004 - Low Dose Naltrexone for the Treatment of Long-COVID
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- เผยแพร่เมื่อ 25 ก.ย. 2024
- In this video, I talk about a treatment that may help reduce Long-COVID symptoms.
I was able to download the full article at the link below yesterday, but when I checked today, the article didn't seem to be available in full.
- Jarred Younger
www.sciencedir...
Dear Jarred Younger,
I'm 22 years old, living in Germany and just finished my bachelor's degree in IT-Security. I have been living with LC for 2 years now after 2 infections with mild symptoms. Fatigue and brain fog are my only symptoms and I have now a long medical history of trying different treatments due to (mostly) misdiagnosis.
I just wanted to leave a big THANK YOU for your work! As you can imagine, a person in my situation will do anything to get well again. For me this means trying to understand the papers published in the medical academic field. For someone without a background, this is already hard enough, but of course, the fatigue and brain fog make it much, much worse.
This is why I am so grateful for your work. I value it just as much as the work of the people doing active research. Critically reviewing papers and understandably presenting the results takes so much work off me and other LC patients. Have a great day!
(ps: can I support this work somehow?)
Guetemorge Tunn3l, fyi Before 2020 the same disease had different names... Chronic EBV, ME, CFS, Fibro, ... You've just fallen for marketing. Hope you can recover from your autoimmunity/loss of immune tolerance, like many others. Davide
Did you have POTS???
@@MaxPayne-fi1mz no
2 things virtually eliminate my brain fog: restricted carbs and MCT oil.
my brain fog comes in the afternoon, and taking a tablespoon of MCT about an hour before the time of onset prevents the brain fog. but then I discovered that restricting carbs also prevents the brain fog so that is what I'm doing
Did LDN help you with brain fog ? If yes what was your dose ?
Those of us in the ME/CFS community have been using LDN for a while. I take 3mg twice a day. More stamina, less pain, crashes are less intense and shorter.
It also took away my depression (with lexapro and Wellbutrin
I'm glad to hear that! - Jarred Younger
Can i ask please, do you notice any side effect LDN I try Naltrexone hydrochloride 50MG i cut it in little pieces were i live is the only form available from my doctor. I notice it give me palpitation hot flashes feeling unwell. I have try may be a 00.002Mg is very tiny bit piece.
@@romygime5822 my doctor found a website that teaches how to mix the 50 mg tablet with distilled water, then use a syringe to easily dose it down to the milligram. Much easier than getting a scale and trying to measure such small amounts dry.
@@Eyes0penNoFearBut doesn't it like? Like how to do we know it's not getting chemically modified if we keep it in water ....
LDN is the first thing in my 9 month long covid illness that actually seems to help
What did it help with ?
I have some coming
How much are you taking?
LDN is fantastic. so gentle, such positive effects, i really just feel better from it. I dont get sudden fatigue crashes nearly as often anymore and i recover faster, much less restless legs and anxiety. I postulated that my sudden strengthening effects from ketamine was due to opioid receptor interaction and decided to try LDN, and it did exactly what i suspected it would do, but better.
Great!!! - Jarred Younger
Thank you! I’m in California and I’ve found doctors know nothing about our long covid. Nor do they care.
I'm in CA too and have had the same experience with doctors here.
Anosmia, tinnitus, extreme fatigue (1st wave 2020)...could LDN potentially have remedial effect on some of these now, esp Anosmia?
I have ME, probably got covid during delta and got symptoms of slowly progressing cauda equina syndrome. But since they didn't suspect an acute bulging disc when I went to the ER I never got any help since they thought it was somatisation when my symptoms progressed and got even worse. It was back in 2021. I still doesn't get any help. They did eventually an MRI over a month after the symptoms started. But it didn't reveal anything. The radiologist how ever, pointed out that a swelling of the nerve roots due to inflammation can't be ruled out without contrast dye. And they didn't use any. And even still they won't let me do another MRI.
A few years have past and I have erectile dysfunction after this. And I still get relapses with worsening pain in the lower back, hips and sensation of electricity going down the left leg and also down in the genitals. And after every relapse like this the erectile function that I have regained a bit, get even worde. I don't have complete ED. But not far from it. And I don't know what to do. My doctors still treat me as if it was somatization syndrome. Just because the first MRI didn't show anything.
Any suggestion what to do? I live in sweden and all doctors share the same journal system.
I feel terrible on LDN, unfortunately. In bed all day throwing up but I wish so much it helped.
what dose did you take?
That is very strange, it has so few side effects
Did you start with an very low dose, 0.5mg or less? If so, could it have been coincidence? Side effects do tend to pass after a couple of weeks.
my clinician told me this happens for some people, and they cannot predict or explain. they said some people with extreme nausea were able to tolerate LDN by taking the dose at mealtime, and they point out that the nausea often fades within a few days of changing the dosage. in my experience, I have tolerable nausea for 2 days each time I change dosage.
What do you think about the lancet's study from January 2024 "Naltrexone 6 mg once daily versus placebo in women with fibromyalgia: a randomised, double-blind, placebo-controlled trial"
Thank you
It has also shown helpful for OCD which I was diagnosed with as a child short after SEVEN bouts of strep in one year. NEUROINFLAMMATION!!!! I had to go on an SSRI which greatly helped and I took through most of my life(still do) after that, but now that I am addressing neuroinflammation more since my Lyme and mold toxicity diagnosis, my anxiety and ruminating thoughts have been at an all time low.
LDN was a saving grace for me for a few months before it suddenly stopped working and my pain came back. I took 6 months off and went back on it, it provided pain relief for a single day, almost euphoric and then immediately back to not working again. Very interesting drug and I wish it could've continued to provide benefit. I experimented with a few dosages and it was no different than a sugar pill once my body figured it out.
I have heard this many times and I can't figure out what the mechanism might be. I am looking into trying naltrexone alternatives that might avoid this problem, and I am still trying to get dextro-naltrexone developed, which is a pharmaceutical that could circumvent this issue. But the drug has to be developed for human use, which is very expensive to do, so it is not available to try right now. - Jarred Younger
Same happened with me😖
As always, thank you for your information. I've been on LDN with some success, but have been off for quite a while. I'll look at trying a new round again with my PCP. Thank you!
My doctor put me on this about 10 yrs ago. By the 2nd pill the LDN had amplified my pain off the charts. Pain medication didn't help. I was running in the yard just to loosen my muscles up from the extreme tension. It was awful. I wish this result could be used to further diagnose what was wrong with me. Gabapentin also amplifies my pain just not near as bad as the LDN did. I can't take either.
I hear about a response like this rarely. I haven't seen any data showing why this happens. I *suspect* (no supporting data) that some people have an exquisitely sensitive endorphin system. If the person's mu-opioid receptors are completely blocked by the naltrexone, their internal pain-combatting systems will be negated, which could cause a flood of pain, and produce symptoms similar to acute opioid withdrawal (anxiety, muscle pain, nausea, and others). If that is the case, LDN would be off the table as an option, or maybe an ultra low dose (below 1.0mg/day) would have to be used, but there is little information about using LDN in such small dosages. - Jarred Younger
When I was much worse, my me/cfs doctor prescribed LDN to me. He gave me a schedule how to build up the dosage. I think it's really important to do for people with me/cfs. I did have adverse reaction to it the first time (increased heart rate). Until I reached my effective dose with was 4,5 mg.
I made the solution from the tablet myself, you don't need an apothecary for that. You just solve it in salty water. First I made salt water, then I put a naltrexone pill in it to solve overnight.
I haven’t tried it yet but I had no idea it has to be in salty water I was told by rheumatologist regular water. Is salty water best?
@@tiatorus yes, google saline. It's a preservative.
I'm just starting LDN. like you I had an immediate adverse response to the initial dose. each time I vary the dosage or dosing schedule I continue to have adverse reactions. I've decided to jump quickly to 4.5mg once daily hoping that I can minimize the lost wages during these dosage changes. fingers crossed!
@@SFDestiny what was your initial reaction
*** do not try this without talking to your doctor *** Grapefruit Juice appears to interact with Naltrexone via cytochrome P450 enzyme group. Does anyone know if you can gain clearance taking it with grapefruit juice?
Dr thank you for all the information you are giving I really don’t understand why doctors are not interested in reading the new researchers and start working with their patients until now I have found out they don’t anything and they not interested to know they just don’t work with long COVID and that’s all. The ghosted me don’t listen at all I have developed a mistrust in most of them because I am feeling some coldness and indifference. I am looking just for some one who help me with my symptoms and not be suffering so much alone and by myself
What is the percentage of’long COVID’ that are vaxed vs non-vaxed?
I feel as though ‘long COVID’ is similar to fibromyalgia or in other words is a diagnosis given when it is either undesirable for the true condition to be revealed OR just impossible to diagnose.
by now there are many studies identifying metabolic differences in LC cohorts; it is a thing. and yet the diagnosis is based on self-reported symptoms, something like, "I was healthy and active before covid infection but now I struggle to get out of bed." yes vaxxed vs unvaxxed is studied, and in fact it was found LC 2x as likely in unvaxxed individuals... but this is easily located info. in order for your suspicions to be true literally millions of people must be actively engaged to deceive you. in a society that struggles to organize a school board how is such an arrangement plausible?
Does it 50 mg pills dissolved in distilled water 50ml to 1 pill 50 gr does do the same effects. Cause here in Europe there are no pills size 1.5, 3 and 4.5 gm. We only can proscribed or buy 50mg pills naltrexone
You have to have the medicine compounded at a compounding pharmacy . 1.5/ 3.0 / then 4.5.
@@KimberlyGodin-mr5ffmy insurance doesn't cover compounding pharmacies. It's $200+ per month to compound it, or around $20 to get 30 pills that are 50 mg each. Which gives me more than a 1 year supply
@popokatapetl6995 which country in Europe? I live in Denmark, and we have access to All the LDN pills. I use the 50 mg pill and disolve myself. I was wondering the same, if it gives the same effect as the smaller LDN pills.
Yes. Ive been doing this for almost 2 years. Works
In the U.S,. a compounding pharmacy charged me ~$50 for 50x 1.5mg tablets. 50qty due to starting at 1.5mg for the first 2 weeks and increasing to 3mg.
Thanks Jared, A question if I may please; in the case of ME/CFS, should one get tested for particular inflammation levels or characteristics before considering LDN? Wondering what makes a good candidate, essentially.
Due to chronic under-investment in research, there are no specific lab tests for ME/CFS inflammation as such. It's a case of trying the meds and seeing how you go. I found LDN helped my insomnia for a while, then stopped working unless I changed the dose. Ultimately it stopped working altogether, so I quit taking it.
Just in my past research, erythrocyte sedimentation rate (ESR) was the best predictor of a positive LDN response. Other studies (including the one in this video) show decreased of C-reactive protein (CRP). Both of these tests are markers of systemic and general inflammation. So, LDN may be particularly useful if someone has abnormally high ESR and/or CRP. But the link between these tests and LDN response is based on small studies and need to be confirmed. - Jarred Younger
Wow thank you so much@@youngerlab , I'll discuss with my clinician at Optimum Health Clinic in UK
Most helpful, many thanks@@FionaEm ! A couple of other posters here have said similarly, that the benefits tailed off
I’m have severe ME/CFS, PoTS and chronic pain. I live in the UK, I haven’t been able to find an NHS Doctor who can actually prescribe LDN for me. My GP, my ME/CFS Consultant, Cardiologist and Pain Management Consultant all said they are not allowed to prescribe LDN. I can’t take Amitriptyline due to my PoTS, I can’t take Gabapentin or Pregabalin due to my ME/CFS. My GP is only giving me 10mg Co-Dydramol. My Pain Management Consultant is refusing to let me try anything else other than relaxation breathing exercises - which don’t work at my current level of pain. I am at my wits end with my pain and the lack of interest my Doctors have when it comes to trying to find something to help my pain. I wish the NHS wasn’t so far behind in authorising some of the meds available in the US, for use in the UK. It’s literally keeping patients like me trapped in our suffering. ☹️
Watched a documentary on LDN and there have been remarkable recoveries from Autistic Children that were basically uncontrollable and aggressive towards their parents and over night responded to a topical LDN Cream applied to the wrist after the Child went to sleep ! Literally a different Child the very next morning , now the Child (a Boy) has been called a prodigy on the piano and has done Television appearances ! Before the Doctor prescribed LDN the Parents couldn't take the Boy out in a Public place , everything set him off !
Dr. Younger that’s for your excellent work here - question: Dr. bernard Bihari talked about LDN’s ability to block the opiate receptors and increase endorphins which he believe regulated the immune system. I know you mentioned the action on TLR 4, but what about the endorphins and immune system mechanism of action? Anything there?
I had the same question! Would love to know more about the mechanism of action.
My siblings are street drug addicts for 40plus years.
Done methadone and nalaxone.
Could function on slow withdrawal of methadone, but sister nearly died withdrawing from nalaxone when she thought she had it and could withdraw.
Brother been off it a couple times for relapse, and went into a spasm and fits.
Sister had to be medically supervised to detox and said never again.
If you KNOW you will never be fixed and pain free, it's a good option.
But if there's any question of going off after months years, I would not take it.
I was born with chronic pain, and my siblings contacted My doc when this was suggested.
In punishment they reduced my oc by half. Taking half my life's work in a week.
I'm 58, never did any drugs till oc clinical trials when I was 31.
It allowed me a productivity i never had, the ability to withstand months of grueling PT.
I still had pain but tolerable after a life worth of pain.
I'll never be pain free but I have good days I don't even take it, and no withdrawal because I've taken as taught by scientists, and clinical physiatrists, running the trials. And have certification for it.
Docs don't learn this.
It's not a perc for a broken ankle , it was created for non cancer chronic pain. But docs didn't get educated and just prescribed it.
Reps for Perdue pharma changed definition of chronic pain from 18minths to 3 then to 6weeks.
Many docs don't know about Suboxone or bupinorphine or nalaxone. And will try it first instead of Percocet, percadan, tramadol . ECT.
It has the worst withdrawal even after just a few days/weeks.
I've done low dose oc for almost 30 years. But my lifestyle is regimented in diet movement and supplemts. Not just pain meds,
If I don't to the physical work to stay on top of it, it don't matter what I take.
I have great days good days and really bad days.
Pain meds are not my end all be all, but I get productivity. And keep from Reflex Dystrophy, from compensating when one leg hurts, or an arm..
So thankful i found this channel. Thanks Dr. Y! (Do you ever hang with Dr. Z? ;))
Daughter betbound 24/7 for 12 months after Covid infection tried LDN 0,1 mg once and could not sleep the whole night (and the following). She is so sick that she says she cannot stand the terrible days without at least having some sleep at night. Any helpful thoughts?
Adderall for me. Could cause insomnia in my case it helps me sleep. Worth a try
Is pain worst symptom
sorry to say, but have you tried pushing through the sleep issue? FOR ME it passed after only 2 nights. I'll also report that the worst symptoms were at the lowest dose. whether I grew accustomed or whether higher dose, my sleep improved on the 3rd night and the other side effects seem to disappear 48 hours after I increase the dose
I have had a neurotoxicity from an antibiotic and have exactly the same symptoms as long covid. I guess CNS injuries have similar symptoms. I am about to be started on LDN. I have autonomic dysfunctions, headaches, muscle loss and pain, tremors and spasms, loss of my periods, etc. It’s quite a nightmare. Wondering what you think of this idea of starting LDN? Thanks! ✨
How are you doing? And did you have muscle twitching as well?
@@anniecrowther8423I do
Thanks for this video!
What about amitriptyline & dementia risk? Is that something to be concerned about, or is it only a problem with long term use or use in the elderly?
As a tricyclic, one of the actions is anticholinergic. There are many drugs that have anticholinergic effects that could increase the risk of cognitive issues. I haven't read any recent papers on the real risk between amitriptyline and dementia. I know that, as you mentioned, almost all of the literature is in older patients. I think most of the supporting papers examine anticholinergic meds in general, and not amitriptyline specifically. Also, I would guess that the effect is mostly seen in higher dosages. I don't know of a paper looking at those taking low dosage amitriptyline having an increased risk of dementia later in life. But it is a complex drug with many sites of action. One warning sign would be acute impacts on cognitive function, which would suggest the dosage is too high or the med is not a good fit for the patient. - Jarred Younger
I wouldn't hold my breath on waiting on a properly powered RCT for LDN. Naltrexone is pretty cheap and nobody will be making lots of money selling more. The paper you linked in the paper is not free. My neurologist was not willing to write a prescription for dextro naltrexone (it might be expensive to isolate) but she did feel comfortable to increasing my dose to 6mg/day. I 'm starting that now.
Yep, that is generally correct. But I am writing a large LDN RCT grant right now. I can't go into specifics, but I will announce it immediately if it gets funded. Your neurologist is right about d-NTX. It actually is not available anywhere for human use and has never been taken by a human. It must be manufactured and then tested with the FDA before we can even use it in research. I hope the increase in the regular LDN dose is helpful! - Jarred Younger
@@youngerlab It's too early to know if the increased dose of the levo-naltrexone is helping. The reason I asked about the dextro stereoisomer is that I suspect the effectivness of LDN is very dose dependent. Even at 6mg/day I might have to wait weeks or months to see benefit. The idea with dextro-naltrexone is that it is active at microglia receptors but has no activity on opioid receptors. This would, in theory, allow one to use much higher doses than the usual 4.5mg/day limit prescribed by most doctors. Perhaps, the same result could be acheived in days at a dose ~ 10x as large. Problem is that wouldn't be safe with the left-handed version. Are there any animal studies? Any research on this at all in the literature?
Amitriptyline has been a wonder drug for me. I was about to point out that the side effects are largely dose-dependent until you did mention it. But I think that’s important here.
I was taking trazadone for chronic insomnia. My urologist suggested switching to amitriptyline to treat both the insomnia and pelvic pain.
My primary doctor prescribed 20mg. At that dose I did experience excessive daytime sleepiness. The urologist said he would’ve started me at 10 mg.
After reducing to 10 the daytime sleepiness pretty much went away.
Since being on it other chronic symptoms greatly improved or disappeared altogether. Gastric pain that had left me miserable and too thin from anorexia greatly improved. Bruxism that had caused significant tooth and joint damage went away completely. This was something I struggled with my whole life. It was not something I could control beyond a minute or do - like breathing. You can only hold your breath so long before your body takes over and forces you to breathe. That’s what the teeth clenching was like for me.
A couple of years later my neurologist increased the dosage to 20mg for migraines. I did not experience a return of the daytime sleepiness when I did that.
So for those keeping score, it’s treating 4 things.
Thanks for sharing that. Yes, the multiple sites of action make it a great fit for one person and a really bad one for another person. That is really nice when a single agent can help with multiple concerns. - Jarred Younger
I've currently been on 0.5mg for 9 weeks. It has helped with energy, and chest pain but I've had leg weakness since starting it and it's made me kind of weird emotional...not sure how I feel about it just yet
Been in it 18 month help energy IBS but not muscle pain
i have also found that .5 seems to be my dose as well
Because it effects endorphins it can impact mood. Some people take it at night to sleep though the low.
@@nataliebutler take 4 after 18 months side effect s have gone
@@nataliebutler100% agree. I take 4.5 each evening for ME/CFS and feel the best in 20 months since getting cfs.
Hi, i would recommend considering some product which is made of 5+ adaptogens. Basically find all in one adaptogenic pills, i use something like that from brand Brainmax in europe. On top of that, i recommend cbd oil, ginko tincture, rhodiola rosea tincture, dragons blood, glutathione/ATP, n-acetyl l-cysteine. Secondly, there is free pdf research paper named long covid protocol that contains food/supplement recommendation. 🍀🌹
I heard about something called P.E.A. supplement, availalbe at local CVS or Walgreens or online. Add to LDN.
I swear by gingko and cbd and overall medical cannabis but apparently they interact
Thank you for sharing this study.
I found similar doxepin superior to amitryptaline. Ive heard similar reports.
I have been taking LDN for a few years now for other things health related. I wonder if this is why covid was so mild for me? I also deal with chronic Lyme and EBV . I had viral meningitis in. college as well. So I will take all the health avenues of ammo I can.
What dose of LDN were those in the study on?
I had a Dr give me Doxeycycine for Covid 19, The enternet said do not take if over 65. Since I'm 83, I did not take it,
Doxycycline or doxipin?
I'm on a 21day round of doxycycline for Neuro Lyme.
I'll research it even if you meant doxipin.
I was told to stay in quarantine through the 3weeks. To prevent possible COVID exposure.
@@candygarfield1479 I am an English teacher and researched it and it was approved for people under 60, however. the death rate goes with age. It has terrible side effects. Do not take if you have heart, kidney,, puts pressure on eyes:or if over 65 your kidneys will not move thru body fast enough. 83 and did not task the crap. Sorry!
I really enjoy these videos - they must be a great exercise for your scientific communication skills too 😊
3:12 I can’t see any of the words in that table. Even on my iPad the entire table is only a few cm across. Maybe helpful to ngl like that full screen in future videos please?
Yep it was a mistake with inserting that image in the video. Remains to be seen whether the scientific communication skills are improved! - Jarred Younger
Does LDN help with steroid withdrawal?
I have been using a liquid drop for acne from hormone replacement, testosterone, I have been using it for over two years now,i didn't know its was addictive.
I have been taking LDN for 6 years for autoimmune conditions, i take 5mg at night, I have been wondering if i could take a smaller dose during the day to get passed this terrible skin reaction to stopping the steroid withdrawal, i stopped for over a week and i had the worst acne out break i have ever had.
Stopped taking the testosterone as apparently it causes acne.
Any help would be appreciated.
Thanks a lot for the video, I found it very interesting. I have one question though if you won't mind:
My neurologist prescribed me Amitryptilin a long time ago for my ME/CFS, (which back then had still been misdiagnosed as a psychological illness) and I've been taking it for multiple years now (she wasn't very knowledgeable about ME/CFS or Long-Covid, so that might have been a lucky guess). From what I gather you would recommend Low Dose Naltrexone over Amitriptylin in most cases, so in your opinion would it make sense for me to switch over to LDN from now on?
Just going by the scientific data, LDN and amitriptyline have comparable effects on things like chronic pain. The group that wrote this paper typically tries amitriptyline first and then goes to LDN if amitriptyline doesn't work or gives troublesome side effects. But for someone who is benefiting from amitriptyline, there is no compelling reason from the scientific literature to switch over to LDN. I suspect additional research will tell us more about whether it is ever useful for someone on amitriptyline to switch to or add LDN. - Jarred Younger
Thank you kindly
Venfaxeline, another antidepressant is very helpful in controlling my pain.
This in fybromyalgia
I have been on remicade for about 20 years for sarcoidosis and a few other autoimmune diseases.. I have chronic pain and my rheumatologist says I have fibromyalgia .. I do not take opioids and am limited with anti inflammatorys because of allergies.. can I take LDN with remicade?
i take it with zymfentra (subcutaneous version of infliximab aka remicade) and have had no issues
What about the dosage? .5 or 4 mg?
work up to 4.5mg
The dream side effect is very true. Other than that, zero side effects for me.
nobody is surprised. Just explain people it's autoimmunity... just like fibro, chronic ebv, ecc..
My neurologist suggested the same. But autoantibodies in CSF cannot be detected by an ANA blood test. She suggested a spinal tap but I'm not sure it's worth it. There's no therapy even if detected. I would just be part of a small long covid cohort at UCSD that have been so tested, i.e. data collection only.
@@bradsalz4084I'd avoid the spinal tap. It's noble you want to help the cause, but it's very risky with no reward. I had a spinal tap to rule out meningitis and had years problems following it with no help from the system. Take excellent and gentle care of yourself. 🙏
@@bradsalz4084 Lumbar punctures have improved recently with special needles and CSF replacement techniques to minimize discomfort, but I agree that there is nothing in the CSF that would suggest a particular course of action in ME/CFS right now. But research groups desperately need more ME/CFS patients to undergo lumbar punctures because it is true there are some important things that cannot be measured with standard blood draws, particularly inflammatory actions confined to the brain. - Jarred Younger
Tha k you!!
I'm not so sure if drugs are the solution to thous illnesses like LC or CFS. Drugs will never solve the root cause of a illness they only manage the symptoms and I think that's not the main solution of a health problem. I guess working on the mind body connection would solve the problem. That's what I learned so far from all the recovery story's I watched. We are so used to it if we are feeling unwell that we just take a drug and we are okay again. But the root cause is so much deeper. Trauma or unprocessed emotions or that the brain is stuck in a fight or flight state is to consider and probably the cause of illness. Taking a pill for those illnesses its like taking a pill to become a better person. Think about that. Taking a drug for a long term is never good for your body, you will get probably different problems in the long term. Selling drugs is all about money, not for helping the sufferer to heal, if so, the pharmacy industry will make no profits. Like my neighbour ones said, a healed person is a lost for a Dr. because they then cant make money of them.
Thanks for the great points. I agree that we ultimately need to move beyond taking medications every day. There are treatment approaches on the horizon (like gene editing and non-invasive neural remodeling) that could have sustained benefits in the future. But even better would be nailing down what the original cause is. - Jarred Younger
Yes but here's the thing. If you don't have a starting point of "Relief " , you may never have the motivation to go on and deal with the rest. I have been on LDN for a short time, and I'm starting to see a difference in my pain, fatigue and depression level. I'm able to think a little more clearly to decide what the next steps are in terms of Diet, Nutrition, ect. It could be a game changer for some people
I think that Microglia activation is part of the explanation on why this happens. If LDN is a solution for that, I think that’s a sustained solution, no?
I love your researches btw. I have done my own to try and find solutions to heal my nervous system after a neurotoxicity. It led me to your work. It’s really not researched, unfortunately, which is terrible knowing it comes from drugs we are being prescribed and then our nervous system are not working well anymore and medicine doesn’t have solutions for us. How sad and unfair and painful.
You obviously don't understand how LDN works.
It tricks your body into producing endorphins.
Except you can't think yourself well. You're only hearing the success stories.
In three years I can't smell shit after covid-19, will Naltrexone works?
How’s your mood?
Try zinc.
@@newbluerugby my mood is great.
@@nataliebutler I will try it, thanks.
Some of the neurological ME symptoms are recognised in protracted benzodiapezine withdrawal too.
With ME, the symptoms exacerbate in every PEM episode. In protracted benzo withdrawal, the gradually resolve.
Is there research going on, that explores this similarity?
th-cam.com/video/U2nyFnnDkIo/w-d-xo.html
55645 Brandi Throughway
Thank you for your time and trustworthy informations 🫶