You're the best - I was in a full on panic over STEP 1 and now I feel like I actually understand material rather than just memorizing little pieces of information after watching several of your videos! Wish I would have found them months ago - will definitely be recommending your program and videos to my MS1/MS2 mentees!
i have a question about 56:42 . Extravascular hemolysis is showing autoimmune hemolytic anemia in the flow chart but on 58:42 the question is showing low haptoglobin and as you mentioned intravascular hemolysis. the answer is coombs positivity and autoimmune hemolytic anemia? so is autoimmune hemolytic anemia also in intravascular hemolysis as well ?
I have a question about pernicious anemia. Within the question, it didn't mention nervous system symptoms. I understand that the patient had a preexisting AI condition, but would we automatically go to PA over folate deficiency without the nervous system symptoms?
Great question - the neurologic symptoms while common are sometimes seen in severe B12 deficiency. You are correct about the autoimmune stigmata in the question. Folate deficiency may have more of a tea-toast/lack of adequate nutrition within the vignette. Just given the most likely cause in an autoimmune patient (she had hypoT4 & Addisons) the best answer here would be pernicious anemia. However your through process is correct! Hope this helps!!
Thank you for all your amazing videos! Quick question at 58:16, although we know the patient is infected with mycoplasma pneumoniae and we see the positive indirect coomb's test causing AIHA, why does the patient have low haptoglobin? Didn't the slides prior say that AIHA is an extravascular hemolysis --> splenomegaly while intravascular hemolysis pathologies lead to low haptoglobin which is described in the vignette?
Hey Brian!! Thanks so much: Cold-sensitive antibodies (cold agglutinins): mostly IgM antibodies cause extravascular hemolysis and acute intravascular hemolysis. Warm-sensitive antibodies (warm agglutinins): polyclonal IgG antibodies that then bind to multiple RBC antigens. Binding of the antibodies leads to ↑ extravascular hemolysis. Hope this helps! Sorry for any confusion!
Thank you very much for your effort to support us…dr I would like to say some of the notes contents are hidden by your video ..would you mind making it on opposite side or free areas?🙏🏼
Hello there i just had a question, at 29:57 why is the answer not B, this is my logical thought, splenectomy suggests asplenia which suggests increased basophillic nuclear remnants like Howell-Jolly bodys - clusters,
HI doctor Rahul, I don't understand, you and the First Aid both say low haptoglobin is a characteristic of intravascular hemolysis but in the question about AIHA and Mycoplasma it says the patient has low haptoglobin and AIHA is a extravascular hemolysis and you said haptoglobin is normal in extravascular hemolysis. Can you please explain that part?
Thanks Emmanuel, Low haptoglobin levels are typically associated with intravascular hemolysis, which occurs when red blood cells break down in the bloodstream. However, in the case of autoimmune hemolytic anemia (AIHA), which is an extravascular hemolysis, low haptoglobin levels can also occur. This is because in AIHA, the immune system targets and destroys red blood cells in the spleen and liver, leading to the release of hemoglobin into the bloodstream. This free hemoglobin can bind to haptoglobin and be removed from the bloodstream, leading to low levels of haptoglobin. So while low haptoglobin is more commonly associated with intravascular hemolysis, it can also occur in certain cases of extravascular hemolysis like AIHA. The context will be important and USMLE will be very explicit! Sorry for any confusion!
@elite medical tutor why are u even here? we get that you're a tutor and im sure you make mistakes aswell but its not cool for you to keep nip picking at everything thats being said
Hi Dr! I have been trying to E mail u for tutoring and notes.... I know you must be super but please respond when you get a chance!! Just writing here in case it went to your Email spam folder.... thanks so much!!
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You're the best - I was in a full on panic over STEP 1 and now I feel like I actually understand material rather than just memorizing little pieces of information after watching several of your videos! Wish I would have found them months ago - will definitely be recommending your program and videos to my MS1/MS2 mentees!
What are you using of his ?
did u pass usmle?
I take my boards in a week and you're helping a lot to coalesce important concepts. Keep doing what you're doing!
Great to hear! Best wishes!
did u pass it?
20 days for step 1, and i found your videos really helpful, really quick go tapping on important topics and esp. how to approach question . thanks :)
Blood science is truly fascinating.
Amazing amazing! Seriously , one of the best summarys that I have seen
Your channel is a hidden gem! Glad I found it. Keep up the good work!
Thank you so much Dr. As always the NBME topics are extremely helpful . You are very much appreciated for all you do .
this video is perfect! after so many searches finally i found some good videos 😊👍🏻👏🏻
thank you for watching!!
@ thank you too for sharing your good knowledge 😇🙏🏻
Thanks sir, i belong to a very poor family I can’t buy subscription of anyone and you clear my concept🙏🏻❤️
Wow! Incredible depth and integration.. thank you!
best platform for integrated learning
eagerly waiting for the leukemia session. This was super helpful, thanks!
Its this weekend :)
@@hyguruprep I can’t seem to find it :( Also thank you for these amazing videos!
Outstanding presentation
This is Great for future Doctors.
Very informative
hello, thank you for your efforts.
You are welcome
Haematology is a very interesting subject for Doctors.
i have a question about 56:42 . Extravascular hemolysis is showing autoimmune hemolytic anemia in the flow chart but on 58:42 the question is showing low haptoglobin and as you mentioned intravascular hemolysis. the answer is coombs positivity and autoimmune hemolytic anemia? so is autoimmune hemolytic anemia also in intravascular hemolysis as well ?
Same question
did you get the answer? I am still confusing this point
I have the same question
Hello!! Just starting my journey with you.
I have a question about pernicious anemia. Within the question, it didn't mention nervous system symptoms. I understand that the patient had a preexisting AI condition, but would we automatically go to PA over folate deficiency without the nervous system symptoms?
Great question - the neurologic symptoms while common are sometimes seen in severe B12 deficiency. You are correct about the autoimmune stigmata in the question. Folate deficiency may have more of a tea-toast/lack of adequate nutrition within the vignette. Just given the most likely cause in an autoimmune patient (she had hypoT4 & Addisons) the best answer here would be pernicious anemia. However your through process is correct! Hope this helps!!
Thank you for all your amazing videos! Quick question at 58:16, although we know the patient is infected with mycoplasma pneumoniae and we see the positive indirect coomb's test causing AIHA, why does the patient have low haptoglobin? Didn't the slides prior say that AIHA is an extravascular hemolysis --> splenomegaly while intravascular hemolysis pathologies lead to low haptoglobin which is described in the vignette?
Hey Brian!! Thanks so much:
Cold-sensitive antibodies (cold agglutinins): mostly IgM antibodies cause extravascular hemolysis and acute intravascular hemolysis.
Warm-sensitive antibodies (warm agglutinins): polyclonal IgG antibodies that then bind to multiple RBC antigens. Binding of the antibodies leads to ↑ extravascular hemolysis.
Hope this helps! Sorry for any confusion!
Suggested errata:Fe and ferritin would be normal in thalassemia;hereditary spherocytosis has negative direct Coombs.
Ty for the high quality lecture
thanks so much for your love and support 🥹
very high quality content. keep at it.
thank you ,for the very helpful video
Thank you very much for your effort to support us…dr I would like to say some of the notes contents are hidden by your video ..would you mind making it on opposite side or free areas?🙏🏼
This is very helpful !!!! Thanks❤️❤️❤️❤️
You are the best ❤
Hello, Rod from South Carolina
Hello there i just had a question, at 29:57 why is the answer not B, this is my logical thought, splenectomy suggests asplenia which suggests increased basophillic nuclear remnants like Howell-Jolly bodys - clusters,
My bad, ijust realised the histology photo is not consistent with the answer being clusters of remnant DNA, the target cell is more likely
Thank you so much for such a wonderful video...
Hello, I'm from South Sudan
Sir extremely helpful lecture .thanks alot .
Thanks dr
Thank you so much
Learnt a lot.
Hi from Texas
Hello sir bundles of thanks
Thank you!
Doc if 58:34 is an AIHA how come you calling it an intravascular anemia ? Isnt AIHA an extravascular anemia ?
Hello from Pakistan
waiting for the leukemia video eagerly!!
Thank you so much 🙏🔥
You're welcome 😊
Anyone know where the leukemia video is?
Hello! Rashmi from Massachusetts.
HI doctor Rahul, I don't understand, you and the First Aid both say low haptoglobin is a characteristic of intravascular hemolysis but in the question about AIHA and Mycoplasma it says the patient has low haptoglobin and AIHA is a extravascular hemolysis and you said haptoglobin is normal in extravascular hemolysis. Can you please explain that part?
Thanks Emmanuel, Low haptoglobin levels are typically associated with intravascular hemolysis, which occurs when red blood cells break down in the bloodstream. However, in the case of autoimmune hemolytic anemia (AIHA), which is an extravascular hemolysis, low haptoglobin levels can also occur. This is because in AIHA, the immune system targets and destroys red blood cells in the spleen and liver, leading to the release of hemoglobin into the bloodstream.
This free hemoglobin can bind to haptoglobin and be removed from the bloodstream, leading to low levels of haptoglobin.
So while low haptoglobin is more commonly associated with intravascular hemolysis, it can also occur in certain cases of extravascular hemolysis like AIHA. The context will be important and USMLE will be very explicit! Sorry for any confusion!
@@hyguruprep thank you so much for taking the time to answer my question, your videos are great and are helping me a lot 🤗
Start at 2;05
Sure
AIHA is extracellular hemotysis ,,,,,, then how come u included in intravascular ( low haptoglobinuria) …?…??
USA Florida
i want you to mentor me one on one for a year for step one. Please let me know where to start
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How to enroll for your session ?
Hi! Please feel free to enroll at hyguru.com [I also have an email list and update my website for my Zoom/TH-cam live sessions!] Thanks!
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@elite medical tutor why are u even here? we get that you're a tutor and im sure you make mistakes aswell but its not cool for you to keep nip picking at everything thats being said
Hello
Pakistan
Hi Dr! I have been trying to E mail u for tutoring and notes.... I know you must be super but please respond when you get a chance!! Just writing here in case it went to your Email spam folder.... thanks so much!!
Hi Sonia, feel free to send another email or reach out via my Instagram @hyguruprep -- thanks!
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