Get the Biopharmaceutical Classification System Sorted!

The Biopharmaceutical Classification System (BCS) is a way of categorising the likely developability of drugs based on solubility and permeability (in reality, partition coefficient) and places drugs in classes 1-4. Find out how the system works, and what the classifications mean, here!
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[@virion-a]

Another a solid video! love it.

[@lyra331]

this helped me a lot with my exams! thanks

[@hazoummm6076]

Extremely informative along with excellent and interesting introduction for the BCS ! Frankly , In Egypt , I'm suffering as a PharmD student with the outdated curriculum which doesn't give a SINGLE OUNCE OF INFORMATION ABOUT THE BCS ! Hope you upload more and more of biopharmaceutical content to keep up with up-to-date scientific data.

[@PharmaDrama]

Thank you for your kind words - my aim is to keep new content coming that will be relevant to all PharmD students!

[@virion-a]

In BCS system, Is there magic number for solubility? such as 2 mg/ml. >2 mg/ml is good solubility for oral drug. < 2 mg /ml is low solubility for oral drug. Thanks

[@PharmaDrama]

Thanks for your kind comments and the Q :) It used to be the case that the magic number for solubility (for an orally delivered drug) was 10 mg/mL, but this of course heavily depends on the potency of the drug, so as potency increases, solubility can decrease.

[@manoharkommanamanchi]

10:46 it was discussed about bcs c3. It was said that it is difficult to develop such a drug and needs to be a potent one....... But in the 2nd part of pre formulations video the graph depicts highest sales of class 3 drugs does that mean most of them are potent?

[@PharmaDrama]

That is a good point! The BCS is only a rough guide to developability, but you are right of course - as drugs are being increasing designed on a computer to ensure very strong interaction to a biological target they are becoming very potent. Hence, if they have poor solubility/permeability (or both!) they can still be effective in the body.

[@hazoummm6076]

Could you send me a reasearch / youtube video link discussing this dazzling assay ? I'd be grateful 😄