Sir... as per Hindus and tamil tradition, 1.mother... 2.father... 3.teacher... 4.God...... God is after u sir... ur videos are life saving.... ur videos are like shadow in summer.... for students like me with lot of dreams and targets ur videos are the pathway that leads us to our destination.....
Excellent job!! Clear, succint summary with repitition to really cement our understanding! I would sign up for any and every science class you teach. I hope you are a professor somewhere - that's your calling!
Why does DNA polymerase not complete its direction with the fork direction .What is the reason for the opposite direction of DNA polemerase??? I hope you answer.
im not clear about how the DNA polymerese manages to recombine the new strand in it is covered by the SSB protiens that prevent the connection.... dose it automaticly removes them in the process ? or there force is not a facter to the DNA polymerese ?
i think there's a small mistake. there should be no ssb on the leading strand because it can immediately add bases to the growing strand without having to worry about it going back to the complement strand.
Are the videos suitable for somebody who is preparing for pre-med? I mean for somebody who wants to study Medicine? A friend of mine said that they are too detailed and are only for somebody who already started studying Medicine. True or?
Hi doctor, Thanks for your lectures. I want to ask a question : what is the direction of lagging strand ?? on which strand is the direction determined, the template or the new strand ?? I didn't watch this lecture, I just want answers for my questions. My regards.
accdg to campbell biochem book, lagging strand has its 5' end nearer to the replication fork than the 3' end. (Strands grow from 5' to 3' in the perspective of the growing strand). The lagging strand will grow towards the opposite direction of where the fork is travelling. So if the fork is moving towards the right, the lagging strand will be polymerized from 5' to 3' end but going to the left. The direction of the new strand is dependent on the template. If the template strand's 3' end is in the left, then the new strand will ofcourse has its 5' end opposite to the 3' end, which is on the left. From there, the direction could be either, I believe, just depending if its the lagging or the leading strand. I don't know if nature actually is so picky which strand gets to be the leading or lagging tho. It just so happens that that's the way we get to differentiate the two strands and their mode of polymerization.
Lagging strand grow from 5' to 3' end but in fragments that form continuously as DNA unwinds giving the overall growth of the lagging strand 3'-5' direction.
the free 3'OH is on the deoxyribose sugar of a nucleotide on the DNA strand that is being synthesized by DNA pol III or on the ribose sugar of a RNA primer nucleotide. it's needed bc that is where the newly synthesized nucleotide from DNA pol III will be added.
oo he's tan in this video, wonder where he got that tan from? was brains out partying in the sun? doing some yard work? guess he does leave his lectures sometimes 😂😂 maybe he does live a little
@@AKLECTURES LOL well that is good, I'm glad to hear it. A little is better than none at all, right?🤪 what an impressive balancing act that must be. Props Mr. brains.
I love how he explains things again and again until it sticks
6:53 is where you can see the entire board.
take a screenshot and then print it :)
Thank you! His notes are amazing.
You can't fully. It's actually 10:35.
I have been watching your videos all through university and you've saved me on so many occasions! Thanks for all of your hard work
This man saved my first year life in university.
This man deserves an Oscar, God bless you so much !! Thank you for all your videos you saved my life man ILY
Your lectures are very helpful in revising molecular biology. I'm student of biotechnology and professor asked us to revise all these basic concepts.
You're the best at teaching!! Thanks for all of your explanations
You've saved me, thanks alot. Please keep going! Never stop helping us
You are too good, the way you explain things i'm just excited
thank you for presenting with complex "fancy" words now I can elaborate more my ideas.
i have a micro test tomorrow and this helped so much! Thank you so much!!
Amazing. Wonderful explanations 🥺 u don’t know how much you’ve helped me in biochem
Sir... as per Hindus and tamil tradition, 1.mother... 2.father... 3.teacher... 4.God...... God is after u sir... ur videos are life saving.... ur videos are like shadow in summer.... for students like me with lot of dreams and targets ur videos are the pathway that leads us to our destination.....
i am loving the way you teach well done you did a good work outstanding and thanks alot
Brilliant lecture! Thank you, thank you, thank you times infinity :)
this is wonderfully described. makes biochemistry simplified. thank you
Thank you so much..... Your lec. Are just quick revision of particular syllabus topic as in detail as I read.... Helped me a lot.. Thanks again
Excellent video & explanation. Thank you!!
thanks alot
ur way of explanation is greaaaat
I am a pharmacy student ,ur videos help me alot.😊
This is the best video on DNA replication.Thank you for this video,really helpful.THank yOu once again
Execellent work i understand more your lecture than any other
Excellent as always! Is there a lecture on DNA repair mechanisms?
your videos are always awesome. thank you so much
great videos ....keep going . have a request can u do a vid on telomere and DNA repair☺
THANK YOU SO MUCH FOR YOUR VIDEOS.
Excellent job!! Clear, succint summary with repitition to really cement our understanding! I would sign up for any and every science class you teach. I hope you are a professor somewhere - that's your calling!
I didn't even realize I commented twice!
Thank you so much!
Thanks, very good lecture! : )
thank you as always
Excellent/great job
Thank you for your amazing videos
Thank you so much sir, superb class
The best ..thnk u so much 🌸
Thank You sooo much sir..
How can you give multiple likes!!!!!?????
Thank you so much 😊
thank you so much.
Sir, can you please post a lecture on bacterial DNA/ Genome replication
Wish I have seen this back in med school
Hi sir,
From where the new nucleotide can come from where the DNA polyerase bind them
very veery very nice.... lecture
My teacher !!🎉
Why does DNA polymerase not complete its direction with the fork direction .What is the reason for the opposite direction of DNA polemerase??? I hope you answer.
You are very good
My "online" husband. I want your brain!
hah :)
😊😂
He’s mine sorry
learn hard and you will get there
SO interesting explaination
Thank you
thanks for good enunciation-can set playback to 2x :)
im not clear about how the DNA polymerese manages to recombine the new strand in it is covered by the SSB protiens that prevent the connection.... dose it automaticly removes them in the process ? or there force is not a facter to the DNA polymerese ?
thank u much 👏👏👏👌👌
On the lagging strand, do we have more than one dna polymerase on the strand since there is more than one primer?
ya
Carmen Tsui DNA polymerase 1 joins the regions between Okazaki fragments in 3 ටto 5 direction with the help of DNA ligase
RIP channel AK.LETURES, high quality channel gone to waste.
Still very much alive and kicking ;-)
Can you do video on telomere replication? very much thanks!
Where is TH-cam at! You should have at least 1 million subscribers and 500k views. So unfair!
Thanks sir !!
i think there's a small mistake. there should be no ssb on the leading strand because it can immediately add bases to the growing strand without having to worry about it going back to the complement strand.
No
They all have
Wow Excellent
Are the videos suitable for somebody who is preparing for pre-med? I mean for somebody who wants to study Medicine? A friend of mine said that they are too detailed and are only for somebody who already started studying Medicine. True or?
Meni traze otprilike ovoliko, uglavnom vise nego manje od ovog. Konkretno, od cele ove lekcije (DNA replication) isto. Gde planiras da se upises? :)
thank youuuuu soo much!!!!
Sir,can you please post video on regulation of DNA replication??
Sir, can you put a video on termination of DNA replication.
You're the besttttt
Hi doctor,
Thanks for your lectures.
I want to ask a question :
what is the direction of lagging strand ??
on which strand is the direction determined, the template or the new strand ??
I didn't watch this lecture, I just want answers for my questions.
My regards.
accdg to campbell biochem book, lagging strand has its 5' end nearer to the replication fork than the 3' end. (Strands grow from 5' to 3' in the perspective of the growing strand). The lagging strand will grow towards the opposite direction of where the fork is travelling. So if the fork is moving towards the right, the lagging strand will be polymerized from 5' to 3' end but going to the left. The direction of the new strand is dependent on the template. If the template strand's 3' end is in the left, then the new strand will ofcourse has its 5' end opposite to the 3' end, which is on the left. From there, the direction could be either, I believe, just depending if its the lagging or the leading strand. I don't know if nature actually is so picky which strand gets to be the leading or lagging tho. It just so happens that that's the way we get to differentiate the two strands and their mode of polymerization.
Lagging strand grow from 5' to 3' end but in fragments that form continuously as DNA unwinds giving the overall growth of the lagging strand 3'-5' direction.
why does dna polymerase need a free 3' OH? And where is it?
the free 3'OH is on the deoxyribose sugar of a nucleotide on the DNA strand that is being synthesized by DNA pol III or on the ribose sugar of a RNA primer nucleotide. it's needed bc that is where the newly synthesized nucleotide from DNA pol III will be added.
thank youuu
❤❤❤❤❤❤❤❤❤no words
um I LOVE YOU. THANK YOU!
Thank you💙💙💛💛💛🇯🇲🇯🇲🇯🇲🇯🇲
thank you for being born
V nice
Are u from USA?
Nadir Hossain Saifullah his accent suggests so. I'm sensing a Boston accent.
No, He's Nigerian
Awesome! DNA Gyrase is specific to Prokaryotes isn's it??
Yep, it is
The common term for the same is Topoisomerase.
It’s a topoisomerase
👍👌
👏🏻👏🏻
one mega likes
can you do my homework
😍😘😘
oo he's tan in this video, wonder where he got that tan from? was brains out partying in the sun? doing some yard work? guess he does leave his lectures sometimes 😂😂 maybe he does live a little
Good observation! I have no idea what I was doing 4 years ago but I definitely do live.. a little :)
@@AKLECTURES LOL well that is good, I'm glad to hear it. A little is better than none at all, right?🤪 what an impressive balancing act that must be. Props Mr. brains.
great lecture, but i am stupid still cannot comprehend 🥲