Hey Moof! I just wanted to say thanks for contributing your time in order to help explain many of the ideas that are discussed for my upcoming final. Your videos were nice refreshers and they take my walls of text in my biochemistry book and turn them into short 15 minute videos. I like that you have pre-written information, it acts kind of like a quiz for me or to kind of understand where you plan on taking the subject. I really do appreciate the depth you go into!
I really thought that i would never understand this regulation of glicogen! But u show me the opposite!! I left my book,and u saved my life!!! Thank u!
Without your help I wouldn't understand and pass Biochemistry... Really Thank you Doctor Moof, you make life easier and I wish you an easy life as well.
Thanks a lot for making these videos! I have an exam tomorrow and this is reaaaaally helping me in understanding the whole mechanism. Keep making these aweeesome educational video !!
I enjoy your videos; they are simple then delve to detail.I shall look at more of them when i need the assistance. Thank you and keep up the good work.
Its relatively good it explained a lot of parts but u didn't mention the b and a form of GP plus after the phosphorilase kinase comes into action it converts forme b inactive (T) into forme a inactive (T) wish then transforms into form a active (R) and goes into the blood stream where it gets transformed into GP b active by phosphorilas of a syrine ( I take biochemistry in French do I might have wrote some terms in French sorry )
Wow, this series on glycogen was SO helpful. It was definitely easier to follow than the way my teacher presented it in class lecture. I'm taking the Intro to Biochem class at my university. Thanks for the help!
"minute 7" I think the covalent modification of glycogen phosphorylase by adding pi group doesn't play a role in converting the enzyme from T form to R form it just makes it little active or we can say"more ionic" with pi group and the enzyme still in T conformation. wrong?
Late, but I am pretty confident that he meant to say that the horizontal arrow=covalent and vertical=allosteric. This is because adding phosphate is always covalent.
So it seems that ATP both inhibits Glycogen Phosphorylase and activates phosphorylase kinase (which activates glycogen phosphorylase)? Isn't that counterproductive?
High ATP levels allosterically inhibit glycogen phosphorylase; yes. However, ATP does not activate phosphorylase kinase; ATP is simply used by phosphorylase kinase to attach phosphate groups to glycogen phosphorylase, thus activating glycogen phosphorylase. Subtle, but important to recognize.
"minute 7" I think the covalent modification of glycogen phosphorylase by adding pi group doesn't play a role in converting the enzyme from T form to R form it just makes it little active or we can say"more ionic" with pi group and the enzyme still in T conformation. wrong?
This is a completely helpful video. You made something that seemed confusing, so straightforward and logical. Thank you!!! :D
Well done
Lizz Ash Awesome! I'm happy you found that to be the case! You're very welcome! Thank you! :]
Hey Moof! I just wanted to say thanks for contributing your time in order to help explain many of the ideas that are discussed for my upcoming final. Your videos were nice refreshers and they take my walls of text in my biochemistry book and turn them into short 15 minute videos. I like that you have pre-written information, it acts kind of like a quiz for me or to kind of understand where you plan on taking the subject. I really do appreciate the depth you go into!
John Downing You're very welcome! I'm glad you liked them and appreciated their structure, and mostly, I'm glad they helped!
thanks! you just added to the amount of educational content in TH-cam and it made my job of studying much easier! :)
I really thought that i would never understand this regulation of glicogen! But u show me the opposite!! I left my book,and u saved my life!!! Thank u!
Without your help I wouldn't understand and pass Biochemistry... Really Thank you Doctor Moof, you make life easier and I wish you an easy life as well.
This video was so helpful! You made this extremely confusing concept so easy to understand! Much appreciation from two first year med students! :)
Thanks a lot for making these videos! I have an exam tomorrow and this is reaaaaally helping me in understanding the whole mechanism. Keep making these aweeesome educational video !!
Your vids got me through biochem I and now it looks like they're gonna get me through biochem II as well! Thanks so much! :D
Lifesaver! So easy to follow. Keep making biochem videos please!
Moof is the best!
I legit had no idea of what I was reading and then this helped a lot, thank you
i must say that these are the most helpful videos i have ever watched !
THANK YOU MOOF !
good job !
renanpumpkin Wow! Awesome, thank you for the kind words! I appreciate it, and I'm glad you've found the videos helpful!
its starting to make sense! thank you!
정리를 정말 잘하시네요!!!! 제 교수님보다 잘 가르쳐주시는것같아요!!
You are very very gooood at summarizing!!! You are better at teaching than my professor!!
YOU'RE A GENIUS, THANK YOU!
"Oh no, glucose is gone!" Lol, nice!
+Meshari AA
صح؟ عنجــــــــــــــــــــد
way better than my university lectures. thanks dude!
Awesome, great explanation, thank you :)
Love your videos!!!
Thank you so much! This makes so much sense now!
-Molly
I'ts 2016 and this video is so helpful, thank you so much for being awesome.
you're a real lifesaver, thank you
I enjoy your videos; they are simple then delve to detail.I shall look at more of them when i need the assistance. Thank you and keep up the good work.
fancytoxicsoda Sweet! I'm happy you like them! Thanks!
Its relatively good it explained a lot of parts but u didn't mention the b and a form of GP plus after the phosphorilase kinase comes into action it converts forme b inactive (T) into forme a inactive (T) wish then transforms into form a active (R) and goes into the blood stream where it gets transformed into GP b active by phosphorilas of a syrine ( I take biochemistry in French do I might have wrote some terms in French sorry )
that was a truly awesome video right there.
OmerRb btw do u have the diagram of thesyntase? is it just opposite?
Wow, this series on glycogen was SO helpful. It was definitely easier to follow than the way my teacher presented it in class lecture. I'm taking the Intro to Biochem class at my university. Thanks for the help!
Anh N Awesome! That's great to hear, and I'm happy it helped!
Nice video. It's clear and detailed
It is helpful to my biochemistry exam.
Thank you^^
"minute 7" I think the covalent modification of glycogen phosphorylase by adding pi group doesn't play a role in converting the enzyme from T form to R form it just makes it little active or we can say"more ionic" with pi group and the enzyme still in T conformation. wrong?
brilliant summary. thank you!
You're very welcome! Thanks for the kind words - and for watching!
Merci! Merci! Meci! Your the best!
Mia miry Je vous en prie. :]
really helpful
thank you
Thank you SO much!
thanks alot!!
i hope i can get access to these notes in a pdf link if you can post them that would be more helpful too!!
Your videos really helped! Thank you so much :)
Khatira Azimy Sweet! Happy to have helped! You're welcome!
Thanks , nice teaching
Really helpfull !
Řz
I think glucose acts as an allosteric modulator in the hepatic isoenzyme and ATP, Glu 6P and AMP acts on the muscle isoenzyme
It's a great help :) thank you :)
thaaaaank you finally i got it!!!! good job
aliki Androutsou You're welcooommmmmeeee! Haha!
Oh my God sir you make it sooooo easy thank you sir
love it , thank you .
Ahmad Gabar You're very welcome! I'm glad you love it!
this is amazing, thank you so much!!!
Morphine Morphine Sure thing, and thank you!
Thank you. Good videos. You do an awesome job. Try having some figures wherever possible as it helps in better understanding.
ontariojo Sounds coolio, dude.
thank you soo much it's really helpful :) regulation was very confusing before I watched the video great job (y)
i really appreciate your effort. this video really helped me a lot. thanks.
young lad Awesome! I'm glad I helped! You're very welcome!
so glucose can only act as an allosteric inhibitor of the PHOSPHORYLATED form of glycogen phosphorylase?
AMAZING! bs eza tzakarto fel imte7an dajawzak ;(
Gr8 vid. what program did you use in this video?
Stiaan Schoeman I used Smoothdraw 4 (free) to write/draw everything, and I used SnagIt ($50) to capture/record the screen.
Moof University Ok thx
Thank you- you are absolutely the best.ever
Do you think I can reach 90% in my exam?
Hi, I just want to confirm that when you said (@11:20)that both the vertical and horizontal arrows are allosterically regulated?
Late, but I am pretty confident that he meant to say that the horizontal arrow=covalent and vertical=allosteric. This is because adding phosphate is always covalent.
+Dib Gill nah it's all good. thanks!
in turkish,we say "adamsin" (meaning you are man!) when someone do something important and be helpful to the others..so "adamsın"!! :)
So it seems that ATP both inhibits Glycogen Phosphorylase and activates phosphorylase kinase (which activates glycogen phosphorylase)? Isn't that counterproductive?
High ATP levels allosterically inhibit glycogen phosphorylase; yes. However, ATP does not activate phosphorylase kinase; ATP is simply used by phosphorylase kinase to attach phosphate groups to glycogen phosphorylase, thus activating glycogen phosphorylase. Subtle, but important to recognize.
Active by epinephrine or glycogen
Holy shit that was amazing
I love you
I just don't understand how he writes so neatly with a mouse.
"minute 7" I think the covalent modification of glycogen phosphorylase by adding pi group doesn't play a role in converting the enzyme from T form to R form it just makes it little active or we can say"more ionic" with pi group and the enzyme still in T conformation. wrong?