basically a type of junk DNA that happens to exist at the end of chromosomes, and very likely evolved out of the same mutational mechanisms that produce certain classes of junk DNA, and the telomerase gene very likely a descendant of a type of selfish parasitic jumping gene that produces junk DNA as a byproduct of its activity. The same mechanisms that prokaryotes use to identify and remove junk DNA from their genomes would very likely recognize telomeres as junk and remove them too, so eukaryotes would have had to turn them off/decrease their activity to avoid losing their telomeres prematurely.

  • @adamwu4565
    @adamwu4565 7 วันที่ผ่านมา

    iirc, there is another bit of cellular machinery that is essentially ATP-synthase, but running in reverse, with more or less the same or similar subparts all doing more of less the same thing. It's a proton pump that consumes ATP to pump hydrogen ions through a membrane against the existing concentration gradient. There is also the bacterial flagellum motor, which uses the energy of a proton gradient and/or ATP to spin in a similar way, except that the other end is attached to the flagellum filament instead of an enzyme complex that synthesizes ATP, so you get a spinning flagellum that can push or pull your cell around in the water like a boat propellor.

  • @alunicat
    @alunicat 7 วันที่ผ่านมา

    thank you

  • @BaroqueViolin
    @BaroqueViolin 7 วันที่ผ่านมา

    Wow! Thank you!

  • @joao5865
    @joao5865 7 วันที่ผ่านมา

    Did this guy DIEDED? 3 yrs since his last video. That was such a disappointment because this video was really really awesome. One gotta luv bchem, my man

  • @CELLPERSPECTIVE
    @CELLPERSPECTIVE 8 วันที่ผ่านมา

    Please make more videos!

  • @wayneeligur7586
    @wayneeligur7586 8 วันที่ผ่านมา

    Only Calcium Fluoride strengthens and protects teeth not the industrial version Sodium Fluoride! There is no safe minimum dose of elemental Fluoride! I suggest redoing the video after more research.

  • @RanLevi
    @RanLevi 8 วันที่ผ่านมา

    This is so beautiful.

  • @josepheridu3322
    @josepheridu3322 8 วันที่ผ่านมา

    death is part of the process of life. only the species is forever, to evolve forever

    • @Clockworkbio
      @Clockworkbio 8 วันที่ผ่านมา

      We are links in the chain--standing on top of 4 billion years of evolutionary history. We push the story as far as we can--and we trust the tree of life to advance ever further. No matter what happens, we boldly go.

    • @josepheridu3322
      @josepheridu3322 8 วันที่ผ่านมา

      @@Clockworkbio Yes, and it is beautiful. Thank you for your video.

  • @halfnelsonchoke
    @halfnelsonchoke 8 วันที่ผ่านมา

    "Since the beginning of time, man has yearned to destroy the sun" - M. Burns

    • @Clockworkbio
      @Clockworkbio 8 วันที่ผ่านมา

      Check back in on this comment in about a year when I put out an updated photosynthesis project. This commenter is onto something big.

  • @FroggyRibbits
    @FroggyRibbits 8 วันที่ผ่านมา

    Woah, so does this mean, like, when we eat animal cells we breakdown the stuff from it (some of which will include the animal cell's ATP synthase itself), that we are powering ATP synthase with Atyp synthase????

  • @WulfgarOpenthroat
    @WulfgarOpenthroat 9 วันที่ผ่านมา

    Biology really is wild nanotechnology.

  • @leewilliam3417
    @leewilliam3417 9 วันที่ผ่านมา

    So obvious I read about it all the time but not many people know

  • @josepheridu3322
    @josepheridu3322 9 วันที่ผ่านมา

    The idea that humans are somehow an anti-natural force is by itself dehumanizing and arrogant. Life cycles and the universe have destroyed the ecosystem multiple times. Humans are not special of that. We do have a responsibility with earth, but destroying earth is not more or less natural than changing it in any other way.

    • @us3rG
      @us3rG 5 วันที่ผ่านมา

      Wait untill they see developing nations developing 😂

  • @manfredpseudowengorz
    @manfredpseudowengorz 9 วันที่ผ่านมา

    Since the cochlea is a kind of a resonance chamber I'd rather expect the brain to evaluate the sound pitch based on the emerging chladni patterns rather than specific stereocilla, as this would probably end up in perfect pitch being common phenomenon of a human hearing. The question here tho is what the source of the pitch recognition mechanism, and whether it is properly verified experimentally. Let's crank some numbers: cochlea is roughly 3cm long and filled with a water based liquid (99%) sound speed in water = 1481m/s ~ 150000cm/s cochlea may be treated as a one-side opened tube, which would resonate at 1/4 wavelength -> 150000 / ( 3 * 4) ~ 12.5kHz which would suggest that around this frequency the stimulation pattern of stereocilla is static and rather the ones near the membrane are waving...

  • @sordidknifeparty
    @sordidknifeparty 9 วันที่ผ่านมา

    The universe is, at least, mind-bogglingly huge. At worst it's literally infinite. I always think it's funny when human beings claimed that something is the biggest, most, least, Etc in the universe. If the universe is just vastly huge, it's extraordinarily likely that there are many things in it which are actually more or less than the superlative you conjectured. If the universe is infinite, there are an infinite number of things which are more or less than the superlative you conjectured