Eczema: What Next After Dupixent Failure?

If you're one of the many eczema patients who has tried Dupixent without achieving satisfactory relief, this video is for you. Dupixent is often portrayed as the ultimate solution for moderate to severe atopic dermatitis, but what happens when it fails to control your symptoms adequately? In this comprehensive guide, we'll explore the reasons behind Dupixent's ineffectiveness for some patients and delve into the various options available to regain control over your eczema.
From ruling out potential misdiagnoses or coexisting skin conditions to combination therapies with topical steroids, phototherapy, or other immunomodulatory drugs, we'll cover a range of approaches backed by recent studies. Additionally, we'll introduce you to the exciting new class of JAK-STAT inhibitors, including medications like Cibinqo, Opzelura, and Rinvoq, which offer promising alternatives for eczema management.
Whether you're seeking relief from severe itching, sleepless nights, or a general improvement in your quality of life, this video will provide you with valuable insights and actionable steps to take control of your eczema journey beyond Dupixent. Join us as we navigate the complexities of this condition and empower you with the knowledge to find the right solution for your unique needs.
For more information , please see the following resources:
Management of inadequate response and adverse effects to dupilumab in
atopic dermatitis.
www.jaad.org/a...
Dupilumab Treatment in Adults with Moderate-to-Severe Atopic Dermatitis
www.nejm.org/d...
Tralokinumab for moderate-to-severe atopic dermatitis: results from two 52-week, randomized, double-blind, multicentre, placebo-controlled phase III trials (ECZTRA 1
and ECZTRA 2)*
www.ncbi.nlm.n...
JAK Inhibitors for Atopic Dermatitis
www.webmd.com/...
Clinical Challenges: Is Recalcitrant Atopic Dermatitis Really Comorbid Disease?
www.medpagetod...
Difficult to control atopic dermatitis
www.ncbi.nlm.n...
GUIDELINES OF CARE FOR THE MANAGEMENT OF ATOPIC DERMATITIS:
www.ncbi.nlm.n...

[@davidsmusic31]

Very helpful! I've been suffering from eczema for years and it had progressed to erythroderma the past 6 months. I do hope i get healed with my new Olumiant treatment.

[@DrKevinLowe]

Hello, I am glad you found the video helpful. I am hopeful that Olumiant works well for you. Be sure to get patch testing done. Olumiant is one of the JAK-STAT inhibitors. If you want to know how this class of medication works, see my video on vitiligo: th-cam.com/video/Jq4dGIOIWQg/w-d-xo.html Thanks for sharing. Thanks for watching.

[@lisuu2080]

Dr Lowe, thank you very much for this video! I tried everything for my eczema and after years of topical steroids, I‘m on dupixent since 3 months. However, my face is still severe and I have eczema on my body. My doctors just want to give me more steroids. What are your thoughts about TSW? Do you have any connections to doctors in Switzerland or the area that you recommend?

[@DrKevinLowe]

Hello, I am very glad you liked the video. TSW is a well recognized phenomenon that can come from prolonged use of topical steroids. Steroids, in general, have many side effects, and for that reason their use is avoided for extended periods of time. No, I don't have any connections to doctors in Switzerland. Your treating dermatologists are the best caregivers to discuss these matters with, since they are most familiar with your history. Give Dupixent a fair chance, and discuss patch testing with your provider. I wish you a speedy recovery. Thanks for watching.