Epigenetics - An Introduction
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- เผยแพร่เมื่อ 1 ต.ค. 2024
- This sketch video about epigenetics was created by Armando Hasudungan, in collaboration with Professor Susan Clark and Dr Kate Patterson at the Garvan Institute of Medical Research. It has been created for a broad, non-expert audience to highlight key messages about the role epigenetics plays in biological processes like development and diseases such as cancer.
Thank you so much. Would you please do more videos about Epigenetics? I want to go more details about DNA and Histone Modifications. Thank you. Your videos are always great and understandable.
Have you checked out the “handwritten tutorials” channel ?
@@LetsBeClear87 I dont see any videos on epigenetics in their channel?
Have you found any good channel explaining it more?
update me if you find them as well
You are a great educator! Thank you for this very good clarification.
Thank you! You are always amazing with your drawing and teaching! Please continued, some of us are visual learner.
If disease processes like cancer can induce altered patterns of genetic expression, it seems like it would follow that healing processes resulting from beneficial lifestyle and dietary practices (eg. turmeric, green vegetables, moderate exercise) can induce positive genetic alterations in that which is encoded and expressed.. I'm finding the term 'epigenetics' is now broadening to accommodate this notion.
I agree. By extension cancer is the anti-nutrition. Also, it gets its foot in the door via mal nutrition. Personally cancer is a virus/parasite. Our actions determine wether we are accommodating hosts to it or not.
Yes. And it does. I know from personal experience
Beautifully done! Nice refresher for me. :)
😊
How does the body know during fertilization where the tags should go?
Armando,
Your videos are awesome! It is not only the drawing, but also, all the knowledge
that is behind them. Congratulations!Greetings from Mexico.
Wonderful presentation, as always! Thank you so much.
how do these gene expression regulators "know" in what part of the body they are located?
I'm not sure if this fully answers your question but environmental cues, demand for certain types of cells and hox/homeobox genes all regulate what cell type the cell differentiates into. Hox genes determine certain parts of a persons/animals body in very early stages of development and this then determines what parts of your body goes where.
bergweg perhaps something is regulating the regulators...
H3K9 deactivates transcription and is a mark of heterochromatin
How do they draw so neatly?
Its a computer design with a fast moving hand drawing nothing dubbed over the many pictures. Maybe I could wrong im only guessing
Beautiful explanation!!!
Very useful explanation of yours. Thanks for your short lecture about introduction of epigenetics.
Wow...really clear.Thanks a lot
If some epigenetic information can be passed down from parent to child how does the sperm/egg know what and how well the heart cells and brain cells did when interacting with products of the environment?
In case of explanation, it was awesome. In such a concise mode everything was elaborated very well. 👍🏻
Your videos are really helpful! Thanks!
THIS was awesome but I am still confused? I understand that every cell in the body has the same DNA replication. AND that expression is caused by changes in this those methyl group thingys...... I mean what made those methy groups in the first place? was a ribosome or an enzyme? Its almost like what came first? The chicken or the egg?
+Jovani Sanchez "A methyl group is an alkyl derived from methane, containing one carbon atom bonded to three hydrogen atoms". It is simply a molecule. The methylation of the histones or the cytosine of the CpG is mediated by methyltransferase enzymes.
where did those methyltransferase enzymes come from physically? an enzyme is a protein, that protein must have been synthysized somewhere.
+Jovani Sanchez well, you're correct. The central dogna concept might be an interesting read for you. The methyltransferase genes are part of the genome which codes for the protein. Transcription factors initiate the Transcription of the gene into mRNA which is translated by the ribosome into the protein.
+Jovani Sanchez the cells would have the genes coding for the specific enzymes where they will be expressed ~ transcribed ~translated @ free ribosomes and modificated in ER or Golgi
You're videos are so groundbreaking. I love you
Who else dances like they are at the club when the opening song comes on for this channel? Me. Only me? Fine.
this is such a great video it helped me understand so much that reading txt books wouldn't help me. please continue making more videos on this topic please :)
thanks for your hard work!
Yeah all that happened by random mutations. Right
There's one thing I am confused about. So if the histones are wrapped around our genes, and say you become a smoker (but no one in your family tree extending hundreds of years smoked) and the chemical tag is added to the histones to make that gene become 'expressed', does that mean that the 'smoker gene' is predetermined? In other words, will I have a 'smoking gene' by default that is turned off, but will only be turned on if I smoke?
2:34 Lance of Longinus!
Epigenetic research uses following molecular biologic techniques -
1.Chromatin immunoprecipitation*
2.FISH*
3.Methylation sensitive restriction enzymes*
4.DamID*
5.Bisulfite sequencing*
One vídeo about histone modifications only plz
awesome
Jeez this is all still so confusing. Any tips on how to grasp the idea better, if that makes sense?
For years I always assume the DNA code itself had the start and stop sequences but I guess it’s these epigenetics that control the start and end
I hope someone would answer my question. I find the epigenetic and mendel's law are somewhat a paradox. As far as I understand, epigenetic regulate, so that only one gene is expressed. It decides the activation of the dna. Whereas in mendel, both genes are activated. I don't know how to formulate my question, but I hope someone understands my confusion
la epichenetics shikillooooooooooo ELEEE
Could you tell me where you do your research from like any website or something it would be real helpful or anybody in the comment section knows becuz i would be happy to know
Nice Saints bracelet you got there. Don't flip it in future videos! Good job, and thanks for your help!
Anyone have any good titles ideas to base An EPQ on based on Epingenetics?
👌👌👌👌👍👍👍👍
I your nucleosomes are octamers until H1 is attached, making it a nucleosome
Good presentation wonderful explanation!!!
keren banget
Thank you! Great explanation, you make a complex concept manageable. Kind of like the histone complexes do with two meters of genetic material... well done.
Uh duhh .. Me stupid.. more videos required
can you explain more detail about modification histon ?
Never seen such a beautiful reprisention of epigenetics
Not clear
great bro
same DNA but diff functions...my thoughts exactly when i understood epigenetics
+sonicbouy I see it as a theatre production - everyone is in the same play but has different lines and so play different parts.
Simply the best - come be my teacher at the University of Copenhagen! ;-) Please
Epigenetics is the Biggity Bomb!
Awesome. Looking forward for more on the topic. Keep it up.
Absolutely brilliant more especially the animation. Absolutely impeccable
And you expect me to believe you?
Very nice drawings and explanations!
Aren't electromagnetic fields a method of epigenetic modification? Also it seems that the mechanism of the placebo affect is also an epigenetic modifier. Great presentation, very well done.
There’s a video on another platform that had a practitioner giving testimony about the proof EM radiation causes the big ones.
Brilliant work! Thanks!
What an explanation!
thank you nice drawing
thank you very much!
Amazing explanation. Thank you!
Thanks really great explanation
wow.. now so clear!!
This is really helpful! Thank so much!!
Premium class video content! Keep it going!
🤩
Nice, thank u
The best explanation!!!
Thank you.
Great video!!
Awesome
Does anybody knows what does he mean by "promoter region" in min 3:19? Also, is it always the case that DNA methylation leads to gene silencing and histone modification to gene activation?
Dna methylation can result in gene silencing but it depends on the type of methylation. For instance the H3K4me3 methylation wich doesnt result in gene silencing --> H3K4me3 is a commonly used histone modification. H3K4me3 is one of the least abundant histone modifications; however, it is highly enriched at active promoters near transcription start sites (TSS) [8] and positively correlated with transcription. H3K4me3 is used as a histone code or histone mark in epigenetic studies (usually identified through chromatin immunoprecipitation) to identify active gene promoters.
@@osmanaltun3737 thank you so much for your response. I'm starting to get into this area. When you say "and positively correlated with transcription", does that mean there could be occasions in which is not? Or do you expect that it will always lead to transcription?
@@garr2991 totally forgot to react but, Yes you will expect transcription in this case
First
excellent classes
THANKYOU!!!!
great !
Great video!
Good intro, thanks.
sir, thank you !
God is a genius.