Nordic Bioscience
Nordic Bioscience
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Webinar | Fibrosis as a Driver of Cancer, Liver, and Heart-related Outcomes
Join us for an insightful webinar, where experts will shed light on the multifaceted role of fibrosis in various health conditions.
Our presentations will cover a wide array of topics, starting with an exploration of the fundamentals of the extracellular matrix in health and disease, emphasizing the impact of fibroblast activity on outcomes. The complex relationship between liver fibrosis and hepatocellular carcinoma (HCC) will be explored, examining whether fibrosis is a cause or consequence of this condition.
Further discussions will delve into the extracellular matrix of cancers and the modulation of the ECM, providing insights into the interplay between fibrosis and cancer outcomes. Lastly, we’ll explore collagen biomarkers and their role in predicting outcomes related to liver, heart, and HCC.
This webinar offers a unique opportunity to gain comprehensive insights into the role of fibrosis in driving outcomes across various health conditions with a common component, providing valuable knowledge for researchers, clinicians, and healthcare professionals alike.
0:00 Intro
6:20 Fibroblast Activity Kills - Dr. Morten A. Karsdal
18:03 The ECM of Cancers and The Modulation of the ECM - Dr. Raghu Kalluri
49:50 Collagen biomarkers of Liver, Heart, and HCC Outcome - Dr. Diana Julie Leeming
1:11:40 Liver Fibrosis and HCC - Cause or Consequence? - Dr. Scott Friedman
1:31:50 Questions from the chat​​​​​​​
#fibrosis #cancer #liver #cardiology #drugdevelopment #webinar
มุมมอง: 123

วีดีโอ

Webinar | Precision Medicine in Lung Diseases: New Developments
มุมมอง 1375 หลายเดือนก่อน
Join us for a webinar focused on tissue remodeling, inflammation and biomarkers for pulmonary diseases. Our panel of experts will shed light on the tissue changes occurring in pulmonary diseases including idiopathic pulmonary fibrosis and chronic obstructive pulmonary disease, and how this is affected by the intricate interplay between fibroblasts, epithelial cells, and immune cells. The speake...
Eosinophilic Esophagitis (EoE) | Differentiating Patients with Blood-based Collagen Biomarkers
มุมมอง 825 หลายเดือนก่อน
Eosinophilic Esophagitis (EoE) is an allergic inflammation of the esophagus, causing progressive fibro-stenosis. Excessive extracellular matrix (ECM) proteins, like fibrillar collagens, lead to esophageal fibrosis, resulting in severe clinical complications. Timely intervention is crucial, but current fibrosis assessment methods involve invasive procedures. In collaboration with Dr. Willemijn d...
Webinar | Arthritic Diseases: Fibroblasts and Tissue Destruction
มุมมอง 2207 หลายเดือนก่อน
Join us for an engaging webinar focused on the intricate interplay between fibroblasts and arthritic diseases. Our panel of experts will unravel mechanisms behind tissue damage and repair, discussing fibroblast activation, collagen overproduction, and scar tissue formation. Discover how blood-based biomarkers of extracellular matrix destruction offer insights into treatment effectiveness and pa...
Webinar | Tumor Fibrosis in Cancer: Fibroblast Activities and New Biomarkers
มุมมอง 2598 หลายเดือนก่อน
Join us for a webinar on tumor fibrosis, where we will explore the latest advancements in cancer research with leading experts in the field. This webinar will provide a unique opportunity to hear from experts in the field and gain valuable insights into the latest advancements in tumor fibrosis research. Join us to learn about cutting-edge approaches to developing new therapeutic targets, and t...
Webinar | HFpEF and Extracellular Matrix Dysregulation: Novel Treatment Strategies
มุมมอง 1328 หลายเดือนก่อน
Extracellular matrix (ECM) dysregulation is the founding cause of tissue fibrosis, a process driving more than 50 pathologies and most chronic diseases. Fibrosis may develop both consequent to either an increase in tissue formation or a decrease in tissue degradation. ​​​​​​​Understanding the ECM and the central components of the basement membrane and interstitial ECM will lead to a better unde...
Webinar | Serum Calprotectin and Mucosal Damage in IBD
มุมมอง 1949 หลายเดือนก่อน
Join us for an engaging webinar focused on the intriguing interplay between inflammatory bowel diseases (IBD) and neutrophil activity, with a special emphasis on the insights provided by the unique CPa9-HNE serum calprotectin. Our experts will unravel the biological processes of mucosal damage and healing in inflammatory bowel disease (IBD), and how it relates to neutrophil activity and the ext...
Neutrophils and Neutrophil Extracellular Traps in IBD | Serum Calprotectin CPa9-HNE Biomarker
มุมมอง 6Kปีที่แล้ว
Inflammatory bowel disease, or IBD, is a chronic intestinal disease where neutrophils play an essential role through the production and release of calprotectin. Fecal calprotectin is an established biomarker for IBD, but because it is measured in fecal samples, patient compliance is low. To better help patients, physicians and clinicians, we need a blood-based biomarker that can accurately quan...
NEJM Evidence Publication in Heart Failure by Nordic Bioscience and Collaborators
มุมมอง 113ปีที่แล้ว
Research published in NEJM Evidence positions Nordic Bioscience’s PRO-C6 as next-generation biomarker assay for trial enrichment in HFpEF. We are extremely proud to be able to announce such a publication. This was made possible with the help of an unrelenting scientific team. It took several years of dedication and collaboration together with Bristol Myers Squibb and the University of Pennsylva...
Fibrosis, The Failing Heart, and Endotrophin | Nordic Bioscience
มุมมอง 145ปีที่แล้ว
Fibrosis is a crucial process that occurs in the failing heart. As shown in our recent NEJM Evidence publication, fibrosis markers such as endotrophin allow us to identify a specific endotype of HFpEF patients who are at higher risk for disease progression. Endotrophin is a very interesting molecule because it not only reflects the activity of fibroblasts, which are the main collagen-producing ...
Patient Segregation in Heart Failure with Preserved Ejection Fraction
มุมมอง 244ปีที่แล้ว
A persistent problem remains a challenge in HFpEF - patient heterogeneity. We need the right patients for the right treatment, but how do we get it to them? We believe one approach to solving this issue is to improve patient segregation and endotyping. In collaboration with BMS and UPenn, we have recently identified a subset of patients with a very high risk of adverse outcomes, all determined ...
Protein Quantification: The right epitope of the right protein
มุมมอง 267ปีที่แล้ว
The common denominator of all chronic diseases is severe tissue damage resulting in cell death and changes in collagen composition. Inflammatory cells migrate to the site of damage, secrete proteases, and consequently break down the collagen fibers releasing collagen fragments into the environment. In patients with chronic diseases, there is an increase in tissue build-up, tissue break-down, an...
Rheumatoid Arthritis | Joint Inflammation Animation | Joint Tissue Profiling
มุมมอง 6K2 ปีที่แล้ว
In this Rheumatoid Arthritis Joint Inflammation animation, Nordic Bioscience showcases the potential benefit of Protein Fingerprint biomarkers for preclinical and clinical research in joint tissue profiling. According to conservative estimates, nearly 26% of all adults in the United States are expected to have at least one form of arthritis by 2040. The tissues of the joints are composed primar...
Heart Failure (HFpEF) | Endotrophin as a Novel Biomarker | PRO-C6
มุมมอง 2442 ปีที่แล้ว
Today, Alexander presents how Endotrophin can be used as a novel biomarker in Heart Failure with preserved Ejection Fraction (HFpEF), using the PRO-C6 biomarker assay. HFpEF is predicted to become the predominant form of HF worldwide. It is a very heterogeneous clinical syndrome with a very high degree of morbidity. The syndrome is determined by age, comorbidities and fibrosis, and there is an ...
Cancer Research | Tumor Fibrosis Biomarkers | Immune Checkpoint Inhibitor Therapy
มุมมอง 2262 ปีที่แล้ว
Today Christina presents how tumor fibrosis and collagen fragments can be used in cancer research as biomarkers that can guide immune checkpoint inhibitor therapy. There is an unmet medical need for predictive biomarkers that can guide patient selection and treatment decisions. Emerging evidence indicates that one central common denominator of resistance to immune checkpoint inhibitors may be f...
Pulmonary Fibrosis | Translational Biomarkers | PRO-C6
มุมมอง 2102 ปีที่แล้ว
Pulmonary Fibrosis | Translational Biomarkers | PRO-C6
Extracellular Matrix Animation: Quantifying Tissue Remodeling through the Nordic ProteinFingerPrint™
มุมมอง 109K2 ปีที่แล้ว
Extracellular Matrix Animation: Quantifying Tissue Remodeling through the Nordic ProteinFingerPrint™
Alzheimer's | Early Detection of Neuron Loss | Tau-C Biomarker
มุมมอง 1242 ปีที่แล้ว
Alzheimer's | Early Detection of Neuron Loss | Tau-C Biomarker
Rheumatoid Arthritis and Psoriatic Arthritis | Blood-Based Tissue Profiling
มุมมอง 2583 ปีที่แล้ว
Rheumatoid Arthritis and Psoriatic Arthritis | Blood-Based Tissue Profiling
Cardiovascular Diseases | From Atherosclerosis to Heart Failure (HFpEF)
มุมมอง 3173 ปีที่แล้ว
Cardiovascular Diseases | From Atherosclerosis to Heart Failure (HFpEF)
Respiratory Diseases | Idiopathic Pulmonary Fibrosis and COPD | Beyond The Interstitial Matrix
มุมมอง 6923 ปีที่แล้ว
Respiratory Diseases | Idiopathic Pulmonary Fibrosis and COPD | Beyond The Interstitial Matrix
In Vitro Diagnostic product (IVD) Approval in 2022 - CLSI Standards Regulatory Landscape
มุมมอง 2813 ปีที่แล้ว
In Vitro Diagnostic product (IVD) Approval in 2022 - CLSI Standards Regulatory Landscape
Liver Fibrosis | NASH and NAFLD | The balance between formation and degradation in the ECM
มุมมอง 6363 ปีที่แล้ว
Liver Fibrosis | NASH and NAFLD | The balance between formation and degradation in the ECM
Kidney Fibrosis | Turnover of The Interstitial ECM as a Predictor of Adverse Outcomes
มุมมอง 1.1K3 ปีที่แล้ว
Kidney Fibrosis | Turnover of The Interstitial ECM as a Predictor of Adverse Outcomes
Cancer Research | The Extracellular Matrix in Oncology
มุมมอง 1.1K3 ปีที่แล้ว
Cancer Research | The Extracellular Matrix in Oncology
Inflammatory Bowel Disease | Crohn's Disease and IBD Early Treatment Response
มุมมอง 2273 ปีที่แล้ว
Inflammatory Bowel Disease | Crohn's Disease and IBD Early Treatment Response
The Extracellular Matrix (ECM) | The Common Denominator In All Chronic Diseases
มุมมอง 6K3 ปีที่แล้ว
The Extracellular Matrix (ECM) | The Common Denominator In All Chronic Diseases
Osteoarthritis | Serum Biomarkers | ARGS
มุมมอง 2323 ปีที่แล้ว
Osteoarthritis | Serum Biomarkers | ARGS
Calprotectin in Inflammatory Bowel Disease | Serum | Eliminating the need for stool samples
มุมมอง 5153 ปีที่แล้ว
Calprotectin in Inflammatory Bowel Disease | Serum | Eliminating the need for stool samples
Drug Discovery | Biomarkers in Drug Development: Protein Fingerprint | Nordic Bioscience
มุมมอง 5K3 ปีที่แล้ว
Drug Discovery | Biomarkers in Drug Development: Protein Fingerprint | Nordic Bioscience

ความคิดเห็น

  • @samanthateoh320
    @samanthateoh320 หลายเดือนก่อน

    May I know what the collagen chemical components are

  • @Sarval-tc6xq
    @Sarval-tc6xq 4 หลายเดือนก่อน

    I love the illustration it’s so simple to understand

  • @wallybjr8926
    @wallybjr8926 9 หลายเดือนก่อน

    Very informative diagnostic tool, can we use AI to suggest some options for repair of COPD damage in smokers using the markers? Some PEMF therapy frequencies may also induce reactive cellular replacement. Introduction of ECM stem cell therapy treatments, possibly injectable as well as treatment of Necrotizing fasciitis? Great work from the whole team.

  • @hervintageheartonfire
    @hervintageheartonfire 10 หลายเดือนก่อน

    Amazing animation

  • @flexn01
    @flexn01 ปีที่แล้ว

    thank you :D

  • @alialiraqi2762
    @alialiraqi2762 2 ปีที่แล้ว

    Thanks

  • @deppert8219
    @deppert8219 2 ปีที่แล้ว

    Absolutely fascinating information. I love the passion.

  • @4hero70
    @4hero70 2 ปีที่แล้ว

    Amazing presentation...full of innovative information that offers chances for new holistic protocols

    • @NordicBioscienceAS
      @NordicBioscienceAS 2 ปีที่แล้ว

      We are glad you enjoyed it! At Nordic, we are working hard to provide insights into all chronic diseases, including insights into tumor fibrosis.

  • @headlesschicken175
    @headlesschicken175 2 ปีที่แล้ว

    ah yes, siens 🙂

  • @steveholmes161
    @steveholmes161 2 ปีที่แล้ว

    Well illustrated and informative content.

  • @theshadow8008
    @theshadow8008 2 ปีที่แล้ว

    Nice vids.

  • @RonniWest
    @RonniWest 2 ปีที่แล้ว

    This is great content - thank you for sharing!

  • @outworld15
    @outworld15 2 ปีที่แล้ว

    Thankyou so much for this video! So enlightening to understand things in a global perspective context

    • @NordicBioscienceAS
      @NordicBioscienceAS 2 ปีที่แล้ว

      Thank you for the appreciation, Maximiliano!

  • @bolapromatoqueejogodecampe9353
    @bolapromatoqueejogodecampe9353 2 ปีที่แล้ว

    What an amazing Designer we have.

    • @deistormmods
      @deistormmods 2 ปีที่แล้ว

      I was going to say the same thing. Intelligent design is at work.

    • @dingbop963
      @dingbop963 11 หลายเดือนก่อน

      Designer of what?

  • @eyadelmenawy1001
    @eyadelmenawy1001 2 ปีที่แล้ว

    Thank you for this great animation