Hepatitis E: What should a nephrologist know? - Prof. Nassim Kamar, Toulouse, France

For stage 2 of our Tour Académique 2024, Prof. Nassim Kamar discusses novel approaches in diagnosis, prevention and treatment of hepatitis E - with a particular focus upon nephrological patients.
Nassim Kamar (MD, PhD) is Professor of Nephrology. He is head of the Department of Nephrology and Organ Transplantation of Toulouse University Hospital in France. His particular interests are viral infection, particularly hepatitis E virus, hepatitis C virus, and cytomegalovirus infections that develop after solid organ transplantation, as well as immunosuppressive therapy in heart, liver, kidney, and kidney-pancreas transplant patients.
The interview was recorded on April 29th, 2024.
Moderators: Prof. Dominique Guerrot (Rouen, France) and Prof. Dr. Gunnar Heine (Frankfurt, Germany).
Articles discussed:
Executive Summary of the KDIGO 2022 Clinical Practice Guideline for the Prevention, Diagnosis, Evaluation, and Treatment of Hepatitis C in Chronic Kidney Disease.
Martin P, Awan AA, Berenguer MC, Bruchfeld A, Fabrizi F, Goldberg DS, Jia J, Kamar N, Mohamed R, Pessôa MG, Pol S, Sise ME, Balk EM, Gordon CE, Adam G, Cheung M, Earley A, Jadoul M
Kidney Int 2022
doi: 10.1016/j.kint.2022.07.012
Hepatitis E virus (HEV)-specific T-cell responses are associated with control of HEV infection.
Suneetha PV, Pischke S, Schlaphoff V, Grabowski J, Fytili P, Gronert A, Bremer B, Markova A, Jaroszewicz J, Bara C, Manns MP, Cornberg M, Wedemeyer H
Hepatology 2012
doi: 10.1002/hep.24738
EASL Clinical Practice Guidelines on hepatitis E virus infection.
European Association for the Study of the Liver. Electronic address: [e-mail]; European Association for the Study of the Liver
J Hepatol 2018
doi: 10.1016/j.jhep.2018.03.005
Hepatitis E virus antibody prevalence in hunters from a district in Central Germany, 2013: a cross-sectional study providing evidence for the benefit of protective gloves during disembowelling of wild boars.
Schielke A, Ibrahim V, Czogiel I, Faber M, Schrader C, Dremsek P, Ulrich RG, Johne R
BMC Infect Dis 2015
doi: 10.1186/s12879-015-1199-y
Pig liver sausage as a source of hepatitis E virus transmission to humans.
Colson P, Borentain P, Queyriaux B, Kaba M, Moal V, Gallian P, Heyries L, Raoult D, Gerolami R
J Infect Dis 2010
doi: 10.1086/655898
Conventional and innate lymphocytes response at the acute phase of HEV infection in transplanted patients.
Abravanel F, Barragué H, Dörr G, Sauné K, Péron JM, Alric L, Kamar N, Izopet J, Champagne E
J Infect 2016
doi: 10.1016/j.jinf.2016.02.016
Characterization of the Specificity, Functionality, and Durability of Host T-Cell Responses Against the Full-Length Hepatitis E Virus.
Brown A, Halliday JS, Swadling L, Madden RG, Bendall R, Hunter JG, Maggs J, Simmonds P, Smith DB, Vine L, McLaughlin C, Collier J, Bonsall D, Jeffery K, Dunachie S, Klenerman P, Izopet J, Kamar N, Dalton HR, Barnes E
Hepatolog 2016
doi: 10.1002/hep.28819
Long-term efficacy of a hepatitis E vaccine.
Zhang J, Zhang XF, Huang SJ, Wu T, Hu YM, Wang ZZ, Wang H, Jiang HM, Wang YJ, Yan Q, Guo M, Liu XH, Li JX, Yang CL, Tang Q, Jiang RJ, Pan HR, Li YM, Shih JW, Ng MH, Zhu FC, Xia NS
N Engl J Med 2015
doi: 10.1056/NEJMoa1406011
Efficacy and safety of a recombinant hepatitis E vaccine in healthy adults: a large-scale, randomised, double-blind placebo-controlled, phase 3 trial.
Zhu FC, Zhang J, Zhang XF, Zhou C, Wang ZZ, Huang SJ, Wang H, Yang CL, Jiang HM, Cai JP, Wang YJ, Ai X, Hu YM, Tang Q, Yao X, Yan Q, Xian YL, Wu T, Li YM, Miao J, Ng MH, Shih JW, Xia NS
Lancet 2010
doi: 10.1016/S0140-6736(10)61030-6
Nepali earthquakes and the risk of an epidemic of hepatitis E.
Basnyat B, Dalton HR, Kamar N, Rein DB, Labrique A, Farrar J, Piot P; 21 signatories
Lancet 2015
doi: 10.1016/S0140-6736(15)61110-2