Korsmeyer Peppas Model Fitting of Drug Release Data | Calculation of Parameters

Calculation of Diffusion Constant, Diffusion Exponent

[@hrushikeshjoshi7816]

Thank you.This would be very precise method to calculate the constants cor PK Model.

[@mayurbiotech1657]

Millions of thnks for this awesome video i hv to fit my release data 🙏

[@dr.q.9174]

This was awesome, thank you.

[@aradhana41]

Thanks alot, very useful

[@elenamunoz4571]

this was very useful, thanks !

[@bio2shameer]

Thank you for the explanation

[@saloninarula1761]

👌👌well explained
,Plz also explain the n values and their release pattern based on geometry.

[@17fernandobarros]

Great job!

[@doaaadam7319]

how to find the K and N, PLEASE?

[@ojamemed1842]

Amazing explanation Thank you :)

[@meilabnitrourkela5314]

Glad you liked it

[@antocharles4203]

Great, thanks

[@OmarEldemiri]

Thank you very much

[@alexandra1234]

Please, can you explain how can we fit to a Higuchi model? Thanks for your help!

[@meilabnitrourkela5314]

Higuchi model is a limiting case of KP model when n=0.5.

[@priyankameena6451]

Sir, plot must be between log(release%) vs log (time)

[@meilabnitrourkela5314]

Log is taken when you want to make the equation a linear one. By doing this, you are creating a bias. This method removes the bias. Due to this, you can get an exact value of K and n.

[@elenamunoz4571]

Higuchi fitting please! You are awesome

[@gswapna6872]

Good explanation

[@memonaimtiaz4116]

After closing the bracket in fit equation what to do next kindly guide me

[@atanu_giri]

Thanks brother!

[@meilabnitrourkela5314]

Any time!

[@anuragkulkarni5455]

Could you elaborate on how to fix the cell am trying to Press F4 but it is failing

[@vigneshk8794]

Click function key and F4

[@panizsiminzare7613]

Thanks a lot!

[@meilabnitrourkela5314]

You're welcome!

[@ydb6061]

9 batches ka disso graph plot kten ke liye fit data chahiye so 9 batches ka fit data alag alag calculate krke fir origin me graph plot kru kya sir ? Plz reply

[@anjanadevids5421]

I don’t have that analysis and solver option in my excel what to do?

[@achmadvandian8371]

im wanna asking question
how we determine M(unlimited) from data?
please answer

[@indrasetyawan1]

M unlimited we assumed that drug is 100% released (loading dose)

[@certainsingh]

How u put 0.5?

[@priyankameena6451]

Sir there is no solver option in my excel

[@maradiyamohyuddin2367]

What is the formula which sir you type at 3.43 time.please write it in comment.

[@253Azeez]

Why is that release calculation has to be done only 60% of the release, Sir?

[@meilabnitrourkela5314]

This is the constrain of the mathematical model. All mathematical models are based on some assumption.

[@dominicsoin-stanley1570]

What is the name of this method of finding the constants?

[@meilabnitrourkela5314]

Non-linear curve fitting method

[@yashchavan6888]

Fit formula is not working ,i have typed same formula as you did but i am getting error in that case whats the issue?

[@meilabnitrourkela5314]

May be solver not installed properly... Or your parameter estimation is not good...

[@abdullahaziz4352]

It is a nice video. But I am facing a problem to understand when you put a equation at Fit cell. $H......

[@shreshthagaur7262]

can you make a video on entrapment efficiency

[@vinygoyal8020]

Entrapment efficiency ko linear me kaise change krenge

[@niravdarji6300]

What is the reason behind to find Square Difference(SD) ??

[@niravdarji6300]

And Sir One more question Why we minimized the Error??? To find Actual K nd n value?

[@meilabnitrourkela5314]

To minimize the model prediction data and the experimental data...

[@ydb6061]

Thank u so much sir if i have 9 batches , to 9 batches ka korsmeyes peppas model kaise calculate kru sir

[@nehamandle5262]

4.00

[@jihadrefola9067]

Im sorry sir, im not a well listener, what is CPDR once again ?? And how can we make the result of concentration to be CPDR ??

[@meilabnitrourkela5314]

CPDR: Cumulative percent drug release

[@nehamandle5262]

Numbers Populate nae ho rha 😢😢

[@priyankameena6451]

Sir joh k ki value assume kr rhe woh hi value aa rhi first

[@meilabnitrourkela5314]

It is not true for each cases. It depends on how close is your chosen approximate value of K

[@gauravpoint453]

sir higuchi model bhi batado kese solve krna h

[@meilabnitrourkela5314]

When n=0.5, the KP model becomes the Higuchi model. KP model is a generalized model.

[@gauravpoint453]

@@meilabnitrourkela5314 but Sir n=0.5 to peppas model me bhi liya h

[@meilabnitrourkela5314]

@@gauravpoint453 Higuchi model is a limiting case of KP model, where n is fixed to 0.5.

[@gauravpoint453]

@@meilabnitrourkela5314 Sir will you mail me the excel sheet for higuchi and peppas model please muje urgent h m pharma ke practical ke liye chahiye plz sir

[@gauravpoint453]

This is my email address [e-mail]

[@jialinfu616]

Really can not undersatnd the content, first time to learn the kinetic model. 😇