Pharmacology - ANTICOAGULANTS & ANTIPLATELET DRUGS (MADE EASY)
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Anticoagulants, commonly referred to as blood thinners, are drugs that prevent or reduce coagulation of blood, prolonging the clotting time. Antiplatelet drugs, also known as a platelet aggregation inhibitors, decrease platelet aggregation and inhibit clot formation. These drugs play an important role in the treatment of various disorders such as myocardial infarction, thrombotic stroke and venous thromboembolism. This pharmacology lecture covers topics such as pathophysiology of blood clot formation and platelet function; activation, aggregation, cross-linking; ADP receptors, glycoprotein IIb/IIIa receptors, cyclooxygenase-1 (COX-1) enzyme, fibrinogen, fibrin mesh, coagulation cascade; intrinsic & extrinsic pathways, clotting factors, antithrombin, heparin induced thrombocytopenia, INR, plasmin, and plasminogen; mechanism of action of platelet inhibitors, anticoagulants, thrombolytic agents, and drugs used for treatment of bleeding. Drugs mentioned include; Aspirin, Clopidogrel, Ticagrelor, Ticlopidine, Prasugrel, Abciximab, Eptifibatide, Tirofiban, Heparin, low molecular weight heparins; Enoxaparin, Dalteparin, Protamine sulfate, Apixaban, Rivaroxaban, Univalent & Bivalent direct thrombin inhibitors; Argatroban, Dabigatran, Bivalirudin, Desirudin, Warfarin, Vitamin K, Alteplase, Reteplase, Tenecteplase, Urokinase, Streptokinase, Aminocaproic acid, Tranexamic acid.
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0:00 Platelet plug formation
2:04 Platelet aggregation inhibitors
5:34 Coagulation cascade
7:38 Anticoagulants
12:03 Warfarin
14:11 Thrombolytics
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Perfect
Update: an antidote for apixaban and rivaroxaban is now available: Andexanet alfa. Came out in 2018, one year after this video was uploaded.
thank you for information
Thanks 👍👍
Thank you
Also, Dabigatran has an antidote, Praxbind
Idarucizumab a monoclonal antibody
since i was pharmacy student i used to watch your videos before mid & final exams and it help me to remember things & make it easier
now i'm officially graduated pharmacist but still love watching your videos😅
so i want to say thank u so much for making pharmacology easier on me ❤️🧸
From which country are you from Ma??
I'm doing my b.pharm 3rd year right now.. Is there any scope for pharmacy after graduation????
Because, I don't see any scope in India as they are paying very low for the pharmacists.
It's nice to have a diagram of the cascade and then interject each drug class where it acts. Thank you! This is how all topics should be taught by all teachers!
Coagulation cascade are the ones I found hardest at med school and it was a pain to revise when comes to finals then I forget about it. Now I'm preparing for core training exams and actually find this video more helpful than ever. I never understood this topic any clearer (I guess with more clinical experience it also helps to understand bit more). Thanks so much for making this video.
Please keep making those videos, it was organized, simple, and really straightforward. You just save my 5-hour listening to recording lectures. Thank you so much
this video is absolute gold. thank you so much for taking your time to make this, you deserve an award.
This was perfect from beginning to end. Information logically categorized, great talking speed, use of graphics that helped anchor understanding... bless you for taking the time to make this!
First time seeing your videos, instantly subscribed. Looking forward to watching the rest of your videos through Pharmacology class!
th-cam.com/video/ynnPMgdEV5M/w-d-xo.html
You are conveying little faster
And your slang make it us difficulty in understanding in some places
WHO KNEW IT WAS THIS EASY!!! I can't thank you even for saving my life
I was struggling with this for hours then I found your video
This is the freaking best!
th-cam.com/video/ynnPMgdEV5M/w-d-xo.html
I would just like to say thank you for captioning your content! As a subtitle person, you're making it easier for me to learn, so thank you.
thanks for keeping your lectures short, simple and to the point
I have just discovered you and u have no idea how grateful I am.
Amazing video. I have been struggling with this topic but this has made it very easy for me . Thank you.
I am self studying some medical subjects without requisite chemistry and without other helpful pre medical information.
Despite the brain damage I got from this, your lecture has really helped me understand the activity of aspirin in coagulation.
Huge thanks for uploading this, it has been a great help to me 😎
you are literally a life saver!!! thank you so much for making my life and concepts easier. God bless you
This was the best video for the Hemostasis drugs!! Thank you!!! Perfect!!!!
EXCELLENT - perfect for nursing students. Thanks for making this!
I'm officially graduated pharmacist still love to watch ur videos , thanku so mch for making pharmacology easier
Thank you for the great video! The reversal agents discovered after this video was made: for apixaban it’s andexanet alfa, and for dabigatran it’s idarucixumab.
you are an amazing person who make everything in pharmacology easier and simple (may god bless you )
Oh my god! I was literally waiting for the upload of video on this topic. Sir, You make learning process in pharmacology so simple and easy to understand. I owe all my good marks to your lectures! Thanks a ton❤
Avneeta Swashna
Thank you so much! I can't believe I was struggling with them from 2 hrs and I got it at once or twice from a 16 min video.
Great summary video! thanks for the post. It was very helpful. I like that you give examples of all the drugs in each class and their mechanisms with visuals. This helps to solidify the information for visual learners.
I can't thank you enough, God bless you, may you achieve more than what you wish for💕
The best lecture so far of this very complicated topics and the use of picture aids is just superb!❤
The overall video was great. I would just like to note that the Mechanism of Action for Fondaparinux is incorrect. Fondaparinux actually binds to Anti-thrombin III and potentiates its selectivity and affinity for Xa. Fondaparinux is in fact Anti-thrombin III mediated which is what distinguishes it from the direct Xa inhibitors (ApiXAban, EdoXAban. RivaroXAban and BetriXAban) which are not Anti-thrombin 3 mediated.
I am fortunate to find your channel and watch your lectures. They are directly oriented to the point and easy to understand. Thanks so much!!!!
Man you’re the best... love your lectures~
Excellent video! Covers everything. Really grateful to you for making this!😀
I watched the first video from your channel 6 years ago when i was in semester one 1 trynna understand autonomic NS drugs.
and now I am doing my internship and wanted to revise.
thank you for being with me throughout the journey
Dude, this is awesome! Thnk you from a struggling pharmacy student.
Hi, Can you make video on Antiemetics..
And Thanks a lot for making the toughest topics of pharmacology EASIEST..!
Buddy ... You are making things damn easy ... Thanks for making such a informative video ... combining all three classes of medications was good idea...
Thank you so much, so clear and simple
May God bless you
Excellent video. Well organized, clear, and logically explained. Thank you!
I am not a doctor or pharmacist but after watching this video I understand each and everything about clotting.
bless you bro (Y) Thumbs up .
Brief but very educative! Thank you. God bless!
God bless ya speed pharmacology. You have cleared my goddamn concepts and eased my existential crisis of proffs.❤️ May God bestow you best rewards!
You are totally genius man...thanks for your hard work...that make our understanding to pharmacology very easy..a billion thanks to your work
bravo! I never understood these really till now!! thanks dude!!!!!!!!!!
I loved this- straight to the point.
All the important points are wonderfully covered with clear explanation 😍😍
thank you so much. the drawings really help me understand much more than powerpoint slides alone
Thank you for taking an effort to make this video .
Thank you so much for making this topic understand in just 16 minutes :)
Thank you so much! So simple and amazing!
This video is incredible! So helpful! Thank you so much!!
Amazing video, pal! Thanks for making the difference in my study process!!!!
Well simplified... Great job..
Thank you.
CONGRATULATION for this video, really easy to understand !!!
Very well explained! Thank you so much
Thank you a lot! This lecture is amazing!
Very clear and so so helpful! Thanks a lot! It has been long time it was not clear, but now it is, praise the Lord! :)
One word speed learning pharmacology.. thank you sir..
perfect lecture thank you very much
Thank you sir for this video..
Excellent video 👌of totally information about all coagulation,anti coagulation,anti platelets,thrombolytic.
Thanking you..
Thanks for this. It's well explained.
Life Saving Pharmacology Tutorials!
thank you so much! life saving lecture!!
thank you very much for posting this video. you made this topic really easy and interesting.
dude you just saved my life, thanks for the vid
just a quick errata; eloquis/(apixaban), xarelto (rivaroxaban) have an FDA approved reversal agent
"Andexxa, the first factor Xa inhibitor antidote indicated for patients treated with rivaroxaban (Xarelto) and apixaban (Eliquis), when reversal of anticoagulation is needed due to life-threatening or uncontrolled bleeding."
Even Dabigatra has an antidote: Idarucizumab
you are the best . the video is awesome you make me love pharmacology thanks & please continue
These videos are literal lifesavers! If you can, could you add mnemonics too?
Very clear , coherent and insightful
Thank you so much for all your hard work in making these!!! I feel so much better after watching your videos! You are an absolute blessing
VERY HELPFUL!! thank you so much!!
Perfect lecture for Anticoagulants and Antiplatelets
Thank you so so SO much for this video. I'm a medical student and have struggled so much with these drug classes for a long time. When I get a question in my exam about this I'll be thinking about this video haha. It was perfect. :)
Glad you liked it!
Great video, it helped me a lot!
This was amazing you made it so easy. 😍 lots of love from india💜💜💜💜💜
exam tomorrow. Really help me understand more ! thank you !
My mind was just blown 🤯🤯🤯 absolutely awesome video! I highly recommend! Very helpful 👌
Thank you, Short and sufficient 👍🏼
These are SOOOOO great! thank you for posting! Can you make a video explaining Antipsychotic drugs?
Best lecture ever, keep going sir!
this is the most awesomest video ever . i ama pharmacy student and all your videos has made my studying so easy . thanks alot
Such an amazing talk. Really made me understand this topic
amazing explanation. you guys rock!
God bless the authors of the internet. I have a test on this in an hour and I have not managed to even read it.
U brought peace to my mind u deserve a Nobel prize
thank you so much , u just saved my life
I love your videos! Please keep up the great work!
Exactly what I needed. Thanks
Thank you for the brilliant lecture ☺️
what a great video .
YOU ARE A SMART MAN .
I discovered this video on Pronto Therapy Folio - there are plenty more great videos there that will help out
Sir, many many Thanks!!
U made this topic so easy... 🤗
Amazing explanation. Thank you very much
Beautiful explanation. Thank you!
Wow! You are gifted to teach.
best pharmacology explanation ever!!!!
Amazing! you made it easy for me
The best video of the topic! Thank you!
your channel is a discovery 4 me
GREAT PRESENTATION .THANKS
Thank you for videos..you make me attention for this mechanism
Lots of helpful videos by speed pharmacology, thank u.
Update on antidote for factor Xa inhibitors (rivaroxaban and apixaban only): ANDEXXA. Approved by FDA early May 2018 for life threatening bleeding. Great lecture!