I'm very detailed oriented and your lectures help give a solid baseline to think from...not to mention med school is busy as hell and it saves me a lot of time! Appreciate it bro #GRINDTIME
I actually am in love with you. Thank you so much for making these videos, you do an excellent job organizing and explaining the information, and I actually understand biochem after I listen to you!
Was wondering the same thing, but remember the hydrolysed ATP during the activation step is converted into AMP instead of ADP and yields 2 pyrophosphates instead of one phosphate. That's equivalent to 2 ATPs.
Really good one! I am Spanish and I understood it perfectly! But I have two questions: How does the CoA get into the matrix to reform the Acyl-CoA? And how do Carnitine and Acyl-carnitine go trough the outter membrane? Thanks!
There are separate reserves of cytoplasmic and mitochondrial CoA; the mitochondrial CoA doesn't move out, but the cytoplasmic CoA moves back in via Cartinine Acyl Translocase II back into the cytoplasm. As for the the second question, the outer mitochondrial membrane is relatively permeable due to porines, so Acyl-Cartinine can simply move in. I know this was asked a year ago, but I thought I should share in case someone else has the same question.
@@MonkeyDLuffy-xr4fl the answer for first question is that not because of acetyl CoA that were produced during pyruvate undergoing oxidative decarboxylation of glycolysis product...??
Hello sir, I have a doubt you haven't explain why acylcoA needs to be converted into acylcarnitine, i mean what is the significance of doing so. Also big fan of your videos, greetings from INDIA 🇮🇳✨
sir i really love ur videos... u always give reasonable xplanatn...bt i hv a question...as acylcoA cannot enter the mitochondria it converts to acylcarnitine n again aftr tht it forms acylcoA on reaching the mitochondrial matrix so what is the purpose of the formation of first acylcoA in cytoplasm???..will u plz answer it sir plz
Mimi Sa'ari It moves from CoA to carnitine, and the fatty acyl carnitine is then transported into the mitochondrial matrix, where the fatty acid switches back to CoA and the free carnitine moves back into the cytoplasm. Did that help?
![[Sub Thai] APT. - ROSÉ & Bruno Mars](http://i.ytimg.com/vi/bYjhzP8x_uc/mqdefault.jpg)
I'm very detailed oriented and your lectures help give a solid baseline to think from...not to mention med school is busy as hell and it saves me a lot of time! Appreciate it bro #GRINDTIME
I realize I'm kinda off topic but does anybody know a good place to watch new tv shows online?
@Eliseo Caden Thank you, I signed up and it seems like a nice service :) I appreciate it!
@Eric Amir No problem =)
Awesome videos. I'm so thankful for the work you have done in order to help us.
You are Awesome and I am jealous on the knowledge you have,
Iron Man Don't be! You will too, you just need to study hard :)
your lectures are a big treasure...and so you are :)...I won't say you saved my life until I pass the exam :P
I have been so enjoyed your lecture,, you have made me so joyful to study biochemistry
Your videos are the only reason I am not failing my biochemistry class!!!! My final exam is tomorrow!
I actually am in love with you. Thank you so much for making these videos, you do an excellent job organizing and explaining the information, and I actually understand biochem after I listen to you!
man you are a super human how can you explain like that !?
awesome work awesome explanation thank you very much
You have explained this so incredibly well. You know how to teach. Thanks to you, I may actually pass my exam tomorrow. Thanks so much. :) :) :)
very insightful lectures very helpful in understanding various biochemistry concepts thanks for the videos
really u r excellent sir. u r very clear and straight on the topic, explaining in simple words. i am thankful to u sir
You are seriously amazing! I love how clear you present the concepts~~
THANK YOU!!
te amo, me acabas de salvar la vida
thank you so much you explain lectures very good. You are the best teacher in the world. angin thank you so much.
Hi thanks for the amazing video.
One thing i need to know is where can I see that the activation of Fatty Acids requires "2" instead of "1" ATP?
Was wondering the same thing, but remember the hydrolysed ATP during the activation step is converted into AMP instead of ADP and yields 2 pyrophosphates instead of one phosphate. That's equivalent to 2 ATPs.
Thank you so much
You have saved me so many times
Real life angel
Thank you so much for the lectures. You really help in my studies!
Sir Ur lectures are the best..Thankuu soo mch for such deep n simple explanations 😊
Does it need 2 mole ATP or 1 for activation??? Because for ATP calculation of palmitic acid you said 2
literally soooooo good, thanks AK
Please do more videos! we love you!!
That is sooo awesome. Thank you so much.🙏🏻
I think the acyl-carnitine is formed in the cytosolic side, not in the mitochondrial intermembrane space. So the drawing is a bit misleading.
Really good one! I am Spanish and I understood it perfectly! But I have two questions: How does the CoA get into the matrix to reform the Acyl-CoA? And how do Carnitine and Acyl-carnitine go trough the outter membrane? Thanks!
Not sure. But in other videos they say that CoA is already there in the matrix. And Acyl-carnitine goes through the outter membrane using porins.
There are separate reserves of cytoplasmic and mitochondrial CoA; the mitochondrial CoA doesn't move out, but the cytoplasmic CoA moves back in via Cartinine Acyl Translocase II back into the cytoplasm. As for the the second question, the outer mitochondrial membrane is relatively permeable due to porines, so Acyl-Cartinine can simply move in. I know this was asked a year ago, but I thought I should share in case someone else has the same question.
Thank you sir.
@@MonkeyDLuffy-xr4fl Thank you so much man. I was trying to figure out why exactly the pool of CoA in the mitochondria is small.
@@MonkeyDLuffy-xr4fl the answer for first question is that not because of acetyl CoA that were produced during pyruvate undergoing oxidative decarboxylation of glycolysis product...??
Sr A best video 👍
Thanks for these videos.
Hello sir,
I have a doubt you haven't explain why acylcoA needs to be converted into acylcarnitine, i mean what is the significance of doing so.
Also big fan of your videos, greetings from INDIA 🇮🇳✨
Thank you so much🙏
This was awesome, Thank you.
Very usefull video thaaanks 👍🏻👍🏻👍🏻👍🏻
Sir what about the reaction.mechanism...
Do.we have to know those mechanisms.
For.eg amp.is kicked out sulphur comes in to form bond with carbon
aka acyl CoA Synthetase must be your favorite enzyme :)
Very nice videos!, thank you :)
from my lecture notes, it stated that fatty acyl carnitine is formed,
really , special thanks
you are awesome
thank you very very much
Thank you!
Thank you so much ❤️❤️❤️❤️❤️
sir i really love ur videos... u always give reasonable xplanatn...bt i hv a question...as acylcoA cannot enter the mitochondria it converts to acylcarnitine n again aftr tht it forms acylcoA on reaching the mitochondrial matrix so what is the purpose of the formation of first acylcoA in cytoplasm???..will u plz answer it sir plz
thank U very much >> awesome video :)
Where did the two hplus comes from in the reaction
I also wonder the same thing
where did the the fatty acid in the stage of transport into matrix go?
Mimi Sa'ari
It moves from CoA to carnitine, and the fatty acyl carnitine is then transported into the mitochondrial matrix, where the fatty acid switches back to CoA and the free carnitine moves back into the cytoplasm.
Did that help?
may i know why activation of fatty acid requires 2 ATP? because i only saw 1 ATP used in this video @@
The ATP breaks down to AMP, therefore the reaction is equal to a lost of 2ATP.
Hectic lad!
Lysosomes
How does he know EVERYTHING?!?!?!
Thank you!