I don't understand why you are so surprised, ANTON is old enough to have played most classic games, it's actually not the first video games reference he made so far :)
Yes, stress can age you quickly. My hair was grey at 45 years old, but my hair color came back when I left my ex. Stress is probably behind many modern health issues.
I didnt have children with my ex, I got remarried and was told there was no way I would get pregnant without medical interventions. I had a baby a month before I was 40, another at 41, and a big surprise at 45 years old! All complication free pregnancies, natural childbirth and three totally amazing children. It’s amazing when you get rid of such extreme stress how much your body can heal, both physically and mentally. Plus for me I have three of my most favorite people on the planet now! ❤
Yet historically speaking we’re healthier than we ever been. In 1900 a little more than a hundred years ago the average life span was 47 years. Now it’s close to 80
@@raynersclips4223 The increase of life span is mainly attributed to reduction of infant mortality. Losing one in four children before the age of 5 really lowers the average. My favorite nonna was born in 1928 and as fit as a fiddle.
You're awarded a degree if you beat the game? Do you do mitochondria research now? Sometimes I get extra sleepy...ahhh...doctor. You think I've got bum mito?
read the video’s title and scrolled down to the comment section looking for the Parasite Eve reference. Even if part of me felt it was inevitable to find one, I’m glad to have done it nonetheless (and so up!).
I like the analogy of humans being ships, and biota being crew, together exploring the world. We even send out colony ships roughly once a day, though now a days, it gets flushed.
I don't really like that analogy because it seems to separate humans as something different from the world. If we were to use something close to that analogy, we are ships full of ships full of ships full of ships, and it's likely that we are on ships that are on ships that are on ships and so on in both directions.
@@Puzzlesocksit entirely depends on if the rest of the world hasn't gone the same way, if it's a commonality for everything on this planet to be structured like this, as currently seems to be the case it wouldn't separate us
I’ve done a small amount of mito research. It’s amazing how different they can be between individuals of the same species and how the Oxphos system is regulated at different stages of stress and energy use.
How different when we (humans) all come from mitochondrial Eve, who lived some 200,000 years ago near the Nile? You must be talking of another species altogether.
Even though paternal mitochondria in most cases are wiped out and their mitochondrial DNA tends to not be passed on, an overwhelming amount of the DNA which encodes the proteome of the mitochondria is actually Nuclear DNA, so both parents contribute significantly to mitochondria, the maternal side just sightly more so. The Mitochondrial DNA only encodes most of the Electron Transport Chain proteins and the mito-ribosomes and mito-tRNA, which couldn’t function without the Citric Acid Cycle proteins which synthesize the NADH and FADH2 required for the ETC to work. This isn’t to downplay the mtDNA as unimportant but rather to just stress the importance of the interconnectedness of the genomes both parents contribute.
Dr Lynn Margolis, "in her formative paper, "On the Origin of Mitosing Cells", appeared in 1967 after being rejected by about fifteen journals.[3] Still a junior faculty member at Boston University at the time, her theory that cell organelles such as mitochondria and chloroplasts were once independent bacteria was largely ignored for another decade, becoming widely accepted only after it was powerfully substantiated through genetic evidence."
@@mechez774a lot of men had the exact same idea (and published it) long before her. In some case before she was born. There wasn’t enough data to be sure in 1967… and when it came, it wasn’t due to her “research”. She also believed to the day she died that lots of other organelles that clearly weren’t symbiotic, were. She had a pet theory and she never stopped being a true believer.
2 billion years, eventually through a leap of faith, some bacteria(he thinks) became a part of cellular life we don't witness until Cambrian explosion, or just before. it's a bit of a leap, turning bacteria into cellular life with multiple functions across a range of areas. Evolution certainly had nothing to do with it, so what did?
Parasite Eve was one of the greatest, yet criminally underrated video games of its era. The fact that it's one of Anton's all time favorites just makes me like him even more than I did. Thank you for reminding me about this classic title. What a wonderful person Anton is. Also, I learned something new about Mitochondria today! Woo hoo. A+ content.
I’m feeling less like an individual and more like a coral reef, a convenient place for a bunch of different life forms to hang out, find shelter, and eat.
I was the only kid in Sophomore Biology to get perfect scores on the Mitochondria chapter. I was usually the kid who got no scores on all chapters. The teacher thought I cheated, but I told her video games carried me through, because they offered a far more interesting science lesson than she could ever muster. Huge thanks to my PS1 and my copy of Parasite Eve.
Damn. I literally experienced the same thing with my middle school biology teacher. I knew everything about the cytology organelle chapter. He was like, how? I told him a video game. I explained parasite eve. We had an awesome conversation and he was floored that a videogame went into such theoretical territory on the subject.
@@BasaBoi The extra reading material attached to the museum labyrinth and other similar things, like articles and books scattered throughout the game, was done similarly to how Assassin's Creed 2 would later map out Italy's historical references. I think SquareSoft did the best job giving the most accurate information on mitochondria in an order that is much easier to understand than any textbook. I'm so excited on this update from Anton, because I've been hard on mitochondria lately, but more on the relations with acids and alkaloids. It kind of led me onto a path about reading on alkaloids and the use of cancer medicines since 2013. I never did watch the live-action movie from Japan, nor did I read the book. But I did play the 2nd game, and The Third Birthday. There was still some good information in the 2nd game, but the original has recently been hitting my happy place, and ironically, I got obsessed again about two weeks back.
@@BasaBoi SquareEnix might still own the property. I wonder if bringing that one back as the original "Cinematic RPG" could bring them a much-needed massive win? I'll have to read the book soon.
"Midi-chlorians in The Phantom Menace are part of a recurring theme throughout the movie, that of symbiotic relationships.[21] They were loosely based on mitochondria, organelles that provide energy for cells; like midi-chlorians, mitochondria are believed to have once been separate organisms that inhabited living cells and have since become part of them; even now, mitochondria act in some ways as independent lifeforms, with DNA all their own. Lucas established this relation with mitochondria, in particular the necessity of midi-chlorians for life to exist, as a metaphor for society; namely, he says all parts of society must get along in much the way the midi-chlorians and their symbiont do.[26]" [source Wookipedia]
The prequels were where everything went downhill. The sequels were ok, but the prequels, and Lucas' propensity for incessant meddling retcons, ruined it for me.
@Receipt i looked mitochondrial gene expression in many ways is influenced by Nuclear gene expression plus has RNA and also mitochondrial membranes sensitivity
Hi Anton. Regarding mitocondria, there is a new field in psychiatry called metabolic psychiatry. Their main tenet is that mitocondria is the primary cause of mental disorders and those can be fixed if you fix your mitocondria. Proponents of this new approach are (among others) Dr Georgia Ede and Dr Christofer Palmer.
It's certainly something that's quite a bit older than this being brought forward using newer techniques and understanding, I certainly will have to read up on this, as this lines up with my own experience and understanding of psychology which I've been using for over 20 years, where a healthy lifestyle and meditation can do a lot to understand your mental state and steer it, though I never would've thought it was actually influencing positively Mitochondria would be a key to possibly control you problems very interesting and maybe reading up on this might end up being the piece I was missing in my own work
"buuut it also involves a lot of murder, and a lot of violence, which basically made this, an amazing video game." lmao had me rolling, i too had a fun time playing this as a small child
*"Without the Mitochondria, life could not exist, and we would have no knowledge of the Force. They continually speak to us, telling us the will of the Force. When you learn to quiet your mind, you'll hear them speaking to you."* -- Qui-Gon Anton
My God, hell must have frozen over. One of my favorite videogames has basically turned into a research paper. Videogames like this taught me how to read and take even more interest in the sciences. The possession and biological hacking of another being through mitochondria doesn't seem so far fetched of a concept now. They're a processor basically taking instructions and can even influence mental states.
Also, note the similarity to Star Wars "midi-chlorians" without which "life could not exist, and we would have no knowledge of the Force. They continually speak to us, telling us the will of the Force. When you learn to quiet your mind, you'll hear them speaking to you."
I have a feeling my mitochondrias talk to each other with the interveins and not face to face. They have to be as antisocial/introverted as me to make me like this.
DUDE! Long time viewer. When I saw the thumbnail, I was totally thinking about "Parasite Eve"! When you mentioned it I started cheering out loud. I also think it was one of the coolest plots of any video game. As a paleontologist that grew up really into biology and science, it really struck a chord w me. I later worked at the American Museum (Im a New Yorker) which was also in the game. Anton, I've always loved your work, but you are even cooler to me after this one. Cheers!
Norwegian here🇳🇴 Finally, this knowledge - both old and new - about mithochondrial function and health, are shared on an "ordinary" TH-cam-channel - by an astrophysicist none the less, in such a simple way, ordinary people are getting aware how important mithocondria are to human health. A circadian, clean lifestyle, is the best way of getting healthy mithocondria, gut- and brain health. I've been working in these fields, and know how they are closely linked to each other in regards to overall human health, also on a psychological, mental, and cognitive level, for about 15 years. But I've never seen basic mithocondrial function described in such a way people can understand. Try attending a medical conference learning about this topic, the wording would sound like gibberish to anybody outside the medical sphere, on such a conference. Anton just saved you from a lot of boring hours - with ONE video. The guy is literally a genious❤ And ppl; please take care of your mithocondrial health; circadian living, grounding barefoot outside - no matter the weather (you can use wool slippers with leather soals in the extreme cold winter season - especially when you have children, they need protection until their bodies are acclimated and used to it) at least 20min a day, spend time in nature, clean eating habits, invested quality sleep, no screens after sunset (or use with protective blue-light blocker-glasses after the sun goes down and the natural light disappears - without, your brain are assuming it is 01pm (13:00) every time you look at the screen. This confuses the brain on such a level, our mithicondria are affected), and working out regularly - having balance between rest and movement on a daily basis. I'm so glad Anton brought up this topic. It is way too important to ignore. Ordinary people needs to hear about the importancy of mithocondria, so I'm hoping he will follow up on this. Gotta love his channel even more, but how that's even possible, I don't know❤
I love Mitochondria, hence my avatar. It was Nick Lane who switched me onto the importance on these little beasts. It's obvious we haven't truly grasped how important they truly are. But it would not surprise me if they were responsible the the very nature of feeling and by extension consciousness.
The ultimate evolution of mitochondria was consciousness. If the ultimate evolution of consciousness is connected collective consciousness, then finding out what physiological changes have to occur for us to evolve, perhaps will trigger its evolution with less trial and error. Mind blowing
what does this mean? collective conciseness is an interesting idea until you realize aliens are probably real and also have one. are we (aliens with consciousness included) all experiencing through consciousness? we probably do and will experience again after death in a new brain. obviously you wouldn’t remember anything before you were born and i’m not saying you’d be the same person “reborn” this isn’t reincarnation. you’d be someone else entirely with an entirely different life and brain. this repeats until there are no more capable brains in the universe to experience consciousness
These are new mind blowing thoughts to me thanks to you and Anton. I can speculate only that a soul is not perpetual till it's capable of residing physically in a nourishing new Symbiosis and the only way is a depository of collective consciousness, like Aiwa in Avatar; and since I'm being ridiculous, Aiwa can be used as a hive mind. Most our studies find chemical (pheromone) like methods of communication in hive mind ants. So maybe our vocal nature is preventing us from developing additional chemical sensors into our physiology for more advance type of communications that can bring mitochondria to its reason for being from the getgo.
@@Moxiumousit's kind of wild how we are now at a point where what is essentially the philosophy behind "the force" in star wars, is now a serious discussion.
Since we remembered Parasite Eve, here's more: "Midi-chlorians are microscopic, intelligent life forms that originated from the foundation of life in the center of the galaxy and ultimately resided within the cells of all living organisms, thereby forming a symbiotic relationship with their hosts. The Force spoke through the midi-chlorians, allowing certain beings to use the Force if they were sensitive enough to its powers."
I saw this video and had a flashback to something a biology teacher once said: A geneticist once went bad, joined a biker gang, and went to jail for murder. When he got to the state pen he announced that the other inmates should call him "mitochondria." A gangster got in his face and asked why. He punched him so hard he flew across the room and he replied " *because I'm the power house of this mother f %^!in' cell!* " We all had that one teacher.
Intriguing/bemusing recall Leon, I took genetics at W.Smith alt. H.s. Aurora, 🇻🇪 CO. Confirmed, I had that one teacher as well. ❤thx4 sharing that memory!
Mitochondria are important in the immune system, particularly in neutrophil cells. They are important in pyroptosis to fight cellular invasion, netosis to 'net' bacteria and parasites in the blood using expelled DNA, production of reactive Nitris oxides also for anti-bacterial effects and vasodialation. By the same methods however, they are also key players when inflammation and immune system goes heywire and very self destructive as in lupus kidney damage, lung damage etc.
This was an amazing episode. Thank you for sharing your knowledge with us. You are an exceptional man and I hope someone hugs you every single day. You deserve it.
We are a multicultural life form. We are a collaboration of multitudes of microscopic life forms working together symbiotically to form an individual human being. So to put it simply we are an intelligent microbial community learning and living as one.
6:11 they share a relative to stabilize and share. The relative is the bridge kinda like how my arm is relative to me so i have potentials connected. Awesome stuff here.
As someone who’s got Mito dysfunction associated with autoimmune disease and neuromuscular dystrophy, as well as having 2 kids with the same (late onset for me) all of this is extremely interesting!
Fascinating and enlightening discoveries. Mood and stress affect us at the celular level and also trigger mental problems, and speed up aging. Thanks Anton. There are physicians in my family who were surprised to learn about this research.
I LOVED Parasite Eve on PS1 and I also own a 1st edition hardcover of the book! I have an obsession with mitochondria and really enjoyed your video! Thanks!
The complexity of the interplay between, quite literally, almost an uncountable amount of molecular machinery, functioning at speeds we cannot perceive, in conjunction with a DNA distinct lifeform, embedded within every one of our cells (Mitrocondria) is mind blowing enough but having them communicate with each other to help keep us physically and mentally healthy is well, just... like a drop the mike moment for me, awesome vid Anton!
I've been fascinated by mitochondria ever since I first learned about them by reading biology books. So weird to me that people learn this stuff through video games, but whatever gets you educated. Reminds me of a book I read long ago which argued that tv (in this case games) were making people smarter.
Then I guess I'm doomed to age quickly and die young because my mitochondria are always stressed from the years of depression and trauma I've been forced to endure alone.
This further explains why different species of animals evolve in similar manners under similar environmental circumstances. Because the Mitochondria design the organisms structure around their own survival. Which limits the range of potential differences in solutions when faced with the similar problems.
That might explain why creatine gives a big response against depression for some people including me, but unfortunately it also leaves me with anxiety/stress so I stopped taking it.
So, let me get this straight. Mitochondria are probably having a little chat among themselves, plotting to get us to build A.I. just to keep them around longer?
1) Humility comes from surrendering to Mitochondria control 2) Mother's vindication comes from own Mitochondria being passed down regardless of offspring wishes.... Conclusuon: The Creator (aka God) has the best sense of humor 😅😅😅 👏👏👏 🙏
I KNEW IT! i knew there was something off about them... like, how can you just be the powerhouse of the cell? It was so obvious that was just a disguise
9:59 well what I’ve always imagined is that the mother is the incubator so the father brings differences so if the mom is the stable then she might hold certain foundations like an egg instead of the difference every time. It’s like sharing the current with potential. A house is a solid foundation to maintain stability and the fathers seed brings difference to help shape difference into a relative foundation. Sounds weird but just my thoughts. 11:48 yeah they might compete or cause mutations. It’s like fitting a puzzle piece into a slot, if the puzzles got an extra thing, it can cause interferences. Destabilization and relative collapse. It causes mutations or deformities probably or causes full collapse.
A wonderful video by a wonderful person. 🙂 It makes us realize how little we know and how much more we need to learn about our world. Not only informative but inspirational. Thank you, Anton.
Parasite Eve (パラサイト・イヴ, Parasaito Ivu) is a Japanese science fiction horror novel by Hideaki Sena, first published by Kadokawa in 1995. The book was published in North America by Vertical, Inc. in 2005. Parasite Eve was adapted into a film and manga series. It was later expanded into three video games which is centered on a different character named Aya Brea; two that serve as sequels to the novel, along with a spin-off third game. The video games have also been adapted into a manga series.
Thanks to the people doing the actual science as I've done none of that, but I have been suggesting that mitochondria were more than dumb generators for decades. Just as some scientists are now asking who serves who in regards to our microbiome, we can also ask whether plants serve our needs or vice-versa. These are all symbiotic relationships where our insecurities convince us that "we" exist as separate entities from other living things or are at least masters over them; somehow a desirable, and thus survival-enhancing, concept to the human mind. Sentience allows us to sustain comfortable beliefs that, in turn, make us better servants to the microbes and plants that partner with us. "We" is something that most humans are too insecure to imagine and that bias is itself an adaptation; ignorance is literally bliss.
Ever since AP biology I realized the human ego is offended by our mitochondrial symbiosis or we would refer to our individual selves as “we.” That’s why we need our ego so we can think critically as individuals. But with too much ego we would forget we are part of the same living macroorganism, bound by a vast biome of microorganisms.
I love♥this topic! Co-existing and the microscopic world is like learning more about inner space which we know very little about but more than I realized has been learned.
No way, one of my favourite science youtubers doing a video involving a cult classic video game like Parasite Eve!
facts i was like....wait what lol
That game had an absolutely amazing soundtrack.
One of us
Antone's let's play Parasite Eve
I don't understand why you are so surprised, ANTON is old enough to have played most classic games, it's actually not the first video games reference he made so far :)
Wait so we're actually 10 Trillion Mitochondria in a trenchcoat??? Awesome. 🎉
Some people have the trans mitochondria.
Wonderful.
Apparently like 100 trillion Mitochondria, but I can’t find a source for that so it could be less.
We are a colonial mecha suit
@@TheKrispyfortI smoke weed, I'm an Orbital Frame 😎.
Yes, stress can age you quickly. My hair was grey at 45 years old, but my hair color came back when I left my ex.
Stress is probably behind many modern health issues.
I didnt have children with my ex, I got remarried and was told there was no way I would get pregnant without medical interventions. I had a baby a month before I was 40, another at 41, and a big surprise at 45 years old! All complication free pregnancies, natural childbirth and three totally amazing children. It’s amazing when you get rid of such extreme stress how much your body can heal, both physically and mentally. Plus for me I have three of my most favorite people on the planet now! ❤
My hair is gray since 19, insomnia sucks man 👻😵
Yet historically speaking we’re healthier than we ever been. In 1900 a little more than a hundred years ago the average life span was 47 years. Now it’s close to 80
@@raynersclips4223 We have better healthcare, better medicine and, as result, longer lifespan. But are we healthier?
@@raynersclips4223 The increase of life span is mainly attributed to reduction of infant mortality. Losing one in four children before the age of 5 really lowers the average. My favorite nonna was born in 1928 and as fit as a fiddle.
As someone who has beaten Parasite Eve 1 & 2, I'm a bit of a mitochondrial expert.
Dr. Klamp?!
Are you something of a mitochondrial expert yourself? :D
Saw this comment before realizing that's a game and thought you'd beaten some rare disease or smth lol
You're awarded a degree if you beat the game? Do you do mitochondria research now?
Sometimes I get extra sleepy...ahhh...doctor. You think I've got bum mito?
read the video’s title and scrolled down to the comment section looking for the Parasite Eve reference. Even if part of me felt it was inevitable to find one, I’m glad to have done it nonetheless (and so up!).
My mitochondria liked this video. They were pleased.
Our masters!
I like the analogy of humans being ships, and biota being crew, together exploring the world. We even send out colony ships roughly once a day, though now a days, it gets flushed.
I don't really like that analogy because it seems to separate humans as something different from the world. If we were to use something close to that analogy, we are ships full of ships full of ships full of ships, and it's likely that we are on ships that are on ships that are on ships and so on in both directions.
@@Puzzlesocksit entirely depends on if the rest of the world hasn't gone the same way, if it's a commonality for everything on this planet to be structured like this, as currently seems to be the case it wouldn't separate us
eww gooner
colony shits* 😊
The ship is in control.
Otherwise, people would instantly stop smoking, drinking, and eating trash food.
I’ve done a small amount of mito research. It’s amazing how different they can be between individuals of the same species and how the Oxphos system is regulated at different stages of stress and energy use.
How different when we (humans) all come from mitochondrial Eve, who lived some 200,000 years ago near the Nile? You must be talking of another species altogether.
@@LuisAldamiz Mitochondrial Eve theory doesn't say we all have the same mitochondrial DNA. It literally traces back the changes in mtDNA since then
How would mitochondrial perfusion change things in an organism?
@@IragmanI Yes, 10 000 generations gives lots of opportunities for mutations/adaptations
@@zer0nixfeeding them has more effect. They eat gluthation, that can be made out of acethylcistein.
Even though paternal mitochondria in most cases are wiped out and their mitochondrial DNA tends to not be passed on, an overwhelming amount of the DNA which encodes the proteome of the mitochondria is actually Nuclear DNA, so both parents contribute significantly to mitochondria, the maternal side just sightly more so. The Mitochondrial DNA only encodes most of the Electron Transport Chain proteins and the mito-ribosomes and mito-tRNA, which couldn’t function without the Citric Acid Cycle proteins which synthesize the NADH and FADH2 required for the ETC to work. This isn’t to downplay the mtDNA as unimportant but rather to just stress the importance of the interconnectedness of the genomes both parents contribute.
Absolutely mind blowing. Thank you once again Anton. Your videos are one of the highlights of my day.
Dr Lynn Margolis, "in her formative paper, "On the Origin of Mitosing Cells", appeared in 1967 after being rejected by about fifteen journals.[3] Still a junior faculty member at Boston University at the time, her theory that cell organelles such as mitochondria and chloroplasts were once independent bacteria was largely ignored for another decade, becoming widely accepted only after it was powerfully substantiated through genetic evidence."
Fun fact - She was Carl Sagan’s ex-wife
Hopefully the man who was smart enough to discover her work will win the Nobel
sagan too? at some point its the medium not the message sister
@@mechez774a lot of men had the exact same idea (and published it) long before her. In some case before she was born. There wasn’t enough data to be sure in 1967… and when it came, it wasn’t due to her “research”. She also believed to the day she died that lots of other organelles that clearly weren’t symbiotic, were.
She had a pet theory and she never stopped being a true believer.
The main thing holding back scientific progress is old scientists.
2 billion year old cell to a bacterium: “Louis, I think this is the beginning of a beautiful friendship.”
2 billion years, eventually through a leap of faith, some bacteria(he thinks) became a part of cellular life we don't witness until Cambrian explosion, or just before.
it's a bit of a leap, turning bacteria into cellular life with multiple functions across a range of areas. Evolution certainly had nothing to do with it, so what did?
I was thinking of the fri me who crashes on your couch for a few day, then never moves out
Information theory makes evolution impossible
peetah the horse is here
Luv it
Aton is a man of taste. Parasite Eve is great. Love the gun upgrade system.
I instantly thought of PE when I saw this thumbnail
It’s a good song by BMTH too
Came here to say it.
"And all this time you thought you were in control." -Mitochondria probably
PARASITE EVE O_o
You're also your mitochondria. Nuclear DNA may be a bit overrated.
@@LuisAldamizOr so the Mitochondria would have us believe!
There will always be symbiosis. All the way up.
Master Blaster species.
Parasite Eve was one of the greatest, yet criminally underrated video games of its era. The fact that it's one of Anton's all time favorites just makes me like him even more than I did. Thank you for reminding me about this classic title. What a wonderful person Anton is. Also, I learned something new about Mitochondria today! Woo hoo. A+ content.
I’m feeling less like an individual and more like a coral reef, a convenient place for a bunch of different life forms to hang out, find shelter, and eat.
And thats Just our Bodys. Our Minds are basicly the Same. A Coral Reef of agents🎉
I was the only kid in Sophomore Biology to get perfect scores on the Mitochondria chapter. I was usually the kid who got no scores on all chapters. The teacher thought I cheated, but I told her video games carried me through, because they offered a far more interesting science lesson than she could ever muster. Huge thanks to my PS1 and my copy of Parasite Eve.
Damn. I literally experienced the same thing with my middle school biology teacher. I knew everything about the cytology organelle chapter. He was like, how? I told him a video game. I explained parasite eve. We had an awesome conversation and he was floored that a videogame went into such theoretical territory on the subject.
@@BasaBoi The extra reading material attached to the museum labyrinth and other similar things, like articles and books scattered throughout the game, was done similarly to how Assassin's Creed 2 would later map out Italy's historical references. I think SquareSoft did the best job giving the most accurate information on mitochondria in an order that is much easier to understand than any textbook. I'm so excited on this update from Anton, because I've been hard on mitochondria lately, but more on the relations with acids and alkaloids. It kind of led me onto a path about reading on alkaloids and the use of cancer medicines since 2013. I never did watch the live-action movie from Japan, nor did I read the book. But I did play the 2nd game, and The Third Birthday. There was still some good information in the 2nd game, but the original has recently been hitting my happy place, and ironically, I got obsessed again about two weeks back.
@@BasaBoi SquareEnix might still own the property. I wonder if bringing that one back as the original "Cinematic RPG" could bring them a much-needed massive win? I'll have to read the book soon.
Classic game, probably the first rpg/horror survival that i've seen, i still listen to the soundtrack
It reminds me that I gave a talk on cytoplasmic inheritance in a high school biology class in 1969. Looking back I realize now, nobody understood it.
"Midi-chlorians in The Phantom Menace are part of a recurring theme throughout the movie, that of symbiotic relationships.[21] They were loosely based on mitochondria, organelles that provide energy for cells; like midi-chlorians, mitochondria are believed to have once been separate organisms that inhabited living cells and have since become part of them; even now, mitochondria act in some ways as independent lifeforms, with DNA all their own. Lucas established this relation with mitochondria, in particular the necessity of midi-chlorians for life to exist, as a metaphor for society; namely, he says all parts of society must get along in much the way the midi-chlorians and their symbiont do.[26]" [source Wookipedia]
It's also worth noting that the midi-Chlorians are sentient, if I'm remembering what wookiepedia said correctly.
The prequels were where everything went downhill. The sequels were ok, but the prequels, and Lucas' propensity for incessant meddling retcons, ruined it for me.
"If i destroy you, what business of it is yours?" - my mitochondria probably.
Why is all the selection on paternal side if all factor especially factors males are selected for are on the maternal side
"My body my choice"- Mitochondria
@Receipt i looked mitochondrial gene expression in many ways is influenced by Nuclear gene expression plus has RNA and also mitochondrial membranes sensitivity
Hi Anton. Regarding mitocondria, there is a new field in psychiatry called metabolic psychiatry. Their main tenet is that mitocondria is the primary cause of mental disorders and those can be fixed if you fix your mitocondria. Proponents of this new approach are (among others) Dr Georgia Ede and Dr Christofer Palmer.
I watch a woman who stopped taking schizo-effective disorder medication for a keto diet.
That sounds fascinating. That and the relationship between the gut microbiome and the digestive tract being like a second brain.
It's certainly something that's quite a bit older than this being brought forward using newer techniques and understanding, I certainly will have to read up on this, as this lines up with my own experience and understanding of psychology which I've been using for over 20 years, where a healthy lifestyle and meditation can do a lot to understand your mental state and steer it, though I never would've thought it was actually influencing positively Mitochondria would be a key to possibly control you problems very interesting and maybe reading up on this might end up being the piece I was missing in my own work
Interesting
That sounds eerily similar to several known forms of woo...
"buuut it also involves a lot of murder, and a lot of violence, which basically made this, an amazing video game." lmao had me rolling, i too had a fun time playing this as a small child
*"Without the Mitochondria, life could not exist, and we would have no knowledge of the Force. They continually speak to us, telling us the will of the Force. When you learn to quiet your mind, you'll hear them speaking to you."* -- Qui-Gon Anton
Perfectly placed movie quote.... nicely done
Mitochochlorians
Immediately thought this, too
Not far from reality
@@auriel8300MMMM... look into this more , I must.
My mitochondria are pissed that you blew their cover!
They would want to be found! They want to be fed!
@jabezcreed How DARE you put words Into their cell membranes!
🧫
☝️😉
My God, hell must have frozen over.
One of my favorite videogames has basically turned into a research paper. Videogames like this taught me how to read and take even more interest in the sciences.
The possession and biological hacking of another being through mitochondria doesn't seem so far fetched of a concept now. They're a processor basically taking instructions and can even influence mental states.
Next month, they're going to discover Lavos is real
You obviously meant midi-chlorians.
I’m late. You beat me to it. 😂
Lol
Also, note the similarity to Star Wars "midi-chlorians" without which "life could not exist, and we would have no knowledge of the Force. They continually speak to us, telling us the will of the Force. When you learn to quiet your mind, you'll hear them speaking to you."
It wasn’t me, it was my mitochondria
I have a feeling my mitochondrias talk to each other with the interveins and not face to face. They have to be as antisocial/introverted as me to make me like this.
"Mitochondria is the powerhouse" ❌
"Mitochondria is all there is"✅
Another wrong one : Planet Earth created life
@@youfoundityoufoundit6675No shit Sherlock.
Alien are into all of US
Just Monichondria
DUDE! Long time viewer.
When I saw the thumbnail, I was totally thinking about "Parasite Eve"! When you mentioned it I started cheering out loud. I also think it was one of the coolest plots of any video game. As a paleontologist that grew up really into biology and science, it really struck a chord w me. I later worked at the American Museum (Im a New Yorker) which was also in the game. Anton, I've always loved your work, but you are even cooler to me after this one. Cheers!
Cool. Thank you! As always this is a great upload for us to enjoy.
Norwegian here🇳🇴 Finally, this knowledge - both old and new - about mithochondrial function and health, are shared on an "ordinary" TH-cam-channel - by an astrophysicist none the less, in such a simple way, ordinary people are getting aware how important mithocondria are to human health. A circadian, clean lifestyle, is the best way of getting healthy mithocondria, gut- and brain health. I've been working in these fields, and know how they are closely linked to each other in regards to overall human health, also on a psychological, mental, and cognitive level, for about 15 years. But I've never seen basic mithocondrial function described in such a way people can understand. Try attending a medical conference learning about this topic, the wording would sound like gibberish to anybody outside the medical sphere, on such a conference. Anton just saved you from a lot of boring hours - with ONE video. The guy is literally a genious❤ And ppl; please take care of your mithocondrial health; circadian living, grounding barefoot outside - no matter the weather (you can use wool slippers with leather soals in the extreme cold winter season - especially when you have children, they need protection until their bodies are acclimated and used to it) at least 20min a day, spend time in nature, clean eating habits, invested quality sleep, no screens after sunset (or use with protective blue-light blocker-glasses after the sun goes down and the natural light disappears - without, your brain are assuming it is 01pm (13:00) every time you look at the screen. This confuses the brain on such a level, our mithicondria are affected), and working out regularly - having balance between rest and movement on a daily basis. I'm so glad Anton brought up this topic. It is way too important to ignore. Ordinary people needs to hear about the importancy of mithocondria, so I'm hoping he will follow up on this. Gotta love his channel even more, but how that's even possible, I don't know❤
❤❤❤❤
2025 first mitochondria defense used successfully in the US court.
My mitochondria are control freaks
I’m sorry for you.
mine are too
My mitochondria are Jesus Christ
@@alb9yours have mental illnesses
Dont worry mine too
Mine want to stay home and watch videos about itself
I love Mitochondria, hence my avatar. It was Nick Lane who switched me onto the importance on these little beasts. It's obvious we haven't truly grasped how important they truly are. But it would not surprise me if they were responsible the the very nature of feeling and by extension consciousness.
Nick Lane! 👍
The ultimate evolution of mitochondria was consciousness. If the ultimate evolution of consciousness is connected collective consciousness, then finding out what physiological changes have to occur for us to evolve, perhaps will trigger its evolution with less trial and error. Mind blowing
what does this mean? collective conciseness is an interesting idea until you realize aliens are probably real and also have one. are we (aliens with consciousness included) all experiencing through consciousness? we probably do and will experience again after death in a new brain. obviously you wouldn’t remember anything before you were born and i’m not saying you’d be the same person “reborn” this isn’t reincarnation. you’d be someone else entirely with an entirely different life and brain. this repeats until there are no more capable brains in the universe to experience consciousness
These are new mind blowing thoughts to me thanks to you and Anton. I can speculate only that a soul is not perpetual till it's capable of residing physically in a nourishing new Symbiosis and the only way is a depository of collective consciousness, like Aiwa in Avatar; and since I'm being ridiculous, Aiwa can be used as a hive mind. Most our studies find chemical (pheromone) like methods of communication in hive mind ants. So maybe our vocal nature is preventing us from developing additional chemical sensors into our physiology for more advance type of communications that can bring mitochondria to its reason for being from the getgo.
@@Moxiumousit's kind of wild how we are now at a point where what is essentially the philosophy behind "the force" in star wars, is now a serious discussion.
@@davedavidson8208 The midichlorian is the powerhouse of the cell
@@rezadaneshi "our vocal nature is preventing hive mind", try yelling FIRE in a crowded theatre
Picard: "Number one, plot heading to planet Mitochondrion, warp 6......... Engage!!"
Wow. Consciousness could be a mere byproduct of an organelle with an appetite.
I think it's some sort of emergent phonemonea once enough faculties are connected
I’m pretty sure every microscopic life in me just argues with each other “I’m right” “No! I’m right!”
That's wild news. Especially the part about paternal mitochondria
This surprised me because I thought the paternal mitochondria were only in the sperm tail which was lost when entering the egg
Since we remembered Parasite Eve, here's more: "Midi-chlorians are microscopic, intelligent life forms that originated from the foundation of life in the center of the galaxy and ultimately resided within the cells of all living organisms, thereby forming a symbiotic relationship with their hosts. The Force spoke through the midi-chlorians, allowing certain beings to use the Force if they were sensitive enough to its powers."
I saw this video and had a flashback to something a biology teacher once said:
A geneticist once went bad, joined a biker gang, and went to jail for murder. When he got to the state pen he announced that the other inmates should call him "mitochondria." A gangster got in his face and asked why. He punched him so hard he flew across the room and he replied " *because I'm the power house of this mother f %^!in' cell!* "
We all had that one teacher.
Intriguing/bemusing recall Leon, I took genetics at W.Smith alt. H.s. Aurora, 🇻🇪 CO. Confirmed, I had that one teacher as well. ❤thx4 sharing that memory!
Parasite eve, there's a great game I haven't heard of in a long while.
Mitochondria are important in the immune system, particularly in neutrophil cells. They are important in pyroptosis to fight cellular invasion, netosis to 'net' bacteria and parasites in the blood using expelled DNA, production of reactive Nitris oxides also for anti-bacterial effects and vasodialation. By the same methods however, they are also key players when inflammation and immune system goes heywire and very self destructive as in lupus kidney damage, lung damage etc.
Thank you so much for not saying "Fun Fact" at the beginning of that.
Hey!
This was an amazing episode. Thank you for sharing your knowledge with us. You are an exceptional man and I hope someone hugs you every single day. You deserve it.
So, mitochondria is a processor with an incalculable algorithm
I come here just to hear that I’m wonderful. Thanks Anton
He said it to me first.
You both are!🍻
We are a multicultural life form. We are a collaboration of multitudes of microscopic life forms working together symbiotically to form an individual human being. So to put it simply we are an intelligent microbial community learning and living as one.
thank you for the video Anton. This subject has been on my mind lately so I was surprised to see a video on it in my feed tonight
My mitochondria just wants to smoke weed and watch Anton videos all day
6:11 they share a relative to stabilize and share. The relative is the bridge kinda like how my arm is relative to me so i have potentials connected. Awesome stuff here.
Midochlorians!
The "scientists" are spelling it incorrectly for some reason.
As someone who’s got Mito dysfunction associated with autoimmune disease and neuromuscular dystrophy, as well as having 2 kids with the same (late onset for me) all of this is extremely interesting!
Far Far Away.. the Jedi call them Midiclorins..
Fascinating and enlightening discoveries. Mood and stress affect us at the celular level and also trigger mental problems, and speed up aging. Thanks Anton. There are physicians in my family who were surprised to learn about this research.
omg that's how I learnt about mitacondria, through parasite eve, that was the best game!
I LOVED Parasite Eve on PS1 and I also own a 1st edition hardcover of the book! I have an obsession with mitochondria and really enjoyed your video! Thanks!
Parasite Eve 1 and 2 got me interested in this topic. Liked both games and wondered how much was true.
The complexity of the interplay between, quite literally, almost an uncountable amount of molecular machinery, functioning at speeds we cannot perceive, in conjunction with a DNA distinct lifeform, embedded within every one of our cells (Mitrocondria) is mind blowing enough but having them communicate with each other to help keep us physically and mentally healthy is well, just... like a drop the mike moment for me, awesome vid Anton!
So that's what they mean when you feel something from inside telling you to do something
Could it be that the brain of schizo person is actually just brain picking up mitochondria signals?
I've been fascinated by mitochondria ever since I first learned about them by reading biology books. So weird to me that people learn this stuff through video games, but whatever gets you educated. Reminds me of a book I read long ago which argued that tv (in this case games) were making people smarter.
So we are under control of tiny legless ratmoles? 😊
🎉 ooooo
You are awesome Anton. Thanks tremendously for this! ☀️
The force does really exist.
Midiclorians for the win!
This is the way....!
May the Four Forces be with you.
That is truly fascinating! The rabbit hole of who we actually are goes even deeper!
Thanks!
😂😂😂 you paid money on here?! It’s free to watch 😂😂😂
@Atok595 you're a simp? I'm very sorry for you.
Wonderful as always Anton. Thank you. ☺️😁
Another gem! Thank you Anton, I've shared with all my thinking friends.
Whoa! That was incredible! Ty Anton, truly mindblowing stuff
Then I guess I'm doomed to age quickly and die young because my mitochondria are always stressed from the years of depression and trauma I've been forced to endure alone.
We're here with you. Cheers ✌🏼🌻
1:39 I’m just an ever changing collection of atoms having a dream of being a human
This further explains why different species of animals evolve in similar manners under similar environmental circumstances. Because the Mitochondria design the organisms structure around their own survival. Which limits the range of potential differences in solutions when faced with the similar problems.
Fascinating stuff! Thanks Anton. 🙂
That might explain why creatine gives a big response against depression for some people including me, but unfortunately it also leaves me with anxiety/stress so I stopped taking it.
This is fascinating! Thank you wonderful person!
So, let me get this straight.
Mitochondria are probably having a little chat among themselves, plotting to get us to build A.I. just to keep them around longer?
1) Humility comes from surrendering to Mitochondria control
2) Mother's vindication comes from own Mitochondria being passed down regardless of offspring wishes....
Conclusuon: The Creator (aka God) has the best sense of humor 😅😅😅
👏👏👏 🙏
Sooo Georges Lucas was right, we got mediclorians XD
I love your videos, Anton! I love learning deeper about our mitochondria.
I need a colorful mitochondria T-shirt, sweatshirt, or hoodie!
I KNEW IT! i knew there was something off about them... like, how can you just be the powerhouse of the cell? It was so obvious that was just a disguise
Amazing video, Anton. Thank you.
Liked and shared.
Godspeed
Good stuff! Thanks Anton! 🎉
9:59 well what I’ve always imagined is that the mother is the incubator so the father brings differences so if the mom is the stable then she might hold certain foundations like an egg instead of the difference every time. It’s like sharing the current with potential. A house is a solid foundation to maintain stability and the fathers seed brings difference to help shape difference into a relative foundation. Sounds weird but just my thoughts.
11:48 yeah they might compete or cause mutations. It’s like fitting a puzzle piece into a slot, if the puzzles got an extra thing, it can cause interferences. Destabilization and relative collapse. It causes mutations or deformities probably or causes full collapse.
A wonderful video by a wonderful person. 🙂
It makes us realize how little we know and how much more we need to learn about our world.
Not only informative but inspirational.
Thank you, Anton.
Parasite Eve (パラサイト・イヴ, Parasaito Ivu) is a Japanese science fiction horror novel by Hideaki Sena, first published by Kadokawa in 1995. The book was published in North America by Vertical, Inc. in 2005.
Parasite Eve was adapted into a film and manga series. It was later expanded into three video games which is centered on a different character named Aya Brea; two that serve as sequels to the novel, along with a spin-off third game. The video games have also been adapted into a manga series.
Wow mind blown, I have always being fascinated by mitochondria in biology class and I loved those games when I found them when I was younger.
this video is mind blowing, thanks Anton.
Thanks again for the excellent post
Excellent topic! Thank you for learning and information!
Anton you are mitochodridically energized.
Thanks to the people doing the actual science as I've done none of that, but I have been suggesting that mitochondria were more than dumb generators for decades. Just as some scientists are now asking who serves who in regards to our microbiome, we can also ask whether plants serve our needs or vice-versa.
These are all symbiotic relationships where our insecurities convince us that "we" exist as separate entities from other living things or are at least masters over them; somehow a desirable, and thus survival-enhancing, concept to the human mind. Sentience allows us to sustain comfortable beliefs that, in turn, make us better servants to the microbes and plants that partner with us. "We" is something that most humans are too insecure to imagine and that bias is itself an adaptation; ignorance is literally bliss.
Ever since AP biology I realized the human ego is offended by our mitochondrial symbiosis or we would refer to our individual selves as “we.” That’s why we need our ego so we can think critically as individuals. But with too much ego we would forget we are part of the same living macroorganism, bound by a vast biome of microorganisms.
Thank you, this is fascinating material.
Very interesting subject matter, I hope to hear more soon.
love hearing a reference to one of my all time favorite games, gotta replay it soon :)
Damn, this is great stuff. Thank you! Now I have to watch it again.
This is just my opinion Anton but I was floored. This was the most amazing video you’ve done yet.
Really informative, thank you!
I love♥this topic! Co-existing and the microscopic world is like learning more about inner space which we know very little about but more than I realized has been learned.
What a great vid, thanks Anton.🏍️🇨🇦
Every time Anton smiles it makes me smile 😊
this is incredibly fascinating - and useful