Thanks for watching this episode with Dr. David Sinclair! If you're finding it valuable, please vote by hitting the LIKE button on the video. This lets me know what type of guests to book for upcoming shows. Thanks! -Jesse 💙
Notice you'll never hear either Bryan Johnson and David Sinclair mention each other or acknowledge what each of them is doing, their approaches, there's no team ups here - no conclusions drawn by me, but let's just say it's a note to myself, I'd like to see more of these guys getting TOGETHER rather than having free reign on a podcast to have ZERO contestation - you know what I'm saying, Jesse. I love what you do, but there needs to be more, Bryans team of scientests and David and his team in one room having a PURE civilised discussion on what they have leaned and how and theorising what steps to take next to move this information FORWARD and draw conslusive evidence - and we are the flies on the walls.
What a great interview. I’ve been following you Jesse for a while and I love your inquisitive style. I admire Dr. Sinclair’s work and love how humble, honest and vulnerable he is and the fact that Love changed his life. Great interview! ❤
He´s out of his mind. The Carnivore diet is the human species specific diet. We evolved over 4.5 million with that diet, homo sapiens and the immediate predecessors.
He thinks that because of blue zones, because of the largest studies showing best results on plant or fish+plant, because the compounds he researches are mostly found in plants. Also personal genetics and experience.
@@LVArturs He uses inferential statistics to try and establish a causal relationship with diet and longevity. While inferential statistics are indispensable for analyzing data and making predictions, they come with significant limitations, particularly regarding causal inference. Establishing a cause and effect relationship typically requires rigorous study design and methodologies, such as randomized controlled trials, which can systematically eliminate confounding variables. Hence, while inferential statistics can point toward relationships and patterns, they alone do not provide definitive proof of causation without corroborating evidence from experimental designs or additional investigative techniques.
His girlfriend is vegan and convinced him. He hasn't been on it long enough to have problems from eating that way. It takes a few years for that to happen. At least that is what I have observed in people around me who have tried to stay vegan.
I always appreciate Dr. Sinclair's perspective. I tried his diet and supplements but had negative results due to a metabolic problem. I just keep hoping he'll come over to the carnivore dark side.
Thank you Jesse for all varied guests you bring. I now always look forward to your questions, love it. I tried to listen to this guest and getting something from it. And yes, it's difficult to listen to him and justifications on optional veganism (what an insult for vegans who eats all really natural non processed) which am not, far from it. And the most "upsetting" part as he says himself it's the nmn chapter in which it clearly self explains itself : he really is the cause of all that has happened to this supplement loved by millions that is now under scrutiny for the wrong reasons. Making a medicine from an already existing supplement! Why.... Yes money and self love. I personally don't take it as I have another great European option. How can he be so vain on trying to credit to himself some supplement s popularity and even blaming other researchers for people like me not baring to listen to him anymore, and we try, shocking and sad. And even taking ownership of some, this is just weird. I really was giving him a chance to redeem himself and this is so disappointing and you, Jesse, are doing such a great job at helping to keep the good side of him we all admired for years till it all fell SO flat. I feel for him from what he was a scientist who was trying to bring knowledge he had learnt from others to someone who became focused on fame. It is not a easy interview to listen to. Of course, it's great for him that he n girlfriend are passionately in love and doing work together and everyone loves a good love story. But it's sad that his focus is on medicalizing supplementation so once again the masses have to pay bigger groups who are laughing at using him.
I don't know why anyone would want to live longerthan 100 or 120 years. I've eaten a natural whole foods diet my whole life, fasted since the eighties, have fasted 18 - 20 hours a day for the past couple years and tend keto. I've also worked a manual labor job since I was 15 and I live within three miles of two wilderness areas. I'm 65 and most 30 year olds can't keep up with me while ski mountaineering and rock and ice climbing. I'm not interested in living longer, but am very interested in quality of life while I'm here. I'm ready for the next stage of the journey and really don't want to wait another 40 -60 years.
Lol 😂 u doing an unfair comparison U can't compare unfit 30yrs old with urself....has to be in the same category ...in conclusion u can't keep up with fit 30 or even 40year olds 😊 Anyway that's life INDEED
Kind of feel sorry for David... he's pretty much been a human punching bag lately....but I guess all that money helps take the sting out of it😅. I really think people like him are necessary to help advance the study of aging. Plus I love his optimistic nature.
I listen to what David has to say about his research, but he tends to impart equal confidence and excitement to what he learns from his girlfriend. This turns me off and I stop listening.
He has credentials at large woke political universities which he justifiably protects by repeating the orthodox “woke” rhetoric where necessary. When you find his position incorrect, as in carnivore diet for example, remember where he metaphorically lives and the gods he must serve to stand there. So relax, Dave is an awesome researcher but don’t expect him to support Malcom Kendrick. No sense getting involved in everyone else’s fight. The goal of ending debilitating aging from inside academia, is a big enough goal.
@@Len1977gt Sorry. I did not realize you were a Troll that likes insulting people. Dave Sinclair is unfairly melined for his fence sitting position on sensitive political arguments. Look at how fast the machine steps on doctors, physicists, researchers who step out with heretical views against their machine. Frankly I don’t think appeasement can save Sinclair in the end but he is making a try at it and I respect that.
Ugh Vegan diet😃, that is his problem. It was hard listening to him being a doctor and researcher but in poor health talking about longevity and good health. he is missing so many good things in his diet.Serena influencing him in a negative way in my opinion
I eat all supplements Sinclair do, I look a lot younger than last year , I have not aged at all, people think I am 30 , but I am 51....😂 But adding hormones and amino acids is important also, all 20 if them, and I eat meat and fish, I think it is important, we are not born vegans😊
How about an expert gives a list, with brand names of what to take. Then do the same with an economy list for those of us that work for a living. Keep this list Online and keep it updated. Simple
He travels 300 days a year, but doesn’t eat meat for the planet 🤔. We’ll have to agree to disagree on many points made in this interview. That said, I respect his life choices and appreciate his dedication, though I feel it’s very myopic
All that knowledge and he knows nothing about nutrition! Putting his dad on a statin 😢 His dad is right, eat more meat 🥩 “I no longer accept the paradigm that high LDL cholesterol is the cause of heart disease” Dr. Philip Ovadia
Science is already proven humans can only live to 120 no matter how healthy you are we have a cap on our DNA they have no idea how I got there but it's there but I do want to be healthy I think 120 would be long enough anyway just go to bed and don't wake up
Really doesn't matter to me never been afraid of death just afraid of who and what I leave behind I know we never really die we just move on from this Temple to another I mean who wants to live forever anywhere Heaven hell I don't care do you understand how long forever is I prefer my energy just to float in the air or find another Temple forever ever ever eternity no thank you all man-made fairy tales for fear and control just be good and spread love
So funny to hear people in the comments section hating him because of whole plant based diet 😂 After doing serious research is clear for years now that whole plant based diet is best for aging, health, etc. Now if you want to eat meat instead nobody cares really do whatever you want but do not hate him because he is on a vegan diet!?
@@khushsingh973 Thats because most people are brainwashed by the the billion dollar meat and dairy industry, which funds the pharmaceutical agency for all the diseases it creates
Very excited to listen to this podcast. I’ve been a fan since the duo couple podcast days when Jesse and his wife did the show together. And Jesse always asks insightful questions. You really get value from watching his episodes! Thank you for all the years of filling my commute with meaningful information. Thanks David love your work as well! You give me hope in my longevity journey.
Doxicycline is pretty cheap here in Nicaragua. But won´t that cause bacterial resistance? I stopped listening when he promoted the Vegan diet, he´s out of his mind.
Yes, to me it indicates that his ability to evaluate research is faulty or biased. The 'research' that supports vegan diets is weak and it's conclusions are misleading
These longevity guys are n=1 and wr are always told, forget n=1. I remember when those calorie restriction people thought that was longevity. I know someone local who was part of that and it essentially made him insane. Vegan. Obsessed with food, about 135 pounds and 6', constantly cold but refuses to wear a sweater in case being cold is part of longevity, etc. It's ridiculous. You don't live forever but it sure feels like forever. No thanks. This is not unlike being bedridden for the last 20 years of your life and living to 100, but why would anyone want that????
I think he is right about fasting. When i do i feel like i get more energy, i feel my mind is sharper, and i feel i heal ailments that bother me. I can see how fasting works.
I'm surprised how little glycation is mentioned any more. Has there been any progress on this front - breaking down glucosepane? Or does addressing other things and increasing turnover address this and the inflammation that comes along with it?
This is an excellent interview. He asks great questions and , unlike many on utube, he backs off and lets the expert talk instead of trying to show how much he knows.
I agree. Jesse asks great questions and is one of the best interviewers. He listens well and knows when to talk. I wish more interviewers on TH-cam would watch him and learn from him how to conduct an interview and they could make me interested in watching more interviews on other channels.
Exercised my whole life, eat well don't smoke or drink. I had to have a f#@ng triple heart bypass at 50. I'm unhealthier than someone who doesn't give a f#£!k. Someone please explain
Get your Lipoprotein-a status checked. (That check can additionally be done when the doctor checks your blood) That's a genetic predisposition that I also have. It gives you the same risk of getting cardiovascular disease (clogging of arteries) as a smoker has, even if you live super healthy. It's important to keep LDL Cholesterol down and HDL Cholesterol up. You can also take statins, you probably already do. If you hadn't lived healthily, maybe the surgery would have been necessary in your 40's?
Health is subjective. What was your diet and exercise regimen leading up to your heart attack? Thinking you are healthy because you think you eat right and exercise is not always so. Folks doing tons of exercise and eating a low fat diet will age the body faster.
sweetr-talking Aussie trixtaire!!! another guest on the show referred to him as a sheel, The Greatest of them all, Dr Caste, clearly stated resverastrol, the magic pil, is uselaisse. it seems he plays with some horrific doses(that cannot be applied to humans)..... whatever, we are Old enough to decide how to quill ourselfsl Thanks, Jesse ciao PS looking forward to your next guest(and please get Dr Cate for a third round! Milk is Great; Yoghurt(live one) is the panacea, I hav eknown this since I have been alive
![[TH] FS vs BME - VCT Ascension Pacific - Lower Bracket Final](http://i.ytimg.com/vi/wnygqsR2Fig/mqdefault.jpg)
Thanks for watching this episode with Dr. David Sinclair! If you're finding it valuable, please vote by hitting the LIKE button on the video. This lets me know what type of guests to book for upcoming shows. Thanks! -Jesse 💙
@@JesseChappus It was definitely interesting.
Notice you'll never hear either Bryan Johnson and David Sinclair mention each other or acknowledge what each of them is doing, their approaches, there's no team ups here - no conclusions drawn by me, but let's just say it's a note to myself, I'd like to see more of these guys getting TOGETHER rather than having free reign on a podcast to have ZERO contestation - you know what I'm saying, Jesse. I love what you do, but there needs to be more, Bryans team of scientests and David and his team in one room having a PURE civilised discussion on what they have leaned and how and theorising what steps to take next to move this information FORWARD and draw conslusive evidence - and we are the flies on the walls.
Fake
Fake, old news, repeats the same story everytime.
Did he do the fast?
transcribethis AI fixes this. Slow and reverse aging secrets.
What a great interview. I’ve been following you Jesse for a while and I love your inquisitive style. I admire Dr. Sinclair’s work and love how humble, honest and vulnerable he is and the fact that Love changed his life. Great interview! ❤
He looked so young and is real living proof.🎉🎉
plastic surgery, filters and makeup
@@hachikoinu5598 Lay off the crack, you will make more sense.
@@hachikoinu5598the ignorant will restore to blanket statement of falsity, rather than accept their lifestyle is a diver in aging.
Why does he think a vegan diet is healthier? Based on what?
He´s out of his mind. The Carnivore diet is the human species specific diet. We evolved over 4.5 million with that diet, homo sapiens and the immediate predecessors.
He thinks that because of blue zones, because of the largest studies showing best results on plant or fish+plant, because the compounds he researches are mostly found in plants. Also personal genetics and experience.
@@LVArturs He uses inferential statistics to try and establish a causal relationship with diet and longevity. While inferential statistics are indispensable for analyzing data and making predictions, they come with significant limitations, particularly regarding causal inference. Establishing a cause and effect relationship typically requires rigorous study design and methodologies, such as randomized controlled trials, which can systematically eliminate confounding variables. Hence, while inferential statistics can point toward relationships and patterns, they alone do not provide definitive proof of causation without corroborating evidence from experimental designs or additional investigative techniques.
His girlfriend is vegan and convinced him. He hasn't been on it long enough to have problems from eating that way. It takes a few years for that to happen. At least that is what I have observed in people around me who have tried to stay vegan.
Look at Sinclair’s eyes. He’s been dosing statin as well, believing statin will prevent heart disease.
I always appreciate Dr. Sinclair's perspective. I tried his diet and supplements but had negative results due to a metabolic problem. I just keep hoping he'll come over to the carnivore dark side.
Why would he, who wants to die an early death from eating carnivore
Only doctor whom I trust very much.
Thank you Jesse for all varied guests you bring. I now always look forward to your questions, love it. I tried to listen to this guest and getting something from it. And yes, it's difficult to listen to him and justifications on optional veganism (what an insult for vegans who eats all really natural non processed) which am not, far from it. And the most "upsetting" part as he says himself it's the nmn chapter in which it clearly self explains itself : he really is the cause of all that has happened to this supplement loved by millions that is now under scrutiny for the wrong reasons. Making a medicine from an already existing supplement! Why.... Yes money and self love. I personally don't take it as I have another great European option. How can he be so vain on trying to credit to himself some supplement s popularity and even blaming other researchers for people like me not baring to listen to him anymore, and we try, shocking and sad. And even taking ownership of some, this is just weird. I really was giving him a chance to redeem himself and this is so disappointing and you, Jesse, are doing such a great job at helping to keep the good side of him we all admired for years till it all fell SO flat. I feel for him from what he was a scientist who was trying to bring knowledge he had learnt from others to someone who became focused on fame. It is not a easy interview to listen to. Of course, it's great for him that he n girlfriend are passionately in love and doing work together and everyone loves a good love story. But it's sad that his focus is on medicalizing supplementation so once again the masses have to pay bigger groups who are laughing at using him.
Yes on the money gravy train. Got everyone interested in NMN and then saw the dollar sign. Total fraud.
Love you sir. I am healthier than ever
Great see a recent interview from David. Thanks for making this content.
💙
Love this interview love David so much ❤❤
I don't know why anyone would want to live longerthan 100 or 120 years. I've eaten a natural whole foods diet my whole life, fasted since the eighties, have fasted 18 - 20 hours a day for the past couple years and tend keto. I've also worked a manual labor job since I was 15 and I live within three miles of two wilderness areas. I'm 65 and most 30 year olds can't keep up with me while ski mountaineering and rock and ice climbing. I'm not interested in living longer, but am very interested in quality of life while I'm here. I'm ready for the next stage of the journey and really don't want to wait another 40 -60 years.
Lol 😂 u doing an unfair comparison
U can't compare unfit 30yrs old with urself....has to be in the same category
...in conclusion u can't keep up with fit 30 or even 40year olds 😊
Anyway that's life INDEED
David is genius love him ❤the interview awesome thanks
Kind of feel sorry for David... he's pretty much been a human punching bag lately....but I guess all that money helps take the sting out of it😅. I really think people like him are necessary to help advance the study of aging. Plus I love his optimistic nature.
Why would you feel sorry for him? He lied about his research and got caught. Nobody should trust this guy
Does anyone else wonder if he is behind the recent FDA seizure of NMN
My intuition tells me David Sinclair is not to be trusted. Tread lightly with this one.
Yes, people who lie repeatedly are generally not to be trusted. David has been caught many times and even got kicked out of his own academic academy
everything except his vegan diet i can get behind, i tried it and it just doesnt work for me
@@christiancrafoord I think like many things, they don't all work the same for everyone.
Okay so who do you recommend for longevity advices?🤔
Your intuition is spot on
Dr looks like val killer on batman . Strong 👍🏻🔥
Yea
Way too many supplements. I enjoy the freedom of carnivore.😁
Eat carnivore and you will also enjoy the freedom of heart disease and cancer and taking drugs to for to deal with that.
Is this a recent interview?
Recorded Sept 3rd 2024 :)
@@JesseChappus Well after he was caught lying about his research. Why would you have such a disreputable guest on your channel?
So if the DNA is also altered what guarantees that the epigenome will read it right now that it's deteriorated too?
why do these proteins turn genes on and off?
Gosh Jesse you must be so confused now about what to eat!! If his diet is so good why so many supplements??
I listen to what David has to say about his research, but he tends to impart equal confidence and excitement to what he learns from his girlfriend. This turns me off and I stop listening.
He has credentials at large woke political universities which he justifiably protects by repeating the orthodox “woke” rhetoric where necessary. When you find his position incorrect, as in carnivore diet for example, remember where he metaphorically lives and the gods he must serve to stand there. So relax, Dave is an awesome researcher but don’t expect him to support Malcom Kendrick. No sense getting involved in everyone else’s fight. The goal of ending debilitating aging from inside academia, is a big enough goal.
@@jillengland3277 Lay off the crack, you will make more sense
@@Len1977gt
Sorry. I did not realize you were a Troll that likes insulting people. Dave Sinclair is unfairly melined for his fence sitting position on sensitive political arguments. Look at how fast the machine steps on doctors, physicists, researchers who step out with heretical views against their machine.
Frankly I don’t think appeasement can save Sinclair in the end but he is making a try at it and I respect that.
Ugh Vegan diet😃, that is his problem.
It was hard listening to him being a doctor and researcher but in poor health talking about longevity and good health. he is missing so many good things in his diet.Serena influencing him in a negative way in my opinion
You should lay off the crack you will make more sense
I eat all supplements Sinclair do, I look a lot younger than last year , I have not aged at all, people think I am 30 , but I am 51....😂
But adding hormones and amino acids is important also, all 20 if them, and I eat meat and fish, I think it is important, we are not born vegans😊
What all supplements do you use
How about an expert gives a list, with brand names of what to take. Then do the same with an economy list for those of us that work for a living. Keep this list Online and keep it updated.
Simple
He travels 300 days a year, but doesn’t eat meat for the planet 🤔. We’ll have to agree to disagree on many points made in this interview. That said, I respect his life choices and appreciate his dedication, though I feel it’s very myopic
All that knowledge and he knows nothing about nutrition! Putting his dad on a statin 😢 His dad is right, eat more meat 🥩
“I no longer accept the paradigm that high LDL cholesterol is the cause of heart disease” Dr. Philip Ovadia
Science is already proven humans can only live to 120 no matter how healthy you are we have a cap on our DNA they have no idea how I got there but it's there but I do want to be healthy I think 120 would be long enough anyway just go to bed and don't wake up
Only 120? That was assuming no epileptic mods. Epileptic mods will cure that 120 limitation
Damn spelling corrector. Epigenetic
Really doesn't matter to me never been afraid of death just afraid of who and what I leave behind I know we never really die we just move on from this Temple to another I mean who wants to live forever anywhere Heaven hell I don't care do you understand how long forever is I prefer my energy just to float in the air or find another Temple forever ever ever eternity no thank you all man-made fairy tales for fear and control just be good and spread love
Hahaha, they made mice young again, we can live far beyond 120 😊
So funny to hear people in the comments section hating him because of whole plant based diet 😂 After doing serious research is clear for years now that whole plant based diet is best for aging, health, etc. Now if you want to eat meat instead nobody cares really do whatever you want but do not hate him because he is on a vegan diet!?
Good point… but will fall on mostly deaf ears …
@@khushsingh973 Thats because most people are brainwashed by the the billion dollar meat and dairy industry, which funds the pharmaceutical agency for all the diseases it creates
David Sinclair finally gave interview! Thanks Jesse!
I’m just partway into it but I’m certainly hoping he asks him some very hard questions and stops lobbing the softballs
Very excited to listen to this podcast. I’ve been a fan since the duo couple podcast days when Jesse and his wife did the show together. And Jesse always asks insightful questions. You really get value from watching his episodes! Thank you for all the years of filling my commute with meaningful information. Thanks David love your work as well! You give me hope in my longevity journey.
Doxicycline is pretty cheap here in Nicaragua. But won´t that cause bacterial resistance? I stopped listening when he promoted the Vegan diet, he´s out of his mind.
Let the masses continue eating processed wheat, veg and fruit. Helps keep the cost of my ribeye steaks down 😊
Agree. He is the system. The Rockefeller mafia
Thanks for saving me the time of listening to this. Anyone pushing the vegan diet is legitimately not worth listening to.
Yes, to me it indicates that his ability to evaluate research is faulty or biased. The 'research' that supports vegan diets is weak and it's conclusions are misleading
@@cassieoz1702 Exactly. Faulty & biased opinions…w/ no ability to impart truth. Reminds me of my niece’s vegan nutritionist. 🤦🏻♀️🤦🏻♀️🤦🏻♀️
These longevity guys are n=1 and wr are always told, forget n=1.
I remember when those calorie restriction people thought that was longevity. I know someone local who was part of that and it essentially made him insane. Vegan. Obsessed with food, about 135 pounds and 6', constantly cold but refuses to wear a sweater in case being cold is part of longevity, etc. It's ridiculous. You don't live forever but it sure feels like forever. No thanks. This is not unlike being bedridden for the last 20 years of your life and living to 100, but why would anyone want that????
I think he is right about fasting. When i do i feel like i get more energy, i feel my mind is sharper, and i feel i heal ailments that bother me. I can see how fasting works.
God bless David Sinclair and you, sir and your podcast.
I'm surprised how little glycation is mentioned any more. Has there been any progress on this front - breaking down glucosepane? Or does addressing other things and increasing turnover address this and the inflammation that comes along with it?
Sinclair needs to check up what AI will do in regards to longevity escape veloicity
Serena has done wonderful contributions in the life of Dr. Sinclair which shows how much healthy relationship is important in longevity.
This is an excellent interview. He asks great questions and , unlike many on utube, he backs off and lets the expert talk instead of trying to show how much he knows.
I agree. Jesse asks great questions and is one of the best interviewers. He listens well and knows when to talk. I wish more interviewers on TH-cam would watch him and learn from him how to conduct an interview and they could make me interested in watching more interviews on other channels.
Exercised my whole life, eat well don't smoke or drink. I had to have a f#@ng triple heart bypass at 50. I'm unhealthier than someone who doesn't give a f#£!k.
Someone please explain
Get your Lipoprotein-a status checked. (That check can additionally be done when the doctor checks your blood) That's a genetic predisposition that I also have. It gives you the same risk of getting cardiovascular disease (clogging of arteries) as a smoker has, even if you live super healthy. It's important to keep LDL Cholesterol down and HDL Cholesterol up. You can also take statins, you probably already do. If you hadn't lived healthily, maybe the surgery would have been necessary in your 40's?
Health is subjective. What was your diet and exercise regimen leading up to your heart attack? Thinking you are healthy because you think you eat right and exercise is not always so. Folks doing tons of exercise and eating a low fat diet will age the body faster.
🙌🏻
You talk.
About protein, but it's very hard to get protein out of plants or very little.
Talking rubbish mate , we're does a rhino get it's protein from
Lay off the crack, you will make more sense.
sweetr-talking Aussie trixtaire!!! another guest on the show referred to him as a sheel, The Greatest of them all, Dr Caste, clearly stated resverastrol, the magic pil, is uselaisse. it seems he plays with some horrific doses(that cannot be applied to humans)..... whatever, we are Old enough to decide how to quill ourselfsl Thanks, Jesse ciao PS looking forward to your next guest(and please get Dr Cate for a third round! Milk is Great; Yoghurt(live one) is the panacea, I hav eknown this since I have been alive
Where to get apygenin
If you cannot buy nmn what is a good substitute thanks
NR 🎉
Resveretol baby. That's the stuff baby! Lol
Lay off the crack, you will make more sense.
Eat more meet no rabbit food
Lay off the crack, you will make more sense.
Yeah... with vegan diet i will definitely live long...... nope thanks! He is for sure sponsored from sort of companies.....
11:28 Lets discuss: what are the natural compounds that can mimic or activate OSK