CFD simulation of packed bed columns - full case study

Packed bed columns are used for various applications, including filtration and catalytic reactions. In this case, a the packed bed is a polymer resin used as a catalyst for a complex chemical synthesis reaction. Various solvents are used, causing different swelling and shrinking patterns of the packed bed, altering the packing height and porosity.
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Would it be possible to get the CFD method for this ? Mostly interested in boundary conditions models and methods used