Neutrophils and Neutrophil Extracellular Traps in IBD | Serum Calprotectin CPa9-HNE Biomarker

Inflammatory bowel disease, or IBD, is a chronic intestinal disease where neutrophils play an essential role through the production and release of calprotectin. Fecal calprotectin is an established biomarker for IBD, but because it is measured in fecal samples, patient compliance is low.
To better help patients, physicians and clinicians, we need a blood-based biomarker that can accurately quantify true neutrophil and disease activity.
Neutrophils are part of the first line of defense of the immune system and play a vital role in inflammatory bowel diseases such as Crohn's disease and ulcerative colitis.
Neutrophils circulate in the body like sentries, which are directed to the site of tissue injury by chemokines
After activation, neutrophils undergo a process known as NETs, neutrophil extracellular traps. During this NETosis or NETs formation, the activated neutrophils release their DNA in a web-like fashion together with its cytoplasmic matter to trap the invading microbes.
Calprotectin and human neutrophil elastase are major components of NETs, since calprotectin make up about 60% of the total cytoplasmic proteins of neutrophils, while human neutrophil elastase is one of the primary neutrophilic proteases.
Human neutrophil elastase is an effective antibacterial protease, but it can also damage local tissues. In fact, neutrophil elastase degrades not only tissue but also calprotectin into small protein fragments, leading to the formation of CPa9-HNE protein fragments.
The CPa9-HNE fragments are in turn released into circulation and can be accurately quantified using an immunoassay utilizing Nordic Bioscience’s Protein Fingerprint technology.
The quantification of neutrophil activity can be applied in a clinical setting. The CPa9-HNE immunoassay assesses pharmacodynamics of anti-inflammatory drugs and the effect of antineutrophil activity in IBD and other inflammatory diseases.
Nordic Bioscience can match biomarker profiling of tissue damage in IBD to other chronic diseases, from a simple blood sample.
For more information, please visit our website: www.nordicbioscience.com
Or contact us: www.nordicbioscience.com/contact
Video by David Ganderup pixanddots.dk/
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[@flexn01]

thank you :D

[@NordicBioscienceAS]

Glad it helped.