RNA polymerse cannot unwind double-stranded DNA, but proteins associated with it can. In prokaryotes this is performed by sigma factor, and in eukaryotes it is performed by TFIIH.
I am really thankful to you for making such great videos and helping to all the students out there. You are an excellent teacher. Keep up with the good work. :) Love from India
You make this so much easier to understand! You explain everything so well in just 12 minutes and my lecturer takes a whole hour and I still dont understand her! Thank you so much!
I am also grateful sir ...my lecturer takes the whole 2_hour trying to explain this but still, I find it difficult to understand him. Please, can you make more biology videos.
AK LECTUREES thank you so much for all your contributions.. i personally had lot of difficulties with biochemistry. i literally had almost no idea what's going on, only just learning by heart.. but now i do understand better... am also recommending some colleagues to get watch your lectures.. You are fantastic in a way of explaining factors precisely and simply.. I have one single question. Could you please or someone from the Commenters give me an answer to it? The question is: What is meant by 3' in the mRNA? TIA
a couple questions: What happens with the RNA polymerase? Does it remain attached to the RNA molecule? Where is the RNA polymerase being produced? Does it free itself from the RNA and DNA and just goes to find another promoter region? Are there multiple promoter regions that are followed by different coding and if so how does it know which region to transcribe from?
A quick question for clarification: Are the initiation factors you reference here the same as general transcription factors referenced by others? Thank you!
"So, just like there is a seque... just like there is a seque... uhm... just like there is a sequence." Finally got it the third time. LOL i cracked up. still great video man! Way better than my lazy professor who doesn't want to explain anything. thanks!
He said that for protein synthesis RNA was used instead of DNA to prevent the DNA strain from getting damaged. Wouldn't the DNA also be at risk of being damaged in the process of transcription?
You only need to copy from DNA once to make a piece of RNA, and then that RNA can be used many times as a template for protein making. (just random numbers here, don't quote me) So if making 1 RNA could be used 100 times to make proteins from copying from DNA 1 time, that is ofcourse better than working directly from DNA 100 times :) So if by comparison you were to use DNA that many times to make the proteins it would greatly increase the risk of damage. Also in Eukaryotes the RNA is transferred out to the cytoplasma where it can actually have access to the "building blocks" it needs, while DNA stays safe in the core :)
At 6:38 - DNA Helicase brakes the Hydrogen bonds in the DNA, the enzyme topoisomerase is the one that unwinds DNA from its helix . Otherwise great lecture!
Unwinding and breaking hydrogen bonds should be read the same but the enzyme topoisomerase adds negative supercoils to alleviate the stress for supercoiling
The Flash Unlimited how is this negative supercoiling done at the particle level at the electron level are you saying that the hydrogen bond antiparallel scheme has to be biased with an electrically stable configuration to separate 1/2 of the DNA strand to become RNA to be used in protein synthesis Albeit that is a scaffolding problem the nut or the magic or the mystery are the four nucleotides the phosphodiester this is a scaffolding structure albeit very important would anybody argue that point or that observation the nucleotides are the magic the other parts are the scaffolding to allow the nucleotides to resonate dialectically housed insulated enough by the phosphodiester backbone with the two nucleotides hydrogen bonded with four nucleotides available as two double ring configuration the other two are single ring configuration as a complementary pair schema As where the DNA lattice is complimentary in-form as a structure created as a phosphor and sugar backbone allowing the nucleotides to be housed on this phosphor lattice as electrically neutral as a purine and pyrimidine nucleotide molecules bonded by a hydrogen bond in complementary form With an innate coding of four nucleotides consisting of Elementary particles using the electron shell Theory these elements hydrogen oxygen carbon nitrogen with a phosphor sugar background as a structural lattice to hold or house these nucleotides as electrically neutral as possible are responsible for weaving our reality as biological species I like to put this out the deeper meaning is going to be the spin trajectory of mass or matter I believe it's going to come down to a force called spin trajectory as an elementary metric of our reality coalescing into what we see as conveyed to some as mathematics string theory Hence the super coiling problem hence the hydrogen bond coiling of thr DNA lattice scaffolding spin trajectory the elementary force of the universe if you can figure out the spin trajectory constant that probably would help a lot in predictability I believe it still comes down to a 50/50 deal it will always be a flip of the coin when it comes to predictability using the sciences physics mathematics and the logic called "predictability" will always be 50/50 Deal
Topoisomerase is a class of enzymes, and the most common example is enzyme gyrase. Their function is to relieve torsional stress that arises during the process of unwinding
abdul shehata meh its hard to give advice on the MCAT because it really depends on how you learn. i didn't take any courses and just studied on my own. i'd say just create a solid study routine and stick to it! don't let anything get in the way of your study time. don't spend too much time trying to learn the minute details and leave plenty of time to take practice exams.
yeah man. I have started but do not have a solid study routine. Some days I do 6 + hours and others I do Nothing. goota get that routine I guess. also if i can teach someone for example transcription like how you exactly do it, you thin thats a good sign for a good mcat grade?
![[TH]FFWS SEA Spring 2024 Point Rush - Day 1](http://i.ytimg.com/vi/_LI5pXZFYhw/mqdefault.jpg)
the way you talk is so weird YET EFFECTIVE like it drills in my brain
First time I saw one of these videos I was like "why are you yelling at me" ! Now I cannot get trough exam season without them :)
You literally explain something my teacher takes a whole 2 lectures to explain in 10 minutes, thank you.
man, ur teaching skills are unparalleled. it makes so much more sense now.
Thank you! I appreciate your kind words Michel!
I am watching from india
@@AKLECTURES sir I am big fan of yours from India
you are THE BEST!! I am a medical student and i am so thankful for your videos. Thank you please keep going!!
samme here! he is the BEST!
11:21 how cute is that? XD, keep up the great work buddy, you are a legend.
AK Lectures for PRESIDENT!
RNA polymerse cannot unwind double-stranded DNA, but proteins associated with it can. In prokaryotes this is performed by sigma factor, and in eukaryotes it is performed by TFIIH.
'and we have termination'
* Video abruptly cuts off *
😂
First i thought those concepts were tough but after watching this ,i got a clear view of the concepts.Thank u so much sir!
You speak so clear and emphatic that even without subtitles I can follow perfectly your explanation. 👌🏻
Your videos give me life. Thank you sooooo much for doing them!!
you are literally the best when it comes to explaining bio
Supernice! Happy holidays, your vids are saving my whole class here in Oslo!
What a beautiful video on Transcription!!
I am really thankful to you for making such great videos and helping to all the students out there. You are an excellent teacher. Keep up with the good work.
:)
Love from India
Thank you so much sir! Your lectures and way of teaching deserves an Oscar! Stay blessed
U explain clearly and so well... It's amazing... And I love the way u lecture... Thanks a lot
OH wow this is amazing. thanks to you i will surely pass my classical genetics exams with flying colours..keep up the good work :)
You're so good... Exactly wat they teach us at school... I learnt a lot... God bless you
Thank you so much for all your help! Great teacher!
i just love your way of delivering lectures❤❤❤❤❤
Respect from India ! 👌👌
You make this so much easier to understand! You explain everything so well in just 12 minutes and my lecturer takes a whole hour and I still dont understand her! Thank you so much!
Mua Josephine You're welcome! thanks for watching! :-)
this is prokaryotic or eukaryotic transcription??
I am also grateful sir ...my lecturer takes the whole 2_hour trying to explain this but still, I find it difficult to understand him. Please, can you make more biology videos.
amazing!!!!!!!!!!!!!you make things so much easier to understand!!thank you!
sir, you give the best lectures i have seen on yt for sure !!!!!
Only because of you I will pass this semester exams and I wanna give all my blessings and well wishes to you sir . Respect ❤
I sware you're the best doctor in the youtube !
Thaaaank you very much for this explanation 🌹💛💛💛
Your videos are everything 😭💓
Thank you! your way of explaining the topic is very clear and easy to understand
you saved many medical students 💜💜
thank you sir ur videos about isoelectric points of proteins are also awesome 👍
AK LECTUREES thank you so much for all your contributions.. i personally had lot of difficulties with biochemistry. i literally had almost no idea what's going on, only just learning by heart.. but now i do understand better... am also recommending some colleagues to get watch your lectures.. You are fantastic in a way of explaining factors precisely and simply..
I have one single question. Could you please or someone from the Commenters give me an answer to it?
The question is:
What is meant by 3' in the mRNA?
TIA
Good video, very helpful! thank you AK lectures 👍🏻
Interesting work Mister
I wish there were more instructors like you out there. Your so clear and eloquent, your lectures are espectacular
Am out of words, thanks AK
Wow! these lectures are AMAZING!! thank you! 👍👍
AK Lectures you guys are on point
a couple questions: What happens with the RNA polymerase? Does it remain attached to the RNA molecule? Where is the RNA polymerase being produced? Does it free itself from the RNA and DNA and just goes to find another promoter region? Are there multiple promoter regions that are followed by different coding and if so how does it know which region to transcribe from?
recently I learned that actually helicase is involved with transcription after all
love your channel, thanks so much
best science vids on youtube
You just earned a subscriber man.
go ahead, I like your way and your sound is very good
You're the best !! THANK YOU !!!!
So helpful and great lecture, thank you so much
screenshot 4:58 for the notes :)
Great job ! Keep on 👋🏻
very good.. so helpful lectures in TH-cam
WONDERFUL!
the way you you teach is soooooooo..... I hope that the way all the teachers teach is like the way you teach
you the best AK i lov all yo lectures
WHAT A LEGEND!
You are my saver 😍😍
Keep on the good work 😁
Thanks for this video..
Great stuff, keep up the good work!
samnater thanks! :)
Doing this now. Thanks
good job man, nice pace of speech
Thanks! It really helped alot!
I have one question:
Is the promoter sequence the same as the TATA box? Are these two things completely different?
U R amazing thank you so much ,keep going 👍👍👍👍👍👍👍👍👍👍👍👍👍👍👍👍👍
YOU ARE THE BEST TEACHER SIR...
Wow Amazing Sir !!!
Gr8 man..keep it up...👏👏👏
You are the best ever thank you very very much
you have a talent a gift from god like seriously I love you. marry me. how can you make the most complex processes easy to learn
From which country u are?
you saved mee you are the best
Uh RNA polymerase doesn’t unzip dna itself.. heliocase does that -> rna polymerase codes it -> ligase zips dna back together in that order
A quick question for clarification: Are the initiation factors you reference here the same as general transcription factors referenced by others? Thank you!
AMAZING ❤️❤️❤️
God bless you 💟💟💟
Juper Anna love you from India🇮🇳🇮🇳🇮🇳
You make everything so easy and everything is understandable :) Will probably pass Histology thanks to your videos :) I'm greatful for your videos
TheSupperBB Just made my day :-) Make sure to post any questions you might have on my website! Best of luck in your course!
Hello did you graduate from med school
Thanks
thank youuu
you're AMAZING
Imma gonna cry watching your vid
You save my gpa
Thank you !!!!!!!
Good video Sir
Thanks from Taiwan.
thanks sir its very interesting
TYSM!
❤️❤️❤️I love this videos
"So, just like there is a seque... just like there is a seque... uhm... just like there is a sequence." Finally got it the third time. LOL i cracked up. still great video man! Way better than my lazy professor who doesn't want to explain anything. thanks!
:-) awesome!
you are the best sir. and also i enjoyed your laugh u should laugh more often
Thank you so much
I love watching your videos cause it's like learning genetics from the godfather
Sir thanks for the compact explanation
but i have 2 questions...
1. Why and how in rna thiamine is replaced by uracil
2.what is the mechanism of proof reading while dna replication?
Thanks for this leacture
Vishakha Jaglian you're welcome :)
Sir you are giving best explanation but can you
also put some videos on immunology topic it should be helpful
check out my website for some :)
I have question.
Is the RNA only synthesised on antisense strand of DNA, and not synthesised on the sense strand?
Please I need a picture of what is written on the whiteboard for all lectures of genetic
Thanks I love you
Thankx sir
Dna polymerase I also have helicase properties
sir ,relly u give compact concept
Is it possible to download the slides that are behind you?
Dna is also contained in Chloroplasts in Plants. Does Transcription also occur there?
He said that for protein synthesis RNA was used instead of DNA to prevent the DNA strain from getting damaged. Wouldn't the DNA also be at risk of being damaged in the process of transcription?
You only need to copy from DNA once to make a piece of RNA, and then that RNA can be used many times as a template for protein making. (just random numbers here, don't quote me) So if making 1 RNA could be used 100 times to make proteins from copying from DNA 1 time, that is ofcourse better than working directly from DNA 100 times :) So if by comparison you were to use DNA that many times to make the proteins it would greatly increase the risk of damage. Also in Eukaryotes the RNA is transferred out to the cytoplasma where it can actually have access to the "building blocks" it needs, while DNA stays safe in the core :)
Ayla X thank you so much!
At 6:38 - DNA Helicase brakes the Hydrogen bonds in the DNA, the enzyme topoisomerase is the one that unwinds DNA from its helix .
Otherwise great lecture!
Moze false
Moze And its breaks not brakes. Otherwise great comment!
Unwinding and breaking hydrogen bonds should be read the same but the enzyme topoisomerase adds negative supercoils to alleviate the stress for supercoiling
The Flash Unlimited how is this negative supercoiling done at the particle level at the electron level are you saying that the hydrogen bond antiparallel scheme has to be biased with an electrically stable configuration to separate 1/2 of the DNA strand to become RNA to be used in protein synthesis
Albeit that is a scaffolding problem the nut or the magic or the mystery are the four nucleotides
the phosphodiester this is a scaffolding structure albeit very important
would anybody argue that point or that observation the nucleotides are the magic
the other parts are the scaffolding to allow the nucleotides to resonate dialectically housed insulated enough by the phosphodiester backbone
with the two nucleotides hydrogen bonded with four nucleotides available as two double ring configuration the other two are single ring configuration
as a complementary pair schema
As where the DNA lattice is complimentary in-form as a structure
created as a phosphor and sugar backbone
allowing the nucleotides to be housed on this phosphor lattice as electrically neutral as a purine and pyrimidine nucleotide molecules bonded by a hydrogen bond in complementary form
With an innate coding of four nucleotides consisting of Elementary particles using the electron shell Theory these elements hydrogen oxygen carbon nitrogen with a phosphor sugar background as a structural lattice to hold or house these nucleotides as electrically neutral as possible are responsible for weaving our reality as biological species
I like to put this out
the deeper meaning is going to be the spin trajectory of mass or matter
I believe it's going to come down to a force called spin trajectory as an elementary metric of our reality coalescing into what we see as
conveyed to some as mathematics string theory
Hence the super coiling problem hence the hydrogen bond coiling of thr DNA lattice scaffolding
spin trajectory the elementary force of the universe if you can figure out the spin trajectory constant that probably would help a lot in predictability
I believe it still comes down to a 50/50 deal
it will always be a flip of the coin when it comes to predictability using the sciences physics mathematics and the logic called "predictability" will always be 50/50
Deal
Topoisomerase is a class of enzymes, and the most common example is enzyme gyrase. Their function is to relieve torsional stress that arises during the process of unwinding
If RNA polymerase can unwind the DNA in this case, then why do we need helixase in the proces of replication?
Hi,
can you please upload videos on sequencing
illimina seq
RNA seq
UR the man ur videos are on point!!!!!
r u currently in MED school?
abdul shehata yes i am! :) and thank you!
how is med school so far?
any tips for the mcats?
abdul shehata meh its hard to give advice on the MCAT because it really depends on how you learn. i didn't take any courses and just studied on my own. i'd say just create a solid study routine and stick to it! don't let anything get in the way of your study time. don't spend too much time trying to learn the minute details and leave plenty of time to take practice exams.
yeah man.
I have started but do not have a solid study routine. Some days I do 6 + hours and others I do Nothing. goota get that routine I guess.
also if i can teach someone for example transcription like how you exactly do it, you thin thats a good sign for a good mcat grade?
Isnt elongation the part where tRNA make the peptide bond (translation)
tnx