Dr. Bikman, If this is how you talk to your kids, they are truly blessed! Your heart comes out when you talk! Thank you, sir, for teaching outside the classroom! We need your lectures!
Thank you for not focusing on gout. I've had gout. Although painful I doubt many people have died from it. In reality, gout is a blessing in that it should alert you to hyperuricemia and the possibility of uric acid crystals elsewhere. We may become aware of gout with a joint hurting but uric acid crystals have been found many places-- in coronary arteries, aorta, heart valves, myocardium, kidneys, prostate, and pancreas amongst others. Crystals have even been found in atherosclerotic plaques. Its frequency is VERY underappreciated because it's hard to detect. Routine tissue fixation with formalin washes out uric acid crystals. Likewise, tissue is usually cut 7 microns thick for microscopy. Uric acid crystals are usually linear and, if they're perpendicular to the slide, will appear as a small dot. To see uric acid crystals one has to preserve the tissue with methanol, not formalin. Following this, special lighting is required to see the crystals. Studies which have employed this method have shown crystals to be far more extensive than the joints. I can't imagine that uric acid crystals in the coronary arteries initiating an inflammasome reaction is good. Uric acid crystals don't show well on routine x-rays and scans. It usually requires a specialized cat scan called dual energy CT (DECT scan). These scans will often show uric acid crystals in the calcium in atherosclerotic plaques. Unfortunately gout is treated poorly. Give an anti-inflammatory and if it recurs we'll "think about" treatment with allopurinol or febuxostat. Hyperuricemia, not JUST uric acid crystals, IS serious. It's like a criminal whose fingerprints are left behind at many crime scenes- the heart, kidneys, liver, pancreas. The tragedy is that we have good drugs and it's usually easy to treat. Anyone diagnosed with gout or hyperuricemia should be thoroughly evaluated for heart, liver, and kidney disease. For every molecule or uric acid produced there is also a molecule of hydrogen peroxide generated. I've often wondered how much pathology is caused by this, as opposed to the uric acid itself.
Excellent comment, thank you. Much of what you describe about uric acid crystals also apply to oxalate crystals. They accumulate in all the tissues if the body and are dissolved by normal tissue processing. When I went on a low carb and a low oxalate diet all of my fibromyalgia and bladder pain went away. I suspect my pain was due to the oxalates as I was eating a ton of almond flour biscuits, almond butter, spinach, black tea, and some dark chocolate on keto and still had pain. Frustrating that a portion of tissue specimens arent collected, processed, and stained for crystal ID. I would love to see how much of these types of crystals are in plaques.
That was v informative; thanks! An interesting point I have also learnt about gout is that 2 individuals with the same uric acid level could behave differently with one going into an acute gouty attack n the other barely feeling it. Therein I understand, comes the confounding metabolic factors n presumably fructose intake. Intriguing also is that 2 different people with the same uric acid level move into different pathways of its precipitation; one in the kidney lumen n another in the tissues. What factors are at play!?
@@lindabirmingham603 I am VERY glad you mentioned the oxalate issue. I believe I have BOTH issues and have worked with Sally K Norton to help control oxalate dumping. However, I have gout like pain in my thumbs and other joints. So time to see if I have elevated uric acid.
I am a retired MD and really appreciate your lessons and what I learn. I am not so sure about allulose though. Side effect bloating always tells me that something messes up your gut microbiome. I prefere reducing sweets to an occasional treat which gets easy the longer you are on a rather low carb diet.
I thought the same thing - but then thought maybe the reason some things cause GI upset is because the biome is already “messed up” and if it was a healthy biome then it wouldn’t cause the issue. Still, I agree with just reducing the sugar to as close to zero as possible is the best way to go.
Allullose's delaying effect on gastric emptying causes horrendous indigestion, burping, and bad acid reflex. As a result, there is no bowel movement as food still sits longer in the upper part of the stomach. I wish someone told me this side effects
In the lecture it is mentioned that allulose competes with fructose absorption. That means that more fructose stays in the gut, where it can feed the microbiome, which might be the cause of the upset GI tract. If this is correct, then you should be able to handle higher allulose doses, if you have a lower fructose consumption. From what I heard in another YT video, it is recommended to take only small doses of allulose. You can slowly increase the dosage to find out how much allulose you can handle without getting these side effects.
@@WideAwakeHuman your gut microbiome changes within days depending on what you eat. high amounts of fructose cannot be absorbed so you feed bacteria that ferments it and builds up gas. If you add allulose which decreases absorbtion of fructose even more it will get worse. The easy way IMO would be to cut down fructose.
Thank you so much for your videos. I have developed fatted liver, Hasimotos, kidney stones and type 2 diabetes. The only one I was told about was the kidney stones when I went to the ER. Fatter liver I learned about when I got a copy of the report. Never once has any doctor told me about any if the issues. The diabetes I found by buying a glucose blood meter. You have given me a path to regain my health. God bless you!!!
@@mystrength5640 They did not check my glucose, uric acid let alone insulin even after events. No instructions in lifestyle or nutrition or anyway to remedy any of this.
As someone who loved chemistry and got through qualitative analysis in college, I love listening to you. as someone who has used the ketogenic diet to go from 180 pounds and 60 units of insulin to 120 pounds and no medicine I am thrilled to listen to you. Thank you.
Not all gout is caused by uric acid. Unless the joint fluid is tested, it is just assumed its the uric acid. For those on carnivore etc, if you have gout, it could be oxalate crystals. Stored up oxalates (from when plants were eaten) get released from the body in cycles (can take years). If the load is too much to excrete at once, the oxalates get 'dumped' around the body waiting for excretion, causing many different symptoms. Its common for the oxalate crystals to be found in joints, and big toe gout. Feels the same as uric acid crystals... Most doctors assume big toe pain and swelling is uric acid crystals but there are other causes for the same symptoms. Sally Norton is the expert for oxalates. She explains how to slow down the 'dumping' and manage the symptoms.
ALL gout is caused by Uric acid - BY DEFINITION. Oxlates are the more common form of kidney stones and has other down sides. Also there is a whole host of arthritis not caused by Uric acid - BUT NONE of these are "Gout".
Thank you Dr Bikman, as always it is a pleasure to be in your classroom. I have someone in my life with gout and they significantly decreased fruit and fruit juice and he is eating more meat, and has not had another gout attack after making those changes.
I just can’t get enough of his classrooms. I look forward to the education , and apply it to my own health journey . The success I have had is miraculous . Thank you Professor Bikman .
Thank you so much for your explanations. I was with you until AMP came into the picture, then I sort of glazed over, but please don't stop giving us the details! I just need to go back and listen again. The college age kids may get it in one try, but at 72, I'm still passionate about learning and improving my health, but need to hear it more than once :) So appreciative for your videos and your gentle style that brings a complicated subject down to our level. You, Sir, are a gift.
This is so appreciated. I'm a healthy 44year old woman and just beginning to develop gout - I am not insulin resistant - and naturally I am concerned over additional issues - so this is really informative and helpful - thank you for taking up these topics and laying them out in accessible language.
One of the first things I noticed when I began a low carb diet three years ago was decreased inflammation. I used to have severe pain in many of my joints, most notably my hands, but soon after giving up the sodas and other processed high carb foods, I stopped hurting!
It still amazes me that we know so much about cells and their specific jobs .but what's even more amazing is the ability of this ADr. to explain it in layman terms! Thanks a lot from a true fan
I feel like I am back in my 2 favorite nursing school classes, Anatomy & Physiology and Endocrinology, with a big twist, up-to-date research and knowledge about what is making us sicker. Thank you Dr Bickman. I am eager to inform my hubby so he/we can implement some changes that may work. He suffers regularly from gout attacks and takes a toxic medication since that is the only thing that alleviates his pain and allows a modicum of relief and mobility. 🎉🎉🎉
Thank you Professor Ben Bikman. I have enjoyed your social media posts over the last three years. Disciplined carnivore for 4 years, Uric Acid 11.7 - 13.2 mg/dL over those three years. This could be life changing for me. More to come.
I always enjoy and learn so much listening to Dr. Ben Bikman. Indeed he is one of my heroes! Dr. Rick Johnson does mention in his book that Vitamin C also reduces uric acid. Dr. David Perlmutter in his book (Drop Acid) says Quercetin also helps to reduce uric acid!
You are my metabolic hero.Thank you for including your personal knowledge and experience and declaring it as such. The liver pathway of breaking down fructose is most enlightening. I bet this uric acid pathway is responsible for other afflictions of arthritic and other autoimmune problems. Thank you for the classroom instructions and sharing of your knowledge.
I just purchased another copy of your book for a gal with PCOS and food addiction. Copies given to both my endo and PCP, husband’s PCP. Excellent presentation/information.
@@jellybeanvinkler4878 not 100% sure. I dropped 90 lbs in 5 months. I only ate and still eat mainly meat, eggs, butter (some fruit occasionally). I fasted and prayed a lot. Cut out all seed oils, high fructose corn syrup.
@@jellybeanvinkler4878 not 100% sure. I dropped 90+lbs in 5 months. I ate and still eat mainly meat, eggs, butter (some fruit occasionally). I fasted and prayed a lot. I quit eating anything with seed oils or high fructose corn syrup.
@@Turbotomass I fasted, cut out all seed oils, and high fructose corn syrup. I lost 90+lbs. I eat only meat, eggs, and butter. I do eat fruit occasionally.
You convinced me to try RX Sugar and I bought Dr Johnson's book - Thanks! What I like most about Allulose is that it doesn't have an excessively sweet taste so adding it to my coffee is not likely to re-trigger my addiction to sugar or raise my insulin.
Dr. Bikman- what great information! I see all this in real time and see all body issues / problems improve with aggressive urate lowering therapy. I am a kidney doctor and have over 500 patients on aggressive urate lowering therapy. Not only does their kidney function stabilize and much of the time improves, but many other body problems and chronic disease processes resolve even after being present for years. Almost all of the diabetics soon require less insulin and have a much easier time regulating their sugars. Blood pressures drop, edema resolves, et cetera. Your in depth discussion/review gave me a better ability to discuss with my patients and colleagues and absolutely gives complete support to what I see. Thank you!
Brilliant, thanks Ben. UA is no longer the black box it once was, thanks to this piece. Will be sharing this with a friend who's deadly afraid of otherwise healthy foods because he fears they'll worsen his gout.
Same for me. I tried the usual cutting back on high purine foods but since eliminating fructose I haven’t had gout. Gone back to high purine foods without any issues.
Yeah I wonder abou that. I first had gout 30 years ago, and was told to avoid red meat, offal, seafood and avoid alcohol. It was unknown then about the role of Fructose. HOWEVER uric acid is still a by-product of purines, and can be triggered with dehydration (hence avoidance of alcohol). Now whilst I want to stop taking Allupurinol every day, and whilst I now understand the role of fructose - and avoid it. How confident am I to risk getting flame up which I have managed to avoid for the last 14 year due to Allopurinol.
This makes so much sense to me. My dad had very bad gout in his 60s before he died of a heart attack. His diet had animal products but he also ate an equal and greater amount of carbohydrates and drank alcohol. He had a lot of visceral fat and an unhealthy metabolic state. I feel the amount of sugars from these latter two items were the triggering issue of his health problems and heart disease. I believe these uric acid crystals caused the damage to his arteries and then cholesterol went in to heal the damage caused by the crystals, causing the clogging of the arteries and ultimately, his heart attack. 😢
There was also a study by Phinney and Volek with athletes put on the keto diet. The UA levels spiked upon initiation of the diet hit returned to normal after around 3 months. So kidneys seem to adapt to the ketone/UA competition in healthy people. But similar studies on gout patients put on keto would be interesting. Maybe some of them lack a proper adaptation process?
I must be a rare bird because allulose does not give me any adverse digestive distress and in fact NO ill effects at all. I have been fascinated by the pathophysiology of uric acid for over a year now. Sadly some of the TH-cam doctors are getting this function incorrect and giving skewed information because they do not truly understand it. But we weren't taught that much about it in med school oher than in relation to kidney function and gout. I so appreciate this topic. Thank you.
I've been making baked custard sweetened with allulose. (Eggs, milk and vanilla with allulose) I have had NO GI upsets. I have also tried the bars the professor talks about without having GI upset.
This was and amazing class. Ben is such a good teacher because he is the ultimate “Student”….i can’t praise him enough. He will help many people in his lifetime.
Thank you. I am really enjoying learning from these lectures. I'm 66 years old and have never done any classes in biology etc (only basic high school science). It wasn't until after I started low carb in Oct 2021 that I started digging a bit deeper to understand how the body works. I have watched several videos on the metabolic pathways in the body (which I found very interesting - however I would not want to sit a test one them ha ha!) so even though some bits of these lectures don't always make absolute sense I do grasp most of it and it really helps keep me encouraged to stick with low carb. And as @fronniebealer7808 said that the more they listen to these the easier they are to understand.
Around minute 13:00 he talks about red meat and seafood being causal for rising levels of uric acid. But he pushed it aside and prefers to focus on fructose. The thing is that a high protein diet which a carnivore diet is, will cause high uric acid, high urea, high creatinine. I am still waiting for the Cystatin C results, as I've heard it is a better marker for kidney function than creatinine. Almost 2 years carnivore, (proper human diet, as some would say), no plant, no milk, and all those markers went up. I am also a little dissatisfied but i will try to reduce the amount of meat and add more fat.
Yeah, but at the end he explains the relation between uric acid being inflammatory and ketones anti inflammatory, high creatinine it's well explained by Anthony Chaffee that's really normal. Even bodybuilders regardless of which diet they're eating, his creatinine is high usually
I wonder if the crystals of uric acid in the blood, paired with high blood pressure could be an insult to the arterial walls which then have to be patched with plaques? Thank you for educating the masses.
Ahhhhhh! My favorite pastime: soaking my feet in ACV while sipping a teeny amount of red wine and listening to Dr. Bikman. Life is good! Thanks, Professor.
@@goldstar846 ACV has an anti-fungal and antibacterial properties. Vinegar may slow the growth of some types of foot fungus and skin infections. The results of the study show that apple cider vinegar is the most economical product to treat Candidiasis and other fungal infections.
A lot of people in this comment section breaking the sugar addiction it looks like. After you've broke the addiction you don't need these weird fake sugars that they're coming up with because you don't crave that stuff anymore.
@@chrisgardhouse9321 , I agree it’s not fake sugar , I also agree that once you break the addiction to sugar or highly processed foods the cravings diminish
I believe is the fructose which cause my gout for 10 years until 2021. My uric acid was high. I was not a meat/fish person that time, just occasionally eating meat, however I drink lots of fruit juice and of course sugar/carbs. Once I stopped the fruit juice strictly, limit veggies/sugar/carbs and even, I started eating more meat/fish, my uric acid is low/normal, and I never had any gout flare again. 1 year ago, I got sprain and muscle spasm, I'm worried the gout might flare again, apparently not happening. So, how I get rid of uric acid is simple, 2~3 days water fasting per month and OMAD for 4 months. I eat more meat now and very low on veggies/sugar/carbs and of course fasting 14~16 hours every day by stop eating at 6pm. It works for me.
Thank you, Doctor Bikman for your engaging summary of the research you have been doing. You are both informative and entertaining. I have been carnivore since August of 2022, which has mostly cleared up my gout. My gout has flared only four times since I started carnivore. One flare was when I slowly reintroduced fruit into my diet in the form of peaches and blueberries. The linkage was so obvious that I stopped immediately and returned to normal. The other three all happened after receiving bad news that elevated my stress to the point of having difficulty sleeping. I will give the allulose a try even though I have no desire for sweets to see if that pulling effect might apply in my case.
A fascinating topic, beautifully presented as ever. The thought that occurred to me, at the beginning, was, "if meat is high in purines, then how can a meat-based ketogenic diet not contribute to gout?" I found it reassuring when you clarified the role of ketones in the regulation of the inflammatory pathway. I look forward very much to the publication of the allulose studies, as there seems to be a lot of talk about the potential benefits and (so far) remarkably little about any drawbacks. It seems too good to be true that there could be a molecule so similar to glucose which has no metabolic consequences.
BAM!! Starting my day with Dr. Ben, Da Best! Thank you for all you do for us. I have some allulose in the house now and it is amazing. I do have questions for you though. Does Allulose have the same gastric slowing effect as the GLP-1 medicines? And I have just watch a Dr. Boz video where she addresses Uric acid and the Polyol pathway for excess glucose to be converted into fructose and then into uric acid, and I was wondering what your thoughts were on the impact of the Polyol Pathway and Uric acid formation? Again THANK YOU!
Thank you! Mystery solved. This explains why I keep getting gout attacks after I come out of ketosis. I was assigning dehydration as the culprit, but I see the competition of ketones could also play a part. It is also explaining why I can eat seafood when I’m in ketosis but not when I come out of ketosis. Brilliant. This will be a life saver! (Side note for your anecdotes. I can drink straight up fructose and not get an attack but if I eat 4 pieces of a sushi roll with fish, I’m having a flair by bedtime). Would fructose have to be more accumulating?
I don’t have the cravings anymore but my husband sure does even though we’ve been off sugar for years now. Hubby does cheat some and that is why. He knows he has food issues and I liken his issue to alcohol addiction. We’ve have never imbibed but the addiction is the same. Once you start it is very difficult to stop.
outstanding. Thanks Dr Bikman. Another bunch of super technical terms and other topics learned from various "experts" have been knitted together a little more by your great delivery, Pertect pitch so far mate, Never heard of allulose before so that was new. Amazing stuff and the more I hear, the more interesting it gets. It's like the human metabolism is a very intricate detective novel! 😀
I’m starting to get dizzy with these podcasts. I’ve started carnivore to DECREASE insulin resistance and my uric acid is up as a result. They tell me it should drop after a while but I’ve heard that insulin’s resistance raises uric acid too.. what causes what and what are we supposed to do?
Thank you Dr. Bikman. I'm very interested in this subject due to the fact that I've been eating a keto diet for the last four plus years. I've moved to nearly carnivore, generally eating less than 20 carbs, mostly less than 5 carbs, yet I still produce occasional kidney stones. I'm 74yo F, 5'8", currently 181lbs, reversed T2DB, NAFLD, and a host of other ills and lost 100 lbs. I drink coffee with cream and monk fruit sweetener. The few vegetables and fruits I sometimes eat are mushrooms, asparagus, avocados, olives, dill pickles, fermented cabbage and very, very rarely tomatoes, blueberries, yellow onions, a strawberry or two. A recent uric acid reading was 5.1. I shall perhaps try the allulose instead of monk fruit in my coffee (decaf).
Fantastic explanation. Last part seems to reflect exactly my case - on ketogenic diet for over 8 months (almost no fruit, very low carbs) with minor breaks, weight down a lot, inflammatory markers CRP down 200% , insulin level and HOMA-IR down but uric acid up quite much and palm's joints pain came. Very discomforting ....
Around minute 13:00 he talks about red meat and seafood being causal for rising levels of uric acid. But he pushed it aside and prefers to focus on fructose. The thing is that a high protein diet which a carnivore diet is, will cause high uric acid, high urea, high creatinine. I am still waiting for the Cystatin C results, as i heard it is a better marker for kidney function than creatinine. Almost 2 years carnivore, (proper human diet, as some would say), no plant, no milk, and all those markers went up. I am also a little dissatisfied but i will try to reduce the amount of meat and add more fat.
Dr. Bikman: Two questions. Can this uric acid create Calcium Oxalate stones or only uric acid stones? How much Allulose should I enjoy each day to help with the uric acid?
I went low carb Keto for 18 months lost close to 100 lbs fought gout many times usually every 15 to 18 days but stayed the course. Took cholchicine when it occurred. It did gradually get less and less frequent. Went full carnivore for last 6 months, 5 months in had gout attack again. Not as bad as in the beginning but still no fun but minor. These where always in my big toe joint. So I had zero fructose. So I ask Dr Ken Berry and he said illuminate dairy but butter would be OK. Only dairy I was eating was cheese. I hope that does the trick.
Also check out Sally Norton. She is an oxalate expert. Even on zero carb, the body excretes stored oxalates in cycles. If too much is secreted back into the body and can't be excreted fast enough, it's called oxalate dumping...this causes many symptoms and very common is joint pain and gout due to the oxalate crystals formation.
Haven't heard the entire video yet, but what almost no one talks about concerning uric acid is the fact that the body stores it in organs and tissue. So when going through such a dramatic weight loss (happened to me, too) the stores of uric acid throughout the body are released into the blood stream spiking serum levels that were otherwise within normal ranges. My experience is that after my weight level stabilized at a healthy point the gout attacks subsided and did not return for over a decade when I gained back weight. Point being, you may not need to drop the dairy in moderation once excess stored uric acid has been excreted.
I went carnivore 8mo ago and experienced the dumping….still dealing with some diarrhea even though I have limited dairy. I guess my concern is now that I am no longer eating calcium oxalates that it will tone down those kidney stones that I developed 30 years ago with many ER visits and surgeries. I am hoping that I do not develop uric acid kidney stones … But time will tell….feeling great! ❤️✌🏼
![กิโลเมตรที่ 0 เดินทางรอบโลกไม่ใช้เครื่องบิน [Around The World Ep. 1]](http://i.ytimg.com/vi/toJG9oofLFY/mqdefault.jpg)
Why don't we have more professors like this gifted educator?
Not all PhDs work with the cellular level stuff.
Grateful for this educator and researcher.
Those that don't need to listen
Are you qualified to understand what he's saying to know that he's gifted?
@@darkpatches every human being is qualified until the day when he or she dies and then qualified for a death certificate
We do and it’s important that their research and institutions of higher learning are supported.
Dr. Bikman,
If this is how you talk to your kids, they are truly blessed! Your heart comes out when you talk! Thank you, sir, for teaching outside the classroom! We need your lectures!
Thank you for not focusing on gout. I've had gout. Although painful I doubt many people have died from it. In reality, gout is a blessing in that it should alert you to hyperuricemia and the possibility of uric acid crystals elsewhere. We may become aware of gout with a joint hurting but uric acid crystals have been found many places-- in coronary arteries, aorta, heart valves, myocardium, kidneys, prostate, and pancreas amongst others. Crystals have even been found in atherosclerotic plaques. Its frequency is VERY underappreciated because it's hard to detect. Routine tissue fixation with formalin washes out uric acid crystals. Likewise, tissue is usually cut 7 microns thick for microscopy. Uric acid crystals are usually linear and, if they're perpendicular to the slide, will appear as a small dot. To see uric acid crystals one has to preserve the tissue with methanol, not formalin. Following this, special lighting is required to see the crystals. Studies which have employed this method have shown crystals to be far more extensive than the joints. I can't imagine that uric acid crystals in the coronary arteries initiating an inflammasome reaction is good. Uric acid crystals don't show well on routine x-rays and scans. It usually requires a specialized cat scan called dual energy CT (DECT scan). These scans will often show uric acid crystals in the calcium in atherosclerotic plaques.
Unfortunately gout is treated poorly. Give an anti-inflammatory and if it recurs we'll "think about" treatment with allopurinol or febuxostat. Hyperuricemia, not JUST uric acid crystals, IS serious. It's like a criminal whose fingerprints are left behind at many crime scenes- the heart, kidneys, liver, pancreas. The tragedy is that we have good drugs and it's usually easy to treat. Anyone diagnosed with gout or hyperuricemia should be thoroughly evaluated for heart, liver, and kidney disease.
For every molecule or uric acid produced there is also a molecule of hydrogen peroxide generated. I've often wondered how much pathology is caused by this, as opposed to the uric acid itself.
Excellent comment, thank you. Much of what you describe about uric acid crystals also apply to oxalate crystals. They accumulate in all the tissues if the body and are dissolved by normal tissue processing. When I went on a low carb and a low oxalate diet all of my fibromyalgia and bladder pain went away. I suspect my pain was due to the oxalates as I was eating a ton of almond flour biscuits, almond butter, spinach, black tea, and some dark chocolate on keto and still had pain. Frustrating that a portion of tissue specimens arent collected, processed, and stained for crystal ID. I would love to see how much of these types of crystals are in plaques.
Im saving this info! THANK YOU
That was v informative; thanks!
An interesting point I have also learnt about gout is that 2 individuals with the same uric acid level could behave differently with one going into an acute gouty attack n the other barely feeling it. Therein I understand, comes the confounding metabolic factors n presumably fructose intake. Intriguing also is that 2 different people with the same uric acid level move into different pathways of its precipitation; one in the kidney lumen n another in the tissues. What factors are at play!?
@@lindabirmingham603 I am VERY glad you mentioned the oxalate issue. I believe I have BOTH issues and have worked with Sally K Norton to help control oxalate dumping. However, I have gout like pain in my thumbs and other joints. So time to see if I have elevated uric acid.
Thank you for this detailed comment! What’s your opinion on Allulose?
Thanks. Youre doing Gods work. For everyone else reading this that wants to go even further, go find the hidden herbs by Anette Ray.
Give it a rest spammer!
Uhhh, God made the gout in the first place, didn't he?
I am a retired MD and really appreciate your lessons and what I learn. I am not so sure about allulose though. Side effect bloating always tells me that something messes up your gut microbiome. I prefere reducing sweets to an occasional treat which gets easy the longer you are on a rather low carb diet.
I thought the same thing - but then thought maybe the reason some things cause GI upset is because the biome is already “messed up” and if it was a healthy biome then it wouldn’t cause the issue. Still, I agree with just reducing the sugar to as close to zero as possible is the best way to go.
Allullose's delaying effect on gastric emptying causes horrendous indigestion, burping, and bad acid reflex. As a result, there is no bowel movement as food still sits longer in the upper part of the stomach. I wish someone told me this side effects
In the lecture it is mentioned that allulose competes with fructose absorption. That means that more fructose stays in the gut, where it can feed the microbiome, which might be the cause of the upset GI tract.
If this is correct, then you should be able to handle higher allulose doses, if you have a lower fructose consumption.
From what I heard in another YT video, it is recommended to take only small doses of allulose. You can slowly increase the dosage to find out how much allulose you can handle without getting these side effects.
@@GerbenWulff If you have a low fructose consumption you propably don`t need allulose .
@@WideAwakeHuman your gut microbiome changes within days depending on what you eat. high amounts of fructose cannot be absorbed so you feed bacteria that ferments it and builds up gas. If you add allulose which decreases absorbtion of fructose even more it will get worse. The easy way IMO would be to cut down fructose.
The more I listen to these lectures, the easier they are to understand.
I agree.
Thank you so much for your videos. I have developed fatted liver, Hasimotos, kidney stones and type 2 diabetes. The only one I was told about was the kidney stones when I went to the ER. Fatter liver I learned about when I got a copy of the report. Never once has any doctor told me about any if the issues. The diabetes I found by buying a glucose blood meter. You have given me a path to regain my health. God bless you!!!
Soo sorry., Most Gps never Check INSULIN, only Glucose which are different!
@@mystrength5640 They did not check my glucose, uric acid let alone insulin even after events. No instructions in lifestyle or nutrition or anyway to remedy any of this.
@@nannygranny9534 keep on listening to this Prof, Try to find an alternative Doctor, , Take Care!
I'm so sorry to hear that. I applaud you for taking your health into your own hands.
How did you find out about hashimotos?
I’m a medical doctor. Love your talks. Only recently found you. I’m a Rob Cywes fan. Thank you
Thank you Dr Bikman, your ability to teach even older folks like me is such a blessing..truly a gifting from God !
Professor Bikman, you are so gifted with your explanations, thank you so much for sharing!
I tell you this man is making BYU look really good on TH-cam science lectures ..
As someone who loved chemistry and got through qualitative analysis in college, I love listening to you. as someone who has used the ketogenic diet to go from 180 pounds and 60 units of insulin to 120 pounds and no medicine I am thrilled to listen to you. Thank you.
Not all gout is caused by uric acid.
Unless the joint fluid is tested, it is just assumed its the uric acid.
For those on carnivore etc, if you have gout, it could be oxalate crystals.
Stored up oxalates (from when plants were eaten) get released from the body in cycles (can take years). If the load is too much to excrete at once, the oxalates get 'dumped' around the body waiting for excretion, causing many different symptoms. Its common for the oxalate crystals to be
found in joints, and big toe gout. Feels the same as uric acid crystals... Most doctors assume big toe pain and swelling is uric acid crystals but there are other causes for the same symptoms.
Sally Norton is the expert for oxalates. She explains how to slow down the 'dumping' and manage the symptoms.
ALL gout is caused by Uric acid - BY DEFINITION. Oxlates are the more common form of kidney stones and has other down sides. Also there is a whole host of arthritis not caused by Uric acid - BUT NONE of these are "Gout".
Yes, and sadly the doctors and pathologists arent proactively seeking to differentiate between uric acid and oxalates crystals.
how / by what means would the doctor learn whether it's oxalates or uric acid, please?
Thank you Dr Bikman, as always it is a pleasure to be in your classroom. I have someone in my life with gout and they significantly decreased fruit and fruit juice and he is eating more meat, and has not had another gout attack after making those changes.
Morning coffee with Ben!!!! My favorite teacher ever🎉
Great topics always❤
I just can’t get enough of his classrooms. I look forward to the education , and apply it to my own health journey . The success I have had is miraculous . Thank you Professor Bikman .
I've watched many
Videos on uric acid
This is the best by far.
Thank you Dr. Bikman for this review of biochemistry. Physicians need to be reminded often of those pathways.
A beautiful lecture with a touch of Ben-Richard Bikjohnsson. Keep up the good job.
🎉🎉🎉🎉🎉
Thank you so much for your explanations. I was with you until AMP came into the picture, then I sort of glazed over, but please don't stop giving us the details! I just need to go back and listen again. The college age kids may get it in one try, but at 72, I'm still passionate about learning and improving my health, but need to hear it more than once :) So appreciative for your videos and your gentle style that brings a complicated subject down to our level. You, Sir, are a gift.
What a great teacher! Thank you Dr. Bikman, the podcast host, the sponsor and the insightful viewers. May our quality of life improve everyday.❤
This is so appreciated. I'm a healthy 44year old woman and just beginning to develop gout - I am not insulin resistant - and naturally I am concerned over additional issues - so this is really informative and helpful - thank you for taking up these topics and laying them out in accessible language.
One of the first things I noticed when I began a low carb diet three years ago was decreased inflammation. I used to have severe pain in many of my joints, most notably my hands, but soon after giving up the sodas and other processed high carb foods, I stopped hurting!
It still amazes me that we know so much about cells and their specific jobs .but what's even more amazing is the ability of this ADr. to explain it in layman terms! Thanks a lot from a true fan
I feel like I am back in my 2 favorite nursing school classes, Anatomy & Physiology and Endocrinology, with a big twist, up-to-date research and knowledge about what is making us sicker. Thank you Dr Bickman. I am eager to inform my hubby so he/we can implement some changes that may work. He suffers regularly from gout attacks and takes a toxic medication since that is the only thing that alleviates his pain and allows a modicum of relief and mobility. 🎉🎉🎉
Thank you Professor Ben Bikman. I have enjoyed your social media posts over the last three years. Disciplined carnivore for 4 years, Uric Acid 11.7 - 13.2 mg/dL over those three years. This could be life changing for me. More to come.
Excellent and clear even for an economist as I am!!!
Gracias, maestro.
Hello, I comer from Dr Robert Cywes channel. Thank you so much for your knowledge, I am so happy to learn from you!
I always enjoy and learn so much listening to Dr. Ben Bikman. Indeed he is one of my heroes! Dr. Rick Johnson does mention in his book that Vitamin C also reduces uric acid. Dr. David Perlmutter in his book (Drop Acid) says Quercetin also helps to reduce uric acid!
You are my metabolic hero.Thank you for including your personal knowledge and experience and declaring it as such. The liver pathway of breaking down fructose is most enlightening. I bet this uric acid pathway is responsible for other afflictions of arthritic and other autoimmune problems. Thank you for the classroom instructions and sharing of your knowledge.
I just purchased another copy of your book for a gal with PCOS and food addiction. Copies given to both my endo and PCP, husband’s PCP. Excellent presentation/information.
Do you mean endometriosis? Can uric acid cause it?
Fantastic classroom. You don't mind if I listen to this twice, do you? Thank you, Dr Bikman.
Absolutely excellent. Thank you.
I eliminated gout which I had for 25+yrs. What a blessing 🙏
Do tell?
From dropping fructose?
@@jellybeanvinkler4878 not 100% sure. I dropped 90 lbs in 5 months. I only ate and still eat mainly meat, eggs, butter (some fruit occasionally). I fasted and prayed a lot. Cut out all seed oils, high fructose corn syrup.
@@jellybeanvinkler4878 not 100% sure. I dropped 90+lbs in 5 months. I ate and still eat mainly meat, eggs, butter (some fruit occasionally). I fasted and prayed a lot. I quit eating anything with seed oils or high fructose corn syrup.
How?
@@Turbotomass I fasted, cut out all seed oils, and high fructose corn syrup. I lost 90+lbs. I eat only meat, eggs, and butter. I do eat fruit occasionally.
Thanks you, Dr. Bikman, for another enlightening lecture. Always a pleasure to listen to you.
You convinced me to try RX Sugar and I bought Dr Johnson's book - Thanks! What I like most about Allulose is that it doesn't have an excessively sweet taste so adding it to my coffee is not likely to re-trigger my addiction to sugar or raise my insulin.
Answers a lot of questions I had. Thank you Dr. Bikman!
He makes the complicated seem simple.
FANTASTIC - the classes are cutting edge - Thankyou Ben Bikman for such an inciteful session.
Dr. Bikman- what great information! I see all this in real time and see all body issues / problems improve with aggressive urate lowering therapy. I am a kidney doctor and have over 500 patients on aggressive urate lowering therapy. Not only does their kidney function stabilize and much of the time improves, but many other body problems and chronic disease processes resolve even after being present for years. Almost all of the diabetics soon require less insulin and have a much easier time regulating their sugars. Blood pressures drop, edema resolves, et cetera. Your in depth discussion/review gave me a better ability to discuss with my patients and colleagues and absolutely gives complete support to what I see. Thank you!
The urate lowering therapy involved drugs? Or just cutting fructose?
Brilliant, thanks Ben. UA is no longer the black box it once was, thanks to this piece. Will be sharing this with a friend who's deadly afraid of otherwise healthy foods because he fears they'll worsen his gout.
I eliminated gout completely by skipping all fructose (fruit & sugar)
My husband has tried that but it has not worked for him. I am hoping this Rxsugar will help.
Same for me. I tried the usual cutting back on high purine foods but since eliminating fructose I haven’t had gout. Gone back to high purine foods without any issues.
and drinking enough water....!
Get ur OXATE tested. Its in spinach, almonds
Yeah I wonder abou that. I first had gout 30 years ago, and was told to avoid red meat, offal, seafood and avoid alcohol. It was unknown then about the role of Fructose. HOWEVER uric acid is still a by-product of purines, and can be triggered with dehydration (hence avoidance of alcohol). Now whilst I want to stop taking Allupurinol every day, and whilst I now understand the role of fructose - and avoid it. How confident am I to risk getting flame up which I have managed to avoid for the last 14 year due to Allopurinol.
First, Thank you so much for this information. Secondly, WOW!!!!
This makes so much sense to me.
My dad had very bad gout in his 60s before he died of a heart attack. His diet had animal products but he also ate an equal and greater amount of carbohydrates and drank alcohol. He had a lot of visceral fat and an unhealthy metabolic state. I feel the amount of sugars from these latter two items were the triggering issue of his health problems and heart disease.
I believe these uric acid crystals caused the damage to his arteries and then cholesterol went in to heal the damage caused by the crystals, causing the clogging of the arteries and ultimately, his heart attack. 😢
I know your pain. It hurts.
@@karenf9137 🥰 TY.
My sister's name is Karen. 👍🏻😁
There was also a study by Phinney and Volek with athletes put on the keto diet. The UA levels spiked upon initiation of the diet hit returned to normal after around 3 months. So kidneys seem to adapt to the ketone/UA competition in healthy people. But similar studies on gout patients put on keto would be interesting. Maybe some of them lack a proper adaptation process?
Insulin IQ needs to do what Ninja Nerd did: take all these classes, put all in one site.
So they can be learned!
This exists already. Called "The Metabolic Classroom", which he tells you about here. You can access as a playlist by clicking on the Insulin IQ icon.
they are on one site.... TH-cam
What an excellent lecture. I will relisten a few times as I explore the urea cycle
I must be a rare bird because allulose does not give me any adverse digestive distress and in fact NO ill effects at all. I have been fascinated by the pathophysiology of uric acid for over a year now. Sadly some of the TH-cam doctors are getting this function incorrect and giving skewed information because they do not truly understand it. But we weren't taught that much about it in med school oher than in relation to kidney function and gout. I so appreciate this topic. Thank you.
You're not the only one!
Better alternative.
This is one of the good professors!
When I use the Allulose my CGM doesn't even flick up!!
I've been making baked custard sweetened with allulose. (Eggs, milk and vanilla with allulose) I have had NO GI upsets. I have also tried the bars the professor talks about without having GI upset.
Allulose gives me chest anxiety after about a week of use.
Like all things, allulose is great for some and not others. I'm using it for baking with no issues for myself or my husband.
This was and amazing class. Ben is such a good teacher because he is the ultimate “Student”….i can’t praise him enough. He will help many people in his lifetime.
Thank you Dr. Ben this is a great informative post which I will pass on to people who have GOUT attacks.
"Why we get sick " should be in every doctor's office: waiting room & exam room
I've done the full read and I will read it again soon!
What? No… then they’d have no-one to treat…😂😂😂 only joking, 🙃 it would be great. 😊 but… doctors don’t like to be educated….
I gave my endocrinologist a copy))
They don't have time to read in the clinics and at home.
You have no idea how badly docs need to listen
Thank you. I am really enjoying learning from these lectures. I'm 66 years old and have never done any classes in biology etc (only basic high school science). It wasn't until after I started low carb in Oct 2021 that I started digging a bit deeper to understand how the body works. I have watched several videos on the metabolic pathways in the body (which I found very interesting - however I would not want to sit a test one them ha ha!) so even though some bits of these lectures don't always make absolute sense I do grasp most of it and it really helps keep me encouraged to stick with low carb. And as @fronniebealer7808 said that the more they listen to these the easier they are to understand.
Around minute 13:00 he talks about red meat and seafood being causal for rising levels of uric acid. But he pushed it aside and prefers to focus on fructose.
The thing is that a high protein diet which a carnivore diet is, will cause high uric acid, high urea, high creatinine. I am still waiting for the Cystatin C results, as I've heard it is a better marker for kidney function than creatinine.
Almost 2 years carnivore, (proper human diet, as some would say), no plant, no milk, and all those markers went up. I am also a little dissatisfied but i will try to reduce the amount of meat and add more fat.
Yeah, but at the end he explains the relation between uric acid being inflammatory and ketones anti inflammatory, high creatinine it's well explained by Anthony Chaffee that's really normal. Even bodybuilders regardless of which diet they're eating, his creatinine is high usually
I wonder if the crystals of uric acid in the blood, paired with high blood pressure could be an insult to the arterial walls which then have to be patched with plaques?
Thank you for educating the masses.
Ahhhhhh! My favorite pastime: soaking my feet in ACV while sipping a teeny amount of red wine and listening to Dr. Bikman. Life is good! Thanks, Professor.
oooh... why do u soak your feet in acv?
this sounds interesting!
@@goldstar846 ACV has an anti-fungal and antibacterial properties. Vinegar may slow the growth of some types of foot fungus and skin infections. The results of the study show that apple cider vinegar is the most economical product to treat Candidiasis and other fungal infections.
@@goldstar846 I'd love to know the same thing!
A lot of people in this comment section breaking the sugar addiction it looks like. After you've broke the addiction you don't need these weird fake sugars that they're coming up with because you don't crave that stuff anymore.
True
Allulose is not fake sugar.
@@chrisgardhouse9321 , I agree it’s not fake sugar , I also agree that once you break the addiction to sugar or highly processed foods the cravings diminish
I use allulose in fasting days to tame hunger if it happens. Works well, do not need much
Still need something to add to tea and recipes
I believe is the fructose which cause my gout for 10 years until 2021. My uric acid was high. I was not a meat/fish person that time, just occasionally eating meat, however I drink lots of fruit juice and of course sugar/carbs. Once I stopped the fruit juice strictly, limit veggies/sugar/carbs and even, I started eating more meat/fish, my uric acid is low/normal, and I never had any gout flare again. 1 year ago, I got sprain and muscle spasm, I'm worried the gout might flare again, apparently not happening. So, how I get rid of uric acid is simple, 2~3 days water fasting per month and OMAD for 4 months. I eat more meat now and very low on veggies/sugar/carbs and of course fasting 14~16 hours every day by stop eating at 6pm. It works for me.
Great Information as always. Love your videos!!😊
You’re a great teacher Dr Ben
Thank you for your teaching this. I am learning so very much from your teaching.
Thank you, Doctor Bikman for your engaging summary of the research you have been doing. You are both informative and entertaining.
I have been carnivore since August of 2022, which has mostly cleared up my gout. My gout has flared only four times since I started carnivore.
One flare was when I slowly reintroduced fruit into my diet in the form of peaches and blueberries. The linkage was so obvious that I stopped immediately and returned to normal.
The other three all happened after receiving bad news that elevated my stress to the point of having difficulty sleeping.
I will give the allulose a try even though I have no desire for sweets to see if that pulling effect might apply in my case.
A fascinating topic, beautifully presented as ever. The thought that occurred to me, at the beginning, was, "if meat is high in purines, then how can a meat-based ketogenic diet not contribute to gout?" I found it reassuring when you clarified the role of ketones in the regulation of the inflammatory pathway.
I look forward very much to the publication of the allulose studies, as there seems to be a lot of talk about the potential benefits and (so far) remarkably little about any drawbacks. It seems too good to be true that there could be a molecule so similar to glucose which has no metabolic consequences.
Great discussion on the physical effects of high uric acid on the body and possible resolutions.
One of the most awe inspiring and comprehensive lectures I've heard here on YT. Subbed and liked. Thank you!
Amazing lecture and I would suggest everyone should listen!!!!
BAM!! Starting my day with Dr. Ben, Da Best! Thank you for all you do for us. I have some allulose in the house now and it is amazing. I do have questions for you though. Does Allulose have the same gastric slowing effect as the GLP-1 medicines? And I have just watch a Dr. Boz video where she addresses Uric acid and the Polyol pathway for excess glucose to be converted into fructose and then into uric acid, and I was wondering what your thoughts were on the impact of the Polyol Pathway and Uric acid formation? Again THANK YOU!
Very comprehensible, ty Dr. Bikman! I enjoyed listening to this. 😊
I have been on been on keto since August of 2023. I rarely take my 300mg of allopurinol. My gout is finally in check.
Thank you! Mystery solved. This explains why I keep getting gout attacks after I come out of ketosis. I was assigning dehydration as the culprit, but I see the competition of ketones could also play a part. It is also explaining why I can eat seafood when I’m in ketosis but not when I come out of ketosis. Brilliant. This will be a life saver! (Side note for your anecdotes. I can drink straight up fructose and not get an attack but if I eat 4 pieces of a sushi roll with fish, I’m having a flair by bedtime). Would fructose have to be more accumulating?
Awesome lecture!
Bless you for being so brilliant and bringing all of this priceless Information to us information to us
This is sooo helpful, dr. Bikman I would love to learn more about all the actions that insulin does 🤔🥳
I don’t have the cravings anymore but my husband sure does even though we’ve been off sugar for years now. Hubby does cheat some and that is why. He knows he has food issues and I liken his issue to alcohol addiction. We’ve have never imbibed but the addiction is the same. Once you start it is very difficult to stop.
outstanding. Thanks Dr Bikman. Another bunch of super technical terms and other topics learned from various "experts" have been knitted together a little more by your great delivery,
Pertect pitch so far mate, Never heard of allulose before so that was new. Amazing stuff and the more I hear, the more interesting it gets. It's like the human metabolism is a very intricate detective novel! 😀
Thank you,you make it so easy to understand!
Dr Bickman! You hit it out of the park again!
This brings together so many things I have been studying. Love this. Thank you.
When are you writing another book? Love your breakdown of complicated science regarding diet.
Thanks Dr. I always noticed that my uric acid test went up and down with my ketones level.😊
I'm such a nerd. I love this stuff so much!!
I mention to customers the changes in fruit over the centuries and they are always so suprised.
Thank you for that talk Dr Bikman, I learn so much from you, much appreciated!😊
I’m starting to get dizzy with these podcasts. I’ve started carnivore to DECREASE insulin resistance and my uric acid is up as a result. They tell me it should drop after a while but I’ve heard that insulin’s resistance raises uric acid too.. what causes what and what are we supposed to do?
Im in the same boat. And now I have heart trouble. Reply here if you find the answer.
You might be oxalate dumping
Thank you Dr. Bikman. I'm very interested in this subject due to the fact that I've been eating a keto diet for the last four plus years. I've moved to nearly carnivore, generally eating less than 20 carbs, mostly less than 5 carbs, yet I still produce occasional kidney stones. I'm 74yo F, 5'8", currently 181lbs, reversed T2DB, NAFLD, and a host of other ills and lost 100 lbs. I drink coffee with cream and monk fruit sweetener. The few vegetables and fruits I sometimes eat are mushrooms, asparagus, avocados, olives, dill pickles, fermented cabbage and very, very rarely tomatoes, blueberries, yellow onions, a strawberry or two. A recent uric acid reading was 5.1. I shall perhaps try the allulose instead of monk fruit in my coffee (decaf).
I love the way u make ur explanations, even for a physician 👍
Absolutely, brilliant! Nothing else to add. Thank you so much!
I hope Jane comes back again ❤️ She deserves to be healthy and to feel amazing 💪🏻
Excellent class; thanks!
I wish he would have shared how much allulose he consumed and when through the day to decrease his uric acid levels.
Excellent podcast. Thank you
Fantastic explanation. Last part seems to reflect exactly my case - on ketogenic diet for over 8 months (almost no fruit, very low carbs) with minor breaks, weight down a lot, inflammatory markers CRP down 200% , insulin level and HOMA-IR down but uric acid up quite much and palm's joints pain came. Very discomforting ....
Around minute 13:00 he talks about red meat and seafood being causal for rising levels of uric acid. But he pushed it aside and prefers to focus on fructose.
The thing is that a high protein diet which a carnivore diet is, will cause high uric acid, high urea, high creatinine. I am still waiting for the Cystatin C results, as i heard it is a better marker for kidney function than creatinine.
Almost 2 years carnivore, (proper human diet, as some would say), no plant, no milk, and all those markers went up. I am also a little dissatisfied but i will try to reduce the amount of meat and add more fat.
I can’t wait to tell my husband who suffers from gout. He just started carnivore diet. This will keep him motivated
This guy is absolutely brilliant 👌🙏
Dr Bikman ❤
Thank you so much for all your information.
I love the science, and you make it relatable.
Keep up your great work!
Dr bikman ur researches sn teachings r great help for humanity
Dr. Bikman: Two questions. Can this uric acid create Calcium Oxalate stones or only uric acid stones? How much Allulose should I enjoy each day to help with the uric acid?
WOW! Excellent! Thank You so much!
This helped me. Thanks!
I went low carb Keto for 18 months lost close to 100 lbs fought gout many times usually every 15 to 18 days but stayed the course. Took cholchicine when it occurred. It did gradually get less and less frequent. Went full carnivore for last 6 months, 5 months in had gout attack again. Not as bad as in the beginning but still no fun but minor. These where always in my big toe joint. So I had zero fructose. So I ask Dr Ken Berry and he said illuminate dairy but butter would be OK. Only dairy I was eating was cheese. I hope that does the trick.
Also check out Sally Norton. She is an oxalate expert. Even on zero carb, the body excretes stored oxalates in cycles. If too much is secreted back into the body and can't be excreted fast enough, it's called oxalate dumping...this causes many symptoms and very common is joint pain and gout due to the oxalate crystals formation.
Haven't heard the entire video yet, but what almost no one talks about concerning uric acid is the fact that the body stores it in organs and tissue. So when going through such a dramatic weight loss (happened to me, too) the stores of uric acid throughout the body are released into the blood stream spiking serum levels that were otherwise within normal ranges. My experience is that after my weight level stabilized at a healthy point the gout attacks subsided and did not return for over a decade when I gained back weight. Point being, you may not need to drop the dairy in moderation once excess stored uric acid has been excreted.
It was, most likely, your body dumping oxalates. Dairy is actually good for that.
I have cut out milk as I'm intolerant, I have lost a load of weight and it's significantly cut the inflammation in my body. I still ear cheese
I went carnivore 8mo ago and experienced the dumping….still dealing with some diarrhea even though I have limited dairy. I guess my concern is now that I am no longer eating calcium oxalates that it will tone down those kidney stones that I developed 30 years ago with many ER visits and surgeries. I am hoping that I do not develop uric acid kidney stones … But time will tell….feeling great! ❤️✌🏼