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- เผยแพร่เมื่อ 25 ก.ย. 2024
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Sometimes, potential new disease treatments turn up in some unexpected places... like potatoes.
Hosted by: Hank Green
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I kind of love it when people present research published in the Proceedings of the National Academy of Sciences.
Cuz they have to be VERY careful to spell out the acronym letter... by... letter.
Wait! Potatoes are hiding in me with those elusive medicines?
I just made my first speech and college paper and it was on bananas. In fact your video on bananas a while back gave me the idea. 😂 Thanks for giving me the key to the banana empire.
Aint nature amazing? Alot of our ideas come from it, gotta love it!
Plagiarism is discouraged but bio mimicking is encouraged. It is the greatest thing ever!
Litteraly! Our ideas physically come from nature! (Neurones)
@@JabranImran Humans arent nature, they are cancer to the planet... Remember this seemingly ominous yet insignificang monologue... You'll be seeing me in 20 years...
A lot*
@@girla9480 or Allot
My favorite color is green
Ditto
Ditto
🌈#YOU RED #YOU🏳️🌈
@@RandomUnited what's ditto?
I come to learn, I come to understand.
Did you?
Both news items were intriguing but you really piqued my interest when you said that we may have a possible solution to the plague that Candida albicans is. I hate that thing with passion.
Yeast infection?
@@allykat5899 but much more general. it can effect the whole body and is treated in alternative medicine with diet/
@@kathysmith6413 okay
Yyeeeahh.
We _do_ have several effective antimycotics already tho with how common yeast infections are among the immunocompromised and/or elderly (even just among young people with or without preexisting risk factors such as diabetes etc.)
Ya gotta love PNAS and Dickeya!
I remember when an antiviral was proposed that would defeat basically any virus that produces long strands of double-stranded RNA called DRACO. Sadly, that’s been slow-moving as it requires effectively modifying intra-cellular viral immune responses which requires a fair bit of gene editing. Some viruses like retroviruses (HIV and Herpes are two biggies) are basically unaffected by it so it’s not full-spectrum, just broader than most.
DRACO does not require any gene editing. It's just a protein that triggers the cell death mechanism in the presence of dsRNA. You could genetically modify an organism to produce DRACO (it has been done with human cells invitro) but it can also be delivered as a drug as it was when it was tested on mice.
It is not effective against retroviruses while they are dormant / not replicating since they are not producing dsRNA.
there is a New Zealand company Kimer Med that has picked it up that is interested in commercialization. They have seed funding at least (a few million). It is frustrating how slow the pace has been.
@@Unifrog_ is it going to make me alien?👽💀
@@demonslayer4951 Wouldn't it be a dragon or snake and not an alien if you think the name of a drug had anything to do with what a drug does? Draco means dragon/snake in Latin. You would need a drug named Xeno-fin or something to get to aliens. I know you are joking but it is kind of sad if the reason the drug has had so much trouble getting funding is that it has a silly name that has existing associations rather than something completely made up that isn't linguistically linked to anything.
v=4KG3v365mq4
@@ArawnOfAnnwnI can only speculate as to why. I think the pace of development was pretty fast while Dr Rider was working on it at MIT, he did test it against a variety of cell types and a variety of viruses and nothing I have been able to find shows anything other than it exceeding expectations in terms of its effectiveness and low toxicity. But there is a point where academic funding dries up.
At that point I think Dr Ryder went from being the talented academic to a liability in that he controlled 2 of the patents (the other being owned by MIT) but was not interested in giving away any amount of equity in his invention. Instead of seeking out investors or even talking to investors who where interested he setup a foundation and started begging for money offering nothing to anyone in return other than further research which is great and all but but it isnt even a good fit for a indigogo/kickstarter since drug development takes years and tens of millions which is really only money you can raise by offering something in return.
There are other things you could speculate on. I mean the reason drug development costs tens of millions is because long term animal and human trials are not cheap and they are important to discover issues that might lead to a drug not being commercially viable. Some questions that need to be answered that have not been answered are whether the particular proteins involved are stable and under what conditions (how long to they last under different temperatures and how pure can they be made in the first place) also it is unknown whether there will be a long term immune response after longer term repeated dosages. But to find out you need funding and to get funding you need investors willing to take the risk which is a much harder sell with a completely novel drug.
I think things have picked up now because Dr Riders patents have elapsed leaving only the MIT patent which is licensed to Kimer Med. Although an Iranian and a Chinese university have shown its effectiveness against H1N1 and porcupine Respiratory syndrome independently invitro between Ryder giving up and Kimer Med coming onto the scene.
I would love to be able to sit down with Dr Rider and ask him why he didn't offer an equity investment when it was in my opinion clearly time to partner up with a company and take it out of an academic setting.
@@Unifrog_ insightful input. What got you so interested in this thread of research? Also your profile pic is creepy af 😂
I think the titlecard would be funny if the magic in the doctor's hands was an excel spreadsheet instead of a cool-looking UI
hello Hank. You have my sympathy and best wishes over your having cancer as shown in a news story by The New York Times. I am relieved to know your cancer is easily treated. I hope to learn you are in remission and doing well. Please continue your part in making SciShow. I enjoy watching
Thank you Hank! You and Olivia are my favorites. Thank you for making learning so fun and interesting!
I hate to be a downer, but you probably know that Olivia left a few years ago. For a while I kind of dismissed SciShow because I liked other channels' graphics and B-roll, but I've come to re-appreciate SciShow's concise style.
@@eaterdrinker000 oh bummer! What other channels do you like?
You will love john (hank's brother) the author of the fault in out stars . vlogbrothers is the channel name you will find it fun . kurgezest is also great for science with great animation😀
@@ravineshsingh3033 did you mean kurzgesagt? I can’t find kurgezest.
@@mrbfros454 yes and also minute physics . yup kurzgesast in a nutshell .
Even the commercials on this channel are informative.
Hank! I have to say, you and the rest of the SciShow crew reignited my passion for science, and expanding my knowledge.
You had me at potatoes
Another big load a potatoes ! lol :)😀
you always bring us hopeful news! ✌️
Awesome science! Thanks for getting us excited about these wonderful developments :D
Thats why i feel immortal!! Potatoes!!
I like potato’s, I’m glad they’re being protected
Very interesting, thanks for sharing 😊
Thank you
I always knew that spuds would be the salvation of us all!
It would be funny if this whole time immortality is something we all can do and it isn't something like the fountain of youth kind of thing
I mean, lets be real, it already is likely that the answer is in us.
I like this line of thought. A deeply held secret carried by us all. Only problem is see with it is, they’ve already sequenced all of our genes. So where is it hiding? My guess: the telomeres! But who knows.
It’s be nice to one day get to a point where herb/pesticides would be manufactured from a plant defense system derived bacteria, instead of chemicals made in a lab
A small suggestion: 4:32 if there is a short description on which disc is indicating the interested antibiotic would be much easier to understand for general audience. 👍
Even having taken micro 1 & 2 (I mean entry level but still) that slide confused the heck out of me. For one thing, where’s the controls?
@@StratospheralNurse I think, usually these kind of experiment involve more than one standard strain of bacteria, so they would need to show a second image. Which may not be possible.
Has Stephen Colbert heard about this? (Is Potato...)
I would recommend a book by Neil Shubin "Your Inner Fish - A Journey into the 3.5 billion year History of the Human body".
Brilliant
Mentions potatoes in the video:
*Samwise Gamgee would like to know your location 🥔
Pretty interesting, smart content hank🧠🧠💯💯❤❤
2:08 it sounds like this makes it so the body's RNA is no longer able to be identified as its own I think that means if this is turned into a drug that it will cause autoimmunity (the body attacking itself for those who don't know)
Unless there is redundancy in the system, which is not uncommon. If the body can recognize its own RNA in multiple ways and only needs one, then this treatment has a lot of potential!
Fingers crossed it doesn't just wreak havoc 🤞
It seems to me that the scientists' intervention heightens the cell's immune response, which makes the cell better able to identify the virus. It is as if the cell is saying "something is wrong! Let's be on high alert and do a thorough search in here." It does not seem to me that the cell will target its own RNA.
@@lia_yin-herr well to me it sounded like it triggered an immune response less "let's do a steak out" and more "put your hands in the air this is a raid!"
(Idk no argument whatsoever I hope u have a nice day:)
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first
Please, sincerely, learn how to pronounce "fungi". I have never seen anyone mispronounce it so badly before and as an educational platform, you should sort that out.
@@___Zack___ when he sees people say "funjai"
Very interesting video! Hopefully, this will help scientists and researchers to understand and create new antibiotics in the future!
My oncologist discovered that I’m missing 2 proteins in my DNA, which goes a long way to explain my complicated medical history. I would Love a video on genetic disorders. I know that there’s not a lot of information out there, but what is available requires a PHD to understand. My condition is so rare that it doesn’t even have a name yet, but if a video is possible, I’d be infinitely grateful!
*🔝🔝Hello you've been selected amongst our shortlisted winner for a prize! 🏆🏆 message number above ”"🥳🎁🎁
This show renews my faith in humanity and hope for the future. It's nice to know there are still smart people out there working on serious problems, and not spending research grants on dumb s*** like studying the effects of cocaine on pigeons. Or trying to prove that people who like gin are antisocial.
Anyone else think Hank called the bacterium "tequila salami"?
My entire food pyramid in one bacterium
It's in the best journal of all P.N.A.S, generally pronounced peanuss.
I did NOT have "potential cure for the common cold" on my 2022 bingo sheet and I am VERY pleasantly surprised!
The mighty bacteria save humanity once again.
The best SciShow title ever
Lovely video it has been long b4 i had such
Awesome news
mine has allready been actived in my imnue sistem antibodys when i had the chicken pox
Nice nod to I'mectin being a soil-born discovery
Hmmm interesting. I have hidradenitis supperativa which is believed to be overproduction in sebaceous glands, which triggers macrophages to accumulate, destroy the bacteria and cause skin craters. M1 macrophages are generally activated by interferon gamma. I have taken my ancestry DNA results and sequenced them on a site I used in grad school which found a risk allele for MTHFR, which transfers a methyl group to folic acid to make L-methyfolate. I wonder if this is why I always have chronic inflammation not just as part of HS but also in my sinuses (although I know other factors also contribute, like I have greater number of histamine H1 receptors and lesser ability to break down histamine)
I dunno how effective the interferone treatment would be in an actual patient. IFNs usually work as a targeted cellular response to the presence of viruses causing an arrest to cellular replication in the vicinity so the virus is limited in reproduction.
If this drug doesn’t actually interact with specifically virus infected cells but much rather causes a general IFN increase, then I feel like mechanistically that would just lead to overall decreased cellular replication which cannot be too good for any usually fast-reproducing tissue (such as the intestinal lining etc.). At that point it would just be some form of mild chemotherapy kinda
*🔝🔝Hello you've been selected amongst our shortlisted winner for a prize! 🏆🏆 message number above ”"🥳🎁🎁
The broad news antiviral sounds pretty risky, as messing with RNA metilation changes protein synthesis a lot, and if the effect lasts the side effects could be pretty drastic
Cranking them out lately thanks hank!
Neat
What a great title👍
So great news for potatoes then... :P
So it's expensive for the bacteria to produce this miracle chemical. Curse those greedy bacteria pharmaceutical companies!
Dickeya and PNAS. That's all I got from this one. I'm waiting for the headline when they discover a fungi on Uranus.
The past of "to lead" is led, not lead like the element
*🔝🔝Hello you've been selected amongst our shortlisted winner for a prize! 🏆🏆 message number above ”"🥳🎁🎁
At last, it's the potato episode!! (Just checking whether the overlap of Horne Section Podcast fans and SciShow comment readers is nonzero.)
Potatoes saved billions from starvation, and now will save even more from disease...truly remarkabe.
Shout out to Antoine-Augustin Parmentier for popularizing them in France. People weren't catching on so uh (taken from the web) "Later, he turned his attention to the poorer classes. He had an excellent idea on how to popularize potatoes among the working class. The king gave him two acres of land to grow the crop for human consumption. He placed armed guards on his fields and instructed guards to accept bribes and let people to “steal” potatoes. He would leave his fields unguarded at night so that the locals could creep in and steal the crop". TL;DR they seemed FANCY
@4:17 huh, my girlfriend uses that phrase alot.
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If we have an universal anti virus med we or any other microbe we could use a modified version of that to cure alot of diseases, like if we had a a handful of viruses that replace or support the immsystems functions.
Especially since it's coming to light that many diseases not obviously connected to viral infections are caused by or at least drastically made more likely after viral infections.
#protectthepotatoes
When does the video come out about the massive rise in SADS?
DOPE! there appears to be a decent amount of science going 'back' to old theories or ideas or studies that have been 'debunk'd. That might be a great idea for a video. Just read an article about the idea dementia and schizophrenia being linked has been re-examined recently. I def think we missed a lot over the years because we didn't have the tools to prove/disprove at the time. It's always good to go back and reexamine our assumptions and see if they still hold up.
*🔝🔝Hello you've been selected amongst our shortlisted winner for a prize! 🏆🏆 message number above ”"🥳🎁🎁
Welcome to science, where "does it still hold up?" is one of the basic rules of the scientific method! (I love the rechecking old stuff and finding out stuff WAS there, just not always in the way that was theorized and tested out. Like Lamarck's evolution theory being a thing-- as epigenetics!
I may be wrong but isn’t the singular of “many bacteria” “one bacterium”?
If I could improve the human immune system, I'd give various parts of the body email. It seems that there are parts of the body that do incredibly well with pathogens, while other parts are pretty weak in comparison.
Think about it, every day, surgeons across the globe operate on areas that are decidedly unclean. Think hemorrhoid surgery or episiotomies. Sure, they do their best to cleans the area, but it's never going to be perfect and recovery can take a few weeks. Yet complications are fairly rare. Expose a wound on your arm to that type of bacterial load and it's a very big deal. Maybe something like email would help...
Actually, on second thought never mind. Once they start using email, PowerPoint isn't far behind.
go back to 1996 and use the Windows XP manual to slice your falanges off
Save the bananas! With potato bacteria?
you're telling me when scientists specifically design a solution to a problem it only solves that problem?
mind = blown
It just goes to show, you never know what living thing could change the future in dramatic ways. Every species that goes extinct is a potential lost secret of the world.
Cool.
But wouldn't disabling RNA methylation make the cells vulnerable to the immune response?
Potatoes? I just think they're neat.
💙
💙
😍👉🥔
Could you guys please tell us we don't need to be afraid of Acanthamoeba? If it is so commonly found why are infections so rare?
I hope that aging science makes some more strides, because the world would be a better place if Hank Green could stay here until the solar system collapses.
Now that's a catchy title; I couldn't help but to click!
Dude you missed a button 😂
Why doesn't the bacterium secrete the fungicide constantly? It has to be careful of resources, yes, but remember that fungi also release antibacterial compounds like, oh, penicillin and tetracycline. This arms race has been going on for hundreds of millions of years, and the more you use a particular weapon, the quicker your enemy can come up with a way to thwart it.
#savethehashbrows
I need to know why river curve? Is there a reason is this how little lakes are made. Can you tell me the answers
@@AndrewTBP I have I just never noticed this particular topic I'll have to look in there videos more thank you 😊
Go Go Sci Show!
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Potatoes are always the answer
Dickeya Solani makes beautiful watches. 🤩
So we found a button to manually trigger our immune system
Wouldn't tricking our cells into thinking ALL loose RNA are pathogens risk causing severe autoimmune disorders or allergic reactions?
Wonder what the side effects of the anti-RNA methylation therapy could be :'(
I like potatoes.
Does this mean we must sacrifice people to the potato god to heal the nation? I'll get the macahuitl...
Cool
And it could also results to immune response disorder in the body complicating the natural immune system of your own body
Lmao true
Can we call potato bacteria tater tots?
Thyme
Idk if it's just me but I've been following you for years and these days you seem a lot more stressed to get through this script, not just this episode. I miss seeing bits of your personalities. I'll always love your content though.
I swear I just saw one where he made like three dad jokes in a row lol, It might have been Bizarre Beasts though, or Journey to the Microcosmos, the man has to many channels. Point being, I think he's fine. And you should definitely watch Scishow Tangents if you aren't already, It'll give you what you're looking for.
@@mayaenglish5424 yeah i follow everything Hank and John does, Hank's amazt
@@mayaenglish5424 thank you for telling me about one of the channels I was missing!
@@neoqwerty No problem! You can find a more complete list at Complexly!
When your solution to a virus is to create a brand-new autoimmune disease...
im sure this wont spike autoimmune conditions.....
RNA methylation?!
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So if you get thrush, rub a manky potato on yer bits.
BTW, I am not a doctor.
That would be medical breakthrough. Just like antibiotics themselves. I’m a nurse in haematology and the patients don’t have immun systems and the only viral prophylaxis we can do is aciclovir which is only for herpes virus. Thins could save them from so many infection
Chicken pox, shingles, hsv1 and hsv2, and on occasion epstein-barr virus.
Also tons of misspellings..
@@sethbieber5127 nah not really. it might help a little but its really just for hsv.
Also im from Germany and I wrote it being stoned lol
There are potatoes in me? So that's where those goddamned englishmen hid them.
New antifungal… is potato.
Thanks. Solanimycin: sounds like the name of a crappy pop star whose music I would hate. tavi.
Button all your shirt buttons Hank! Or I'm not watching this show no more!
From Whatsapp to Facebook? Boo those are owned by the same company that's like saying your kitchen has everything, from a fridge to a freezer
You missed a button on your shirt