Gluconeogenesis from lactate, glycerol, propionyl coA and glucogenic amino acids and Regulation

📌 𝐅𝐨𝐥𝐥𝐨𝐰 𝐨𝐧 𝐈𝐧𝐬𝐭𝐚𝐠𝐫𝐚𝐦:- / drgbhanuprakash
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Gluconeogenesis from lactate, glycerol, propionyl coA and glucogenic amino acids and Regulation
Gluconeogenesis is the process of synthesizing glucose from noncarbohydrate precursors.
The major substrates are the glucogenic amino acids, lactate, glycerol, and propionate.
The liver and kidneys are the major gluconeogenic tissues.
Glucocorticoids and glucagon-stimulated cAMP induce synthesis of key enzymes of gluconeogenesis.
Hexokinase, phosphofructokinase, and pyruvate kinase are the steps in glycolysis differing from gluconeogenesis. These steps are replaced by glucose-6-phosphatase; fructose-1,6-bisphosphatase; and a combination of pyruvate carboxylase and PEP carboxykinase, respectively.
No cell in the human body can have both glycolysis and gluconeogenesis working alongside each other because of the opposing hormonal and allosteric regulators of these cycles.
PFK-1 is allosterically activated by a high concentration of AMP and ADP, but the most potent activator is fructose-2,6-bisphosphate.
PFK-1 is inhibited by glucagon through repression of synthesis and by citrate and ATP.
Glucagon-stimulated cAMP-dependent protein kinase inactivates phosphofructokinase-2 and activates fructose-2,6-bisphosphatase by phosphorylation.
Insulin-mediated increase in fructose-2,6-bisphosphate activates phosphofructokinase-1 and inhibits fructose 1,6-bisphosphatase.
Glucokinase-regulatory protein (GKRP) maintains an inactive reserve of glucokinase. This glucokinase reserve is used in response to increasing levels of portal vein glucose, favoring glycolysis.
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[@varshayadav6650]

Simplyyy amazing explained very clear n easy explanation🙌❤️

[@madhuuppara7381]

Thanks a lot sir hope u upload more lectures of biochemistry ❤

[@astaghfirullah10000]

Brilliant !

[@utetemaphosa6294]

Dr Jain thanks so much,i guess its a great injustice to you wisdom to just express gratitude to your clear to the point teaching in all the teachings. Thanks so much

[@doctorbhanuprakash]

You are most welcome

[@nafsinbelay957]

Thank you so much it helped a lot.

[@abdulbasitghauri8934]

Mitochondrial membrane is impermeable for O.A.A so it converts to Malate and Malate shifts toward Cytosol because mitochondrial membrane is permeable for malate and there it converts to O.A.A.

[@bae3m4n]

this exact point is the entire reason why im watching these videos, and NO ONE mentions it

[@iceking7045]

All video on youtube that goes in depth on this stuff. Thank you.

[@irumbibi4157]

Sir ya oxaloacetate Kaisa direct mitochondria sa bhair nikla hum na too parha hai ka membrane of mitochondria Jo wo impermeable hai for oxaloacetate and oxaloacetate first convert into malate inside mitochondria and then come out to the mitochondria membrane and then convert to pyruvate

[@-sb3qf]

You have studied right

[@user-db7kt9iu3k]

Malate

[@medicogems1684]

Wow crystal clear❤️…

[@gursikhichannel7282]

Thanks sir

[@doctorbhanuprakash]

Welcome

[@shreerajpaudel8257]

fructose 1,6 bisphosphatase or fructose 1,6biphosphatase
i found f 1,6 bisphosphatase in book???????

[@malikishfaq9541]

❤❤❤

[@shreerajpaudel8257]

where can i get notes