POD: Does WATER FASTING Increase our MITOCHONDRIA? What about being OVERWEIGHT?
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- เผยแพร่เมื่อ 23 ก.ค. 2024
- Study: journals.physiology.org/doi/f...
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0:00 - Introduction
4:00 - Study Background
9:07 - Study Results
16:00 - Conclusion/Take Away
#waterfasting #fastingforweightloss #waterfastingforweightloss
![Fasting and Overeating - How you Change your Mitochondria. [Study 32]](http://i.ytimg.com/vi/KQBmtzT4VTU/mqdefault.jpg)
![Fasting and Overeating - How you Change your Mitochondria. [Study 32]](/img/tr.png)
![เปิดบ้านสุดหรู "เเจ็ค the ghost" ลั่นถ้าป๋องกพลลำบากผมเลี้ยงเอง!! l [Nickynachat]](http://i.ytimg.com/vi/1xbW4vULqGc/mqdefault.jpg)
![5 Days Water Fasting: What happens to your Health? [Study 55]](/img/n.gif)
Just found your channel. Love how you simplify very complex topics. Keep it up bud. PS Agreed. Tool is top tier.
Glad I found your channel. Your info short and to the point.
Thanks, Lar!
hi, I think you should not excuse because you might attack some of the fasting guys. actually I'm one of these guys who followed you after I excerced different fasting protokols. In fact I'm doing a 48 hour fast just in this moment. btw:. your video "you can't have it all " impressed me a lot. It really changes my perspective of fasting.
If someone really follows a path(concept)such as nutrition style or religion etc, the one should be able to deal with counterarguments.
Haha, I appreciate it, vairotsana - I wish we had more people that are open minded in the areas they subscribe. Don't worry, I always say things in jest - I don't much care if people get upset; I'm going to present the data as is.
Well done Nic..
Thanks, Dev!!
0:00 - Introduction
4:00 - Study Background
9:07 - Study Results
16:00 - Conclusion/Take Away
A study on the effects of photo biomodulation (red and near infra red light) on mitochondria would be interesting.
I don't know how many people would be interested in that, but if you know of people that would be interested, I could spend some time on that. Thanks, George.
I have been doing red/light NIR for some time and it is great. Would love to see more studies
Thank you for this!
Wouldn't mitochondria only be theoretically increased upon refeeding, though?
Hello, do u know anything about C0Q10, it protects and supports mitochondria, but do u know if it helps repair mitochondria? Thanks
Fascinating topic, and well presented. I am on the tail end of a 48 hour fast(8 hours to go). I am a "nose to tail" Carnivore eater.
This is particularly interesting for me as I am an avid back country hiker/backpacker, and I am often hiking 20 - 30 km in a day over steep terrain, while in a fasted state. Depending on how many days I'm out I may carry as much as 50 - 60 lbs of pack weight.
I have found that for activities that require endurance/stamina, I can hike for days without "bonking". However, in the weight room, I'm finding it just doesn't translate as well to pure strength training, if that makes any sense? Maybe it's just comparing apples to oranges, as it were? When i switch from hiking to the weightroom is it just a matter of trying to use 2 different energy systems - glucose/weight room vs fat/hiking. I'm guessing the absence of glucose is why my weight room performance isn't as good? How would this tie in with what you are saying regarding mitochondria?
Anyway, curious to know your thoughts. Your presentation has given me a lot to think about.
Your intuition is right, Jack. You can go for days with the hiking, because the actual intensity is much lower, therefor it can rely on fat metabolism. In the weight room, if your glycogen levels are low, you'll tire more quickly at a particular high intensity.
@@Physionic thank you very much for taking the time to respond. Folks may not say so, but it means alot when yourself or any public figure takes the time to respond to public inquires; especially without making the asker feel stupid😀.
Backcountry is my passion, so I will likely just pick that and stick with it.
Just curious....if people have specific questions they want to ask you, is their a specific place/forum you prefer, so we don't end up hijacking other topics?
I really love your approach and have a shit ton of questions I'd like to get some science on.
Hey Nicolas, thank you for taking the time to bring us this study and covering the topic . One question pops up from seeing the results of the study : is there any proof that over weight individuals could genetical have less mitochondria compared to lean individuals ? . the reason i am asking this , usually an obese person is obese because they feel the need to eat more than a lean person, this made me wander if this was trying to compensate for the lower levels of mitochondria? . I was always under the impression that fasting promoted autophagy ? from all the studies proving AMPK increase in connection with nutrition control i.e. fasting . what can explain this particular study results ?. i am thinking they missed something :)
Is it possible overweight individuals have less mitochondria innately? Sure, definitely. Fasting does promote autophagy, but many things promote autophagy and not always for "good" reasons. It makes sense for obese individuals to have lower mitochondria, because lean individuals have been known to have higher mitochondrial density, because leaner muscle encourages more generation of mitochondria (through exercise and lack of fatness). It's also possible that obese individuals may have elevated mitophagy (autophagy of mitochondria), simply because their mitochondria are less structurally sound, which would reduce their mitochondrial number without fasting. Ultimately, what we know is that muscle from obese individuals has less mitochondria than lean before and after fasting. So, fasting for 24 hours does not lead to decreases or increases in mitochondria (maybe due to greater turnover, creation/destruction both increase).
@@Physionic WOW really impressed with your explanation , thank you . It is great to have you reaching out to so many people and have great skilled in explaining things in easy to understand small chunks.
Thanks, supernova. I like the questions.
For me 48h is not long term fasting...Besides, a lot of the positive outcomes of fasting happen upon refeeding... And then again, is aerobic physical activity, which is touted for producing Mitochondria, effective after only 48h? Cheers!
Fair enough, Mark. Maybe in the future I'll run across studies longer than 48 hours. Unfortunately, people complain when its fasting that lasts over a day, or they say its not long enough if not at least a week, or they want me to cover intermittent fasting. Ultimately, we need studies, sometimes multiple, on each one of those topics to cover it all. Until then, I'm going to just assume, based on this data, that there is no increase in mitochondrial creation with fasting.
Interesting. Would like to see the same data after eating since supposedly gains don't come from fasting but set one up for increases once one refeeds. FWIW, saw an ad by Dave Asprey - BulletProof coffee guy - snake oil salesman - promoting Urolithin A supplement to boost mitophagy. Thoughts?
Can't say I've looked into it, but I just generally don't believe a word that guy says.
You inspire me, but it's too late for me to pursue a Phd. Now I just enjoy reading science books🙂
Well, if you want to spend 8-10 years back in school, you could do it. :) thanks, WH. Which science books are you reading?
I literally just started my fast 3 hours ago how strange 🤣
How long will you be doing it, Cavan?
@@Physionic 3 days just. Been piled up with work and think it’s just a good time to give it a go whilst I’m stuck in. My dissertation is coming along nicely though, about to send questionnaires. Unfortunately my lab experiment had to be cancelled due to COVID.
@@CavanHaganInvesting Dang, that sucks. You're doing a questionnaire based thesis, then?
@@Physionic yeah, just a few adjustments were needed to change the data collection methods. But it actually works better due to the bigger sample size, as I need over 100 participants to meet the minimum for multiple regression, which I wouldn’t have achieved in the lab study. It also makes the research more useful due to the data required being common knowledge rather than tests (e.g. VO2 max) so I’m quite excited to get the results.
@@CavanHaganInvesting Makes sense. I'll be curious how it turns out, let me know.
46&2 ❤
I wonder if overweight individuals have larger amounts of muscle mass and the mitochondrial density is lower but total volume or mass of mitochondria is the same as lean individuals
You must have noticed a correlation between the like/dislike ratio and the seeming complexity of the video topic. People averse to sticking around for over 4 minutes to think about something are not like to dislike out of emotional reaction lol
I would love to read your paper. I am sort of an enlightened ignoramus.
I'm assuming you got your PHD from your thesis.
Here you go, Manuel: faseb.onlinelibrary.wiley.com/doi/abs/10.1096/fasebj.2018.32.1_supplement.589.8
No, I received my Masters for this thesis - I'm still in my PhD working on my dissertation.
Hopefully last, I just try and find truth on yt.
You should try and find what does improve the "bio-genesis?" of mitochondria on your off-time. I am a little chubs and can't walk because of a stroke after workout.
It says fool
The shirt?
maybe having fewer mitochondria leads to obesity