Gluconeogenesis (Part 1 of 3) - Intro and Steps

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You are a huge help. I can't stress this enough! There a lot of small details I would have easily missed without you! Thank you so much :)

[@successneedstime96]

By far you are one of two best biochemistry channels that I like to watch and learn. However, I do hope the words can be bigger haha.
Keep up the good works !

[@MoofUniversity]

+Zack Yeung Wow! Awesome! Thanks, dude! What's the other biochemistry channel, and what, specifically, about them do you like? Maybe I can learn a thing or two from the way they do things and perhaps up the quality of my content.

[@successneedstime96]

Moof University It's AK lectures~

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[@SnowAndReef]

Excellent videos. Such clear explanations and very well thought out. Your videos have been a huge help in my biochem class this semester, so THANK YOU!!

[@MoofUniversity]

***** Sweet! You're very welcome! I'm glad the videos have helped.

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[@valentfaithjaromay3427]

thank you so much for this video!

[@halbastnabaz2810]

Thank you! You are the best!!

[@patriciaselestine2166]

Thank you! It was very helpful! :)

[@muhammadbia1158]

that is so helpfull thanks !

[@elanyg4807]

that was very helpful thansks alot !

[@forgivenessmagano60]

Thank you

[@dalalzeyad7897]

thanx sooooo much

[@zakz_7356]

How would I answer this?
Describe the transport of pyruvate out of the mitochondria in gluconeogenesis.

[@MrNelzya]

Does Oxaloacetate go to Malate in order to get out of the mitochondrial matrix? Then, once outside, it goes back to Oxaloacetate then to PEP as you described? Any thoughts on that?

[@tjbiel1446]

Moof University ***** Pyruvate is not made into OAA until it gets into the mitochondria. The enzyme that catalyzes this step, pyruvate carboxylase, is a mitochondrial protein. OAA can either go all the way to PEP in the mitochondria and then be transported out. Alternatively OAA can be reduced by NADH to malate before leaving the mitochondria in order to move a hydride ion out. The malate is then oxidized to OAA again and converted to PEP by cytosolic PEP-CK.

[@sebastiantommitandar5430]

glucose needs to be turned into glucose 6-phosphate in order to undergo either glycolysis and glycogen synthesis, right? So why would the cell want to convert glucose 6-phosphate into glucose (and by doing so lose another molecule of ATP) instead of using glucose 6-phosphate directly to, for example, make glycogen?

[@sebastiantommitandar5430]

and btw, awesome tutorial!

[@sebastiantommitandar5430]

uhh kinda noticed glucose 6-phosphatase exists only in liver ER... does it mean that gluconeogenesis would only go as far as converting G6P into glucose when the cell wants to send glucose to other cells on other parts of the body? (via blood, perhaps?)

[@hafizirosmadi2874]

Thank you! :)

[@MoofUniversity]

hafizi rosmadi You're welcome! :]

[@TheMrjosegusmao]

Thanks from Portugal :D

[@MoofUniversity]

TheMrjosegusmao You're welcome from California. :D

[@jkman10]

8:35 Gluconeogenesis happens when dietary glucose is not available and when the liver has run out of glycogen. So how is gluconeogenesis a storing pathway? Unless it's stored when it's not needed.

[@megan5495]

It stores energy in the way that it "creates" an ADP and a Pi so that the body can convert that to ATP when it needs. Glycolysis creates a lot of ATP, so gluconeogenesis is a way of temporarily holding that ATP as ADP and Pi

[@CharityRidgley]

Thank you! This was VERY helpful! :) Do you charge for tutoring?

[@MoofUniversity]

Charity Ridgley You're very welcome! I'm glad you found it helpful! :] To answer your question: yes. I do charge for tutoring. My rates on listed on my website under the "Tutoring" section found here: www.moofuniversity.com/tutoring Shoot me an email if you're interested in more details.

[@lololove999]

holy shit I love you

[@lololove999]

and your videos

[@manuelcouto2190]

ATENTION:
irreversable doesn't mean that the enzyme can't do it it means free gibbs energy is positive, so the reaction doesn't occur in nature in that way, so it was to follow a differten pathway...

[@wrath642]

This made no sense to me

[@varunpatel1006]

LMAOOO