Purine Metabolism (De Novo, Salvage, Degradation, Uric Acid)
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- เผยแพร่เมื่อ 27 มิ.ย. 2024
- Purine Metabolism (De Novo, Salvage, Degradation, Uric Acid)...Hyperuricemia and gout.
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Gout is an inflammatory, crystalline arthritis characterized by the deposition of monosodium urate crystals in the first metatarsophalangeal joint (MTP)...The Crystals are needle-shaped, and negatively birefringent.
Gout and hyperuricemia are not exactly the same thing.
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Once i become a Doctor I definitely must paypal this guy, he makes medical subjects even PHARMACOLOGY simple. Thanks very much man! I appreciate your cheeky sayings here and there too.
Thank you so much 😊
I really appreciate you!
This is one of the few times I have watched a video about the metabolism of anything and was motivated (even excited) to watch another one and learn more. Thanks for the awesome explanation.
You’re very welcome 😊
Learning is fun!
as a pharmacy student, thank you for also mentioning the drugs 🥲
My mam take 1hr class for this but u nailed it within 15 minutes.. straight to the point. Hats off..From India..
Thank you!
If only all professors are like you who obviously LOVES teaching. Understanding something hard is possible with the right teacher. Thank you!!
You're very welcome, Audrey!
I really like the way you jump between different topics and remind me of every important fact.
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You on fire man! You helped me through pre-med 2 years ago and now I'm watching your videos as a first year medical student.
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My pleasure 😇
Good luck to you!
@@MedicosisPerfectionalis /
YOU ARE AMAZING! God bless. I got overwhelmed with all the integration you did in this video ngl, but I love it.
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Just watch it more than once, read your textbook, and you will be fine!
Before ending your video...i come here just to say ..you are talking in an attractive way and make aknowledge easy by this way ..i love it
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Amazing teaching style!!!! You give great tips on how to remember things which is lovely for someone with my terrible memory. Thanks so much!!!! We are blessed with people like you on TH-cam. Only one bit of feedback... you speak very fast. More a defect in my ability to listen but others may have the same defect. lol
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My pleasure 😇
Holy shit Im a software engineer who has acute gout flare up right now and I actually followed and understood this whole video.
It is very rare to find explanations that tells the whole story while going deep into fundamentals and explaining each layer. Love the break down of DNA.
Thank you 🙏
Best of luck to you!
I had a smiling face while watching the video. It really helped me understand about purine metabolism. Plus the jokes does not make it boring after all the process. A great thumbs up!!! :)
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You're hilarious! Thanks, its fun learning with your videos!
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absolutely the best professor ever. You developed my concepts so well. Thank you :)
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I am honored!
Can you please help me sharing?
@@MedicosisPerfectionalis yes I shared with my sister who really needs it. Do you have a lecture on pyrimidine Metabolism? Because I searched and didn't find yours.
Thank you so much 😊
Unfortunately, I don’t!
@@MedicosisPerfectionalis oh ok.
I love your video, it was precise and I didn't even feel bored . Thank youuuu so much you made it so easy . God bless you 😇❤️
God bless you too!
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This is a gold explanation. Thank you I can finally get this topic. It makes perfect sense
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I think this is the best video for me. Suscribing. I really love the language and the accent. Got my professor here!!!
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Thank you so much sir for making us understand the concept of purine metabolism and teaching in a fun and interesting way ❤❤
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Very greatfull
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I need a Video for Pyramidines Metabolism aswell PLEASE
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@@MedicosisPerfectionalis My thanks to you people for the best available info. cv Thomas
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This is grate work!Could you explain something- I am confused about how human cells get adenine from adenosine directly to use it to get AMP in salvage pathway.Does the enzyme APRT use adenosine or adenine? Thanks)
Hello, it was just wonderful. I just have a question, why did you say Geoffrey? I am just curious. Thanks
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Again, your videos are awesome. I’m on methotrexate and have been quite curious as to how exactly it’s working in my body. I’m taking folic acid the days I don’t take the methotrexate. What would happen to my body if I didn’t take the folic acid like I’m supposed to?
Carla Vegas I’m not so sure about folic acid itself, but i know that FOLINIC ACID (aka leucovorin - a form of folic acid) provides tetrahydrofolate (the substrate/what you need to produce DNA) for the use of normal, non-harmful cells. (Methotrexate doesn’t know it’s destroying normal cells too, all it knows is to destroy all fast growing cells! This is bad news for your GIT cells and bone marrow, because they are rapidly dividing cells) in short, folic acid will provide the needed tetrahydrofolate for DNA synthesis for your GIT and bone marrow.
You can think of it this way: taking folic acid is a way of “rescuing” normal and unharmful cells!
Knowing this, if you stop taking folic acid, you will have bone marrow toxicity/myelosuppression (fatigue, paleness, shortness of breath etc) and GIT toxicity (serious nausea, vomiting, and diarrhea). Hope i made sense 😅
dge omg it actually does! Thank you! That kind of sounds scarier than taking methotrexate. But would that happen at low 12.5 mg dose?
Thank you man. Any updates about Pyrimidine's Metabolismo?
Do not wanna hurry you up, just to know if it will be
No plans as for now.
I am so sorry!
@@MedicosisPerfectionalis Sorry for what? It is already tto much what you do for us! I am thanked to you, have a good day or whatelse is in the Country where you live.
🥳
Cosimo
Jeffrey, 😂. Thanks for the video 👍👍
My pleasure 😇
🔥🔥🔥
You are the best! But a lil' detail during reactions would have been much more helpful.
Which reactions?
How about doing this video using foods or unadulterated whole herbs instead of drugs to salvage the purines?
could u pls post metabolism of pyrimidines video?
I love you so so much
Thank you!
Great
Thank you 🙏
Hi me again :)
My stool analysis shows my pancreatic elastase1 is normal, however I have elevated putrefactive short chain fatty acids, indicating protein maldigestion.
If I have normal pancreatic function, what causes maldigested protein?
Another thing however showed I have low Chymotrypsin, but how can this be when my pancreatic elastase1 result is normal?
I think this is the root cause of my neurotransmitter issues. I have to find the break in the chain of digestion I believe.
Sorry if I posted on the wrong video!
Thanks
Any help appreciated!
WOW.
Thank you so much 😊
It seems then that some uric acid reapsorption is good for anti-platelets . (Reinforcement prostacyclin pathway)
Interesting
👍
First comment
Thanks very much about all this please do video about complications of MI🍀🤍
Thank you so much 😊
I was so sad there was no Pyrimidine metabolism!
Someone needs to comfort jeffrey😂😂
your video is really good but could you talk a bit more slow? Coz as non native Speaker its a bit difficult to listen the explanation and understand the map mechanism in very fast
Thank you so much for your feedback!