ฝัง
- เผยแพร่เมื่อ 29 ก.ย. 2024
- Hey guys, today we're going to be making denatonium benzoate from lidocaine, benzoic acid and benzyl chloride that I made in previous videos.
Benzyl chloride video: • Making Benzyl Chloride
The intro video was made by user Linus Tuttle (www.youtube.co.... Thank you!
The music for it is from Incompetech (Severe Tire Damage Kevin MacLeod (incompetech.com)
Licensed under Creative Commons: By Attribution 3.0 License
creativecommons...)
Procedure adapted from: www.google.com/...
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Nile talks about lab safety: • Chemistry is dangerous.
I used this to keep the horse from chewing on our trees.
Cody'sLab Hi Cody!
Vix vapour rub works too
Cody'sLab that's awesome
i think i will use Denatonium Benzoate to stop some crazy peoples form eating/drinking me
mercury How would you drink it yourself? Maybe a dummy straw?
But I’d probably forget about it and getting the taste stuck in my mouth for weeks.
I came back here because I was shocked to learn...
HE ACTUALLY HAD AN INTRO
"From his fingers, to the cards, to his friend's cards, to his friend's fingers, to his friend's mouth". This should be used as an experiment to demonstrate how COVID can spread.
Could you do some organometallic reactions?
YES PLEASE!!!!!!!!!!!
+The Chemistry Kid n-Butyllithium flamethrower, baby!
...
Oh, and useful stuff like Grubbs catalysts too....
+Sword of Apollo I would LOVE to see dimethyl Mercury, but it is incredibly toxic, which is like saying the sun is a bit warm.
DO DIETHYL ZINC IT IS PYROPHORIC
madz bush do you mean the positive nitrogen ion on the right with the negative chlorine ion? That's funny 😉
2:56 - 3:32
Me not knowing at all what he’s talking about: “I like your funny words magic man.”
Your description makes me want to eat this stuff
its also used as the bitter coating on nintendo switch games
diabolical prank idea: dump a concentrated solution of denatonium benzoate into a swimming pool. primary effect, no one is going to want to swim for the rest of the day. secondary effect, i expect it would be pretty difficult to clean out, unless there's a way to do it chemically that's safe for use in a swimming pool
Nice intro! But maybe you can add something related to chemistry. One idea could be putting a molecule inside the red circle and depending on the video you could change it.
The N at the end of the Denatonium Chloride looks like a dude playing basketball with a benzene ring while throwing a chlorine in the trash.
DTB (Bittrex) is used in rodenticide to prevent ingestion. I can attest it tastes foul but I have seen dogs wolf down trays of rodenticide and they say dogs can taste it.
I found nail polish remover that said 100% acetone and I was going to use it as a solvent but the I looked at the ingredients and it said acetone and denatonium benzoate. 100% acetone my ass.
It might’ve said that because the amount of acetone in the nail polish remover is so close to 100% that they just rounded up
9:35 I assume you meant to write chloride in the bottom left equation? No big deal, just noticed it, and you do say it correctly, and have it correct on the right side of the bottom equation.
Love and appreciate your videos! It's not possible to do all of these myself, so it's nice to see them done. =)
It's worrying that it eventually transferred to your friend. What's to stop a more toxic chemical being transferred? I'm sure you're really careful. It makes you think about viruses and the spread of chemicals.
Maybe we could make a new 'virus', and those who don't follow stay-at-home orders will get a very bitter taste in their mouth!
Ah the one they use in Nintendo cartridge thingy?
9:36 says denatonium hydroxide both places
Been on the dark web for an hour looking for NileBlack, Nigel’s drug and explosive synthesis channel
12:12 no officer, thats not cocaine, thats a bitterant
Nice paper clip as a stir bar lol
mmm.... just a heads up to anyone reading this comment and watching the video, if the mechanism is either SN1 or SN2, it has both E1 and E2 as competing side reactions which explains the bad yield.
I agree with nile though, there's no reason to optimize this reaction.
Hahaha love the custom stir bar!
Uh oh, snazzy intro, he's going commercial :)
Not that is anything wrong with that.
Niejole have you ever felt a sense of discovery while doing these experiments?
You forgot the most important use! Coating switch cartridges to discourage kids from eating them. Jokes on Nintendo: my ritual is licking every new cartridge. It’s not that bitter. I’ve tasted more bitterness from angostura bitters and IPAs.
Codeine from headache/flu tablets :P
great video.i whant to see methylamine,acetone
+antiswattt3 yes
ionel anonimul perform a reduction of nitromethane to get methylamine-use iron metal in refluxing acetic acid
At 10:55 you might have reached it’s saturation point or super saturated so it couldn’t dissolve any more it’s possible but I’m not completely sure.
cool intro, and great video!
I love a woman with a copious amount of Acetone.
Whoa, never seen that intro before
during this video, 470 users accessed wix to make their fucking page, apparently.
THIS WOULD BE A PERFECT PRANK!!!!!
Well, that would make a great tool for using in pranks
I keep licking my switch cartridges this doesn't deter me at all
Nile Red always uses the most scientific measurements like, "a bunch"
+Kid Kirby Perfect SI unit ;)
At least not something horrible like fluid ounce.(No, as I'm from central Europe I do not even know how much that is exactly, I think somewhere in the region of 1 liquor shot)
namibjDerEchte The US uses freedom units, You use heathen units. Freedom units > heathen units.
Yup, nilered is quite sloppy. But we don't mind.
Did you see that his stirbar is actually a paper clip?!
Your search is over. This is the only NileRed video with an intro. Congratulations
Really?
@@addyshorhnr3544 yes
This is a monumental discovery
Oh cool
Hahahaha. Thank you. I literally was going to search.
You don't need an intro, you're classy already
+DerFlugzeugTV I probably wont include it in the future videos, but it was made for me and I wanted to credit the person for making it. They took their time to do it and it was the least i could do
+Nile Red keeeeep it is awesome
+Nile Red I'd suggest using it in about half of the videos, as some people like it and some don't.
Chester TheMolester Yh I agree. Well tbh I think no intro necessary but if you want one then at least include your logo and stuff
@@NileRed You should've kept the intro it looks so cool man.
Your story about bitterness was still less insane than my organic chemistry prof's story.
He made a small amount of sweetener(I don't remember which one, but he said it was about 10.000 times sweeter than normal sugar) for an experiment, and decided to try a little bit of it. It tasted sweet but not insane, just like regular sweetness. He then tried to wash it off, surprisingly it didn't wash off. A day later, still, everything tasted sweet. A week later still the same picture. He couldn't get the sweetness out of is mouth for 3 weeks. Literally everything he ate was sweet for 3 weeks.
+MrGurkentomate that is crazy. At least it was enjoyable though?
He could have drunk straight up black coffee for that whole period of time to assert how much of an alpha male he was.
What is it?
@@petevenuti7355 Probably neotame, it's roughly 10,000x sweeter than sugar. I believe it's the 3rd most sweet substance out there
Did he accidentally make miraculin, the stuff on miracle berries?
I thought Denatonium Benzoate was bitter but then I remembered how my ex was.
+zubmit oooooo
oh my god! oh my god! oh baby a triple! oh my! oh my God! MLG!!
@@theterminator3907 this made me physically cringe.
@@NileRed So basically, you made Denatured Alcohol...am I right?
@@theterminator3907 yikes
Nintendo switch cartridges
Yea I licked one. Quite nasty
And your fingers after handling switch cartridges. Yes, this is true.
@@memememegaming I learned that the hard way. Never change cartidges with freshly washed damp hands, never lunch after said cartridge switching.
I licked one once. It wasn't so bad
Wtf
I watched a whole bunch of videos from 2010-2019 but I haven't seen an intro.
Based on another comment it looks like he only used it once as a favor to the person who created it.
Brandon, I figured it out, I finally did it ! “Nodnarb “ IS JUST BRANDON IM SO STUPID OMG
@@bradleyholland4984 WHO'S brandon!?
@@Tommo. Nodnarb is Brandon.
this is a pretty fascinating and scary illustration of how, even when taking precautions when working with carcinogenic or other dangerous chemicals, a small amount still gets on your skin and even in your mouth. Glad I'm not a chemist!
You mean, a good illustration of why wearing gloves is important?
@@kirayoshikage4057 at 11:10 he says some gets on your mouth just from the fumes that evaporate. Unless you do everything in a fume hood, which most chemists don't, you are still getting some in your mouth
@@roblarssen249 Not my problem if "most chemists" ignore the fact that chemical reactions release fumes that are possibly toxic.
@@kirayoshikage4057 then you clearly have never worked in chemistry since even a chemistry college student could tell you that it is impossible to do every reaction in a fume hood. There isn't that much space and you are severely limited in what you can do by what you can physically get in a fume hood. Most reactions happen at the bench and only those most likely to be dangerous happen under the fume hood
@@roblarssen249 you clearly never worked with chemicals if you're scared of every single one of them.
Hate someone? Pour the whole bottle into his meal!
Put a small amount in their toothpaste, salt shaker, pepper, sugar, water piping, shampoo, soap, ect.
ᴠᴧᴨᴛᴧᴃᴌᴧcᴋ lol
Put in a woman's lipstick, ruin their dates.
+Cyberw4y omg xD
@@Cyberw4y Put it in her douche water, really ruin her dates!
The stir bar looks vaguely paperclip like.
Jake Kim It is
Indeed
It is the stir bar for the oil Bath
The stir bar is in the round bottom flask --- the shadow on the hot plate makes it look big and paperclip-like.
It's really Clippy from Microsoft word.
In all seriousness though, the paperclip is used to stir oil bath to evenly distribute the heat. There's another stir bar in the round bottom flask.
I think the reason the multiple acetone-evaporation cycles worked is that you were removing some water each time. Wet denatorium benzoate was probably soluble in acetone, but the dry one, much less.
+supersmashsam That might be possible!
That was the cheesiest intro I have ever seen. I love it.
+NeedSkillNow haha thanks
+Nile Blue wha-
+Ben Sullivan XD
@@NileBlue what
Linus Tech Tips worthy?
“Ill try to remember to post a link in the description but ill forget” Im dying 😆😆😂
I had one of those compressed air cans get punctured a while back in my apartment and for the better part of a day while I aired out my plave, the air itself tasted bitter from this stuff - Really amazing how potent it is.
Yeah I have a more embarrassing but similar story. I used to huff air dusters and they had denatonium benzoate to discourage that. Usually I would use a balloon but one day I decided to just inhale straight from the nozzle. I almost threw up and was tasting it for the next 2 days. I can still remember the taste, yuck.
How long did it stick around? Did it take long to dissipate? My carpet is full of the crud at the moment…
nice video. interesting substance.
like the intro.
"... it's honestly probably better to use a seperatory funnel. But I decided not to for some reason..." comments often remind me a bit of myself when I'm in the lab ;)
"I realized that it wasn't supposed to"
I'm done :'DD
We should fix a goal for Nile, the day he puts al reagents in the beginning of this video, he would get some sort of bonus.
Like a free hot plate paid for by patreon?
I think he does it on purpose.
I work at an ice cream factory and we use bixtrex in our pasteurization process. It’s a fail save so we know if anything goes wrong. I tried some straight up because I’m dumb, and yeah extremely painful bitter and then that taste lingered for days. Don’t mess with it 😂
This happens quite frequently to me. Especially when working with toluene, its really hard to fully remove most of the time as toluene has such a low boiling point. This means that often tiny amounts stick to the otherwise clean product, sometimes even after some washing steps (If you were gonna do it again I would wash it a little more, maybe using something less polar like hexane). One thing I learned to remove the remaining toluene is to add a little bit of low boiling point solvent (in my cases often chloroform or dichloromethane) and then quickly reduce the pressure below the boiling point using a rotary evaporator to quickly pull off the solvent which might strip some toluene with it. oc be careful so you dont create a mess. I believe that something similar happens when adding a little bit of acetone to the allready hot syrupy liquid.
At 9:33, you labeled denatonium chloride as "denatonium hydroxide." Great video, by the way!
Glad your channel is growing and nice intro
+Janusz Januszowski Thanks!
did you see that nazi nitrogen atom?
oy brotha!
Savage nitrogen
I guess N does not stand for Nitrogen there😂
no, i did nazi it
Nitro Nazi... sounds like some sort of metal band
You claim in the title that denatonium benzoate is the most bitter compound known, but wikipedia claims that denatonium saccharide is five times more bitter, being detectable at 0.01 ppm as opposed to the benzoate's 0.05 ppm threshold.
Both of these are still absurdly bitter, of course.
Sounds like you just found ourselves a new challenge for playing cards 🤣
Ironically, saccharides are usually sweet.
@@GRBtutorials reminds me, saccharin actually has a nasty bitter aftertaste
basically people lump the denatoniums together. the practical difference is trivial
Time for some super-scientific self experimentation.
"When I was playing cards one day..."
It's cool, man. We know you're not playing poker, blackjack or baccarat. You can tell us. Was it MTG, Pokemon, or Yu Gi Oh?
Best chem channel everrrrr
I thought nurd rage was the best, but when I found Nile Red about a year ago, I changed my mind totally. He releases a lot of videos, all of the videos are high quality and he does a brilliant job of explaining the steps and what reactions are taking place.. Only problem I have with this channel is that he doesn't have enough subscribers. This channel deserves a lot more.
+Terry McAnear Thanks :)
4k, awesome intro and quality active content. What's next?! Amazing Nile Red. Keep it up!
Oh, I forgot, new mic?
+ZeroGames intro is gay
billied_2003 Thx for the feedback! :D
+ZeroGames wtheeck
+billied_2003 me too
These videos remind me of the organic chemistry lab in undergrad. As a grad student in RNA biochemistry my chemistry has gotten really rusty - so I always stop and look at how I would explain the reaction, how I would go about it etc - great revision!
Now teach us how to get this thing out of my hand sanitizer
Try distillation
Oh god this aged like milk
@@hiiammatthew8735 LMAAAO
Not using hand sanitizer in the first place works just fine. If you accidentally took a shit straight into your palm, try soap or something, should be more than enough.
If you work in medical field... Just use pure alcohol?
I want to see you proceed to make the most sweet chemical in the world (afaik)
Lugduname
Is it sweeter than Alitame?
@@mubasshir yes, by more than hundreds of times.
Please no intro. It does not fit with your videos
Hey Nile, I've been watching your videos for sometime and I really like them, and are one of the things that made me REALLY interested in organic Chemistry. They also helped me with making a project that I have to do in my Organic Lab course :D THANKS!!
I would like to see the Calcium Acetate from Vinegar and Egg shells! and for future videos Nonivamide and Vanillylamine have my votes.
I also second +TheRedKnight 's motion for organometallics reactions if you can.
+Emanuel Rivera Torres I am glad you enjoy! The video you want will be out eventually :)
+Nile Red Hey Nile! I'm really enjoying your videos...
A question, how much money have you spent on equipment so far?
InbredDucks I would go with "a lot". I dont have a dollar amount though. At least a couple thousand dollars on glassware and chemicals
I wonder if this is on the switch cartridges to prevent choking
Edit I checked! It is and it’s freaking disgusting lol. It’s gotta be a minuscule amount tho because it doesn’t transfer to your hands upon using them
I love tricking people into trying it to see their reaction my son was the best lol
Lick your Switch carts everyone
Could you use this stuff to dissuade/find out an office food thief, by lacing your food with it?
Yes.
Would you jump through so many hoops just for that? There are cheaper things you can buy at the pharmacy.
Cyanide works better. Nobody will ever steal your food again. Unless you're caught.
Staple their fingers,
@@ethangoldsmith9332 it hurts when that happens
hey nile, can you make a video about liquid/solid ozone? it would be very interesting :P
Oh yeah
Heck yeah
When I was a child, my mother used one of those nail preventative nail biting polishes on my nails. I didn't know why I had a bitter taste in my mouth after eating or biting my nails whenever I felt anxious, but about 20 years later I know something for sure: that stuff didn't work in my case.
Those nail polishes don't really work if you regularly eat bitter foods like acorns or drink bitter things like black coffee. If anything, my nails ended up between my teeth more because the taste helped me concentrate.
@@callfororion8846 I don't eat or drink anything bitter on a regular basis, much less when I was a child. I believe that the reason the nail polish didn't work with me is that it was directed at the symptom, not the cause, which is my anxiety.
That stuff doesn't work in any case. It is as simple as telling your child not to do it in the first place.
If some jerk synthesized 50 tons of this stuff and dumped it in the ocean... rip everyones tastebuds for the next 200 years lol
😮
Hi Nigel, would you make a bitter blocker substance? That would complement this video nicely.
Immagine the police come to his house while he’s doing this...
I never thought you'd get an intro, and you finally got one. It especially suits you.
+Xylofuse This. I've been hoping form some grignard synthesis
Wow, really interesting compound, I could only imagine how bitter it is. Also, kudos for your new mic and intro. Keep up the good work, I can't wait for more videos!!!
Hey! I actually understand the mechanism and types of reactions! That's cool! O Chem is actually useful
“This chemical ruined my life for a few days nonstop”
“Anyway we’re making it with these few ingredients”
I'm not surprised lidocaine is involved. The lidocaine suspension I got after GI surgery was horrific. The only thing that's maybe worse is the barium chalk drink before a CT
Nice intro!
Nintendo Switch
Fun fact: it's also used for covering of nintendo switch game cards, so kids wouldn't eat them
Toluene. That reminds me of trinitrotoluene. [TNT]
Will you ever make this? I just find it interesting. Because it releases its energy so amazingly fast. But if you do produce this, please make a tiny batch, and exercise safety.
You dont wanna have "a hand" in this reaction lol.
Accidentally distilled off Denatured Isopropyl, and my resulting product was chock full of Denatonium... Not sure which one (Hydroxide, Chloride, Sulphide, Benzoate, etc), but ever since then I have always pre-tested my Technical-grade Alcohol to ensure that it isn't generating this Godawful substance. If you need this chem in the future, I think distilling it from Dollar Store bottles of Rubbing Alcohol would be a cheaper and easier way to get it.
Thanks for the awesome chemistry and synthesis videos... 🙏 They help me understand complex reactions, and infer other potential reactions, most of which are entirely Undesired, Unintentional, Uncontrolled, and Unhealthy for Human exposure. There are a lot of idiots in industries... Mis-labeled chems, improperly substituted chems, dirty chems, and lapses of logic seem to be the major factors that will RUIN all the hard work and time spent.
Do you know why the cost of potassium (1,095/kg) is so much more than sodium (220/kg). Is it because it is more hard to make potassium via electrolysis than sodium or is it because of regulations on the sale and production of potassium. If anybody knows please help. Just wondering, thinking about making a small electrolysis cell to make some lithium and sodium based off of some patents I have been reading and was wondering if I could do it for potassium because it was not specifically talked about in the patents or anywhere else.
Prices are based off of gallium source so they are probably quite high
It's also used to coat some smaller video game cartridges to keep kids from putting them in their mouths.
But, why would you make it into the benzoate salt rather than keep it as the chloride? Does that affect its bitterness?
If so, how? benzoate ions aren't bitter.
+piranha031091 I am honestly not sure
My mum used to put this on my figers to prevent me from biting them when I was a kid. Despite the bitterness of it, I did it anyways lmao.
Wait what?
Hi Nile. Can you do some different thermite reactions to capture different metals like manganese, silicon etc. Keep up with good work!
The degree of consistency in your video production is incredible, I know you changed filming hardware and location since, but your narration was exactly the same, and the production quality was already top notch!
Hi Nile, I started watching your videos a few months ago and I have always enjoyed everyone of them. you know what? I'd like you to show us how to produce hydrogen peroxide.
+Luca Maistrello making it is way too hard. I do plan to concentrate it at some point though
Why do I feel like you used this for a prank?
dudee same i was like this would be so awesome to pour into someones sweet drink like your expecting a sweet milk pr sugar nope
John Pfeifer this would be a ver bad joke
They will physically attack you once they finish vomiting.
*If* they ever finish vomiting...
use the anti nail biting stuff and put a dab of it on a stick of lip balm or something
Do a video on making ceasium metal from lithium and ceasium chloride
Damn, that's an epic intro. If only you kept it.
Here comes everyone that put the new zelda game in their mouth
Scourge i forgot that was thing. Just grabbed my copy of zelda and licked it to test it out. Fucking gross how bitter it was.
@@David-qj1mr oof
Dang, I never knew he had an old intro!
That is a tasty intro.
Nicolas Giandrea So tasty, it could balance the flavour of the subject of the video.
3:20 Calm down there.
There is a way to make it more bitter stiil; by adding a certain amount of (you won't believe this) saccharin! But that combination makes it, some claim, the bitterest substance on earth.
Not really enjoying new intro, but great video :D
+Mario Borras Why dont you like it?
+Nile Red In my opinion the intro is fine, it adds value to the content (which is great :) )
+Nile Red I agree with Mario, it feels slow and out of place in my opinion. Amazing video as always though :D
+Nile Red Well it seems like a good edited intro, but I think it's a little too long and the music doesn't quite fit.
Martynas Malikėnas yeah true. I felt like that could be the case. Thanks for the input. I put it in because it was made for me and I wanted to show my thanks. I probably won't include an intro in the future
I love the fact he’s using a paper clip as a stir bar lmao I’m going back and rewatching a lot of your videos
ok but imagine, using this on surfaces in public places to make people wash their hands. would probably backfire somehow but still