Fasting and Overeating - How you Change your Mitochondria. [Study 32]
ฝัง
- เผยแพร่เมื่อ 8 ก.ค. 2024
- Study, Notes, & Amendments: www.physionic.org/examine/%5B...
JOIN THE PHYSIONIC INSIDERS [PREMIUM CONTENT]
Join the Physionic Insiders [Standard Tier]: bit.ly/PhysionicInsiders2
Join the Physionic Insiders [Pro Tier]: bit.ly/PhysionicInsidersPro
Standard Tier: Access to the Premium Video Library, Full Study Analyses (+ Summaries), Insider Podcast, , Research Reviews, and More
Pro Tier: All benefits of the Standard Tier + Live Sessions with Me, Consulting Lite, and More
HEALTH AUTONOMY [COURSE]
Learn to Analyze & Apply Studies for Yourself: bit.ly/healthautonomy
JOIN THE COMMUNITY
Join my Community [It’s Free!]: bit.ly/PhysionicCommunity2
EMAIL LIST
One Weekly Email of Value: bit.ly/2AXIzK6
HIRE ME FOR CONSULTING:
Consulting: bit.ly/3dmUl2H
DONATIONS FOR A SCIENCE BASED CAUSE
Patreon: bit.ly/PhysionicPatreon
OTHER SOCIAL MEDIA
Instagram: bit.ly/2OBFe7i
Created with Biorender
0:00 - Introduction
3:45 - Study Introduction
4:45 - Two Mitochondria Effects
6:44 - Nutrition's Role in Mitochondrial Behavior
10:52 - Overconsumption Mitochondria Effect [Scenario 1]
25:05 - Undernutrition/Fasting Mitochondria Effect [Scenario 2]
29:27 - Autophagy of Mitochondria
31:47 - Conclusions/Take Aways
Created with Biorender.
#fasting #mitochondria #health
JOIN THE PHYSIONIC INSIDERS [PREMIUM CONTENT]
Join the Physionic Insiders [Premium]: bit.ly/PhysionicInsiders
I have just watched this, and am watching it again. please, what are those other energy-currencies in living Organisms, other than ATP and GTP? this is super-interesting. I feel like They rob Us when They teach Us because We've only been told about ATP, this is the 1st time I'm hearing about anything other than it. where can I find more comprehensive Info about it? thank You, best regards.
in fact your voice is too low and not clear, idk what reasons are. But can you increase the volume up?
ATP a good supplement?
What does it mean when you take DHEA and it makes you tired natural testosterone supplements and it makes you tired 80P Works per week that makes you tired?
How do you EQ speech. Sir please response.
“Epigenetics.”
"The mitochondria is the powerhouse of the cell" ☝️
Excellent. :)
we need more TH-camrs like you who are actually certified experts in the fields they talk about
certifications can be gamed and corrupted
@@ClaimClamyes, and people talking on topics they have no certification for or any sort of formal education on can be corrupted and malicious at a much higher rate.
@@bojanpejovic7691 they have less credibility so harder 2 hoodwink others
@@ClaimClam as true as that is, i suppose you've been around enough to see how huge alternative medicine propagated by uneducated grifters is on youtube.
I do agree there is a plethora of "doctors" on yt, mostly guilty of holding a phd in one field but believing they have complete understanding of every branch of medicine spewing a lot of lackluster information to large audiences.
But every doctor on yt usually does analysis of studies, which allows and encourages dialogue in the comments, while grifters encourage echo chambers of anecdotal evidence, trapping regular folk much harder.
@@bojanpejovic7691 @claimclam
Everyone should do their own research after hearing information.
Agree with both of you, but more with clam, but only if you do your own research.
“Trust the science “ talk comes in, science is always changing, always wrong. Derek from @MorePlatesMoreDates is near an experts knowledge from just doing his own research and has had real world experience
I've been low-carb OMAD fasting for a half year, looking good, feeling great.
Do you consume all your calories in one meal or in a very short period..say, 4 Hours? Do you check your bloods for Testosterone/hormone changes?
Good job, Nicholas. I am a retired physicist, trying to learn some biology for about a year now. This kind of material helps.
Thanks, Ted!
me too, now i know why i went into physics
Look up Morley Robbins, Dr Chris Palmer, and Dr. Thomas Seyfried. They all discuss addressing mitochondrial function from different angles (optimal nutrition minus key toxin), neurological disorders, and cancer as a metabolic disorder.
They all work with clients who have seen some profound positive changes.
This information is no magic oil, though - welcome to complex systems.
ATP, the energy molecule output of mitochondria, is badly misrepresented. It is actually Mg-ATP, the ATP is a doorstop in the cell without a magnesium 2+ attached to it. For some fun, try to find magnesium listed on a “nutrition label” inside your local grocery store. Seems Big Brother doesn’t want our Mg-ATP functioning at peak capacity!
Copper runs cytochrome c oxidase, which spilts oxygen to produce ADP (and water) that can be flipped into Mg-ATP, the TRUE energy molecule of the cell. Want more fun? Try to find copper on a “nutrition label!” Big Brother strikes again!
Copper is actually toxic, so it has to be complex with a protein called ceruloplasmin (blue blood) before it can be transported to 40 quadrillion mitochondria and every else it goes. ATP7B is the enzyme that loads copper into ceruloplasmin, and ATP7B depends on magnesium and retinoic acid to function. There is that pesky magnesium again!
Ceruloplasmin levels are very often less than half the levels as seen in the 1940s. Worse, ceruloplasmin May or May not even contain copper.
Ascorbic acid bleaches the copper out of ceruloplasmin.
Glyphosate chelates copper to a oH below stomach acid.
HFCS block copper absorption.
NPK fertilizer has no copper or magnesium in it.
The more I learn, the more I find that unlocking the secrets of mitochondria will lead to a greater understanding of so many diseases. The human body is amazing!
All of the Diseases of Civilisation…!!
Personally when I fast I can feel an abundance of energy in my body, like bouncing off the walls. Walking becomes easier, jumping, etc. When eating it's totally opposite. I feel sluggish, bloated, low energy, and more cravings.
Might have to start cutting out foods and see what is causing your symptoms
^ this. Could be certain foods in your diet.
@nadias64
Nothing wrong with food . With you ...
Fasting triggers different cascades outside of what's being discussed here cf. senescent cell cleaning. only dry fasts promote fat tissue lypolysis over muscle/organ tissues as shown in The Phoenix Protocol by August Dunning.
I have the opposite sadly :(
Beautiful. An Elegant explanation of something that was really so dull to learn 40 years ago when I studied biochemistry. Additionally- the way in which Krebs and ultimately our health - responds to our lifestyle choices is such a wonderful teaching angle , one we did not receive in the 1970s.
The only thing I would add from a teaching perspective is the amazing fact that mitochondria are actually bacteria that have adapted to living symbiotically in our cells ( have I got this right ?) . So mind blowing. All of it. So pleased I found this site. Thank you.
In these bleaky times your channel is like a fresh air of optimism blowing to our minds and hearts. Thank you Nicolas for your good heart and for your efforts to share valuable knowledge about the welfare of our lives.I wish you many many and happy 😊 years my man!
That's incredibly kind of you, thank you, Constantine. I'm trying my best.
Bleaky??
@@judylloyd7901 😀😀😀 Sure, why not?
@@judylloyd7901in between bleak and not bleak. 😂
@@judylloyd7901why not be kind and assume it’s a typo.
It occurs to me that smaller mitochondria have a greater surface area to volume ratio than larger/longer ones. Because of the selective semi-permeable membrane coupled to energy production, this greater ratio gives them a greater potential throughput which helps them cope with processing greater amounts of available "nutrition" (energy surplus). Conversely, a larger mitochondria will be able to leverage smaller quantities of available nutrition in order to maintain adequate energy production. In other words, the mitochondria adjust their surface area to volume ratio in response to nutrition availability in order to maintain metabolic homeostasis.
It is not the size of a mitochondrion that matters but the amount of the inner membrane folds. The energy processes happen on the whole surface of the inner membrane, so the more folds within the mitochondrion the more effective it is.
@@monikasalaga larger mitochondria, more folds possible
I was coming to say something about this but you did it better!
I’ve been looking for a video explaining the molecular aspects of fasting and this is just so good in its depth 🙌🏻
Great content on a subject that’s getting a lot of controversy from academia lately. Hormesis is the mechanism that was thrust on our ancestors, resulting in our survival. Today that process has been replaced by chronic comfort and convenience. Fasting is something some of us fly across the world to pay exorbitant fees to a glamorous spa somewhere on a European coast!
This is absolutely fascinating!!! I teach 8 to 13 year old children about neurons, protons, neutrons, atoms and molecular structure of DNA. This helps me to understand and teach better!! Give thanks my brother 🙏🏾☀️💛🌻🧘🏿♀️🪶💋
This is my first time and I am impressed. Getting explanations at this level is a near impossible task. Very much appreciated.
Thank you, David.
This was so cool and informative, I've always been super interested in anything biology related but due to a slew of circumstances was unable to pursue it in an academic manner. I really appreciate how you really boil it all down to an easily digestible format that allows even someone like me, who doesn't have the necessary background knowledge to read the academic papers, to understand.
Thank you for the video, also thank you to the algorithm for introducing me to your channel, I will definitely be watching more!
Just found your channel. This was a fabulous explanation of the mitochondria. Now I finally understand the concept of coupling and uncoupling! Thanks
I’m thrilled to hear it!
thankful this popped into my recommended vids, incredibly interesting, i have been attentively playing around with my own diet in recent months and my experience aligns perfectly with what is described here.
I am grateful to find your channel! Thanks for sharing your field of interest and study.
Nic thank you so much for your channel content and passion
You are extremely relatable at taking what is complex information and making it understandable for the layman
You truly bless me
Andy
I'm always afraid I fail to make it understandable to a determined audience - thank you, Andy.
Just an anthropology person stopping by lol. This aspect of the research is particularly relevant for my interests of study. I will readily admit that the chemistry is OUT of my league. That’s why we refer people like you who like this stuff! You got me to understand the important parts so I got what I came for
This is amazing Nic. Just discovered your channel today. You are doing a great service to humanity by sharing this cutting edge knowledge. More power to you! Subscribed! ❤
Very cool video, thank you for bringing new stuff to the light of public. I always appreciate these kinds of news/videos.
Just found your channel...full of useful information. Also your voice is so soothing! Thank You for this great content
Haha, I've heard that a few times about my voice, but I don't hear it. Really kind of you, Lisa - thank you.
Really pleased to see this information. I have EDS ( a genetic connective tissue disorder ) which is challenging and my 14 years of studying health has enabled me to manage the difficulties better.
Hey. I have hEDS too. Which ones is yours?
And here you for comorbids like CFS/POTS etc?
@@alperenylmaz1344 yes 👍 keeping as fit as possible at age 71. I was prescribed a stairlift, a bath hoist and an electric wheelchair 12 years ago after a year in hospital. I was very weak. I refused all and Im still trying to manage without. I have Classic Ehlers-Danlos. I now eat plant based and gluten free. Makes a huge difference to my inflammatory state and energy/ recovery from injuries. Good luck.
This makes a lot of sense, as an engineer this resembles how dam's manage pressure and energy generation. I think it would be interesting if you could integrate the role of storage to dampen the fluctuations in demand and supply "flow" rates. As we usually never see a perfect match between demand rate and supply rate, I think that would bring the system full circle.
Such a fantastic argument for the benefits of fasting and the dangers of overeating or under exercising. Thank you so much! I just discovered your channel today and subscribed and I'm looking forward to digging in!
Just found the channel today 🙌.. brilliant... amazing insider lnowledge... Adds to Dr. Berg's keto channel... n the fight for REAL information as opposed to bs from the fda... 💯 subbed
Been looking for this type of information and explanation. Thanks greatly.
That was fascinating! You have the skill of teaching and knowing how to teach something complicated in a "simple" way. Thank you!
Kind of you, thank you.
we need everyone to understand what this is and how we all work thanks for this good explanation glutoney
Oh my goodness. This is so interesting. This is the first video on your channel that popped up on my feed. I’m off to view others now. Thank you for doing these.
Welcome aboard!
Love this channel!! 💪🏽
Thanks!
Man, I've just discovered your channel now and you're doing some really cool stuff, already subscribed!
This is fascinating! Thank you!💐
Wow. You explain these things so very well, many thanks. I'm once again astounded by the seemingly miraculous complexity, efficiency and sheer beauty of our body. I've been intermittently fasting for a while now and see many benefits ~ but now I can be urging those protons in the mitochondria to travel well !
Loved the content! Thanks for sharing this information! Subscribed👍🏽
Thank you!
It's indeed a PhD lecture thank you very much. Work on your gift they will make room for you.
This is by far the best explanation of how mitochondria react to nutrition overload and deficiency I've ever seen.
Nick , it is a pleasure ,
Love the presentation and knowledge
I would be interested in understanding the timescales at which these processes take place.
Thank you for this content. 🆙
Brilliant exposition!!
I’ve just subscribed to your channel. You explain the subject very well to the lay person. Thanks for your information.
Thank you!
Found you through Rich. Excellent content. Don't change!
Loved the explanation, thank you!
This is very good, so to take it a step further, what we need to grasp is how to effectively/optimally an average person expend/retain (this has to be measured) energy, if we zoom out, this is basic physical flexibility, movement and exercise. What I imagine will happen is a more nutrient organic food with proper portion sizes, times to consume, and appropriate variety composition, using smart food processing & prepackaging. Labels on foods would be more about the type of activity a person is planning, and the approximate time of consuming it before hand.
Excellent graphics and explanation. Since I just learned the mechanism of ATP demand versus nutritional availability, it is exciting to learn what my limited fasting’s effects are on my cells’ metabolism.
Hi Nick, please don’t beat yourself up (as in the follow up video) you did an excellent job of making this process understandable and clear, and for an elderly biology wannabe, you make this cellular micro ecology more sensible. Time and increased understanding by Scientists such as you and your colleagues have unraveled the Krebs Cycle we were taught in high school biology, was taught as “the multiple blind individuals describing an elephant”, while that was >60 years ago, today thanks to your presentation I can see most of the Elephant.
Well done look forward to part II.
Yup, good things happen when your body is not constantly forced to digest and metabolize unneeded food. Fasting is much easier, and I belive more effective if starting from a ketogenic/fat burning state.
Thank you for promoting health knowledge for all in à simple fashion. Good Luck with your research. From Tunisia wirh admiration.
Nic, this is a great presentation. I am semi retired and enjoy these conversations/presentations. Some of my favorites are Dr. Peter Attia, Dr. Bruce Liption and Dr. Joe Dispenza. I also like Dr. Perry Nickelston and Dr. Gabrielle Lyons. Dr. Ben Bickman and Dr Steve Phinney, Dr. Jeff Volek. I listen to these fine doctors whenever i have time and I am very grateful.
Thanks, I love your content. I like geeking out on the Biochemistry.
Thank you for your explanations, I found them most helpful.
I was a teacher myself many years ago, and I found that trying to teach a subject caused me to go back to square one and re research the subject in order to try to teach it, especially if the students were really intelligent themselves..!!
Best wishes for your Thesis..!!
Well presented. Thank you.
Finally a real expert! Just found you yesterday. We really need you Nicholas. So much contradictory info out there! My sister and I are delighted to have discovered your podcast. We also enjoy your "bedside manner". Our father was a physicist, BTW😊😊❤. THANK YOU FOR EVERYTHING.
No problem. I’m happy to create this content for you.
In the year 2010, and continuing to this day, doctors at the VA giggle then refer me to mental health, for describing exactly what you say in this video. A healthy mitochondria is a healthy you.
Thank you so much for the wonderful contents
Excellent. Thank you!
Mitochondria is the powerhouse of the cell.
Nick, you really have a gift for teaching.
I STRONGLY disagree!!! He wasted 3 times more words then necessary, to explain a topic that could have EASILY been described in well under 10 minutes...
@@AscendingApsolut haha you must be a fun person to be around
@@teddybearroosevelt1847 ...well, that depends on who am i "around"
@jamespatric53
Gift for teaching ?! Gotta be joking
Amazing... Can't follow every electron in the explanation but the mechanism is painted very well here 👍👍👍
Very good content thank you!!
Nice. You made this easy to understand
Thankyou. It's great to be able to se inside and understand mitochondria.
@physionic as a side note, i had to max out the volume to hear you clearly. liked and subbed
I really enjoyed this video. A fellow academic and teaching professor here in psychology and neuroscience. I kniw you are passionate about your work and what you are doing. This work is absolutely critical for all to learn and understand given how incredibly unhealthy our society has become, and obesity is at 42% in the West. Actually, it's soread to much of Europe and part of Asia,those most Asian cou tries have normal BMIs. I just wanted to thank you because I can include sone of your findings with my Health Psychology class. You are an excellent instructor and those most R1 jobs are reaearch focused. Please consider teaching because it's so important to get this work out. And you are quite good at taking a complex topic, and making information easier for a lay audience to understand. You will make a great faculty member if that is your career path. Congrats on being advanced to candidacy. Well done!!
This makes me smile, thank you. I’ve been teaching undergraduates for a number of years and hope to continue long term.
Asian countries have lower BMI because it is partially genetic, I guess...?
@@untonsured Asians' catabolism a bit faster than anabolism, I think. And they also lead an active lifestyle.
Yes, in part genetics play a small role.
@@TheSenatory ok, thanks. That's interesting. I'm reading Peter Attia's book and he mentioned the genetic part.
@@untonsuredhowever their BMI might be normal, but their blood works not so much. A lot of these thinner bodies are sometimes metabolically unsound, believe it or not. I’m more on the lab work.
Outstanding clear information well done from Scotland
Thank you, Steven!
This is so cool!
Interesting information. Suscribed.
It's simply awesome how understandable these processes are when presented in such a clear and concise manner.
I'm a software engineer from Eastern Europe, the last time I was trying to learn anything related to biology whatsoever was in high school ~15 years ago.
Watching your videos makes a layman like me feel like I could actually have a grasp on topics like this which is completely mind-blowing. 😅
Thank you for sharing your knowledge in such a comprehensible and digestable way.
Keep up the good work! 😄
Excellent content ❤
just random place to post this: thank-you for your work, and videos.
Good stuff, well explained.
Great explanation. Thanks
Thank you for the interesting elightening information. I appreciated it.
Glad it was helpful!
Great explanation, You are an excellent teacher, needless to say good practice for the future, enjoying the experience
Well my microbiology class last semester really helped me understand this information.
I truly appreciate your style and efforts the way you present and explain your valuable content for your audience to understand it well. Impressive! Thank you so much, Nicolas! I am grateful that you and your channel exist in YT. Please keep educating people your way (making it easy to understand ) Blessings!
So nice of you - thank you.
@@Physionic- Totally agree with the commenter above. The easy to understand portion makes you different for sure. Keep it up!
Pure gold.
Great presentation skill!
Thank you kindly!
Very interesting topic. I learnt something new today.
I have a mitochondrial DNA mutation rare disease LHON and this is the most fantastic breakdown of the mitochondrial function. Thank you for this! :-)
Brilliant explanation and info, thank you so much for yr time and valuable knowledge.
The powerhouses of the cell! 💪🏽💥
Exceptional video!
Thank you!
Thank you, that’s a is great material. I feel more energetic intermittent diet, now I know why.
This the first time I watch a video on your channel and I really Glad i find it.
I'm in a fasting period and theses explanation are so great I hope your friends
and Familly find time to listen to you (would really like to have such a knowledgeable
person close to me). Btw if you haven't look to it yet your teaching and clothing style
Remind me of the INTJ personnality Type from MBTI system.
Amazing video, well digested complicated material, i really like this ❤
Glad you liked it!
So what would happen in the sense of overeating but also fasting
This video showed up at a good time for me. I read ine of Dr Gundry's books discussing mitochondrial function and how you can use it to acheive weight loss. I always like to get second opinions on things like that just to know that the info i get is factual.
If I understand correctly Dr. Gundry’s information is inconsistent with the information presented in this video. Gundry says in addition to polyphenols, fasting in general & ketones in particular are signaling molecules that invoke mitochondrial uncoupling whereas this video suggests it’s nutrient surplus that prompts uncoupling proteins. If there’s something I’m missing, please fill me in.
excellent video!
Thank you very much!
U have a talent for teaching.
Kind of you, thank you.
Most excellent!
Fascinating. Today I learned that an ATP is a self charging capacitor driving a chemical motor. And you are saying that these capacitors are chronically over charged. The mitochondria breaking must be so the structure can handle the stress produced by the surplus charge. UCP is safety valve.
Insulin resistance and photobiomodulation is what you need to learn
It seems like the intermembrane space acts as a H+ buffer. Splitting into multiple mitochondria increases the ratio of volume of intermembrane space with the volume intracellular matrix. Inversely, elongation reduces that ratio, making the H+ buffer smaller, which is unnecessary when the energy production doesn't grossly outpace the energy needs
Excellent content 🎉
thanks for that!
Thank *you*, KK. Hope you're okay.
struggling with long covid since 8/2020 with extreme fatigue. early on I realised that when I fasted, I could do more than was my baseline. Still doing one day fasts several times a week. Your video provides theory to that :)
Fasting helps clear the inflammation that allowed long covid to even permeate your body
I hope you feel better soon!
It's April 2024 and I've been watching you for 2 years and it's amazing to see the way you explained your findings these days and just how funny you are😊 just saw you on Gabrielle Lyons she was trying to get you to show you're dry sense of humor 😁😁!! Have a beautiful day
Thanks, Lucretia :)
(Love your name, btw!)
Great reminder wow..many thanx..🤩🤭😏👏👏👏💥😆😍
Links to relevant articles on mitochondrial transformation in fasting vs. non-fasting states and ROS production would be helpful.