I'm 26 min into this video and all I keep thinking is "wow this guy is amazing." Thank you for your love, passion, and teachings. Words can't express how thankful I feel right now!
You are such a blessing. I’m an IMG working full time in a rural hospital based ER, listening to these to and from work, while cooking and screenshooting all high yield charts and using them as flash cards is super helpful for me. I really hope I do well on the exam ❤️🙈
I wish I would have found this guy at the beginning of med school. I could have implemented his course into my studies and step study would have been cake.
I thought the aminoglycosides little "song" was pretty catchy and I decided to give it a try....... It only took me 23 recordings of myself to get it right, singing "So what are your aminoglycosides? Gentamicin, Neomycin, Amikacin, Tobramycin" 😂 goodness, recording one self its not easy, hats off to you and all youtubers. Anyway, Thank you Dr. Damania I will never forget the Aminoglycosides now 😂❤
![SAFEPLANET - ดาวเคราะห์ [ THE PLANET ]](http://i.ytimg.com/vi/4X1XL3I_k3c/mqdefault.jpg)
I'm 26 min into this video and all I keep thinking is "wow this guy is amazing." Thank you for your love, passion, and teachings. Words can't express how thankful I feel right now!
HY Points
-Flat Nasal Bridge, Prminent Epicanthal Folds, Low Set Ears, Speckled Irirs ("Brushfueld Spots"),
Single Palmar Crease, wide gap between firt & Second toes --> Down's Syndrome
-Down's Syndrome children + Atrioventicular Valve Regurgitation on Echo --> Endocardial Cushion Defects
-Down's Syndrome Newborn + has NOT passed stool since birth & Has Abdominal distension --> Hirschsprung'S
(Failure of Migration of the Auerbach "Myenteric" Plexus - Neural Crest Cells)
-Cystic Fibrosis Newborn + has NOT passed stool since birth --> "Meconium Ileus"
-Bilious Emesis + "Double-bubble" Sign--> Duodenal Atresia (Failure of the Endodermal gut-Tube to Recanalize)
-Down's Syndrome children + Bilious Emesis caused by External Gut-tube Compression --> Annular Pancreas
[Annular Pancreas --> Failure of the Dorsal and Ventral bud of Pancreas to Fuse]
-Atrioventricular Septal Defect (Endocardial Cushion defect), Ostium Primum ASD & VSD --> Down Syndrome
-Duodenal Atresia, Annular Pancreas, and Hirhchsprung's Disease --> Down syndrome
-Hypothyroidism and T1DM --> Down syndrome
-Down syndrome --> Airway Hypotonia --> Obstructive Sleep Apena --> Pulmonary HTN & RV failure
-Down syndrome is assoacited with Muscle Hypotonia and AtlatoAxial Instability
-Down syndrome Cancer --> Acute Megakaryoblastic Leukemia (AML) & ALL
-Genetic Inheritance Pattern of Down Syndrome ? --> Meiotic Non-disjunction
-Trisomy 13 + Microcephaly/Cleft Palate/Microphthalmia + Rocker Bottom Feet--> Patau Syndrome
+ Omphalocele + VSD/PDA
-Trisomy 18 + Micrognathia/Low Set Ears + Rocker Bottom Feet --> Edwards Syndrome
Clenched Fists with Overlapping Fingers + VSD/ASD/ToF
-S-Adenosyl-Methionine (SAM) [Methyltransferase Enzyme]--> causes DNA Methylation -> "Mute DNA" --> Imprinting
-Prader-Willi Syndrome --> Paternal Gene Deleted + Maternal gene Imprinted (Silenced)
-AngelMan's Syndrome --> Maternal Gene Deleted + Paternal gene Imprinted (Silenced)
-Almond-sjaped Eyes + Thin Upper Lip + Short Stature(GH deficiency )+ Obesity + Hypotonia --> Prader Willi
-Thin Upper Lip --> Also related to Fetal Alcohol Syndrome
-Microcephaly + Intellectal disability & Laughing+ Epilepsy/Hyperrreflexia/Truncal Hypotonia --> AngelMan's
-Marfan's Syndrome , Homocystinuria, Klynefelter's, MEN2B --> Marfanoid Habitus
-Klynefelter's Syndrome --> HyperGonadotropic Hypogonadism
-Ectopia Lentis (SuperoTemporal direction)/Cataracts + Hyperextensive Skin + Joint Hypermobility + Winged Scapula
+ MVP/Aortic Root Abnormalities 2/2 "Cystic Medial Degeneration" + SAH 2/2 Berry Aneurysms --> MARFAN'S Syndrome
-Long Thoracic Nerve (Medial Winging of the Scapula) Injury --> "Winged Scapula"
-Ectopia Lentis (inferior or nasal direction) + HyperCoagulable State --> Homocystinuria
-COLA--> Type V collagen / COL3A1--> Type III Procollagen Mutation ---> Ehlers Danlos Syndrome
+ Retinal detachment + MVP + Easy bruising/Poor wound healing + Hernia (GI tract)
-"Purine Salvage Pathway" is Essential in Creating Nucleotides from degradation of DNA & RNA
-HGPRT deficiency --> ↑PRPP ↑Guanine/Hypoxanthine/Uric Acid --> Lesh-Nyhan Syndrome
[Elevated amounts of Uric ACid --> Striatal Dopaminergic Damage --> Self-Injurious Behavior]
-HyperUricemia -->Urate Crystal in urine ("Rhomboid Shape" Crystals with Precipitate in ↓pH)
-Uric Acid Kidney Stones --> RadioLucent on X-ray --> Txt Urine Alkalinization
-Normal 9 + 2 Microtubles (ATPase)
-Dynein Arm Defect (Primary cilliary Dyskinesis) --> immotile cilia --> Poor Epithelia --> Kartagener Syndrome
--> Bronchiectasis/Sinusitis + Displaced Heart Sound (Dextrocardia) + infertility
-Mutated CFTR gene (ΔF508) on Chrm 7 --> Misfolded ATP-gated Chloride Channel -> Cystic Fibrosis (CF)
-CF patient has an Abnormal DEXA Scan test, What is the likely mechanism ?
--> Poor Vitamin D Metabolism --> Osteopenia & Osteomalacia
-Normal Sweat Glands reabsorb cL & Exocrine glands Secrete cL (to thin secretion)
-Staph Aureus--> Gram (+) Cocci Clusters, Catalase + & Coagulase (+) in infancy/childhood--> Pneumonia in Cystic Fibrosis Patients
-Pseudomonas Aerug--> Gram (-) Bacillus, Oxidase(+) in Adults --> Pneumonia in CF patients
-Burkholderia Cepasia --> Necrotizing Pneumonia and Sepsis in CF Patients
-Nasal Polyps, Bronchiectasis/Pneumonia, Obstructive Lung Disease, Hemoptysis
+ digital clubbing + Obstructive Azoospermia (Vas deferens absent) Infertility
+ Meconium Ileus (Newborn) + distal Intestinal Obstruction (Adults) --> Cystic Fibrosis
-Precocious Puberty + "Cafe-Au-Lait"Spots + bone tumors --> McCune Albright Syndrome (Gs-Protein Activating Mutation --> ↑cAMP)
[Polyostotic Fibrous Dysplasia + Prec Puberty/Cushing Syndrome]
-HLA-DR2 & HLA-DR3 subtypes--> Associated with SLE
-BM Deposits of Antigen-Antibody IC (Type III HSR) + Spike & Dome appearance on EM + Nephrotic Syndrome --> Membranous Nephropathy
-Wire-Looping of Capillaries + Nephritic Syndrome --> DPGN
-"Crescents made up of Fibrin & Macrophages" on Renal Biopsy --> RPGN
Superb! Tnq so much doc♥️🎉
Thanks!
You are such a blessing. I’m an IMG working full time in a rural hospital based ER, listening to these to and from work, while cooking and screenshooting all high yield charts and using them as flash cards is super helpful for me. I really hope I do well on the exam ❤️🙈
Can you please share the flashcards ?
Hi Anna! Your story resonates with me so well. How did you do in your exam?
I wish I would have found this guy at the beginning of med school. I could have implemented his course into my studies and step study would have been cake.
watching this the morning of my step 1 exam... you are the best!
Beth!! You got this!! Super excited for you- go get it! You’re gonna do amazing
I love this account. I'm so so grateful I found you!!
You are saving my life. Thank you so much 🙏🏾
I thought the aminoglycosides little "song" was pretty catchy and I decided to give it a try....... It only took me 23 recordings of myself to get it right, singing "So what are your aminoglycosides? Gentamicin, Neomycin, Amikacin, Tobramycin" 😂 goodness, recording one self its not easy, hats off to you and all youtubers. Anyway, Thank you Dr. Damania I will never forget the Aminoglycosides now 😂❤
Gnat the bug
Aminoglycosides are gnats
Your videos are really helping me….
Thank you Dr.Damania….
A newborn cholesterol with TS that has not passed stools can't it be duodenal atresia ? Help me clarify this thanks
Outstanding presentation
Wao! Amazing lecture 💪🏽💪🏽 Super helpful. Thanks!
The USMLE test is really frustrating, I can't believe I failed again after studying so much🥺🥺😓😭😭
You will pass everyone has their own season, just keep praying and believe you will receive
I used some Kaplan, and took some much time in my online classes still my step 1 result came back failed
It's my first time I'm scared, I don't wanna fail
Wow Mrs Catherina Moore has really made name for herself
She is the best person you can work with dear,Mrs Catherina Moore Always keep to her Words
Thank you Doctor
Do you have a genetic version of usmle step 1
you are genius
Where can I find biochemistry review videos?
Hi they are in my P/F course!! :)
hyguru.teachable.com/p/usmle-step-1-pass-fail-course
Awesome sir ♥️👌
Thanks ✌️I'm so glad you enjoyed it!!
You are great
Yes
Yes